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Search Results: 1 - 10 of 462025 matches for " A. Eswar "
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Impact of Age on Surgical Outcomes after Robot Assisted Laparoscopic Hysterectomies  [PDF]
A. Eddib, S. Hughes, M. Aalto, A. Eswar, M. Erk, C. Michalik, V. Krovi, P. Singhal
Surgical Science (SS) , 2014, DOI: 10.4236/ss.2014.53018

Objective: To estimate the impact of patient’s age on surgical outcomes in patients undergoing robotic hysterectomy. Methods: A retrospective review of prospectively collected cohort data for a consecutive series of patients undergoing gynecologic robotic surgery. Patient’s age and perioperative variables were collected from the database, charts, and other hospital records of all patients undergoing robotic hysterectomy. Results: 399 patients underwent robotic surgery for gynecologic disease. 370 patients who were under age 70 were compared with 29 patients who were over age 70. When comparing all patients under age 70 with patients over age 70, the mean age was 48.4 and 77 (P < 0.05), mean BMI was 32.1 and 28.3 kg/m2 (P < 0.05), mean procedure time was 185 and 211 minutes (min) (P = 0.09), mean console time was 123 and 148 min (P = 0.056), mean OR (Operating room) time was 237 and 273, mean EBL (Estimated blood loss) was 71 and 65 ml (P = 0.74), Hb (Hemoglobin) drop was 1.4 and 1.2 (P = 0.45), uterine weight was 212 and 95 gm (P = 0.98), and length of stay was 1.4 and 1.6 days (P = 0.33) (Table 1). The patients over age 70, when procedures were combined, had a statistically significant lower mean BMI, uterine weight and longer Operating room (OR) time. However, when stratified by the type of procedure performed, there was no difference in surgery times among those under 70 and over 70 years of age. The elderly patients were more likely to have cancer, which was in almost half the elderly patients, and thus necessitate staging. Thus adding the performance of lymph node dissection likely resulted in the increased length of the surgery time that was noted in the combined group (Tables 1,

Performance of Dominating and Adaptive Partial Dominating Sets in AODV Routing protocol for MANETs
A. Nagaraju,,S. Ramachandram,,B. Eswar
Journal of Emerging Technologies in Web Intelligence , 2010, DOI: 10.4304/jetwi.2.2.80-85
Abstract: A mobile ad hoc network (MANET) is a wireless network that does not rely on any fixed infrastructure (i.e., routing facilities, such as wired networks and access points), and whose nodes must coordinate among themselves to determine connectivity and routing. The broadcast can target a portion of the network (e.g. gathering neighborhood information), or the entire network (e.g., discovering routes on demand). Broadcasting of signaling and data in MANETs raise redundant transmission of control packets to overcome these problems we applied dominating set and Adaptive partial Dominating (APDP) approach to existing routing protocols such as Ad-hoc On-demand Distance Vector (AODV). The focus of this paper is to apply the concept of DS and APDP to AODV and evaluate the performance of dominating sets in AODV that improve broadcasting, End-to-End Delay, Network load, Packet Latency, and also maintains secure packet transmission.
Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats
Satyanarayana Sreemantula, Eswar K Kilari, Vishnu A Vardhan, Rajasekhar Jaladi
BMC Endocrine Disorders , 2005, DOI: 10.1186/1472-6823-5-2
Abstract: L- ascorbic acid/tolbutamide/L-ascorbic acid + tolbutamide were administered orally to 3 different groups of albino rats of either sex in normal and diabetic condition. Blood samples were collected from retro-orbital puncture at different time intervals and were analyzed for blood glucose by GOD-POD method. Diabetes was induced by alloxan 100 mg/kg body weight administered by I.P route.L-ascorbic acid/ tolbutamide produced hypoglycaemic activity in a dose dependant manner in normal and diabetic condition. In the presence of L-ascorbic acid, tolbuatmide produced early onset of action and maintained for longer period compared to tolbutamide matching control.Supplementation of antioxidants like L-ascorbic acid was found to improve tolbutamide response in normal and diabetic rats.Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycaemia. It requires life long treatment with drugs coupled with diet control and exercise. It may be due to decrease in the synthesis of insulin (Type-I diabetes) or due to decrease in the secretion of insulin from β-cells of islets of Langerhans of pancreas (Type-II diabetes). Insulin is the drug of choice in type – I diabetes and sulfonylureas are the drugs of choice in type II. Among sulfonylureas, tolbutamide is the drug of choice for geriatrics because of its short duration of action and lower incidence of hypoglycaemia in early hours of night.Diabetes is one of the stress related disorder. Diabetic subjects are shown to have increased oxidative stress and decreased antioxidant levels [1-3]. It was also shown that tight control of blood glucose is possible with decrease in oxidative stress [4]. Antioxidants are claimed to work as antistress agents by decreasing oxidative stress. L-ascorbic acid used in therapy for disorders like scurvy produces antioxidant activity. Earlier reports show that the relationship between scurvy and diabetes mellitus indicates the low levels of plasma ascorbic acid in diabetic rats compar
Qureshi Absar A.,Kumar K. Eswar,Omer Shaista
International Journal of Research in Ayurveda and Pharmacy , 2010,
Abstract: From ancient days to recent civilization, human beings depend on nature for running their life smoothly from day to day. Plants remain a vital source of drugs and now a day’s much emphasis have been given to nutraceuticals. Feronia limonia belonging to family Rutaceae is well known in Indian traditional systems for its traditional uses. Various parts of the plant have astringent, constipating, tonic for liver and lung, diuretic, carminative, and cardiotonic traditional uses. Various important phytoconstituents like alkaloids, phenolic compounds, triterpenoids, coumarins, tannins, steroids etc. have been isolated from Kavith. But only few pharmacological activities like antimicrobial, antiviral, antitumour, antifungal and CNS depressant activity have been scientifically reported. From enormous traditional uses documented in various traditional system of medicine and presence of vital phytoconstituents make Kavith (Feronia limonia) an important plant to be studied scientifically to prove various traditional uses. In present review we explore Kaitha’s description, traditional medicinal uses, phytoconstituents and investigated pharmacological activities in various parts of the plant to show potential ethnopharmacological importance of the plant. So that this review can serve as ready to use material for further research on the plant.
Reduced Glomerular Function and Prevalence of Gout: NHANES 2009–10
Eswar Krishnan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050046
Abstract: Background The renal tubule is a major route of clearance of uric acid, a product of purine metabolism. The links between reduced glomerular filtration rate (GFR), hyperuricemia, and gout in the general population are not well understood. The objective of the present study was to estimate prevalence of gout and hyperuricemia among people with impaired GFR in the US general population. Study Design Cross-sectional, survey-weighted analyses of data on adults (age>20 years) in the 2009–10 cycle of the US National Health and Nutrition Examination Surveys (n = 5,589). Associations between self-reported physician diagnosis of gout and degrees of renal impairment were the primary focus of the present analyses. Results In the 2009–2010 period, there was an estimated 7.5 million people with gout in the US. There were 1.25 million men and 0.78 million women with moderate or severe renal impairment and gout. The age standardized prevalence of gout was 2.9% among those with normal GFR compared to 24% among those with GFR<60 ml/min/1.73 m2.In multivariable logistic regression analyses that adjusted for age, gender, body mass index, hypertension, diabetes, hypertension medications, including diuretics, blood lead levels, and hyperlipidemia, the odds ratios of gout and hyperuricemia were 5.9 (2.2, 15.7) and 9.58 (4.3, 22.0) respectively among those with severe renal impairment compared to those with no renal impairment. Approximately 2–3 fold increase in prevalence of gout was observed for each 30 ml/min/1.73 m2 decrease in GFR, after accounting for the above factors. Conclusions Renal glomerular function is an important risk factor for gout. The prevalence of hyperuricemia and gout increases with decreasing glomerular function independent of other factors. This association is non-linear and an eGFR of 60 ml/min/1.73 m2 appears to be a threshold for the dramatic increase in the prevalence of gout.
