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Pain and Radiographic Outcomes in Adult Idiopathic Scoliosis Patients Using a Scoliosis Activity Suit: An 18-Month Case Controlled Chart Review  [PDF]
Mark W. Morningstar, Aatif Siddiqui, Clayton J. Stitzel, Brian Dovorany
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.69080
Abstract: There are few conservative treatment options for patients with adult idiopathic scoliosis. These typically include pharmacologic pain management, epidural injections, and generalized CAM treatments such as massage and chiropractic manipulation. The purpose of this study was to compare the post-treatment results in patients wearing the scoliosis activity suit versus baseline assessments as well as adult scoliosis patients who did not wear the activity suit. The pain and Cobb angle outcomes of 53 consecutive patients with adult idiopathic scoliosis following a trial of a scoliosis activity suit were reviewed. The average scores and measurements at 18 months were statistically significantly improved for both the quadruple numerical pain rating scale as well as Cobb angle. The scoliosis activity suit may be a viable supportive therapy for the treatment of chronic pain associated with adult idiopathic scoliosis. Further prospective studies should evaluate treatment effects of this suit using intent-to-treat methodology.
Radiographic, Pain, and Functional Outcomes in an Adult Post-Fusion Patient Using a Scoliosis Activity Suit: Comparative Results after 8 Months  [PDF]
Mark W. Morningstar, Brian Dovorany, Clayton J. Stitzel, Aatif Siddiqui
International Journal of Clinical Medicine (IJCM) , 2016, DOI: 10.4236/ijcm.2016.74028
Abstract: There are few conservative treatment options for adult patients with idiopathic scoliosis who are status post-fusion surgery. These typically include pharmacologic pain management, epidural injections, and generalized CAM treatments such as massage and chiropractic manipulation in the non-fused areas of the spine. The purpose of this study was to compare the post-treatment results in an adult post-fusion patient who wore a scoliosis activity suit for 8 months. Pain was evaluated using a quadruple visual analog scale (QVAS), while function was measured using an SRS-22r questionnaire. After 8 months of wearing the scoliosis activity suit, her pain scores improved, here SRS-22r improved, and a significant correction in radiographic Cobb angle was observed. This case report is the first to document a Cobb angle change in an adult patient wearing a scoliosis activity suit who is status post-fusion. Given that pain and dysfunction are primary reasons for scoliosis treatment in the adult population, more studies need to address the disparity between available treatments for adult scoliosis and the incidence of adult scoliosis, especially in the post-meno-pausal population. Future prospective studies should consider evaluating treatment effects of this suit using intent-to-treat methodology.
Chiropractic Rehabilitation of a Scoliosis Family: Results from a 9-Year Follow-Up  [PDF]
Mark W. Morningstar, Aatif Siddiqui, Clayton Stitzel, Brian Dovorany
Open Journal of Therapy and Rehabilitation (OJTR) , 2017, DOI: 10.4236/ojtr.2017.51003
Abstract: Scoliosis bracing is typically prescribed when the curvature reaches to between 30° - 50°. Although there has been a vast amount of bracing literature published, the results remain equivocal. Many patients face issues of compliance, comfort, and decreased self-esteem due to social stigmas with bracing. This has caused many patients to seek non-bracing options. Although these treatments are plausible, they lack the research background that bracing has. Therefore, many physicians are reluctant to prescribe exercise-based rehabilitation for their scoliosis patients. This study reports on 3 patients who sought non-bracing, exercise-based chiropractic rehabilitation for their scoliosis. Their results before, after, and at long term follow up are included.
Association between Urinary Neurotransmitter Status and Scoliosis Progression: A Case-Controlled Series  [PDF]
Mark W. Morningstar, Clayton J. Stitzel, Brian Dovorany, Aatif Siddiqui
Open Journal of Clinical Diagnostics (OJCD) , 2018, DOI: 10.4236/ojcd.2018.83003
Abstract: Previous investigations into the relationship between neurotransmitter abnormalities and idiopathic scoliosis have been mixed. The purpose of the present study was to evaluate the differences in a urinary neurotransmitter profile across three different groups. These groups included a progressive scoliosis group, a non-progressive scoliosis group, and a non-scoliotic control group. When evaluating urinary neurotransmitter levels across all groups, statistically significant differences were observed between all three groups for multiple neurotransmitters. The differences seemed to increase as the scoliosis increased in Cobb angle measurement. Further studies should seek to distinguish a potential cause or effect relationship between these neurotransmitter abnormalities and idiopathic scoliosis onset and/or progression.
