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Search Results: 1 - 10 of 463641 matches for " A. Anil "
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Modeling Directionality of Liquid Crystalline Polymers on Arbitrary Meshes  [PDF]
Arash Ahmadzadegan, Michael A. Zimmerman, Anil Saigal
Modeling and Numerical Simulation of Material Science (MNSMS) , 2013, DOI: 10.4236/mnsms.2013.31001
Abstract:

The orientation of crystals in liquid crystalline polymers (LCPs) during the processing method affects the properties of these materials. In this paper, the main components of modeling the directionality of LCPs, namely Franks elastic energy equation, evolution equation and translation of directors are studied. The complexity of flow channels in polymer processing requires a more robust method for modeling directionality that can be applied to varieties of meshes. A method for practically simulating the directionality of crystallines on a macroscopic scale is developed. This method can be applied to any combination and type of meshes. The results show successful modeling of the directionality for each component of the model. Here, a 2D case with structured and unstructured mesh is considered and the rheology is simulated using ANSYS? FLUENT?. C++ codes written for user defined functions (UDFs) are used to implement the directionality simulation.

Optimizing Containment and Control of Candida parapsilosis Fungemia among Neonates in the Outbreak Setting Using a Mathematical Modeling Approach
Anil A. Panackal
Journal of Mycology , 2013, DOI: 10.1155/2013/413874
Abstract: Candida is the second leading cause of sepsis related death in the neonatal intensive care unit (NICU). Using the C. parapsilosis paradigm, the endogenous and exogenous routes of infection were simulated in order to enhance prevention among neonates at highest risk. A deterministic model was constructed with transmission parameters calculated from the basic reproductive number ( ), derived from the mean serial interval from two published outbreaks. Uncertainty and sensitivity analyses were performed via Latin hypercube sampling. Prevention measure effects were ascertained by incorporating percent coverage and efficacies into the existing model. The colonized and infected neonatal prevalence peaked at 17.4% and 39.4%, respectively, and reduction was achieved by compartmental replacement with susceptibles. Containment of greater than 60% of the cohort had minimal effect on the effective reproductive number ( ) unless hand hygiene compliance dropped below 40% at a fixed ratio of nurses to neonates. Antifungal prophylaxis in combination with hand hygiene and cohorting extinguished an outbreak 14 days sooner than baseline. The critical proportion ( ) requiring prophylaxis in order to stop an outbreak increases, as rises, and the prophylaxis efficacies decrease. Internal and external sources of Candida lead to invasive disease in neonates differentially. Optimal prevention is dependent upon understanding the dynamics of this disease process under diverse circumstances. 1. Introduction Candida species are commensals of the human gastrointestinal tract and skin but can become pathogenic, being the fourth leading cause of bloodstream infections in the United States [1]. Candida parapsilosis is an “emerging fungal pathogen,” with infection incidences increasing globally [2]. According to data from the ARTEMIS DISK Surveillance Program (1997–2005), C. parapsilosis was the fourth most common yeast isolated with an estimated prevalence of 4%–7% and the second most common yeast associated with bloodstream infections [3, 4]. C. parapsilosis candidemia prevalence is 4%–34%, depending upon the time period, location, and host factors [5]. In particular, neonates—defined as infants whose age is within 30 days following birth—are especially vulnerable to this infection. Though attributable mortality is 10% over 10 years in neonates despite therapy—lower than that due to other Candida species, overall, the genus is the second leading cause of death from sepsis in the neonatal intensive care unit (NICU) [6, 7]. Colonization precedes infection. The gastrointestinal tracts of
Disaster Recovery of Data by Using Data Guard
Anil
International Journal of Computer Science and Management Studies , 2012,
Abstract: Oracle Data Guard is the management, monitoring, and automation software infrastructure that creates, maintains, and monitors one or more standby databases to protect enterprise data from failures, disasters, errors, and data corruptions. Data Guard maintains standby databases as consistent copies of the production database as far as transactions are concerned. These standby databases can be located at remote disaster recovery sites thousands of miles away from the production data center, or they may be located in the same city, same campus, or even in the same building. If the production database becomes unavailable because of a planned or an unplanned outage, Data Guard can switch any standby database to the production role, thus minimizing the downtime associated with the outage, andpreventing any data loss. The document explains the structure of a physical standby database with Oracle Data Guard in an SAP environment. It indicates all the steps needed to successfully install and configure an Oracle Data Guard system with a physical standby database and the logical order in which they must be carried out. To enable you to operate the standby database (Oracle DataGuard), a description of how to configure the Data Guard Brokeris also provided. In just a few steps this service allows you toswap the database roles. This means that in the event of a disaster,what is known as a switchover or failover is undertaken almostautomatically. The database administrator can initiate the processwith just one command.
