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Search Results: 1 - 10 of 461674 matches for " A;Rezayat "
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Journal of Research in Medical Sciences , 2003,
Abstract: Objective: In order to primary prevention in cardiovascurlar diseases to establish the relationship lipid peroxidation (Malon De Aldehide) and antioxidation capacity with posttraumatic stress disorder (PTSD). Method: MalonDeAldehide and antioxidation capacity in 30 case of PTSD were compared with 30 normals in ISFHAN Cardiovascular Research Center, using Symptoms check List 90 revised (SCL 90 R) to determine Global Symptom Index and using laboratory tests to measure MDA and antioxidation capacity. Results: The mean of GSI for cases was 2.13 and for controls was 0.41 (p < 0.05). MDA level was higher for cases (0.822 microgramg/DL in cases, 0.634 micorgramg/DL in normals, p < 0.05) while peroxidation capacity was higher for control group group (20.04% glubular hemolysis in controls, 13.16% in cases, p < 0.05). Conclusion: Lipid peroxidation and antioxication capacity as an index for primary prevention in cardiovascular and metabolic diseases, and aging process have relation with PTSD, and may be viewed as risk factor for PTSD. Imipermain and other antioxidatants were recommended for PTSD to reduce lipid peroxidation.
Preparation and in vitro characterization of chitosan nanoparticles containing Mesobuthus eupeus scorpion venom as an antigen delivery system
Mohammadpour Dounighi, N;Eskandari, R;Avadi, MR;Zolfagharian, H;Mir Mohammad Sadeghi, A;Rezayat, M;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2012, DOI: 10.1590/S1678-91992012000100006
Abstract: hydrophilic nanoparticles have been widely investigated in recent years as delivery systems for therapeutic macromolecules such as antigens. in the present study mesobuthus eupeus venom-loaded chitosan nanoparticles were prepared via ionic gelation of tripolyphosphate (tpp) and chitosan. the optimum encapsulation efficiency (91.1%) and loading capacity (76.3%) were obtained by a chitosan concentration of 2 mg/ml, chitosan-to-tpp mass ratio of 2 and m. eupeus venom concentration of 500 μg/ml. the average nanoparticle size at optimum conditions was determined by zetasizer (malvern instruments, uk). the nanoparticle size was about 370 nm (polydispersity index: 0.429) while the zeta potential was positive. transmission electron microscope (tem) imaging showed a spherical, smooth and almost homogenous structure for nanoparticles. fourier transform infrared (ftir) spectroscopy confirmed tripolyphosphoric groups of tpp linked with ammonium groups of chitosan in the nanoparticles. the in vitro release of nanoparticles showed an initial burst release of approximately 60% in the first ten hours, followed by a slow and much reduced additional release for about 60 hours. it is suggested that the chitosan nanoparticles fabricated in our study may provide a suitable alternative to traditional adjuvant systems.
Surgical Radiofrequency MAZE III Ablation for Treatment of Atrial Fibrillation During Open Heart Surgery
Rezayat Parvizi,Fariborz Akbarzadeh
Journal of Tehran University Heart Center , 2006,
Abstract: Background: Atrial fibrillation is a common arrhythmia in patients with rheumatic mitral and other valve diseases who are candidates for valve repair surgeries. Conversion of rhythm to sinus has positive effects on quality of life and lower use of medications. The aim of this clinical study was to evaluate the effectiveness of the radiofrequency ablation Maze III procedure in the treatment of atrial fibrillation associated with rheumatic heart valve disease. Methods: We applied a modified Cox III Maze procedure using radiofrequency ablation in the treatment of atrial fibrillation associated with rheumatic heart valve disease and evaluated the outcome of 20 patients of atrial fibrillation associated rheumatic valve disease who underwent radiofrequency ablation Maze III procedure plus heart valve surgery. Demographic, echocardiographic, Electrocardiographic and Doppler study data were calculated before surgery, six month and one year after surgery.. Results: No perioperative deaths occurred in the study group. Duration of additional time for doing radiofrequency ablation was about 22 minutes. Freedom from atrial fibrillation was 85% and 75% at six months and one year follow-up respectively... Conclusions: The addition of the radiofrequency ablation Maze procedure to heart valve surgery is safe and effective in the treatment of atrial fibrillation associated with rheumatic heart valve disease.
