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Search Results: 1 - 10 of 10261 matches for " ?ke Sj?holm "
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Liraglutide Therapy for Type 2 Diabetes: Overcoming Unmet Needs
ke Sjholm
Pharmaceuticals , 2010, DOI: 10.3390/ph3030764
Abstract: Although advances have been achieved in the management of type 2 diabetes, current treatment options for patients with this disease still fail to address disease progression, glycaemic control remains suboptimal and therapies are often associated with weight gain and hypoglycaemia. Thus, new antidiabetes therapies are being sought. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretin hormones that have been the recent focus of research. The physiological action of GLP-1, in particular, has demonstrated its potential in addressing the therapeutic needs of patients with type 2 diabetes. To exploit this action, liraglutide, a human GLP-1 analogue that shares 97% of its amino acid sequence identity with native GLP-1, has been developed. In a recent phase 3 trial programme (LEAD, Liraglutide Effect and Action in Diabetes), treatment with liraglutide was associated with substantial improvements in glycaemic control and low risk of hypoglycaemia. In addition, reductions in weight and systolic blood pressure were reported. There is also an indication that liraglutide is capable of improving β-cell function and increasing β-cell mass. Thus, liraglutide may overcome the limitations with current therapies and help to address the unmet clinical needs of patients with type 2 diabetes.
复旦学报(医学版) , 2008,
Abstract: 目的测定GLP-1和Exendin-4对大鼠胰岛微循环的影响。方法大鼠随机分为生理盐水组(NS)和葡萄糖组(GLU);每组再分为3个亚组,分别为对照组、GLP-1组和Exendin-4组。采用微球技术测定大鼠胰腺血流(pancreaticbloodflow,PBF)和胰岛血流(isletbloodflow,IBF)。用ELISA法测定血清胰岛素。结果GLP-1和Exendin-4不影响基础胰岛微循环,但降低糖负荷后IBF/PBF比值(GLP-1组为11.47%±1.11%vs14.33%±0.53%;Exendin-4组为11.25%±1.26%vs14.33%±0.53%,P<0.05),阻断高血糖诱导的胰腺血流向胰岛内重分布。GLP-1对基础和糖负荷后血糖无影响,Exendin-4显著降低基础血糖(4.1±0.23mmol/Lvs5.4±0.37mmol/L,P<0.05)和糖负荷后血糖(17.9±0.97mmol/Lvs22.0±0.69mmol/L,P<0.05)。结论GLP-1和其长效拟似物Exendin-4能有效调节糖负荷后的胰岛微循环。
Early signs of atherosclerosis are associated with insulin resistance in non-obese adolescent and young adults with type 1 diabetes
Bj?rn Rathsman, Stefan Rosfors,ke Sjholm, Thomas Nystr?m
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-145
Abstract: Forty adolescent and young adult individuals (20 type 1 diabetics and 20 non-diabetics), age 14–20 years, without characteristics of the metabolic syndrome, participated in this cross-sectional study. After an overnight fast, Si was measured by hyperinsulinemic euglycemic clamp (40 mU/m2) and calculated by glucose infusion rate (GIR). Carotid intima-media thickness (cIMT) was measured in the common carotid artery with high-resolution ultrasonography. Risk factors of atherosclerosis (Body mass index [BMI], waist circumference, systolic blood pressure [sBP], triglycerides, low HDL-cholesterol and HbA1c) were also investigated.cIMT was increased (0.52?±?0.1 vs. 0.47?±?0.1 mm, P?<?0.01), whereas GIR was decreased (5.0?±?2.1 vs. 7.1?±?2.2 mg/kg/min, P?<?0.01) in type 1 diabetics vs. non-diabetics. The differences in cIMT were negatively associated with Si (r?=??0.4, P?<?0.01) and positively associated with waist circumference (r?=?0.34, P?=?0.03), with no such associations between BMI (r?=?0.15, P?=?0.32), sBP (r?=?0.09, P?=?0.58), triglycerides (r?=?0.07, P?=?0.66), HDL-cholesterol (r?=?0.10, P?=?0.55) and HbA1c (r?=?0.24, P?=?0.13). In a multivariate regression model, between cIMT (dependent) and group (explanatory), only adjustment for Si affected the significance (??=?0.08, P?=?0.11) vs. (??=?0.07, P?<?0.01) for the whole model. No interaction between cIMT, groups and Si was observed.cIMT is increased and associated with insulin resistance in adolescent, non-obese type 1 diabetic subjects. Although, no conclusions toward a causal relationship can be drawn from current findings, insulin resistance emerges as an important factor reflecting early signs of atherosclerosis in this small cohort.Recent advances in diabetes treatment have been successful in postponing the development of microvascular complications through better glycemic control following intensive insulin treatment [1]. In contrast, macrovascular complications have been less affected by this intervention an
Effects of some anti-diabetic and cardioprotective agents on proliferation and apoptosis of human coronary artery endothelial cells
Linnéa Eriksson, ?zlem Erdogdu, Thomas Nystr?m, Qimin Zhang,ke Sjholm
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-27