Single Visit Apexification with Mineral Trioxide Aggregate
Anil Kumar G,Kavitha A
Indian Journal of Dental Advancements , 2010,
Abstract: Aim: To create an apical barrier in non vital immature permanent teeth with Mineral Trioxide Aggregate (MTA). Summary: Two case reports where the patients presented with fractured upper anteriorteeth.Radiographic evaluation revealed open apices with blunderbuss canals. Apical stop was created with mineral trioxide aggregate by apexification and the root canals were obturated with thermoplasticized gutta-percha. Key learning points: Mineral trioxide aggregate appears to be a promising alternative to calcium hydroxide apexification because of its high biocompatibility, superior sealing ability and reduced treatment time.
Evaluation of Gutta-Percha and Resilion- Retreatment -an in-vitro study
Anil Kumar G,Aliveni A
Indian Journal of Dental Advancements , 2009,
Abstract: Persistent or secondary intraradicular infection is a major cause of endodontic failures. Nonsurgical retreatment is the treatment of choice for the management of endodontic failures when access to the root canals is feasible. Endodontic retreatment consists of cleaning, shaping, and three-dimensional obturation of previously obturated root canals. Various techniques are employed to remove the root canal filling materials including the use of hand or rotary instruments with or without heat application, solvents, and/or ultrasound Ni-Ti rotary instruments have also been used for removing filling materials from root canal walls. Gutta-percha, in combination with a variety of sealers, is the most commonly used material for root canal obturation. Resilon, a thermoplastic, synthetic, polyester polymer-based root canal filling material, was recently proposed as an alternative to gutta-percha. The purpose of this study was to compare the amount of residual filling material on the canal walls in root canals filled with gutta-percha or Resilon and retreated using the Protaper treatment files.
FORMULATION AND EVALUATION OF METOPROLOL SUCCINATE PULSATILE DRUG DELIVERY SYSTEM FOR CHRONO BIOLOGICAL DISORDER: ANTI HYPERTENSION
A. Anil Kumar et al
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: The objective of the present study was to develop and evaluate an oral pulsatile drug delivery system to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined log time of 5 hrs (+ 0.25 hrs). The basic design of the pulse in cap formulation of metoprolol provides time controlled release to treat the nocturnal symptoms of hypertension and angina pectoris. The pulsincap formulation of Metoprolol provides time controlled release to treat the nocturnal symptoms of hypertension and angina pectoris. If the formulation is administered in the night at 10.00 pm symptoms that are experienced in early morning hours could be avoided. In the present study, polymer such as Guargum selected for colon targeting of Metoprolol succinate. Metoprolol succinate granules were prepared using these polymers to prolong and target to the colon. Granules were prepared by wet granulation technique using different polymers in different ratios. These granules filled into the formaldehyde treated capsules and plugged with optimized HPMC plug, to maintain the 5hr lag time. Finally capsules are enteric coated with enteric coating polymers and conducted dissolution studies with different pH mediums.
