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Search Results: 1 - 10 of 2520 matches for " Abdoulaye Barry "
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Pyramidal and Granule Cells Distribution through Hippocampal Fields: An Index for Sensory Information Processing  [PDF]
Abdoulaye Ba
Journal of Behavioral and Brain Science (JBBS) , 2015, DOI: 10.4236/jbbs.2015.55018
Abstract: Background: This work aims at investigating the histology of hippocampus formation as structural model of information processing. The study addressed the question whether the pattern of cellular type distribution within hippocampal fields could be used as support of information processing in the hippocampus. Method: Pyramidal-shaped neurons presenting both cytoplasm and nucleus outlined clearly were measured systematically on brain slides, using a light microscope connected to a microcomputer equipped with a scanner software for measuring particles. Morphological types of cells were identified following class sizes and their distribution determined through hippocampal fields. Results: A battery of statistical tests: Sturges’ classification, class sizes distribution around overall mean, Bartlett’s sphericity test, principal components analysis (PCA) followed by correlations matrix analysis and ANOVA allowed two cellular groups to be identified in the hippocampus: large and small pyramidal-shaped cells. Conclusion: The results show that sensory information processing in the hippocampus could be built on two classes of pyramidal neurons that differed anatomically with probably different physiological functions. The study suggests combination ensembles clustering large and small pyramidal cells at different rates, as fundamental signaling units of the hippocampus.
Multi-Scale Characteristics of Precipitation and Temperature over West Africa Using SMHI-RCA Driven by GCMs under RCP8.5  [PDF]
Abdoulaye Sarr
American Journal of Climate Change (AJCC) , 2017, DOI: 10.4236/ajcc.2017.63024
Abstract: In this paper, we use simulations from the Swedish Meteorological and Hydrological Institute (SMHI) regional climate model (RCM) version 3.5 (SMHI-RCA3.5) following a multi-GCM boundary forcing approach. The model is run at a horizontal resolution of 50 km on the CORDEX-AFRICA domain. Key characteristics of precipitation, mean temperature and its extremes (minimum and maximum temperature) have been investigated over West Africa and on 3 designed sub-domains, the Sahel (SAH), the Senegal-Gambia (SEN) and the Gulf of Guinea (GOG). The analysis covers a historical period 1981-2005 and two future time slices, an intermediate term (IT) 2031-2055 and a fat term (FT) 2071-2095, under the Representative Concentration Pathways 8.5 (RCP8.5). The regional climate model RCA, forced by the reanalysis ERA-Interim, 6 CMIP5 GCMs and their ensemble, reproduces realistically the climatology of precipitation and temperatures over West Africa. Compared to observed datasets GPCP for precipitation and CRU for temperature, the ensemble outperforms both other GCMs and the verification model (ERA-Interim). The major biases in precipitation are the early onset over the Sahel and the little dry season (LDS), from mid-July to mid-September over the Gulf of Guinea, and a few models either overestimate and/or reflect rather poorly. The strong warming in extreme temperatures (minimum and maximum) combined with the drying mainly over Western Sahel (SEN) found in this study will very likely impact notably a vital sector like agriculture, both during the near and far terms.
Imagination and Thematic Reality in the African Novel: A New Vision for African Novelists  [PDF]
Abdoulaye Hakibou
Advances in Literary Study (ALS) , 2018, DOI: 10.4236/als.2018.61002
Abstract: The present study on the topic “Imagination and thematic reality in the African novel: a new vision to African novelists” aims to show the limitation of the contribution of the African literary works to the good governance and development process of African countries through the thematic choices and to propose a new vision in relation to those thematic choices and to the structural organisation of those literary works. The study is carried out through the theory of narratology by Genette (1980) and the narrative study by Chatman (1978) as applied to the novels by Chinua Achebe, essentially on the notion of order by Genette and the elements of a narrative by Chatman. It is a thematic and structural analysis that helps the researcher to be aware of the limitation of the contribution of African fiction to the good governance of African States and their real development, for the reason that themes and the structural organisation of those works are past-oriented. In such a context, readers are supposed to decode the different messages so as to put forth the necessary behaviour from the depicted ones. But, when one compares the literary effort of the novelists with the actual positive change, one realises that the gap is still obvious. This brought the researcher to the proposal of a new thematic orientation that does not depict societal misbehaviour but rather builds an ideal society in which the character embodies what the African society should be, African society which is here our particular concern so as to be able to make up the challenge of globalisation. This is not to deny the “fictionality” of the novels, but to reinforce it with stories that are not only past-oriented. This change may constitute a new source of attraction for African future literary works.