Catechol-O-Methyl Transferase (COMT) Enzyme Gene Variations in Patients with Idiopathic Scoliosis: A Clinical Chart Review  [PDF]
Mark W. Morningstar, Megan N. Strauchman, Clayton J. Stitzel, Brian Dovorany, Aatif Siddiqui
Open Journal of Genetics (OJGen) , 2018, DOI: 10.4236/ojgen.2018.83004
Abstract: The effects of genomic variations and their associations with idiopathic scoliosis have been the discussion of many research trials. Previous investigations into catechol-o-methyl transferase (COMT) have identified its importance in dopamine and estrogen metabolism. While many genetic influences on idiopathic scoliosis have been observed, there has been no report of any relationship between COMT mutations and idiopathic scoliosis. The present study compared two groups of patients who received COMT genetic testing. The first group had a history of idiopathic scoliosis, while the other served as a non-scoliotic control group. The scoliosis group showed a positive COMT mutation in 33 out of 58 patients, while the control group showed 22/58 (P < 0.05). The homozygous genotype Met/Met occurred significantly more frequently in the scoliosis group. The increased incidence of COMT defects in the current scoliosis patient group warrants further study into how COMT variations may relate to the development or progression of idiopathic scoliosis.
Numerical Investigation of Phase and Group Propagation of Time-Domain Signals in a Novel Band-Reject Metamaterial Ring Hybrid  [PDF]
Omar Siddiqui
Journal of Computer and Communications (JCC) , 2015, DOI: 10.4236/jcc.2015.36002
Abstract: Phase and group propagation in metamaterial-based microwave components has always been intellectually challenging for students and engineers new to the area of periodic structures and metamaterials. This paper aims in tackling this important topic by studying the wave propagation in a metamaterial-based microwave device. Hence, the contribution of this paper is twofold. First, design of a novel metamaterial ring hybrid (or rate-race) is presented which has a large rejection band so that the second and third harmonics are effectively suppressed. Second, the electromagnetic phase and the group propagation in the ring hybrid are investigated by numerically exciting the input ports with band-limited Gaussian pulses and then finding their responses at various locations in the device.
Experimental Study of Surface and Solution Properties of Gemini -conventional Surfactant Mixtures on Solubilization of Polycyclic Aromatic Hydrocarbon  [PDF]
M. Kamil, Huma Siddiqui
Modeling and Numerical Simulation of Material Science (MNSMS) , 2013, DOI: 10.4236/mnsms.2013.34B004

Experimental data are presented on the enhanced solubilities of fluorene (FLR) resulting from solubilization in aqueous solutions of two conventional surfactants: cationic cetyltrimethylammonium bromide (CTAB) , anionic sodium dodecyl sulfate (SDS), nonioinic polyethylene glycol dodecyl ether (Brij35) and a cationic gemini bis (hexadecyldimethylammonium) pentane dibromide (G5). The critical micellar concentration of surfactants was determined by surface tension measurements and aqueous solubilities of fluorene compound in surfactant solutions were measured spectrophotometrically. Solubilization of PAH compound commenced at the surfactant critical micelle concentration and was proportional to the concentration of surfactant in micelle. The results of the mixed systems were analyzed with the help of regular solution theory, in which the deviation of CMCexp values for mixed surfactant systems from CMCideal was measured by evaluating the interaction parameter, βm. Negative values of βm were observed in all equimolar binary systems which show synergism in the mixed micelle. Attraction force between two oppositely charged head groups lead the strongest synergism effect between cationic gemini and anionic conventional surfactant. In addition to molar solubilization ratio (MSR) solubilization efficiency is also quantified in terms of micelle-water partition coefficient (Km).