Outcome of Coronary Artery Bypass Grafts: Comparison between on Pump and off Pump
Rasoul Ibrahim Abdulrahman,Rezayat Parvizi
Acta Medica Iranica , 2010,
Abstract: The present study was undertaken to compare the in hospital results of coronary artery bypass graft (CABG) with (on pump) or without (off pump) cardiopulmonary bypass (CPB). Data were collected on all first-time isolated CABGs with saphenous vein and/or artery grafts at Shahid Madani Hospital in Tabriz-Iran, between 2006 and 2009. Age and clinical profile were marched between on pump and off pump group patients. Patients with concomitant cardiac operations or beating pump technique were excluded from the study. The study included 994 patients; CABG with CPB (ONCABG) was done in 578 (58%) and CABG without CPB (OPCABG) in 416 (42%). For pump and off pump group respectively, mortality rate was 2/3%, and 0.2%, the number of grafts was2/92 ± 0.82 and 2/12 ±o.73 and the use of intra aortic balloon-pump (IABP) was1.5% and5.4%. Post operative ejection fraction (EF) was improved in off pump group (47.9±0.6) versus on pump group (44.53±1.5) and the latter group had more post operative atrial fibrillation, Stroke, acute renal failure, bleeding rate and blood products transfusion, prolonged intubation time but was not statistically significance. Meanwhile Hospitalization time and use of inotrops was less in comparison with former patients group. Off pump CABG was a safe method in our series. Patients with comparable risk profiles have similar prevalence's of selected complications after ONCABG and OPCABG, though some clinical and hemodynamic results are better with off pump technique.
The Role of Immune System in Depression Disorder  [PDF]
Fatemeh Hoseinzadeh, Porya Hassan Abadi, Mehdi Agheltar, Arvin Aghayinejad, Farnaz Torabian, Arash Akhavan Rezayat, Farzad Akbarzadeh, Hamid Reza Rahimi
Health (Health) , 2016, DOI: 10.4236/health.2016.815167
Abstract: In order to diagnose a major depressive disorder, patients must have at least 5 depres-sive symptoms out of 9 criteria, present for at least two weeks. Depressive symptoms include absence of concentration, fatigue and suicidal ideation. The intensity of de-pression symptoms affects the severity of depression and the degree of the impact on the quality of life. Major depressive disorders (MDD) are defined as a significant health problem, and are estimated to rise in prevalence in the future years. Immune cytokine, associated with major depression for instance, is the interleukin IL-6 and tu-mor necrosis factor (TNF-α) which is defined as pro-inflammatory cytokines, can ac-tivate an inflammatory response. The effects of other inflammatory cytokines on the central nervous system are of controversy. There is an increasing interest about the ef-fect of cytokines derived from innate immune system on the brain and behavior. Cytokines are defined as large sized proteins, mainly produced by immune cells. Two subtypes of cytokines exist: pro-inflammatory cytokines, facilitating inflammatory re-sponses and neural activities; and anti-inflammatory cytokines, inhibiting inflammatory processes. Besides microglia and astrocytes, immune cells such as monocytes, macrophages, and lymphocytes also produce cytokines. At the times of immunological alterations, infections or inflammation, cytokines will be in an activated form. The main goal of the current review study is to investigate the role of the immune system in the depression disorder.