Vesicovaginal Fistulas: Anatomical Clinical and Surgical Aspects in the Conakry University Hospital Center  [PDF]
Abdoulaye Bobo Diallo, Thierno Mamadou Oury Diallo, Ibrahima Bah, Mamadou Diawo Bah, Mamadou 2 Barry, Daouda Kanté, Oumar Raphiou Bah, Sékou Guirassy, Mamadou Bobo Diallo
Open Journal of Urology (OJU) , 2015, DOI: 10.4236/oju.2015.512036
Abstract: Objective: To analyze the management of VVF in the Service of Urology-Andrology Obstetrics and Gynecology of the University Hospital in Conakry. Materials and Methods: From January 2012 to December 2013, 152 patients with a mean age of 30 years (14 - 80 years) were hospitalized in the Departments of Urology-Andrology and Gynecology-Obstetrics of the Conakry University Hospital Center. Clinically fistulas were divided according to the classification of Benchekroun as single, complex and complicated. The fistulas were diagnosed after a minimum period of three months and the results were assessed with a mean follow-up of 7 months (range 3 to 10 months) according to the following criteria: complete healing, intermediate healing and failure. Results: Fistulas occur mainly in young multiparous women. The obstetric etiology was dominant (98%). Clinically, there were 30% simple fistulas, 46% complex fistulas and 24% of complicated fistulas. From a therapeutic standpoint, the treatment consisted of a single fistulorraphie (Chassar Moir) in 82% of cases and a fistulorraphie with interposition of healthy tissue in 18% of cases. After a mean follow-up of 7 months we obtained a healing in 62% of cases, a failure in 31% of cases and the results were intermediate in 7% of cases. Conclusion: It appears that the VVF represents a public health concern in Guinea and surgical treatment is technical difficult due to the higher frequency of complex fistulas.
Conservative Treatment in Grisel’s Syndrome Following Tonsillectomy  [PDF]
Youssouf Sogoba, Abdoulaye Barry, Issa Amadou, Boubacar Sogoba, Drissa Kanikomo, Seybou Hassane Diallo, Oumar Coulibaly, Youssoufa Maiga, Siaka Soumaoro, Dianguina dit Noumou Soumaré, Kadidiatou Singaré, Mohamed Keita
World Journal of Neuroscience (WJNS) , 2018, DOI: 10.4236/wjns.2018.81004
Abstract: Grisel’s syndrome is a rare complication that is characterized by non-traumatic atlantoaxial subluxation. It is most commonly seen in children after an upper respiratory tract infection or neck surgery, such as an adenoidectomy, tonsillectomy and mastoidectomy. Grisel’s Syndrome is characterized by torticollis and a limited range of motion of the neck with pain. Here the authors report a case of a Malian 5-year-old girl with Grisel’s syndrome following tonsillectomy. The patient’s complaints were fully resolved after 2 weeks of conservative treatment.
