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Search Results: 1 - 10 of 842907 matches for " A. K. L. Kabir and A.S.S. Rouf "
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DEVELOPMENT AND IN VITRO EVALUATION OF ONCE DAILY CARBAMAZEPINE MATRIX TABLET FROM HYDROPHILIC POLYMERS
Sharifa Sultana , Harun-Or-Rashid , Shimul Halder*, A. K. L. Kabir and A.S.S. Rouf
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: ABSTRACT: The purpose of study was to develop and characterize once daily extended release matrix tablets of Carbamazepine (CBZ), an antiepileptic drug. Tablets were prepared by wet granulation method. Methocel K15M CR and Methocel K100LV CR polymers were used as rate retarding agents in fourteen formulations. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity, drug content etc. and showed satisfactory results. The tablets were subjected to thickness, weight variation test, drug content, hardness, friability and in vitro release studies. All the tablet formulations showed acceptable pharmacotechnical properties and complied with pharmacopoeial specifications for tested parameters. The in vitro dissolution study was carried out for 24 hour in distilled water as the dissolution medium. The release mechanisms were explored and explained by Zero order, Higuchi, First order, Korsmeyer-Peppas and Hixson-Crowell equations. Primarily nine formulations were prepared by using three variable ratios of the two polymers, with 1% sodium lauryl sulphate. The optimized formulations F-5, F-6 and F-9 were further studied to know the effect of solubilizer on release by using various concentration of sodium lauryl sulphate and glyceryl mono stearate. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism followed anomalous type or non-Fickian transport and super case II transport. The release of drug was extended for 24 hour by polymer combinations which indicated the usefulness of the formulations for once daily dosage form. Besides, these studies explored both of the optimum concentration, effect of polymers and the use of sodium lauryl sulphate on CBZ release pattern from the tablet matrix for 24 hour period.
Evaluation of bisphenol A content in food from lacquered cans
G.H.M. Biego, A.S.S. Oga, K.D. Yao, L.P. Kouadio
Bulletin of the Chemical Society of Ethiopia , 2010,
Abstract: This study describes the migration of bisphenol A from the cans to the food content through experimental tests using internal lacquered cans full of distilled water. Bisphenol A concentrations ranged between 3 and 320 μg.L-1 and increased with the increment of the storage duration, the temperature of storage and the temperature of sterilization. The highest concentrations were found in the set and sterilized cans. If such concentrations were found in canned foods, they could give rise to toxicological effects on the consumer. KEY WORDS: Lacquered can, Bisphenol A, Migration, Epoxyphenolic resin Bull. Chem. Soc. Ethiop. 2010, 24(2), 159-166.
Evaluation of bisphenol A content in food from lacquered cans
G.H.M. Biego,A.S.S. Oga,K.D. Yao,L.P. Kouadio
Bulletin of the Chemical Society of Ethiopia , 2010,
Abstract: This study describes the migration of bisphenol A from the cans to the food content through experimental tests using internal lacquered cans full of distilled water. Bisphenol A concentrations ranged between 3 and 320 μg.L-1 and increased with the increment of the storage duration, the temperature of storage and the temperature of sterilization. The highest concentrations were found in the set and sterilized cans. If such concentrations were found in canned foods, they could give rise to toxicological effects on the consumer.
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR NITAZOXANIDE IN POWDER FOR SUSPENSION DOSAGE FORM
Sharifa Sultana*, Tanbir Ahammad , Md. Ashraful Islam and A.S.S. Rouf
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: A simple, precise, accurate, rapid and reproducible RP-HPLC method has been developed for the determination of Nitazoxanide in powder for suspension dosage form. Chromatography was carried out on an ODS C18 column (250 x 4.6 mm x 5 μm length), using a mixture of acetonitrile and 0.005 mol L-1 tetra n- butyl ammonium hydrogen sulphate (54:46 v/v) as the mobile phase at a flow rate of 1 mL/min and the detection was done at 240 nm. The method produced linear responses in the concentration range from 50 to 150 μg/mL of Nitazoxanide with correlation coefficients of 0.999, accuracy of 98.90% and precision of 0.811%. The method was found to be reproducible for analysis of the drug in suspension dosage form. The results of the analysis were tested and validated statistically for various parameters according to ICH guidelines and recovery studies confirmed the accuracy of the proposed method.
Tratamento da hiperplasia supra-renal congênita por deficiência da 21-hidroxilase
Bachega Tania A.S.S.,Madureira Guiomar,Brenlha Enecy M.L.,Ueti Rosy C.