Unregistered Trials Are Unethical
Eswar Krishnan
PLOS Medicine , 2005, DOI: 10.1371/journal.pmed.0020048
Chronic kidney disease in gout in a managed care setting
Mahesh J Fuldeore, Aylin A Riedel, Victoria Zarotsky, Bhavik J Pandya, Omar Dabbous, Eswar Krishnan
BMC Nephrology , 2011, DOI: 10.1186/1471-2369-12-36
Abstract: This was a retrospective study using data from a large US health plan. Claims and laboratory data were analyzed for enrollees from the health plan database from January 2002 through December 2005. Patients with gout were identified from pharmacy and medical claims data based on the presence of codes for gout medication or gout diagnosis. Severity of CKD was determined using the estimated glomerular filtration rate (eGFR). Allopurinol titration was defined as a change in average daily dose from first prescription to last prescription of ≥ 50 mg.A total of 3,929 patients were identified for inclusion in this study, 39% of whom had CKD (based on having an eGFR < 90 mL/min/1.73 m2). Subjects with CKD were older (p < 0.01) and more likely to be women (p < 0.01), had a greater number of comorbid conditions (p < 0.01), and were more likely to be prescribed allopurinol (p < 0.01) compared to those with no CKD. The average starting dose of allopurinol was lower among those with CKD, and it decreased with worsening kidney function. Among the 3,122 gout patients who used allopurinol, only 25.6% without CKD and 22.2% with CKD achieved a serum uric acid concentration of < 6.0 mg/dL (p = 0.0409). Also, only 15% of allopurinol users had an upward dose titration (by ≥50 mg), but the average increase in dose did not differ significantly between those with and without CKD.About two out of every five patients with gout in this population had CKD. Allopurinol doses were not adjusted in the majority of CKD patients. Serum uric acid control in gout was poor among patients without CKD and even worse among those with CKD.Gouty arthritis (gout) is relatively common in the general population, with an estimated prevalence of 4%, and it is associated with approximately 3.9 million ambulatory care visits per year [1,2]. Chronic kidney disease (CKD) is also common, affecting approximately 26 million adults in the United States over the age of 20 [3,4]. Specific lifestyles choices can influence t
Indian Streams Research Journal , 2012,
Abstract: Girish Karnad's use of folk forms is neither casual nor incidental. In his Hayavadana, he has made innovative experiment to offer a new direction to modern theatre. The dramatist has proved that the traditional forms need not be treated as precious artifacts, but can be adapted to treat modern themes suitable for the urban audience. This paper is an attempt to portray how Karnad used the ancient story to explore the theme of human identity in a world of tangled relationships and a struggle for perfection.
The Galactic Thick Disk: An Observational Perspective
Bacham Eswar Reddy
Physics , 2009,
Abstract: In this review, we present a brief description of observational efforts to understand the Galactic thick disk and its relation to the other Galactic components. This review primarily focused on elemental abundance patterns of the thick disk population to pin down the process or processes that were responsible for its existence and evolution. Kinematic and chemical properties of disk stars establish that the thick disk is a distinct component in the Milky Way. The chemical enrichment and star formation histories hold clues to the bigger picture of understanding the Galaxy formation.
Deterministic Solution of the Boltzmann Equation Using Discontinuous Galerkin Discretizations in Velocity Space
Alexander Alekseenko,Eswar Josyula
Physics , 2013, DOI: 10.1016/j.jcp.2014.03.031
Abstract: We present a new deterministic approach for the solution of the Boltzmann kinetic equation based on nodal discontinuous Galerkin (DG) discretizations in velocity space. In the new approach the collision operator has the form of a bilinear operator with pre-computed kernel; its evaluation requires $O(n^5)$ operations at every point of the phase space where $n$ is the number of degrees of freedom in one velocity dimension. The method is generalized to any molecular potential. Results of numerical simulations are presented for the problem of spatially homogeneous relaxation for the hard spheres potential. Comparison with the method of Direct Simulation Monte Carlo (DSMC) showed excellent agreement.
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