Structural Plasticity and Conformational Transitions of HIV Envelope Glycoprotein gp120
Anil Korkut, Wayne A. Hendrickson
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052170
Abstract: HIV envelope glycoproteins undergo large-scale conformational changes as they interact with cellular receptors to cause the fusion of viral and cellular membranes that permits viral entry to infect targeted cells. Conformational dynamics in HIV gp120 are also important in masking conserved receptor epitopes from being detected for effective neutralization by the human immune system. Crystal structures of HIV gp120 and its complexes with receptors and antibody fragments provide high-resolution pictures of selected conformational states accessible to gp120. Here we describe systematic computational analyses of HIV gp120 plasticity in such complexes with CD4 binding fragments, CD4 mimetic proteins, and various antibody fragments. We used three computational approaches: an isotropic elastic network analysis of conformational plasticity, a full atomic normal mode analysis, and simulation of conformational transitions with our coarse-grained virtual atom molecular mechanics (VAMM) potential function. We observe collective sub-domain motions about hinge points that coordinate those motions, correlated local fluctuations at the interfacial cavity formed when gp120 binds to CD4, and concerted changes in structural elements that form at the CD4 interface during large-scale conformational transitions to the CD4-bound state from the deformed states of gp120 in certain antibody complexes.
Transit universe with time varying $G$ and decaying $Λ$
Anil Kumar Yadav,A. Sharma
Physics , 2012, DOI: 10.1088/1674-4527/13/5/001
Abstract: We present the model of transit universe from early deceleration phase to current acceleration phase under the framework of general relativity in presence of gravitational coupling $G(t)$ and cosmological terms $\Lambda(t)$. The Einstein's field equations have been solved by considering time dependent deceleration parameter (DP) which renders the scale factor $a = (t^{n}e^{kt})^{\frac{1}{m}}$ where $m$, $n$ and $k$ are positive constants. The cosmological term $(\Lambda(t))$ is found to be positive and a decreasing function of time which supports the result obtained from supernovae Ia observations. The geometrical and kinematical features of the model are examined in detail.
Stereochemistry of Polypeptide Conformation in Coarse Grained Analysis
Anil Korkut,Wayne A Hendrickson
Quantitative Biology , 2013,
Abstract: The conformations available to polypeptides are determined by the interatomic forces acting on the peptide units, whereby backbone torsion angles are restricted as described by the Ramachandran plot. Although typical proteins are composed predominantly from {\alpha}-helices and {\beta}-sheets, they nevertheless adopt diverse tertiary structure, each folded as dictated by its unique amino-acid sequence. Despite such uniqueness, however, the functioning of many proteins involves changes between quite different conformations. The study of large-scale conformational changes, particularly in large systems, is facilitated by a coarse-grained representation such as provided by virtually bonded C{\alpha} atoms. We have developed a virtual atom molecular mechanics (VAMM) force field to describe conformational dynamics in proteins and a VAMM-based algorithm for computing conformational transition pathways. Here we describe the stereochemical analysis of proteins in this coarse-grained representation, comparing the relevant plots in coarse-grained conformational space to the corresponding Ramachandran plots, having contoured each at levels determined statistically from residues in a large database. The distributions shown for an all-{\alpha} protein, two all-{\beta} proteins and one {\alpha}+{\beta} protein serve to relate the coarse-grained distributions to the familiar Ramachandran plot.
Detection of Blood Traces in Human Pericardial Fluid Using Microwaves  [PDF]
Anil Lonappan
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2010, DOI: 10.4236/jemaa.2010.210077
Abstract: This communication reports a novel method of analyzing pericardial fluid and finding blood traces present based on the measurement of the dielectric properties at microwave frequencies. The experiment was performed by cavity perturbation method in the S-band of microwave frequency with the pericardial fluid from healthy persons as well as from patients suffering from pericardial bleeding. It is noted that considerable variation in the dielectric properties of patient samples with the normal healthy samples and these measurements were in good agreement with clinical analysis. This measurement technique and the method of extraction of pericardial fluid are simple and both are non invasive. These results give light to an alternative in-vitro method of diagnosing onset pericardial bleeding abnormalities using microwaves without surgical procedure.
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