The effect of acetaminophen nanoparticles on liver toxicity in a rat model
Esmaeil Biazar, S Mahdi Rezayat, Naser Montazeri, et al
International Journal of Nanomedicine , 2010, DOI: http://dx.doi.org/10.2147/IJN.S5894
Abstract: t of acetaminophen nanoparticles on liver toxicity in a rat model Original Research (6408) Total Article Views Authors: Esmaeil Biazar, S Mahdi Rezayat, Naser Montazeri, et al Published Date March 2010 Volume 2010:5 Pages 197 - 201 DOI: http://dx.doi.org/10.2147/IJN.S5894 Esmaeil Biazar1, S Mahdi Rezayat2, Naser Montazeri1, Khalil Pourshamsian1, Reza Zeinali3, Azadeh Asefnejad3, Mehdi Rahimi3, Mohammadmajid Zadehzare3, Mehran Mahmoudi3, Rohollah Mazinani3, Mehdi Ziaei3 1Department of Chemistry, Islamic Azad University, Tonekabon Branch, Mazandaran, Iran; 2Department of Pharmacology, School of Medicine, Tehran University of Medical Science, Tehran, Iran; 3Biomedical Engineering, Islamic Azad University, Research and Science Branch, Tehran, Iran Abstract: Acetaminophen, a pain-reliever, is one of the most widely used medications in the world. Acetaminophen with normal dosage is considered a nontoxic drug for therapeutic applications, but when taken at overdose levels it produces liver damage in human and various animal species. By a high energy mechanically activated method, we produced acetaminophen in a nanometer crystalline size (24 nm). Forty-eight hours after injection of crystalline particles with normal and reduced size of our drug, the effect of liver toxicity was compared by determination of liver transferase enzymes such as alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase (ALT). These enzymes were examined by routine colorimetric methods using commercial kits and pathologic investigations. Statistical analysis and pathological figures indicated that ALT delivery and toxicity in reduced size acetaminophen was significantly reduced when compared with normal size acetaminophen. Pathology figures exhibited reduced necrosis effects, especially the confluent necrosis, in the central part of the lobule in the reduced size acetaminophen samples when compared with the normal samples.
Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy
Asieh Hosseini, Mohammad Sharifzadeh, Seyed Mahdi Rezayat, et al
International Journal of Nanomedicine , 2010, DOI: http://dx.doi.org/10.2147/IJN.S11643
Abstract: enefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy Original Research (7856) Total Article Views Authors: Asieh Hosseini, Mohammad Sharifzadeh, Seyed Mahdi Rezayat, et al Published Date July 2010 Volume 2010:5 Pages 517 - 523 DOI: http://dx.doi.org/10.2147/IJN.S11643 Asieh Hosseini1, Mohammad Sharifzadeh1, Seyed Mahdi Rezayat2, Gholamreza Hassanzadeh3, Shokoufeh Hassani1, Maryam Baeeri1, Vahid Shetab-Bushehri4, Dmitry A Kuznetsov5, Mohammad Abdollahi1 1Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran; 2Faculty of Advanced Science and Technology in Medicine, Tehran University of Medical Sciences and Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran; 3Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 4Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; 5Department of Medicinal Nanobiotechnologies, N. I. Pirogoff Russian State Medical University, Moscow, Russian Federation Abstract: Diabetic neuropathy (DN) is a debilitating disorder occurring in most diabetic patients without a viable treatment yet. The present work examined the protective effect of 25Mg-PMC16 nanoparticle (porphyrin adducts of cyclohexil fullerene-C60) in a rat model of streptozotocin (STZ)-induced DN. 25Mg-PMC16 (0.5 lethal dose50 [LD50]) was administered intravenously in two consecutive days before intraperitoneal injection of STZ (45 mg/kg). 24Mg-PMC16 and MgCl2 were used as controls. Blood 2,3-diphosphoglycerate (2,3-DPG), oxidative stress biomarkers, adenosine triphosphate (ATP) level in dorsal root ganglion (DRG) neurons were determined as biomarkers of DN. Results indicated that 2,3-DPG and ATP decreased whereas oxidative stress increased by induction of DN which all were improved in 25Mg-PMC16-treated animals. No significant changes were observed by administration of 24Mg-PMC16 or MgCl2 in DN rats. It is concluded that in DN, oxidative stress initiates injuries to DRG neurons that finally results in death of neurons whereas administration of 25Mg-PMC16 by release of Mg and increasing ATP acts protectively.
