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Search Results: 1 - 10 of 602695 matches for " A.C.;Castillo-Henkel "
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The methyl ester of rosuvastatin elicited an endothelium-independent and 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent relaxant effect in rat aorta
López-Canales, J.S.;López-Sanchez, P.;Perez-Alvarez, V.M.;Wens-Flores, I.;Polanco, A.C.;Castillo-Henkel, E.;Castillo-Henkel, C.;
Brazilian Journal of Medical and Biological Research , 2011, DOI: 10.1590/S0100-879X2011007500032
Abstract: the relaxant effect of the methyl ester of rosuvastatin was evaluated on aortic rings from male wistar rats (250-300 g, 6 rats for each experimental group) with and without endothelium precontracted with 1.0 μm phenylephrine. the methyl ester presented a slightly greater potency than rosuvastatin in relaxing aortic rings, with log ic50 values of -6.88 and -6.07 m, respectively. unlike rosuvastatin, the effect of its methyl ester was endothelium-independent. pretreatment with 10 μm indomethacin did not inhibit, and pretreatment with 1 mm mevalonate only modestly inhibited the relaxant effect of the methyl ester. nω-nitro-l-arginine methyl ester (l-name, 10 μm), the selective nitric oxide-2 (no-2) inhibitor 1400 w (10 μm), tetraethylammonium (tea, 10 mm), and cycloheximide (10 μm) partially inhibited the relaxant effect of the methyl ester on endothelium-denuded aortic rings. however, the combination of tea plus either l-name or cycloheximide completely inhibited the relaxant effect. inducible no synthase (nos-2) was only present in endothelium-denuded aortic rings, as demonstrated by immunoblot with methyl ester-treated rings. in conclusion, whereas rosuvastatin was associated with a relaxant effect dependent on endothelium and hydroxymethylglutaryl coenzyme a reductase in rat aorta, the methyl ester of rosuvastatin exhibited an endothelium-independent and only slightly hydroxymethylglutaryl coenzyme a reductase-dependent relaxant effect. both no produced by nos-2 and k+ channels are involved in the relaxant effect of the methyl ester of rosuvastatin.
Efectos contráctiles dependientes del calcio intracelular inducidos por la serotonina en la arteria umbilical humana
Briones-Gardu?o, Jesús Carlos;Castillo-Henkel, Carlos;López-Canales, Jorge Skiold;Díaz de León-Ponce, Manuel;
Gaceta médica de México , 2005,
Abstract: background: absence of innervation is a hallmark of human umbilical vessels. intervillous space blood flow is regulated by vasoactive substances and calcium dependent contractility, both in normal and pathological conditions such as preeclampsia eclampsia. objective: to obtain additional information on the intracellular calcium contractile effects of serotonin in human umbilical arteries. materials and methods: umbilical arteries from normal pregnancies were dissected, cut in 5 mm rings and mounted in a temperature controlled isolated organ chamber, using calciumfree krebs solution. the contractile effects of serotonin, lantane, verapamil and cyclopiazonic acid were evaluated at different concentrations using a computer coupled biopac polygraph. results: no differences in response were observed in the presence and absence of intracellular calcium. the positive contractile effects observed with serotonin were significantly decreased with repeated stimulation. an increase in the basal tone of the vessel was observed after calcium supplementation was added to the solution. this effect was minimized in the presence of verapamil and lantane. the contractile effects of serotonin in the calcium free solution were not affected by the presence of cyclopiazonic acid. conclusions: serotonin contractile effects in the human umbilical artery depend mainly on intracellular calcium levels which favor the gradual entrance of this ion over time. calcium influx induced by serotonin is possible through l and non-l channels apparently insensitive to cyclopiozonic acid.
