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Search Results: 1 - 10 of 592321 matches for " A. L.;Sanson "
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Factors associated with consultation behaviour for primary symptoms potentially indicating colorectal cancer: A cross-sectional study on response to symptoms
Courtney Ryan J,Paul Christine L,Sanson-Fisher Robert W,Macrae Finlay A
BMC Gastroenterology , 2012, DOI: 10.1186/1471-230x-12-100
Abstract: Background Little data exists on the factors associated with health care seeking behaviour for primary symptoms of colorectal cancer (CRC). This study aimed to identify individual, provider and psychosocial factors associated with (i) ever seeking medical advice and (ii) seeking early medical advice for primary symptoms of colorectal cancer (CRC). Methods 1592 persons aged 56–88 years randomly selected from the Hunter Community Study (HCS) were sent a questionnaire. Results Males and those who had received screening advice from a doctor were at significantly higher odds of ever seeking medical advice for rectal bleeding. Persons who had private health coverage, consulted a doctor because the ‘symptom was serious’, or who did not wait to consult a doctor for another reason were at significantly higher odds of seeking early medical advice (< 2 weeks). For change in bowel habit, persons with lower income, within the healthy weight range, or who had discussed their family history of CRC irrespective of whether informed of ‘increased risk’ were at significantly higher odds of ever seeking medical advice. Persons frequenting their GP less often and seeing their doctor because the symptom persisted were at significantly higher odds of seeking early medical advice (< 2 weeks). Conclusions The seriousness of symptoms, importance of early detection, and prompt consultation must be articulated in health messages to at-risk persons. This study identified modifiable factors, both individual and provider-related to consultation behaviour. Effective health promotion efforts must heed these factors and target sub-groups less likely to seek early medical advice.
Alumina ceramics obtained by chemical synthesis using conventional and microwave sintering
Thomazini, D.;Gelfuso, M. V.;Chinelatto, A. S. A.;Chinelatto, A. L.;Sanson, F. K.;Teixeira Neto, F.;
Ceramica , 2011, DOI: 10.1590/S0366-69132011000100006
Abstract: it is well known that the heating mechanism and powder precursor define the microstructural characteristics of ceramics. especially abnormal grain growth of pure alumina ceramics developed during conventional sintering method suggests that this material is a potential candidate to be treated in microwave sintering process. alumina ceramics produced with commercial (a1k) and chemically synthesized powders were sintered in conventional and microwave furnaces. two methods were employed to prepare the chemically synthesized nanosized powders: pechini method and emulsification with oleic acid. the microwave sintered samples were characterized by apparent density and scanning electron microscopy and compared with the samples sintered in a conventional furnace. alumina ceramics sintered in the microwave furnace had fine grained microstructure, not related with the starting powders. this characteristic was achieved in a sintering time shorter than those produced in the conventional furnace. however, satisfactory densification was observed only to a1k ceramics (3.95 g/cm3) sintered during one hour in microwave furnace.
Colorectal cancer risk assessment and screening recommendation: a community survey of healthcare providers' practice from a patient perspective
Ryan J Courtney, Christine L Paul, Robert W Sanson-Fisher, Finlay A Macrae, Mariko L Carey, John Attia, Mark McEvoy
BMC Family Practice , 2012, DOI: 10.1186/1471-2296-13-17
Abstract: 1592 persons aged 56-88 years randomly selected from the Hunter Community Study (HCS), New South Wales, Australia were mailed a questionnaire. 1117 participants (70%) returned a questionnaire.Thirty eight percent of respondents reported ever being asked about their family history of CRC. Ever discussing family history of CRC with a health care provider was significantly more likely to occur for persons with a higher level of education, who had ever received screening advice and with a lower physical component summary score. Fifty one percent of persons at "moderately/potentially high risk" were notified of their "increased risk" of developing CRC. Thirty one percent of persons across each level of risk had ever received CRC screening advice from a health care provider. Screening advice provision was significantly more likely to occur for persons who had ever discussed their family history of CRC with a health care provider and who were at "moderately/potentially high risk".Effective interventions that integrate both the assessment and notification of familial risk of CRC to the wider population are needed. Systematic and cost-effective mechanisms that