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Search Results: 1 - 10 of 461234 matches for " A. Beeghly-Fadiel "
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Polymorphism Study of the Insulin Receptor Substrate IRS1 and IRS2 Genes Associated with Type 2 Diabetes in Ethnic Groups of Djerba Island
T. Baroudi Ouederni, J. Sanchez-Corona, A. Fadiel, T. Johnson-Scalise, A. Beeghly-Fadiel, S. Flores Martinez, H. Ben Maiz, H. Kammoun Abid, H. Aounallah Skhiri, A. Benammar-Elgaaied and A. Hamza
Clinical Medicine Reviews in Vascular Health , 2012, DOI: 10.4137/CMRVH.S3378
Abstract: Aim: We aimed to evaluate the influence of the Gly972 Arg and Ala513Pro variants of the insulin receptor substrate1 gene (IRS1) and the Gly1057 Asp variant in IRS on type 2 diabetes mellitus (T2DM) in Arab and Berber men and women from Djerba Island, Tunisia. Methods: Genotypes, allelic and genotypic frequencies were studied. The amplified products were analyzed by Restriction Fragment Length Polymorphism (RFLP) methods by comparing T2DM with healthy controls from the same ethnicity. Results: No differences in genotype or allelic frequencies were found between T2DM and healthy controls in either Arab or Berber ethnic groups. Conclusion: The Gly972 Arg and Ala513Pro variants in IRS1 and Gly1057 Asp in IRS2 polymorphisms are not associated with T2DM in the Arab or Berber populations of Djerba Island
INCREASING FLAME RETARDANCY FOR POLYETHYLENE RESIN REINFORCED BY HYBRID FIBERS BY USING SURFACE COATING LAYER FROM ZINC BORATE - ANTIMONY TRIOXIDE
Fadiel D. Bader
Academic Research International , 2012,
Abstract: zinc borate and antimony trioxide was used as a surface coating layer of (5mm) thickness with weight percentage (50%:50%) for each other to increase the flame retardancy for polyethylene resin (GT 8010) reinforced by Boron fibers ,this system was exposed to gas flame (2000oC) with (10 mm and 20 mm) exposure distances. Method of measuring the surface temperature opposite to the flame was used to determine the heat transferred to composite material. The best results were obtained with large exposed distance and percentage from protective layer which is zinc borate and antimony trioxide.
Remarkable sequence signatures in archaeal genomes
Ahmed Fadiel,Stuart Lithwick,Gopi Ganji,Stephen W. Scherer
Archaea , 2003, DOI: 10.1155/2003/458235
Abstract: Complete archaeal genomes were probed for the presence of long (≥ 25 bp) oligonucleotide repeats (words). We detected the presence of many words distributed in tandem with narrow ranges of periodicity (i.e., spacer length between repeats). Similar words were not identified in genomes of non-archaeal species, namely Escherichia coli, Bacillus subtilis, Haemophilus influenzae, Mycoplasma genitalium and Mycoplasma pneumoniae. BLAST similarity searches against the GenBank nucleotide sequence database revealed that these words were archaeal species-specific, indicating that they are of a signature character. Sequence analysis and genome viewing tools showed these repeats to be restricted to non-coding regions. Thus, archaea appear to possess a non-coding genomic signature that is absent in bacterial species. The identification of a species-specific genomic signature would be of great value to archaeal genome mapping, evolutionary studies and analyses of genome complexity.