Role of ACTH receptor in adrenocortical tumor formation
Latronico, A.C.;
Brazilian Journal of Medical and Biological Research , 2000, DOI: 10.1590/S0100-879X2000001000016
Abstract: adrenocorticotrophin (acth) is the major regulatory hormone of steroid synthesis and secretion by adrenocortical cells. the actions of acth are mediated by its specific membrane receptor (acth-r). the human acth-r gene was recently cloned, allowing systematic determination of its sequence, expression and function in adrenal tumorigenesis. the presence of oncogenic mutations of the acth-r gene in adrenocortical tumors has been reported. direct sequencing of the entire coding region of the acth-r gene of sporadic adrenocortical adenomas and carcinomas did not reveal constitutive activating mutations, indicating that this mechanism is not frequent in human adrenocortical tumorigenesis. recent studies demonstrated allelic loss of the acth-r gene in a subset of sporadic adrenocortical tumors using a psti polymorphism located in the promoter region of the acth-r gene. loss of heterozygosity of the acth-r was analyzed in 20 informative patients with a variety of benign and malignant adrenocortical tumors. three of them showed loss of heterozygosity of the acth-r gene. in addition, northern blot experiments demonstrated reduced expression of acth-r mrna in these three tumors with loss of heterozygosity, suggesting the functional significance of this finding at the transcriptional level. deletion of the acth-r gene seems to be involved in a subset of human adrenocortical tumors, contributing to cellular dedifferentiation.
Algumas observa??es sobre o círculo de Apol?nio e o seu emprego no método das imagens
Tort, A.C.;
Revista Brasileira de Ensino de Física , 2011, DOI: 10.1590/S1806-11172011000100028
Abstract: in plane geometry, the circle is defined as the set of all points at the same distance from an arbitrary point , also belonging to the plane. the great greek mathematician apollonius of perga (c. 262 b.c - 190 b.c.) discovered an alternative way of defining the circle. the circle of apolonius can be used in the solution of the problem concerning the electrostatic interaction between a conducting sphere and a point charge.
Quaternions, números complexos e os ensembles de matrizes aleatórias
Bertuola, A.C;
Revista Brasileira de Ensino de Física , 2009, DOI: 10.1590/S1806-11172009000400011
Abstract: in this work two ensembles of random matrices are built with refinements of details. they are them ensemble unitary gaussian whose elements of the matrices are complex numbers and ensemble gaussian symplectic containing matrices with quaternions elements.
Gauss's law, infinite homogenous charge distributions and Helmholtz theorem
Tort, A.C.;
Revista Brasileira de Ensino de Física , 2011, DOI: 10.1590/S1806-11172011000200020
Abstract: we rediscuss the validity of gauss's law in the case of homogenous discrete and continuous charge distributions fulfilling all space.
Dois problemas práticos de eletricidade Vitoriana e sua discuss?o no ensino secundário e universitário
Tort, A.C.;
Revista Brasileira de Ensino de Física , 2009, DOI: 10.1590/S1806-11172009000200005
Abstract: two problems inspired by paul nahin's biography of oliver heaviside, the home illumination problem and the determination of the leakage point in an undersea telegraphic cable are presented, discussed and solved in the framework of the applied electricity of the victorian age. the two problems are concrete and at the same time relatively simple illustrations of the intricate interconnections between physics and the world of practical affairs. basic elements of the theory of direct current circuits, as for example ohm's law, and high school algebra are the only tools we need to discuss them in class, at the high school level or at the fundamental university physics one.
Hospitais universitários: passado, presente e futuro
Revista da Associa??o Médica Brasileira , 2001, DOI: 10.1590/S0104-42302001000200034
Abstract: purpose: this article discusses the evolution of university hospitals, their characteristics, functioning and financing and their role in medical education and research. methods: data come from a workshop organized by the world health organization on university hospitals in 22 countries. results: the main finding is that these institutions are increasingly inadequate to the reality of the health sector in which they operate and to the challenges posed by the profound changes currently taking place in the health system of most countries. conclusion: a reform is needed, and the article presents a few possible strategies for reforming these hospitals.
The preparation, separation and kinetic studies of the opening of the chelate rings of the isomers of bis(-aspartato) and trls(-glycinato) copper(II) complexes
A.C. Ukwueze
Bulletin of the Chemical Society of Ethiopia , 1992,
Abstract: BuII. Chem. Soc. Ethiop. 1992, 6(2) 87-95.
The implications of culture for dictionaries of the African languages
A.C Nkabinde
Lexikos , 2003,
Abstract: This article attempts to show how culture or aspects thereof can be used to comple-ment linguistic and other information in the compilation of dictionaries of African languages. Some obstacles in the way of achieving this goal are identified and proposals made on how to deal with them. Although only some cultural aspects of a single language are examined, the conclusions are valid for cultural aspects of all African languages.
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