facilitate family history collection, risk assessment and provision of screening advice within the primary health care setting are required.Worldwide, CRC comprises 9.4% of all cancer cases with one million diagnoses annually [1]. Survival from CRC is highly stage-dependent yet fewer than 40% of CRCs are diagnosed at a localised stage [2]. Screening is a cost-effective mechanism that reduces the incidence and mortality associated with CRC [3-5]. Population-based screening is recommended for those aged 50 years or older, with average-risk persons recommended to receive periodical Faecal Occult Blood Test (FOBT) screening or endoscopy screening, dependent on screening guidelines [6,7]. Several randomised controlled trials (RCTs) have indicated it is possible to reduce mortality from CRC mortality by 15% to 33% with Faeca
VapC from the Leptospiral VapBC Toxin-Antitoxin Module Displays Ribonuclease Activity on the Initiator tRNA
Alexandre P. Y. Lopes, Luana M. Lopes, Tatiana R. Fraga, Rosa M. Chura-Chambi, André L. Sanson, Elisabeth Cheng, Erika Nakajima, Ligia Morganti, Elizabeth A. L. Martins
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101678
Abstract: The prokaryotic ubiquitous Toxin-Antitoxin (TA) operons encode a stable toxin and an unstable antitoxin. The most accepted hypothesis of the physiological function of the TA system is the reversible cessation of cellular growth under stress conditions. The major TA family, VapBC is present in the spirochaete Leptospira interrogans. VapBC modules are classified based on the presence of a predicted ribonucleasic PIN domain in the VapC toxin. The expression of the leptospiral VapC in E. coli promotes a strong bacterial growth arrestment, making it difficult to express the recombinant protein. Nevertheless, we showed that long term induction of expression in E. coli enabled the recovery of VapC in inclusion bodies. The recombinant protein was successfully refolded by high hydrostatic pressure, providing a new method to obtain the toxin in a soluble and active form. The structural integrity of the recombinant VapB and VapC proteins was assessed by circular dichroism spectroscopy. Physical interaction between the VapC toxin and the VapB antitoxin was demonstrated in vivo and in vitro by pull down and ligand affinity blotting assays, respectively, thereby indicating the ultimate mechanism by which the activity of the toxin is regulated in bacteria. The predicted model of the leptospiral VapC structure closely matches the Shigella's VapC X-ray structure. In agreement, the ribonuclease activity of the leptospiral VapC was similar to the activity described for Shigella's VapC, as demonstrated by the cleavage of tRNAfMet and by the absence of unspecific activity towards E. coli rRNA. This finding suggests that the cleavage of the initiator transfer RNA may represent a common mechanism to a larger group of bacteria and potentially configures a mechanism of post-transcriptional regulation leading to the inhibition of global translation.
HDL Induces the Expression of the M2 Macrophage Markers Arginase 1 and Fizz-1 in a STAT6-Dependent Process
Marie Sanson, Emilie Distel, Edward A. Fisher
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074676
Abstract: Our lab has previously shown in a mouse model that normalization of a low HDL level achieves atherosclerotic plaque regression. This included the shift from a pro (“M1”) to an anti-inflammatory (“M2”) phenotypic state of plaque macrophages. Whether HDL can directly cause this phenotypic change and, if so, what the signaling mechanism is, were explored in the present studies. Murine primary macrophages treated with HDL showed increased gene expression for the M2 markers Arginase-1 (Arg-1) and Fizz-1, which are classically induced by IL-4. HDL was able to potentiate the IL-4-induced changes in Arg-1, and tended to do the same for Fizz-1, while suppressing the expression of inflammatory genes in response to IFNγ. The effects of either IL-4 or HDL were suppressed when macrophages were from STAT6-/- mice, but inhibitor studies suggested differential utilization of JAK isoforms by IL-4 and HDL to activate STAT6 by phosphorylation. Overall, our results describe a new function of HDL, namely its ability to directly enrich macrophages in markers of the M2, anti-inflammatory, state in a process requiring STAT6.
Stolen Manuscript: Lessons Learnt
Jacqueline Sanson
Liber Quarterly : The Journal of European Research Libraries , 2008,
Abstract: In 2000, the 13th-century Hebrew Bible, known as Hebrew 52, was discovered missing at the National Library of France. Investigations led to the arrest of the National Library of France's chief curator of Hebrew Collection Michel Garel in 2004. In response to this event the National Library of France has implemented a security plan which includes four main fields: spaces and access controls, preservation and control of collections, measures applied to library staff and readers, and national and international cooperation.