Deep Vein Thrombosis in HIV and Tuberculosis Treatment in a Case of a 19-Year-Old Guinean Student  [PDF]
Djibril Sylla, Amadou Kake, Abdoulaye Camara, Ibrahima Sory Barry, Ibrahima Camara, Boh Fanta Diane, Fodé Amara Traore, Mariame Beavogui, Mamadou Dadhi Balde
Open Journal of Internal Medicine (OJIM) , 2019, DOI: 10.4236/ojim.2019.91001
Abstract: The objective of this study was to describe Thrombotic manifestations and therapeutic management during HIV infection and tuberculosis in a 19-year-old male student. The objective of this study was to describe Thrombotic manifestations and therapeutic management during HIV infection and tuberculosis in a 19-year-old student. Observation: It is Mr. S. C., aged 19, admitted for pain and swelling of the right lower limb, physical asthenia and notion of fever. Evolution 5 days, with no particular history of cardiovascular disease, anti-retroviral treatment for 1 year and anti-tuberculosis treatment for 3 months. On clinical examination heart sounds are irregular with a heart rate at 115 bpm, blood pressure at 110/70 mmhg. A febrile red painful swelling at right lower limb with positive Homans sign. 0°C (Temperature 37.7°C), Weight at 58 Kg. The rest of the clinical examination is without particularity. Venous Doppler echo of the lower limbs: shows the presence of acute deep vein thrombosis of the right lateral vein. Mr. S. C. to benefit the following Medical Treatment: lovenox 0.6 UI subcutaneously morning and evening, Sintrom 4 mg 1 comprimed at night, Tramadol 50 mg morning and evening; with a good clinical evolution. CONCLUSION: TB and HIV are chronic infections that result in widespread inflammation predisposing patients to a MTVE (Venous thromboembolic disease) table as well as rifampicin and anti-proteases.
Safety of epoietin beta-quinine drug combination in children with cerebral malaria in Mali
Stéphane Picot, Anne-Lise Bienvenu, Salimata Konate, Sibiri Sissoko, Abdoulaye Barry, Elisabeth Diarra, Karidiatou Bamba, Abdoulaye Djimdé, Ogobara K Doumbo
Malaria Journal , 2009, DOI: 10.1186/1475-2875-8-169
Abstract: An open-labelled study including cerebral malaria children (Blantyre coma score below 3) was conducted in Mali. The objective was to assess the short-term safety (seven days) of erythropoietin at high doses (1,500 U/kg/day during three days) combined to quinine.35 patients with unrousable coma were included in the study. None of expected side effects of erythropoietin were observed during the seven days follow-up. No significant increase in the case fatality rate (7/35 patients) was observed compared to other studies with mortality rates ranging from 16 to 22% in similar endemic areas.These data provide the first evidence of the short-term safety of erythropoietin at high doses combined to quinine. A multicentre study is needed to assess the potential of Epo as an adjunctive therapy to increase the survival during cerebral malaria.ClinicalTrials.gov ID: NCT00697164Malaria is one of the most common life-threatening diseases in sub-Sahara Africa with a dramatic impact on public health: more than one million deaths each year. Cerebral malaria (CM) carries unacceptable case fatality rate in children despite timely and adequate chemotherapy. The SEAQUAMAT group provided the first evidence of artesunate superiority (mortality rate: 15%) compared to quinine (mortality rate: 22%) during severe falciparum malaria in adults [1]. However, available artemisinin-based combination therapy (ACT) is not associated with a complete recovery in case of severe malaria, suggesting a potential role for adjunctive therapies in the early phase of the disease. Most adjunctive therapies tested in human cerebral malaria were focussed on the modulation of the inflammatory response [2]. However, none of the trial using adjunctive therapies from data obtained in animal models provides an increase in survival or an improvement of patient outcome [3-5]. It was highlighted that most of these studies were underpowered [6]. In some cases, these adjunctive drugs were responsible for deleterious effect
Tropheryma whipplei, the Agent of Whipple's Disease, Affects the Early to Late Phagosome Transition and Survives in a Rab5- and Rab7-Positive Compartment
Giovanna Mottola, Nicolas Boucherit, Virginie Trouplin, Abdoulaye Oury Barry, Philippe Soubeyran, Jean-Louis Mege, Eric Ghigo
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089367
Abstract: Tropheryma whipplei, the agent of Whipple's disease, inhibits phago-lysosome biogenesis to create a suitable niche for its survival and replication in macrophages. To understand the mechanism by which it subverts phagosome maturation, we used biochemical and cell biological approaches to purify and characterise the intracellular compartment where Tropheryma whipplei resides using mouse bone-marrow-derived macrophages. We showed that in addition to Lamp-1, the Tropheryma whipplei phagosome is positive for Rab5 and Rab7, two GTPases required for the early to late phagosome transition. Unlike other pathogens, inhibition of PI(3)P production was not the mechanism for Rab5 stabilisation at the phagosome. Overexpression of the inactive, GDP-bound form of Rab5 bypassed the pathogen-induced blockade of phago-lysosome biogenesis. This suggests that Tropheryma whipplei blocks the switch from Rab5 to Rab7 by acting on the Rab5 GTPase cycle. A bio-informatic analysis of the Tropheryma whipplei genome revealed a glyceraldehyde-3-phosphate dehydrogenase (GAPDH) homologous with the GAPDH of Listeria monocytogenes, and this may be the bacterial protein responsible for blocking Rab5 activity. To our knowledge, Tropheryma whipplei is the first pathogen described to induce a “chimeric” phagosome stably expressing both Rab5 and Rab7, suggesting a novel and specific mechanism for subverting phagosome maturation.