Acidulation and Regeneration of Bamboo Derived Sorbents for Gas Phase Adsorption of Elemental Mercury  [PDF]
Naved Siddiqui, Jarlen Don
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.102008
Abstract: This paper presents results that illustrate the recycling of a bamboo derived sorbent used for the capture of elemental mercury (Hg0). The bamboo derived sorbent used is essentially a HCl functionalized activated carbon prepared from carbonization and CO2 activation of raw bamboo, that could potentially provide an alternative way to existing methods in removing mercury from flue gases from coal-fired plants. In this study, the bamboo derived sorbents were tested in a batch test using a mercury permeation tube as the source and nitrogen as a carrier gas. The recycling or regeneration of an activated carbon is an important issue to address from a coal-fired power plant point of view, and an attempt has been made to test the behavior of bamboo derived sorbents with various treatments including carbonized, carbonized-activated, carbonized-activated-acidulated, and then a follow-up recycled run after sample treatments in gas phase. From the study, it was found that bamboo derived activated carbon can be successfully acidulated using various normalities of HCl where weak solutions can be very effective in functionalizing the surface of the sorbent and capturing mercury. In order to recycle and reuse bamboo derived sorbents, stronger normalities of HCl would be desired.
Numerical Simulation of Asymmetric Merging Flow in a Rectangular Channel  [PDF]
Abuzar Abid Siddiqui
World Journal of Mechanics (WJM) , 2016, DOI: 10.4236/wjm.2016.64010
Abstract: The steady, asymmetric and two-dimensional flow of viscous, incompressible and Newtonian fluid through a rectangular channel with splitter plate parallel to walls is investigated numerically. Earlier, the position of the splitter plate was taken as a centreline of channel but here it is considered its different positions which cause the asymmetric behaviour of the flow field. The geometric parameter that controls the position of splitter is defined as splitter position parameter a. The plane Poiseuille flow is considered far from upstream and downstream of the splitter. This flow-problem is solved numerically by a numerical scheme comprising a fourth order method, followed by a special finite-method. This numerical scheme transforms the governing equations to system of finite-difference equations, which are solved by point S.O.R. iterative method. In addition, the results obtained are further refined and upgraded by Richardson Extrapolation method. The calculations are carried out for the ranges -1 < α < 1, and 0 ≤ R < 105. The results are compared with existing literature regarding the symmetric case (when a = 0) for velocity, vorticity and skin friction distributions. The comparison is very favourable. Moreover, the notable thing is that the decay of vorticity to its downstream value takes place over an increasingly longer scale of x as R increases for symmetric case but it is not so for asymmetric one.
Alpha-linolenic acid protects against gentamicin induced toxicity
Priyadarshini M, Aatif M, Bano B
Research and Reports in Biochemistry , 2012, DOI: http://dx.doi.org/10.2147/RRBC.S37404
Abstract: lpha-linolenic acid protects against gentamicin induced toxicity Original Research (832) Total Article Views Authors: Priyadarshini M, Aatif M, Bano B Published Date November 2012 Volume 2012:2 Pages 25 - 29 DOI: http://dx.doi.org/10.2147/RRBC.S37404 Received: 27 August 2012 Accepted: 04 October 2012 Published: 06 November 2012 Medha Priyadarshini, Mohammad Aatif, Bilqees Bano Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India Background: Recent studies indicate that reactive oxygen species are the major culprits behind the renal damage induced by gentamicin, an aminoglycoside antibiotic used to treat serious and life threatening Gram-negative infections. Experimental evidence suggests a protective role of alpha-linolenic acid supplementation against oxidative stress. The aim of the present study was to investigate the possible beneficial role of alpha-linolenic acid against gentamicin induced renal distress. Methods: Male Wistar rats were divided into three groups of eight rats each, with the first group serving as a control. The other groups were treated intraperitoneally with gentamicin 100 mg/kg body weight per day for 10 days ± alpha-linolenic acid and vitamin E (each given as 250 mg/kg body weight per day). Concentrations of creatinine, urea, cholesterol, inorganic phosphate in serum, malondialdehyde and total sulfhydryl levels, and glutathione-S-transferase, superoxide dismutase, and catalase activity in kidney tissues were determined. Results: Administration of gentamicin to rats induced marked renal failure, characterized by a profound increase in serum creatinine, urea, and cholesterol concentrations, accompanied by significant lowering of renal alkaline phosphatase and acid phosphatase activity, an increase in malondialdehyde, a decline in total sulfhydryl levels, and lowered superoxide dismutase, catalase, and glutathione-S-transferase activity. Cotreatment with alpha-linolenic acid produced amelioration in these biochemical indices of nephrotoxicity in serum as well as in tissue. Further histopathological and human studies are necessary to demonstrate the beneficial effects of alpha-linolenic acid in renal disease. Conclusion: Alpha-linolenic acid may represent a nontoxic and effective intervention strategy in gentamicin induced nephrotoxicity.
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