Abstract: The effect of anti-diabetic and cardioprotective agents on HCAEC viability, proliferation and apoptosis was studied. Viability was assessed using Trypan blue exclusion; proliferation in 5 mM and 11 mM of glucose was analyzed using [3H]thymidine incorporation. Lipoapoptosis of the cells was investigated by determining caspase-3 activity and the subsequent DNA fragmentation after incubation with the free fatty acid palmitate, mimicking diabetic lipotoxicity.Our data show that insulin, metformin, BLX-1002, and rosuvastatin improved HCAEC viability and they could also significantly increase cell proliferation in low glucose. The proliferative effect of insulin and BLX-1002 was also evident at 11 mM of glucose. In addition, insulin, metformin, BLX-1002, pioglitazone, and candesartan significantly decreased the caspase-3 activity and the subsequent DNA fragmentation evoked by palmitate, suggesting a protective effect of the drugs against lipoapoptosis.Our results suggest that the anti-diabetic and cardioprotective agents mentioned above have direct and beneficial effects on endothelial cell viability, regeneration and apoptosis. This may add yet another valuable property to their therapeutic effect, increasing their clinical utility in type 2 diabetic patients in whom endothelial dysfunction is a prominent feature that adversely affect their survival.The prevalence of diabetes among adults worldwide was estimated in 2010 to 6.4%, thus affecting 285 million adults. This figure is predicted to rise to 7.7%, in numbers 439 million, by 2030 [1]. In patients with diabetes, the major cause of death is macrovascular disease [2,3], and in individuals with type 2 diabetes, the main etiology for up to 75% of the mortality is atherosclerotic cardiovascular disease [4]. In contrast to microangiopathies (e.g. nephropathy and retinopathy), where the causal relation to hyperglycemia is well supported, the link between hyperglycemia and macroangiopathy is uncertain, at least in terms of
Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice
Henrik Orts?ter, Nina Grankvist, Swen Wolfram, Nicolas Kuehn,ke Sjholm
Nutrition & Metabolism , 2012, DOI: 10.1186/1743-7075-9-11
Abstract: Young (7 week-old) db/db mice were randomized and assigned to receive diets supplemented with or without EGCG or rosiglitazone for 10 weeks. Fasting blood glucose, body weight and food intake was measured along the treatment. Glucose and insulin levels were determined during an oral glucose tolerance test after 10 weeks of treatment. Pancreata were sampled at the end of the study for blinded histomorphometric analysis. Islets were isolated and their mRNA expression analyzed by quantitative RT-PCR.The results show that, in db/db mice, EGCG improves glucose tolerance and increases glucose-stimulated insulin secretion. EGCG supplementation reduces the number of pathologically changed islets of Langerhans, increases the number and the size of islets, and heightens pancreatic endocrine area. These effects occurred in parallel with a reduction in islet endoplasmic reticulum stress markers, possibly linked to the antioxidative capacity of EGCG.This study shows that the green tea extract EGCG markedly preserves islet structure and enhances glucose tolerance in genetically diabetic mice. Dietary supplementation with EGCG could potentially contribute to nutritional strategies for the prevention and treatment of type 2 diabetes.The WHO and CDC (U.S. Center for Disease Control) predict that by today some 26 million people in the U.S. only are afflicted by diabetes (http://www.cdc.gov/diabetes/ webcite). Previously viewed as a disease of the elderly, type 2 diabetes is now seen in ever-younger age groups. In the U.S. about one third of all newly diagnosed diabetes in children and adolescents (age 10-19 years) now is type 2, an alarming scenario considering the magnitude of premature cardiovascular and cerebrovascular morbidity in these individuals. Recent estimates by the CDC indicate that the life-time risk of getting diabetes is not less than 40% for people born in 2000 in the U.S., with certain ethnic groups being significantly overrepresented (http://www.cdc.gov/diabetes web
The Ambiguity of Modern Sculpture
Jessica Sjholm Skrubbe
Nordlit : Tidsskrift i litteratur og kultur , 2007,
The Ambiguity of Modern Sculpture
Jessica Sjholm Skrubbe
Nordlit : Tidsskrift i litteratur og kultur , 2007,
Angular Momentum of Electromagnetic Radiation. Fundamental physics applied to the radio domain for innovative studies of space and development of new concepts in wireless communications
Johan Sjholm,Kristoffer Palmer
Physics , 2009,