Influence of socioeconomic lifestyle factors and genetic polymorphism on type 2 diabetes occurrences among Tunisian Arab and Berber groups of Djerba Island
Thouraya Baroudi Ouederni, Ahmed Fadiel, Nejla Stambouli, et al
Pharmacogenomics and Personalized Medicine , 2009, DOI: http://dx.doi.org/10.2147/PGPM.S5850
Abstract: fluence of socioeconomic lifestyle factors and genetic polymorphism on type 2 diabetes occurrences among Tunisian Arab and Berber groups of Djerba Island Original Research (4297) Total Article Views Authors: Thouraya Baroudi Ouederni, Ahmed Fadiel, Nejla Stambouli, et al Published Date August 2009 Volume 2009:2 Pages 49 - 57 DOI: http://dx.doi.org/10.2147/PGPM.S5850 Thouraya Baroudi Ouederni1, Ahmed Fadiel2,3, Nejla Stambouli1, Trudy J Scalize3, Hedi Ben Maiz4, Hafaona Kammoun Abid1, Rim Bouhaha1, Jose Sanchez-Corona5, Adel Hamza1,6*, Amel Benammar-Elgaaied1,* 1Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, Tunis, Tunisia; 2New York University School of Medicine, NYU Medical Center, New York, NY, USA; 3Biomedical Informatics, OBGYN Department, Meharry Medical College, Nashville, TN, USA; 4Charles Nicolle Hospital, Internal Medicine A, Tunis, Tunisia; 5División de Medecina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano Del Seguro Social, Guadalajara, Jalisco, México; 6Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA; *These authors contributed equally to this work and are the corresponding authors Abstract: Type 2 diabetes mellitus (T2DM) is characterized by three major metabolic abnormalities: impaired insulin-stimulated glucose uptake in muscle and adipose tissues, alterations in glucose-stimulated insulin secretion, and increased hepatic glucose production. Both genetic and environmental factors contribute to its development. The insulin gene (INS), insulin receptor gene (INSR), and insulin receptor substrate 1 gene (IRS1), identified by polymerase chain reaction and digestion with selected restriction enzymes PstI, NsiI, and BstnI, have been proposed as T2DM candidate genes. To determine the contribution of genetic and environmental factors on the occurrence of T2DM, we examined the frequency of T2DM among two ethnically diverse populations, Arabs and Berbers, who have shared the same environment, the island of Djerba, for thousands of years. Both populations have a high prevalence of obesity, T2DM, and a high consanguinity rate. A total of 162 T2DM men and women were matched to 110 healthy male and female controls. Results showed that the NsiI polymorphism in INSR and BstnI polymorphism of IRS1 were significantly associated with T2DM only among the Berber group. The PstI polymorphism in INS, was not associated with T2DM in either group. Sedentary lifestyles, lower physical activity, and lower educational levels were associated with T2DM among the Berber group. These findings suggest that the insulin receptor gene and lifestyle factors in combination may contribute to the occurrence of T2DM in the Berber portion of this island population.
Influence of socioeconomic lifestyle factors and genetic polymorphism on type 2 diabetes occurrences among Tunisian Arab and Berber groups of Djerba Island
Thouraya Baroudi Ouederni,Ahmed Fadiel,Nejla Stambouli,et al
Pharmacogenomics and Personalized Medicine , 2009,
Abstract: Thouraya Baroudi Ouederni1, Ahmed Fadiel2,3, Nejla Stambouli1, Trudy J Scalize3, Hedi Ben Maiz4, Hafaona Kammoun Abid1, Rim Bouhaha1, Jose Sanchez-Corona5, Adel Hamza1,6*, Amel Benammar-Elgaaied1,*1Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, Tunis, Tunisia; 2New York University School of Medicine, NYU Medical Center, New York, NY, USA; 3Biomedical Informatics, OBGYN Department, Meharry Medical College, Nashville, TN, USA; 4Charles Nicolle Hospital, Internal Medicine A, Tunis, Tunisia; 5División de Medecina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano Del Seguro Social, Guadalajara, Jalisco, México; 6Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA; *These authors contributed equally to this work and are the corresponding authorsAbstract: Type 2 diabetes mellitus (T2DM) is characterized by three major metabolic abnormalities: impaired insulin-stimulated glucose uptake in muscle and adipose tissues, alterations in glucose-stimulated insulin secretion, and increased hepatic glucose production. Both genetic and environmental factors contribute to its development. The insulin gene (INS), insulin receptor gene (INSR), and insulin receptor substrate 1 gene (IRS1), identified by polymerase chain reaction and digestion with selected restriction enzymes PstI, NsiI, and BstnI, have been proposed as T2DM candidate genes. To determine the contribution of genetic and environmental factors on the occurrence of T2DM, we examined the frequency of T2DM among two ethnically diverse populations, Arabs and Berbers, who have shared the same environment, the island of Djerba, for thousands of years. Both populations have a high prevalence of obesity, T2DM, and a high consanguinity rate. A total of 162 T2DM men and women were matched to 110 healthy male and female controls. Results showed that the NsiI polymorphism in INSR and BstnI polymorphism of IRS1 were significantly associated with T2DM only among the Berber group. The PstI polymorphism in INS, was not associated with T2DM in either group. Sedentary lifestyles, lower physical activity, and lower educational levels were associated with T2DM among the Berber group. These findings suggest that the insulin receptor gene and lifestyle factors in combination may contribute to the occurrence of T2DM in the Berber portion of this island population.Keywords: polymorphism, insulin, insulin receptor, lifestyle, insulin receptor substrate-1, Berbers, Arabs, Djerba Island
USING OF ARAMID FIBRES REINFORCED POLYSTYRENE FOR MANUFACTURING AUTOMOTIVES PARTS
Abed Noor Jamel,Fadiel D.Bader,Mohammed Ali J.Dakhel
Academic Research International , 2012,
Abstract: The present research aim to study the effect of the reinforcement by fibres on mechanical properties of composite material consist of polystyrene resin reinforced by aramid fibres which can be used to manufactures auto motives parts such as bumpers .The propertiesincluded compressive and flexural strength , where the mechanical properties were extracted for polystyrene resin before reinforcement by fibres, then we reinforced the resin by different weight percentage from aramid fibres (%15,%30, %45, %60)and studied the effect on the above mechanical properties. The result obtained show An improvement in these properties after reinforcement by fibres The value of mechanical properties will increase with increasingpercentage of reinforcement .Compressive strength increased from(92Mpa) to (163Mpa) and flexural strength from (0.08Gpa) to (0.165Gpa) for reinforcing percentages 0% and 60% respectively .
