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Search Results: 1 - 10 of 687336 matches for " A Séguéla "
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A new Robertsonian translocation in Holstein-Friesian cattle
A Pinton, A Ducos, HM Berland, A Séguéla, MF Blanc, A Darré, S Mimar, R Darré
Genetics Selection Evolution , 1997, DOI: 10.1186/1297-9686-29-4-523
Abstract:
A pericentric inversion of chromosome 4 in pigs
A Ducos, A Pinton, A Séguéla, HM Berland, MF Blanc, A Darré, P Pinton, M Yerle, R Darré
Genetics Selection Evolution , 1997, DOI: 10.1186/1297-9686-29-3-383
Abstract:
Re-figuring Hayden White
María Inés La Greca
Revista Latinoamericana de Filosofía , 2010,
Abstract:
Tumor Transcriptome Sequencing Reveals Allelic Expression Imbalances Associated with Copy Number Alterations
Brian B. Tuch,Rebecca R. Laborde,Xing Xu,Jian Gu,Christina B. Chung,Cinna K. Monighetti,Sarah J. Stanley,Kerry D. Olsen,Jan L. Kasperbauer,Eric J. Moore,Adam J. Broomer,Ruoying Tan,Pius M. Brzoska,Matthew W. Muller,Asim S. Siddiqui,Yan W. Asmann,Yongming Sun,Scott Kuersten,Melissa A. Barker,Francisco M. De La Vega,David I. Smith
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009317
Abstract: Due to growing throughput and shrinking cost, massively parallel sequencing is rapidly becoming an attractive alternative to microarrays for the genome-wide study of gene expression and copy number alterations in primary tumors. The sequencing of transcripts (RNA-Seq) should offer several advantages over microarray-based methods, including the ability to detect somatic mutations and accurately measure allele-specific expression. To investigate these advantages we have applied a novel, strand-specific RNA-Seq method to tumors and matched normal tissue from three patients with oral squamous cell carcinomas. Additionally, to better understand the genomic determinants of the gene expression changes observed, we have sequenced the tumor and normal genomes of one of these patients. We demonstrate here that our RNA-Seq method accurately measures allelic imbalance and that measurement on the genome-wide scale yields novel insights into cancer etiology. As expected, the set of genes differentially expressed in the tumors is enriched for cell adhesion and differentiation functions, but, unexpectedly, the set of allelically imbalanced genes is also enriched for these same cancer-related functions. By comparing the transcriptomic perturbations observed in one patient to his underlying normal and tumor genomes, we find that allelic imbalance in the tumor is associated with copy number mutations and that copy number mutations are, in turn, strongly associated with changes in transcript abundance. These results support a model in which allele-specific deletions and duplications drive allele-specific changes in gene expression in the developing tumor.
Emulsifying Activity and Stability of a Non-Toxic Bioemulsifier Synthesized by Microbacterium sp. MC3B-10
Juan Carlos Camacho-Chab,Jean Guézennec,Manuel Jesús Chan-Bacab,Elvira Ríos-Leal,Corinne Sinquin,Raquel Mu?iz-Salazar,Susana del C. De la Rosa-García,Manuela Reyes-Estebanez,Benjamín Otto Ortega-Morales
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140918959
Abstract: A previously reported bacterial bioemulsifier, here termed microbactan, was further analyzed to characterize its lipid component, molecular weight, ionic character and toxicity, along with its bioemulsifying potential for hydrophobic substrates at a range of temperatures, salinities and pH values. Analyses showed that microbactan is a high molecular weight (700 kDa), non-ionic molecule. Gas chromatography of the lipid fraction revealed the presence of palmitic, stearic, and oleic acids; thus microbactan may be considered a glycolipoprotein. Microbactan emulsified aromatic hydrocarbons and oils to various extents; the highest emulsification index was recorded against motor oil (96%). The stability of the microbactan-motor oil emulsion model reached its highest level (94%) at 50 °C, pH 10 and 3.5% NaCl content. It was not toxic to Artemia salina nauplii. Microbactan is, therefore, a non-toxic and non-ionic bioemulsifier of high molecular weight with affinity for a range of oily substrates. Comparative phylogenetic assessment of the 16S rDNA gene of Microbacterium sp. MC3B-10 with genes derived from other marine Microbacterium species suggested that this genus is well represented in coastal zones. The chemical nature and stability of the bioemulsifier suggest its potential application in bioremediation of marine environments and in cosmetics.
