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Search Results: 1 - 10 of 462484 matches for " A Jamie Cuticchia "
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The Legal Treatment of the Parental Rights and Obligations of Sperm Donors
A. Jamie Cuticchia
The Open Law Journal , 2008, DOI: 10.2174/1874950X00801010016]
Abstract: The increasing availability and use of donor sperm for artificial insemination along with the changing definition of family has created a new and evolving area of law. Where sperm donation initially was a completely anonymous procedure, there is increasing interest both in the progeny of artificial and insemination to learn more about their donor father. This has largely been driven by advances in the Human Genome Project and a better understanding of genetics, family history, and disease. Additionally, studies have shown a rapid increase in the desire of sperm donors to know more about their offspring. Singe women who wish to have children as well as lesbian couples are more likely to seek donor sperm from men with whom they have some existing relationship. In these cases, the actions of the donor can have significant impact on the obligations that such donors may incur as such as financial support.
NIDDK data repository: a central collection of clinical trial data
A Jamie Cuticchia, Philip C Cooley, R David Hall, Ying Qin
BMC Medical Informatics and Decision Making , 2006, DOI: 10.1186/1472-6947-6-19
Abstract: The NIDDK Data repository is a web-enabled resource cataloguing clinical trial data and supporting information from NIDDK supported studies. The Data Repository allows for the co-location of multiple electronic datasets that were created as part of clinical investigations. The Data Repository does not serve the role of a Data Coordinating Center, but rather as a warehouse for the clinical findings once the trials have been completed. Because both biological and genetic samples are collected from many of the studies, a data management system for the cataloguing and retrieval of samples was developed.The Data Repository provides a unique resource for researchers in the clinical areas supported by NIDDK. In addition to providing a warehouse of data, Data Repository staff work with the users to educate them on the datasets as well as assist them in the acquisition of multiple data sets for cross-study analysis. Unlike the majority of biological databases, the Data Repository acts both as a catalogue for data, biosamples, and genetic materials and as a central processing point for the requests for all biospecimens. Due to regulations on the use of clinical data, the ultimate release of that data is governed under NIDDK data release policies. The Data Repository serves as the conduit for such requests.The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH), part of the U.S. Department of Health and Human Services, have established central repositories for DNA, biospecimens, and data collected in clinical studies. The purpose of the Central Repositories is to increase the utility of NIDDK sponsored research by providing access to the samples and data to a wider research community than those research groups involved in the studies.The repositories involved in this initiative are:Research Triangle Institute (RTI International)Research Triangle Park, NCMcKesson Bioservice Corporations (Now Fisher Bioservices)Rock
The cancer translational research informatics platform
Patrick McConnell, Rajesh C Dash, Ram Chilukuri, Ricardo Pietrobon, Kimberly Johnson, Robert Annechiarico, A Jamie Cuticchia
BMC Medical Informatics and Decision Making , 2008, DOI: 10.1186/1472-6947-8-60
Abstract: caTRIP has been developed as an N-tier architecture, with three primary tiers: domain services, the distributed query engine, and the graphical user interface, primarily making use of the caGrid infrastructure to ensure compatibility with other tools currently developed by caBIG. The application interface was designed so that users can construct queries using either the Simple Interface via drop-down menus or the Advanced Interface for more sophisticated searching strategies to using drag-and-drop. Furthermore, the application addresses the security concerns of authentication, authorization, and delegation, as well as an automated honest broker service for deidentifying data.Currently being deployed at Duke University and a few other centers, we expect that caTRIP will make a significant contribution to further the development of translational research through the facilitation of its data exchange and storage processes.In order to have an impact in society, discoveries in cancer research need to be translated into knowledge that can be directly applied to treatment and prevention. These discoveries usually start within the basic sciences, from experiments developed at the molecular level, slowly progressing to clinical research. Although this translational process is at the very basis of our ability to generate new biomedical knowledge, to date few tools have been developed to successfully link the basic and clinical science fields in a way that researchers from both arenas can easily make connections. More specifically, cancer research would benefit from the development of applications that can aggregate clinical and molecular data in a repository that is user-friendly, easily accessible, as well as compliant with regulatory requirements of privacy and security.In alignment with the requirements outlined above, the Duke Comprehensive Cancer Center (DCCC), in collaboration with SemanticBits LLC, has developed the Cancer Translational Research Informatics Platform (c
Developmental biologists' choice of subjects approximates to a power law, with no evidence for the existence of a special group of 'model organisms'
Jamie A Davies
BMC Developmental Biology , 2007, DOI: 10.1186/1471-213x-7-40
Abstract: The results demonstrate that the distribution of attention paid to different organisms has a smooth distribution that approximates to a scale-free power law, in which there is no clear discontinuity that divides organisms into 'models' and the rest. This is true for both individual years and for the aggregate of all years' data. In other systems (eg connections in the World Wide Web), such power-law distributions arise from mechanisms of preferential attachment ('the rich get richer'). Detailed analysis of the progress of different organisms over the years under study shows that, while preferential attachment may be part of the mechanism that generates the power law distribution, it is insufficient to explain it.The smoothness of the distribution suggests that there is no empirical basis for dividing species under study into 'model' organisms and 'the rest', and that the widely-held view about organism choice in developmental biology is distorted.This brief report is about the research discipline of developmental biology, rather than being about the development of any specific organism. It applies a scientific method of analysis to resolve two incompatible but widely held assumptions about the structure and development of the field, specifically the way that attention is focussed on different organisms. The results shed new light on how developmental biologists collectively organize their research.Both assumptions concern developmental biologists' choice of experimental subject, a key aspect of the structure of any science. It is generally acknowledged that most developmental biology research is performed on a small number of organisms that are genetically tractable, easily manipulated, or relevant to human biomedicine. The organisms are often referred to as 'model organisms', with the term 'model' being used to signify universality of developmental mechanisms within a broad taxonomic group [1], even though this has been argued to be a misuse of the word 'model' [2]
Morphogenesis of the Metanephric Kidney
Jamie A. Davies
The Scientific World Journal , 2002, DOI: 10.1100/tsw.2002.854
The Galactic Transient Sky with Swift
Jamie A. Kennea
Physics , 2015,
Abstract: The unique capabilities of Swift that make it ideal for discovery and follow-up of Gamma-Ray bursts also makes it the idea mission for discovery and monitoring of X-ray Transients in the Milky Way and the Large and Small Magellanic Clouds. The Burst Alert Telescope allows for detection of new transient outbursts, the automated follow-up capabilities of Swift allow for rapid observation and localization of the new transient in X-rays and optical/UV bands, and Swift's rapid slewing capabilities allows for low-overhead short observations to be obtained, opening up the possibility of regular, sensitive, long term monitoring of transient outbursts that are not possible with other currently operational X-ray missions. In this paper I describe the methods of discovery of X-ray transients utilizing Swift's BAT and also collaboration with the MAXI telescope. I also detail two examples of X-ray transient science enabled by Swift: Swift discovery and monitoring observations of MAXI J1659-152, a Black Hole candidate Low Mass X-ray Binary in the Galactic Halo, which has the shortest known orbital period of any such system; and Swift monitoring of IGR J00569-7226, an edge on Be/X-ray binary that displayed a outburst in 2013 and 2014, and which monitoring by Swift allowed for detection of dips, eclipses and the determination of the orbital parameters, utilizing a measurement of doppler shifts in the pulsar period.