A Comparative Investigation of Lead Sulfate and Lead Oxide Sulfate Study of Morphology and Thermal Decomposition  [PDF]
S. A. A. Sajadi
American Journal of Analytical Chemistry (AJAC) , 2011, DOI: 10.4236/ajac.2011.22024
Abstract: The compound lead oxide sulfate PbSO4.PbO was prepared in our laboratory. The Thermal behavior of PbSO4 was studied using techniques of Thermogravimetry under air atmosphere from 25 to 1200°C. The identity of both compounds was confirmed by XRD technique. Results obtained using both techniques support same decomposition stages for this compound. The electron microscopic investigations are made by SEM and TEM. The compound is characterized by XRD and the purity was determined by analytical Methods. Also a series of thermogravimetric analysis is made and the ideal condition is determined to convert this compound to pure lead oxide.
Metal ion-binding properties of L-glutamic acid and L-aspartic acid, a comparative investigation  [PDF]
S. A. A. Sajadi
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.22013
Abstract: A comparative research has been developed for acidity and stability constants of M(Glu)1, M(Asp)2 and M(Ttr)3 complexes, which have been determined by potentiometric pH titration. Depending on metal ion-binding properties, vital differences in building complex were observed. The present study indicates that in M(Ttr) com-plexes, metal ions are arranged to the carboxyl groups, but in M(Glu) and M(Asp), some metal ions are able to build chelate over amine groups. The results mentioned-above demonstrate that for some M(Glu) and M(Asp) complexes, the stability constants are also largely determined by the affinity of metal ions for amine group. This leads to a kind of selectivity of metal ions, and transfers them through building complexes accompanied with glutamate and aspartate. For heavy metal ions, this building complex helps the absorption and filtration of the blood plasma, and consequently, the excursion of heavy metal ions takes place. This is an important method in micro-dialysis. In this study the different as-pects of stabilization of metal ion complexes regarding to Irving-Williams sequence have been investigated.
Determining the Basaltic Sequence Using Seismic Reflection and Resistivity Methods  [PDF]
A. Alanezi, A. Qadrouh
Open Journal of Geology (OJG) , 2013, DOI: 10.4236/ojg.2013.32B004
Abstract:

This study was carried out in Harat Rahat (south of Almadinah Almonwarah) using seismic reflection and resistivity methods. The main objectives of this study are to determine the extent of the basaltic layer and to define the subsurface faults and fractures that could affect and control the groundwater movement in the study area. A 2D seismic profile was acquired and the result shows that the subsurface in the study area has a major fault. We obtained a well match when the seismic result was compared with drilled wells. As a complementary tool, the resistivity method was applied in order to detect the groundwater level. The results of the resistivity method showed that six distinct layers have been identified. The interpretation of these six layers show that the first three layers, the fourth layer, the fifth layer and the bottom of the section indicated various subsurface structures and lithologies; various basaltic layers, fractured basalt, weathered basement and fresh basaltic layers, respectively. It is obvious that the eventual success of geophysical surveys depend on the combination with other subsurface data sources in order to produce accurate maps.

Equilibria and Stability in Glycine, Tartrate and Tryptophan Complexes, Investigation on Interactions in Cu(II) Binary and Ternary Systems in Aqueous Solution  [PDF]
S. A. A. Sajadi
Open Journal of Inorganic Non-metallic Materials (OJINM) , 2014, DOI: 10.4236/ojinm.2014.41001
Abstract:

The acidity and stability constants of M(Gly)1, M(Ttr)1, and M(Trp)1 M: Cu2+, Cu(Bpy2)2+, and Cu(Phen3)2+ complexes, were determined by potentiometric pH titration. It is shown that the stability of the binary Cu(L), (L: Gly, Ttr, and Trp) complex is determined by the basicity of the carboxylate group on one side and amino group on the other side. It is demonstrated that the equilibrium, Cu(Ha4)2+ + Cu(L) \"\"Cu(Har)(L) + Cu2+, is displacement due to the well known experience that mixed ligand complexes formed by a divalent 3d ion, a heteroaromatic N base and an O donor ligand possess increased stability. The stability constants of the 1:1 complexes formed between Cu2+, Cu(Bpy)2+ or Cu(Phen)2+

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