Arquivos Brasileiros de Endocrinologia & Metabologia , 2001,
Abstract: O tratamento da hiperplasia supra-renal congênita por deficiência da 21-hidroxilase (HSRC-21OH) tem como objetivos repor glico e mineralocorticóides, evitar a viriliza o dos genitais externos, prevenir a desidrata o por perda de sal, controlar o hiperandrogenismo sem afetar a velocidade de crescimento, preservar a fun o gonadal, fertilidade e estatura final. Relatamos a nossa experiência no acompanhamento de 96 pacientes com HSRC-21OH. Nas crian as utilizamos como glicocorticóide o acetato de cortisona (18-20 mg/m2/dia) e nos adultos a dexametasona (0,25-0,75 mg/dia). Quando necessário, a reposi o do mineralocorticóide foi feita com 9alfa-fluor-hidrocortisona 50-250 μg/dia dependendo da faixa etária. Apesar da substitui o adequada com glico e/ou mineralocorticóides o resultado final do tratamento da HSRC-21OH ainda deixa a desejar, principalmente em rela o ao crescimento, já que a estatura final na maior parte das casuísticas está entre -1 e -2 DP em rela o a estatura alvo. Novas terapêuticas da HSRC-21OH, como a associa o de hidrocortisona, fludrocortisona, flutamida e testolactona ou a suprarrenalectomia cirúrgica ainda est o em fase experimental e a evolu o a longo prazo é necessária para avaliar seu real efeito.
Bases Moleculares da Hiperplasia Adrenal Congênita
Mello Maricilda Pallandi de,Bachega Tania A.S.S.,Costa-Santos Marivania da,Mermejo Lívia Mara
Arquivos Brasileiros de Endocrinologia & Metabologia , 2002,
Abstract: Hiperplasia adrenal congênita (HAC) é uma doen a autoss mica recessiva decorrente da altera o de enzimas que participam da síntese do cortisol. As manifesta es podem ser causadas pela deficiência do cortisol e, em alguns casos, aldosterona e pelo acúmulo de precursores. O objetivo desta revis o é apresentar os mecanismos moleculares dos principais defeitos enzimáticos envolvidos na etiopatogênese da HAC. A deficiência da 21-hidroxilase (21OH) ocorre em 95% dos casos de HAC. Existem dois genes que codificam o P450c21: um ativo, CYP21, e um pseudogene CYP21P. Ambos s o altamente homólogos (98%), o que favorece o emparelhamento desigual dos cromossomos homólogos durante a meiose, levando a duplica es e/ou dele es ou convers es desses genes. Adicionalmente, foram também descritas muta es de ponto, muitas delas presentes no pseudogene sugerindo microconvers es. Muta es no gene CYP11B1 causam HAC por deficiência da 11beta-hidroxilase, forma esta que corresponde a 5% dos casos. Algumas muta es s o recorrentes, situando-se principalmente entre os exons 6-8 que representaria uma área hot-spot no gene CYP11B1. A deficiência de 17-hidroxilase é causada por muta es no gene CYP17, que codificam uma proteína alterada, levando a deficiência total ou parcial de 17-hidroxila o e 17,20-liase ou deficiência isolada de 17,20-liase. Finalmente, deficiência de 3beta-HSD é causada por muta es no gene HSD3B2, que codifica a enzima 3beta-HSD tipo II e estas muta es têm sido associadas tanto com a forma clássica como com a forma n o clássica da deficiência da 3beta-HSD.
Bases Moleculares da Hiperplasia Adrenal Congênita
Mello, Maricilda Pallandi de;Bachega, Tania A.S.S.;Costa-Santos, Marivania da;Mermejo, Lívia Mara;Castro, Margaret de;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2002, DOI: 10.1590/S0004-27302002000400017
Abstract: congenital adrenal hiperplasia (cah) is a recessive autossomic disease caused by inherited defects in cortisol biosynthesis. the manifestations are caused both by the deficient synthesis of cortisol, and sometimes of aldosterone, and by accumulation of the precursor steroids. the objective of this review is to present the molecular mechanisms of the main enzymatic defects involved in the etiopathogenesis of cah. deficiency of 21-hydroxylase (21oh) accounts for more than 95% of all cases of cah. the human genome contains two cyp genes: one active, cyp21, and a pseudogene, cyp21p. both are highly homologous (98%), facilitating recombination events during meiosis, leading to duplication and/or deletion or conversion of these genes. additionally, point mutations have also been described. deficiency of 11b-hydroxylase (11boh) is caused by mutations in the cyp11b1 gene, and accounts for 5% of all cases. some mutations are recurrent, and mainly located on exons 6-8, which is considered a hot-spot area in cyp11b1 gene. deficiency of 17a-hydroxylase (17oh) is caused by mutations in the cyp17 gene, producing a truncated or impaired protein. these mutations have been described in patients with combined deficiencies of 17oh and 17,20-lyase or with isolated 17,20-lyase. finally, cah caused by 3b-hsd deficiency is the consequence of mutations in the gene hsd3b2 that encodes 3b-hsd type ii. in the classical form of the disease nonsense mutations, insertion and deletions have been described, while in non classical forms, mutations result in diminished enzyme affinity and loss of enzyme activity.