Breaking Down the Stereotypes of Science by Recruiting Young Scientists
Jamie Schaefer,Steven A. Farber
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0020279
Breaking Down the Stereotypes of Science by Recruiting Young Scientists
Jamie Schaefer ,Steven A Farber
PLOS Biology , 2004, DOI: 10.1371/journal.pbio.0020279
The AAA+ superfamily of functionally diverse proteins
Jamie Snider, Guillaume Thibault, Walid A Houry
Genome Biology , 2008, DOI: 10.1186/gb-2008-9-4-216
Abstract: The 'ATPases associated with diverse cellular activities' (AAA+ proteins) form a large and diverse superfamily found in all organisms. These proteins typically assemble into hexameric ring complexes that are involved in the energy-dependent remodeling of macromolecules [1]. Members of the AAA+ superfamily contain a highly conserved ATPase module of 200-250 amino acids, which includes an αβα core domain where the Walker A and B motifs of the P-loop NTPases are found [2-4].AAA+ proteins are involved in a wide variety of different functions in which the energy extracted from ATP hydrolysis is used in molecular remodeling events. They are involved in processes as diverse as protein unfolding and degradation, peroxisome biogenesis, bacteriochlorophyll biosynthesis, and DNA recombination, replication and repair. AAA+ proteins include the molecular motor dynein, helicases involved in DNA replication, metal chelatases, and proteasome-associated proteins. As a consequence of their diverse functions, AAA+ proteins can be found in most subcellular compartments of eukaryotic cells, as well as in archaea, bacteria and viruses (Table 1). Interestingly, there is little correlation found between the clade an AAA+ protein belongs to and a specific remodeling activity. This suggests that the evolution of AAA+ proteins involved the initial emergence of a small number of defined AAA+ clades that, subsequently, expanded and adapted to allow the processing of a wide variety of targets. Furthermore, the emergence of partner proteins and cofactors has increased the functional diversity of AAA+ proteins [1,5].Sequence and structure analyses reveal that the AAA+ superfamily underwent considerable divergence both before and since the appearance of the last common ancestor of the bacterial, archaeal and eukaryotic divisions of life [1,3,6]. Phylogenetic studies based on sequence and structural information divide the AAA+ superfamily into defined groups, clades and families [3,5,6]. The clades
Keystone symposium: The role of microenvironment in tumor induction and progression, Banff, Canada, 5–10 February 2005
Jamie L Bascom, Paraic A Kenny
Breast Cancer Research , 2005, DOI: 10.1186/bcr1030
Abstract: It is now apparent that reciprocal interactions between tumor cells and their microenvironment – extracellular matrix (ECM), growth factors, fibroblasts, immune and endothelial cells – play an essential role in the earliest stages of transformation to malignant progression and metastasis. By better understanding the complex interactions between all of these factors, it is hoped that therapies might be effectively targeted against both epithelial and stromal determinants of tumor progression. In this regard, there were several encouraging presentations on novel clinical approaches that target these processes.Skiers and snowboarders among the delegates were blessed with 67 cm of fresh snow just prior to arrival, resulting in a stampede for the ski buses each day at 11 am. The quality of the meeting was perhaps best reflected by an equally urgent stampede back to the conference center in time for the evening sessions and posters.Zena Werb (University of California, San Francisco) set the scene for the meeting with a wide ranging plenary lecture detailing crucial interactions between epithelial and stromal cells during both normal mammary development and tumorigenesis. She described a series of wild-type/knockout tissue recombination experiments used to dissect the requirements for epithelially and stromally expressed growth factors and receptors in mammary gland development. In a lecture that was both visually and intellectually stimulating, she showed that intravital imaging technology is a valuable tool with which to interrogate the interactions between stromal and epithelial cells in tumorigenesis. Time-lapse fluorescent videos using mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) transgenic mice bearing various fluorescent markers demonstrated the dynamic interactions between the tumor and host cellular components.In the second keynote address, Joan Massagué (Memorial Sloan Kettering Cancer Center, New York), described a series of experiments that pr
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