A Dual Polybasic Motif Determines Phosphoinositide Binding and Regulation in the P2X Channel Family
Louis-Philippe Bernier, Dominique Blais, éric Boué-Grabot, Philippe Séguéla
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040595
Abstract: Phosphoinositides modulate the function of several ion channels, including most ATP-gated P2X receptor channels in neurons and glia, but little is known about the underlying molecular mechanism. We identified a phosphoinositide-binding motif formed of two clusters of positively charged amino acids located on the P2X cytosolic C-terminal domain, proximal to the second transmembrane domain. For all known P2X subtypes, the specific arrangement of basic residues in these semi-conserved clusters determines their sensitivity to membrane phospholipids. Neutralization of these positive charges disrupts the functional properties of the prototypical phosphoinositide-binding P2X4 subtype, mimicking wortmannin-induced phosphoinositide depletion, whereas adding basic residues at homologous positions to the natively insensitive P2X5 subtype establishes de novo phosphoinositide-mediated regulation. Moreover, biochemical evidence of in vitro P2X subunit-phospholipid interaction and functional intracellular phosphoinositide-binding assays demonstrate that the dual polybasic cluster is necessary and sufficient for regulation of P2X signaling by phospholipids.
Norepinephrine Drives Persistent Activity in Prefrontal Cortex via Synergistic α1 and α2 Adrenoceptors
Zizhen Zhang, Steven Cordeiro Matos, Sonia Jego, Antoine Adamantidis, Philippe Séguéla
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066122
Abstract: Optimal norepinephrine levels in the prefrontal cortex (PFC) increase delay-related firing and enhance working memory, whereas stress-related or pathologically high levels of norepinephrine are believed to inhibit working memory via α1 adrenoceptors. However, it has been shown that activation of Gq-coupled and phospholipase C-linked receptors can induce persistent firing, a cellular correlate of working memory, in cortical pyramidal neurons. Therefore, despite its importance in stress and cognition, the exact role of norepinephrine in modulating PFC activity remains elusive. Using electrophysiology and optogenetics, we report here that norepinephrine induces persistent firing in pyramidal neurons of the PFC independent of recurrent fast synaptic excitation. This persistent excitatory effect involves presynaptic α1 adrenoceptors facilitating glutamate release and subsequent activation of postsynaptic mGluR5 receptors, and is enhanced by postsynaptic α2 adrenoceptors inhibiting HCN channel activity. Activation of α2 adrenoceptors or inhibition of HCN channels also enhances cholinergic persistent responses in pyramidal neurons, providing a mechanism of crosstalk between noradrenergic and cholinergic inputs. The present study describes a novel cellular basis for the noradrenergic control of cortical information processing and supports a synergistic combination of intrinsic and network mechanisms for the expression of mnemonic properties in pyramidal neurons.
Importancia de las imágenes radiológicas para el diagnóstico de la condrocalcinosis
Guía Galipienso,F. de la; Vázquez Perfecto,G.; Pérez Villacastín,B.;
Medifam , 2001, DOI: 10.4321/S1131-57682001000700007
Abstract: deposit of dihydrate calcium pyrophosphate crystals on fibrous cartilage and joint hyaline cartilage is called chondrocalcinosis. because the release of those crystals into the synovial fluid induces an acute arthritis similar to gout arthritis, the clinical syndrome is refered to as pseudogout. here we report a case of 38-years old man, caracterized by two years of a strong backache radiating to gluteal and posterior region of the left thigh with diffuse pain affecting several joints, inflammatory signs and joint functional disability. the patient has symptoms for ten days periods, intermittent outbreaks and intercalated non-symptomatic periods.
DNA injury induced by 5-aminouracil and caffeine in G2 checkpoints path of higher plant cells
Del Campo,A.; Bracho,M.; Marcano,L.; Guí?ez,J.; De la Torre,C.;
Biocell , 2005,
Abstract: this work evaluated the qualitative and quantitative cellular changes induced by treatment with 5-aminouracil (5-au) and a combination of 5-au and caffeine in plant cells in relation to dna damage, repaired damage, and residual damage. as biological material, allium cepa l. root tips were used, grown in filtered water, in darkness, with aeration at constant temperature of 25 °c ± 0.5. cell populations were synchronized using 5 mm caffeine in order to study the effects of 5-au and caffeine/5-au combined treatment on the dna content and their incidence in the entrance to mitosis. the results showed a delay in the g2 period due to induced dna damage by the 5-au and caffeine/5-au combined treatment, shown by aberrant metaphases, anaphases and telophases. the effect of caffeine in the combined treatment was heightened in spite of lengthening the checkpoints route that retains the cells in g2. the existence of g2 checkpoints was shown in the cell population studied, inducing lesions in the dna, chromosomic aberrations and cellular instability.
Investigation and Analysis on Ideas of Time Medicine in the Study of Warm Disease in Mongolian Medicine
蒙医温病学中时间医学思想探析

Wang Yuehong,A Gu La,
王月洪
,阿古拉

世界科学技术-中医药现代化 , 2012,
Abstract: Through investigating and analyzing the ideas of time medicine in study of warm disease in traditional Mongolian medicine, we try to analyze ideas of time medicine in the study of warm disease in traditional Mongolian medicine from different aspects. This investigation and analysis was aimed to play a certain enlighten role in the diagnosis, treatment and prevention of the study of warm disease in traditional Mongolian medicine.
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