Les collections deux ans après le déménagement
Jacqueline Sanson
Liber Quarterly : The Journal of European Research Libraries , 2000,
Abstract: Toutes les bibliothèques – et particulièrement les bibliothèques nationales dont la mission essentielle est de conserver le patrimoine – sont confrontées à des problèmes de place. Le batiment de Tolbiac a été en grande partie créé pour répondre aux besoins croissants de stockage de la Bibliothèque nationale et par conséquent assurer une meilleure conservation à ses collections. Mon exposé s’articulera en trois parties: en premier lieu, il me para t nécessaire de donner un bref rappel de la situation antérieure; ensuite, seront abordées la logique d’implantation, les spécifications techniques de magasinage et de conservation dans les nouveaux batiments; enfin, le point sera fait sur les améliorations et les difficultés rencontrées à peine deux ans après le déménagement des collections.
La mise en ouvre de la réplique d'Ekain et de sa scénographie : Mon hommage à Jesús Altuna
Renaud Sanson
Munibe Antropologia-Arkeologia , 2005,
Abstract: Réflexions à propos de la mise en oeuvre de la réplique de la Grotte d’Ekain:* Une pratique innovante du fait pariétal et l’invention d’une technologie appliquée spécifique.* Lé création d’une scénographie au service de la révélation de l’Art d’Ekain alliant émotion et connaissance. Respect de l’oeuvre originale et du visiteurs : une dimension éthique de l’art de la réplique.
A population-based cross-sectional study of colorectal cancer screening practices of first-degree relatives of colorectal cancer patients
Courtney Ryan J,Paul Christine L,Carey Mariko L,Sanson-Fisher Robert W
BMC Cancer , 2013, DOI: 10.1186/1471-2407-13-13
Abstract: Background The aim of this study was to determine the proportions and predictors of first-degree relatives (FDRs) of colorectal cancer (CRC) patients (i) ever receiving any CRC testing and (ii) receiving CRC screening in accordance with CRC screening guidelines. Methods Colorectal cancer patients and their FDRs were recruited through the population-based Victorian Cancer Registry, Victoria, Australia. Seven hundred and seven FDRs completed telephone interviews. Of these, 405 FDRs were deemed asymptomatic and eligible for analysis. Results Sixty-nine percent of FDRs had ever received any CRC testing. First-degree relatives of older age, those with private health insurance, siblings and FDRs who had ever been asked about family history of CRC by a doctor were significantly more likely than their counterparts to have ever received CRC testing. Twenty-five percent of FDRs “at or slightly above average risk” were adherent to CRC screening guidelines. For this group, adherence to guideline-recommended screening was significantly more likely to occur for male FDRs and those with a higher level of education. For persons at “moderately increased risk” and “potentially high risk”, 47% and 49% respectively adhered to CRC screening guidelines. For this group, guideline-recommended screening was significantly more likely to occur for FDRs who were living in metropolitan areas, siblings, those married or partnered and those ever asked about family history of CRC. Conclusions A significant level of non-compliance with screening guidelines was evident among FDRs. Improved CRC screening in accordance with guidelines and effective systematic interventions to increase screening rates among population groups experiencing inequality are needed. Trial Registration Australian and New Zealand Clinical Trial Registry: ACTRN12609000628246
A cross-sectional study assessing the self-reported weight loss strategies used by adult Australian general practice patients
Sze Lin Yoong, Carey L Mariko, Robert W Sanson-Fisher, Catherine D'Este
BMC Family Practice , 2012, DOI: 10.1186/1471-2296-13-48
Abstract: Adult patients completed a touchscreen computer survey while waiting for their appointment. Responses from 1335 patients in twelve Australian practices are reported.A larger proportion of obese patients had tried to lose weight in the past 12?months (73%) compared to those who were overweight (55%) and normal weight (33%). The most commonly used strategy used was changing diet and increasing exercise in all BMI categories. Less than 10% used strategies such as prescription medication, over the counter supplements and consulted a weight loss specialist. Low calorie and low fat diets were the most frequently reported diets used to lose weight in those who were normal weight, overweight and obese. Overall, the proportion seeking GP advice was low, with 12% of normal weight, 15% of overweight and 43% of obese patients consulting their GP prior to trying to lose weight.A large proportion of overweight or obese patients have tried to lose weight and utilized strategies such as changing diet and increasing exercise. Most attempts however were unassisted, with low rates of consultation with GPs and weight loss specialists. Ways to assist overweight and obese general practice patients with their weight loss attempts need to be identified.
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