Evaluation of potency of measles vaccine used in Iran: comparison of WHO and NIBSC method in cell culture
Shohreh Tavajohi,Hossein Rastegar,Seyed Nasser Ostad,Seyed Mehdi Rezayat
Iranian Journal of Pharmaceutical Research , 2005,
Abstract: Measles has been a major cause of illness and death in children and vaccination against the disease is part of the WHO global immunization program. A suitable vaccine should create maximum immuneresponse against the pathogen and must be safe for the user. Thus, after production, vaccines must be analyzed and controlled by the producer and confirm by relevant governmental organizations. TheFood and Drug Control Lab (FDCL), Ministry of Health, is the secondary control center on potency of vaccines in Iran. In this study, we have set up the WHO and NIBSC methods in FDCL and comparethese methods on determining the potency of measles vaccine.Measles vaccines were obtained from Razi Institute Iran. Nine dilutions of vaccine (10-1 to 10-5) in 0.5 log interval were mixed with Vero cell suspension and seeded. In WHO method, the cells wereincubated at 36oC for 10 days, during which the cells were checked for cytopatic changes everyday. To set up the assay, we tested the vaccine dilution with four different cell suspensions (2×105-5×104/well) and four different concentration of serum (2.5-10%). Based on our results, in the assays, 5% serum and 1×105 cells were used. The potency assay was performed with six different vaccines produced in one batch and the mean potency for Measles was 104.32 ± 0.24 CCID50/vial for a ten-dose vial. In NIBSC method following seeding of Vero cells, the medium was removed after 3 hours and overlay was added. Then the plates were incubated at 35oC for 10 days. After incubation period, the overlay was removed, the plaques were stained with methyl violet and counted. This assay was repeated three times and the mean of the results was 5.83 ± 0.03 log10 PFU/dose. In this study, we have set up the WHO and NIBSC methods and results indicated that the potency of the vaccine is in acceptable range in either method. Furthermore, the WHO method is simple and less time consuming compared to NIBSC which is complicated and requires more effort to produce reproducible results.
H. R. Jamshidi,M. Rezayat M. R. Zarrindast
Acta Medica Iranica , 2004,
Abstract: In the present study, the effect of apamin (potassium channel blocker) on tolerance to cocaine-induced locomotor activity in mice has been investigated. Locomotor activity was measured by locomotor activity meter, Animax, type S (LKB, Farrad). Intraperitoneal (IP) injection of different doses of cocaine (2.5, 5, 10 and 15 mg/kg) produced dose-dependent locomotor activity in mice.Animals were treated with a dose of cocaine (60 mg/kg, IP) once daily, for 2, 3 or 4 days in order to produce tolerance to cocaine-induced locomotion. Twenty-four hours after the last dose of cocaine, locomotor activity induced by a test dose of cocaine (10 mg/kg) was assessed. Animals pretreated with apamin (0.1 mg/kg) 30 min before the test dose of cocaine had a decreased cocaine response. However, daily treatment of animals with apamin (0.1 mg/kg), 30 min after cocaine (60 mg/kg) for 3 days (during development of tolerance to cocaine-induced locomotion), did not alter the cocaine effect. Single administration of apamin to mice did not cause any response. It is concluded that, apamin as a potassium channels blocker may decrease tolerance to cocaine-induced locomotion due to blockade of potassium channels.
J. Esmaeili,M. Mohebali,G. H. Edrissian,S. M. Rezayat
Acta Medica Iranica , 2008,
Abstract: Cutaneous leishmaniasis is endemic in 88 different countries. There are an estimated 1.5 million new cases each year, with over 90% occurring in Afghanistan, Algeria, Iran, Iraq, Saudi Arabia, Syria (Old World) and in Brazil and Peru (New World). Miltefosine is effective in vitro and in vivo against Leishmania species and it was demonstrated efficacy in animals via the oral route. This study is the first one for evaluating the effect of miltefosine on cutaneous leishmaniasis of L. major (MRHO/IR/75/ER) by in vivo and in vitro studies in the BALB/c mouse model. As it was shown, miltefosine has a better effect on reduction of size of lesion compared to Glucantime , also it was not significant by statistical analysis. The results of this study show that miltefosine has a good activity against the proliferation of amastigotes of L. major. The results suggest that oral miltefosine might be a promising approach for developing new anti-Leishmanial drugs.
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