Inter Atrial Communication in Adults: About 5 Cases in Guinea  [PDF]
Barry Ibrahima Sory, Baldé El Hadj Yaya, Camara Abdoulaye, Samoura Aly, Koivogui Diarra, Koivogui Kokoulo, Baldé Mamadou Dadhi, Condé Mamady
World Journal of Cardiovascular Diseases (WJCD) , 2019, DOI: 10.4236/wjcd.2019.911073
Abstract: Inter auricular communication (AIC) is the most common congenital heart disease after aortic bicuspid disease with an incidence of 5%-10% in children and 30%-40% in adults. It represents 6% to 10% of congenital heart defects with septal defect. Inter auricular communications (AIC) are the most common cardiac malformations in adults. This was a retrospective study of 5 cases of inter-auricular communication discovered in adulthood in the cardiology department of the Ignace Deen National Hospital between 01 November 2018 and 31 May 2019. The diagnosis was made by the Cardiac Doppler ultrasound. During the study period,?5 cases of AIC were registered at the cardiac department Ignace Deen. The average age of our patients was 51.8 years with extremes of 20 and 70 years. This average age is comparable to that of the literature that reports most develop symptoms after 40 years. In this study, male dominance was noted with 60% versus 40% of female cases. The evolution was marked by a death case of 20% who had AIC associated with an?inter ventricularcommunication (CIV) with signs of global heart failure and four cases had a favorable evolution or 80%.
The Geodynamic Context of the Cenozoic Volcanism of the Cap-Vert Peninsula (Senegal)  [PDF]
Abdoulaye Ndiaye, Papa Malick Ngom
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.512124
Abstract: The Cenozoic alkaline volcanism of the Senegalo-Mauritania sedimentary basin presents an episodic long-lasting volcanic activity from the Eocene-Oligocene boundary up to the Quaternary. Two volcanic episodes are usually distinguished on stratigraphical grounds: a Miocene one and a Quaternary one separated by a period of quiescence of several million years corresponding to the main phase of lateritic weathering. The Tertiary lavas are highly silica-undersaturated alkaline rocks ranging from nephelinites to basanites. They contain nepheline and fassaite-type clinopyroxene in their mineralogy. The Quaternary lavas are more evolved with Hy-normative in comparison to the Tertiary ones; they are composed of basanites and medium to coarser-grained dolerites. The distribution of the REE and other incompatible elements are typical of alkaline lavas with generally strong LREE enrichment without significant Eu anomaly. The Cenozoic Cap-Vert lavas have OIB (oceanic islands basalts)-affinities as shown by their relatively radiogenic Nd and unradiogenic Sr characters closed to the HIMU-OIB. This suggests a HIMU-type end member in the magma sources which is fairly comparable to those erupted in the Canaries and Cape Verde archipelagoes during the same period.
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