Abstract: In this diploma thesis we study the characteristics of electromagnetic fields carrying orbital angular momentum (OAM) by analyzing and utilizing results achieved in optics and then apply them to the radio domain to enable innovative radio studies of space and the development of new concepts in wireless communications. With the recent advent of fast digital converters it has become possible, over a wide radio frequency range, to manipulate not only the modulation properties of any given signal carried by a radio beam, but also the physical field vectors which make up the radio beam itself. Drawing inferences from results obtained in optics and quantum communication research during the past 10-15 years, we extract the core information about fields carrying orbital angular momentum. We show that with this information it is possible to design an array of antennas which, together with digital receivers/transmitters, can readily produce, under full software control, a radio beam that carries electromagnetic orbital angular momentum, a classical electrodynamics quantity known for a century but so far preciously little utilized in radio, if at all. This electromagnetic field is then optimized with the help of various antenna array techniques to improve the radio vector field qualities. By explicit numerical solution of the Maxwell equations from first principles, using a de facto industrial standard antenna software package, we show that the field indeed carries orbital angular momentum, and give a hint on how to detect and measure orbital angular momentum in radio beams. Finally, we discuss and give an explanation of what this can be used for and what the future might bring in this area.
Dietary fiber, organic acids and minerals in selected wild edible fruits of Mozambique
Telma Magaia, Amália Uamusse, Ingegerd Sj holm and Kerstin Skog
SpringerPlus , 2013, DOI: 10.1186/2193-1801-2-88
Abstract: The harvesting, utilization and marketing of indigenous fruits and nuts have been central to the livelihoods of the majority of rural communities in African countries. In this study we report on the content of dietary fiber, minerals and selected organic acids in the pulps and kernels of the wild fruits most commonly consumed in southern Mozambique. The content of soluble fiber in the pulps ranged from 4.3 to 65.6?g/100?g and insoluble fiber from 2.6 to 45.8?g/100?g. In the kernels the content of soluble fiber ranged from 8.4 to 42.6?g/100?g and insoluble fiber from 14.7 to 20.9?g/100?g. Citric acid was found in all fruits up to 25.7?g/kg. The kernels of Adansonia digitata and Sclerocarya birrea were shown to be rich in calcium, iron, magnesium and zinc. The data may be useful in selecting wild fruit species appropriate for incorporation into diets.
Does evidence really matter? Professionals' opinions on the practice of early mobilization after stroke
Sj holm A, Skarin M, Linden T, Bernhardt J
Journal of Multidisciplinary Healthcare , 2011, DOI: http://dx.doi.org/10.2147/JMDH.S24592
Abstract: es evidence really matter? Professionals' opinions on the practice of early mobilization after stroke Original Research (2790) Total Article Views Authors: Sj holm A, Skarin M, Linden T, Bernhardt J Published Date October 2011 Volume 2011:4 Pages 367 - 376 DOI: http://dx.doi.org/10.2147/JMDH.S24592 Anna Sj holm1,2, Monica Skarin1,2, Thomas Linden1,2, Julie Bernhardt2 1Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden; 2Stroke Division, Florey Neuroscience Institutes, La Trobe University, Melbourne, Australia Introduction: Early mobilization after stroke may be important for a good outcome and it is currently recommended in a range of international guidelines. The evidence base, however, is limited and clear definitions of what constitutes early mobilization are lacking. Aims: To explore stroke care professionals' opinions about (1) when after stroke, first mobilization should take place, (2) whether early mobilization may affect patients' final outcome, and (3) what level of evidence they require to be convinced that early mobilization is beneficial. Methods: A nine-item questionnaire was used to interview stroke care professionals during a conference in Sydney, Australia. Results: Among 202 professionals interviewed, 40% were in favor of mobilizing both ischemic and hemorrhagic stroke patients within 24 hours of stroke onset. There was no clear agreement about the optimal time point beyond 24 hours. Most professionals thought that patients' final motor outcome (76%), cognitive outcome (57%), and risk of depression (75%) depends on being mobilized early. Only 19% required a large randomized controlled trial or a systematic review to be convinced of benefit. Conclusion: The spread in opinion reflects the absence of clear guidelines and knowledge in this important area of stroke recovery and rehabilitation, which suggests further research is required.
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