Tratamento da hiperplasia supra-renal congênita por deficiência da 21-hidroxilase
Bachega, Tania A.S.S.;Madureira, Guiomar;Brenlha, Enecy M.L.;Ueti, Rosy C.;Inácio, Marlene;Dènis, Francisco T.;Silva, Frederico A. Queiroz;Arnhold, Ivo J.P.;Mendon?a, Berenice B.;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2001, DOI: 10.1590/S0004-27302001000100010
Abstract: the purpose of the treatment for congenital adrenal hyperplasia due to 21-hydroxylase deficiency (cah-21oh) is to replace gluco and mineralocorticoids, prevent virilization of the external genitalia, salt loss and hyperandrogenism and preserve gonadal function, fertility and final height. our experience in the treatment of 96 patients with cah-21oh is presented. children have been treated with cortisone acetate (18-20 mg/m2/day) and adults with dexamethasone (0.25-0.75 mg/day). if necessary, mineralocorticoid replacement was accomplished with 9a-fludrocortisone, 50-250 μg/day, according to chronological age. despite therapy with gluco and mineralocorticoids the end results for cah-21oh is still inadequate, especially when growth is concerned; in most reports final height reaches between 1 to 2 sd bellow target height. new therapeutic approaches for cah-21oh, such as the association of flutamide and testolactone to hydrocortisone and fludrocortisone, and even surgical or chemical adrenalectomy, are still experimental and long-term follow-up is necessary to evaluate their validity.
A New Laccase Biosensor For Polyphenols Determination
S. A.S.S. Gomes,M. J.F. Rebelo
Sensors , 2003, DOI: 10.3390/s30600166
Abstract: The relevance of polyphenols in human health is a well known fact. Prompted by that, a very intensive research has been directed to get a method to detect them, wich will improve the current ones. Laccase (p-diphenol:dioxygen oxidoreductase EC 1.10.3.2) is a multi-copper oxidase, wich couples catalytic oxidation of phenolic substrates with four electron reduction of dioxygen to water [1]. A maximum catalytic response in oxigenated electrolyte was observed between 4.5 and 5.5 [2], while for pH > 6.9 the laccase was found to be inactive [3]. We prepared a biosensor with laccase immobilised on a polyether sulphone membrane, at pH 4.5, wich was applied at Universal Sensors base electrode. Reduction of the product of oxidation of several polyphenols, catalysed by laccase, was done at a potential for wich the polyphenol of interest was found to respond. Reduction of catechol was found to occur at a potential of -200mV, wich is often referred to in the literature for polyphenolic biosensors. However other polyphenols did not respond at that potential. It was observed that (+)- catechin produced a very large cathodic current when +100mV were applied to the laccase biosensor, both in aqueous acetate and 12% ethanol acetate buffer, whereas caffeic acid responded at -50mV. Other polyphenols tested were gallic acid, malvidin, quercetin, rutin, trans-resveratrol
Expectativas dos alunos de enfermagem frente ao primeiro estágio em hospital
Carvalho, Maria Dalva de Barros;Pelloso, Sandra Marisa;Valsecchi, Elizabeth A.S.S.;Coimbra, Jorséli A.H.;
Revista da Escola de Enfermagem da USP , 1999, DOI: 10.1590/S0080-62341999000200012
Abstract: the first experience in hospital training may create tensions and anxieties. these feelings interfere negatively in the teaching - learning process. the aim of this paper was to investigate the expectations of nursing fundamentals ii students regarding their initial hospital training. second-year students of the nursing course offered by universidade estadual de maringá (state of paraná, brazil,) were chosen as subjects of this investigation. the students revealed a state of anxiety when confronting technical procedures, relationship with patients and evolution. by reflecting on these aspects instructor the may increase the teaching-learning efficiency and humanize the professional training.
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