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Search Results: 1 - 10 of 311531 matches for " 王政昆 "
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脂肪组织转化关键因子的研究进展
Research Progress of Key Factors for the Transformation of Adipose Tissue
 [PDF]

朱万龙, 陈金龙,
QianRen Biology (QRB) , 2015, DOI: 10.12677/QRB.2015.22002
Abstract:
脂肪组织科分为褐色脂肪组织(Brown adipose tissue, BAT)和白色脂肪组织(white adipose tissue)。BAT为一种特化的产热组织,是小型哺乳动物非颤抖性产热的主要部位。PRDM16 (PR domain-con- taining 16)锌指蛋白在BAT中特异性表达,可触发BAT细胞中PGC-1α (Peroxisome proliferators-ac- tivated receptor-γcoactivator-1)和解偶联蛋白1基因等的表达,是促进褐色脂肪细胞形成的关键调控因子。BMP7 (Bone morphogenetic proteins 7)也可激活PRDM16和PGC-1α等基因的表达,刺激BAT细胞分化及产热增强。COXII (cyclooxygenase-2)、PPARα (peroxisome proliferator-activated receptor α)、PGC-1α是褐色脂肪细胞分化与代谢中的关键调控因子。在WAT中COXII是肾上腺素信号通路的一个效应分子,对于WAT中诱导形成褐色脂肪细胞是必需的。PPARα在BAT中的表达水平高于WAT,能诱导BAT中的产热相关基因的表达及原代褐色脂肪细胞的生成。PGC-1α也能诱导WAT中褐色脂肪细胞的形成,在褐色脂肪细胞分化的过程中PGC-1α表达量上升。本论文对脂肪转化过程中关键因子进行研究,并且对于小型哺乳动物的脂肪转化研究给出一些展望。
Adipose tissue is divided into brown adipose tissue (BAT) and white adipose tissue (WAT). BAT was a specialized thermogenic tissue, which was the main site of nonshivering thermogenesis in small mammals. PR domain-containing 16 (PRDM16) was a brown adipose determination factor. It was selectively expressed in BAT and induced the expression of α subunit of peroxisome proliferators-activated receptor-γcoactivator-1 (PGC-1α) and uncoupling protein 1. BMP7 could stimulate brown adipocyte differentiation and enhance thermogenesis by activating the expression PRDM16 and PGC-1α genes. COXII, PPARα and PGC-1α were the key regulatory factors of differentiation and metabolism in brown adipocyte. COXII was an effector molecule of adrenergic pathway in WAT. It was necessary for the formation of brown adipocytes. PPARα expression level in BAT was higher than WAT. It could induce the expression of thermogenesis related genes and promote the generation of primary brown adipocyte. PGC-1α also could induce the formation of brown adipocytes in WAT. In the process of brown adipocytes differentiation, PGC-1α expression level increased. In this paper, the key factors of transformation of adipose tissue were studied, and some prospects for the study of the fat tissue transformation of small mammals were given.

褐色脂肪组织分化及其调节机制研究进展
Brown Adipose Tissue Differentiation and Control Mechanism
 [PDF]

张麟, 朱万龙, 蔡金红, 练硝,
Bioprocess (BP) , 2011, DOI: 10.12677/bp.2011.12004
Abstract: 人类和其他哺乳动物主要有两种脂肪组织:白色脂肪组织(又分为内脏和皮下两大类)和褐色脂肪组织;相对于内脏白色脂肪组织,皮下白色脂肪组织和褐色脂肪组织有利于改善糖代谢和能量消耗。人体内出现两种褐色脂肪组织的分化途径。BMP7 (bone morphogenetic proteins 7)是转化生长因子-β超家族成员(transforming growth,TGF-β)的多功能分泌型信号分子,在胚胎发生、个体形成、非对称器官的形成、胚胎的发育和损伤组织的修复中起关键作用。最近发现BMP7能促进褐色脂肪细胞的分化,可能是由于BMP7诱导PRDM16及PGC-1α等的基因表达,进一步增加了UCP1等基因的表达,最终诱导褐色脂肪细胞中线粒体的生物生成和随后的细胞分化。这些研究显示通过激活 BMP7和PRDM16 来增加褐色脂肪组织在治疗肥胖及相关疾病方面具有很大潜力。最近采用监测癌症及癌症转移的氟化脱氧葡萄糖–正电子发射计算机断层显像技术与(或)X-射线断层显像技术(18F-FDG-PET/CT)扫描技术并结合定位组织取样进行分子鉴定发现在成年人体内的确存在有功能活性的褐色脂肪组织,人们将其作为一个寻找治疗肥胖症新方法的重要靶标。
Humans and other mammals have two main adipose tissue depots: white adipose tissue (include visceral- and subcutaneous- white adipose tissue), and brown adipose tissue, each of which possesses unique cell-autonomous properties. In contrast to visceral adipose tissue, which can induce detrimental metabolic ef-fects, subcutaneous white adipose tissue and brown adipose tissue have the potential to benefit metabolism by improving glucose homeostasis and increasing energy consumption. BMP7 (bone morphogenetic proteins7) is one of members of the transforming growth factor-β (TGF-β) superfamily and control multiple key steps of embryonic development and differentiation. In recent studies, people found that BMP7-induced UCP1 ex-pression was markedly diminished in brown preadipocytes deficient in both PRDM16 and PGC (PGC-1α and PGC-1β), it ultimately induces BAT mitochondrial cells in the biological production and cell differentiation. There are two ways in development of brown adipose tissue. These researches indicate the potential to treat obesity and related diseases through activating BMP7 and PRDM16 to produce brown adipose tissue. Re-cently, using 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomographic and computed tomographic (PET-CT) scans showed that adults retain metabolically active BAT depots that can be induced in response to cold and sympathetic nervous system activation. These findings high light BAT as a potenial relevant tar get for pharmacological and gene expression manipulation to combat human obesity. We reviewed the recent re-search progresses of BAT in human and its potential functional significance.
解偶联蛋白-1(UCP1)的研究进展及其应用前景
The Research Progress and Application Prospect of Uncoupling Protein 1 (UCP1)
 [PDF]

高文荣, 张麟, 余婷婷, 朱万龙,
Bioprocess (BP) , 2012, DOI: 10.12677/BP.2012.23021
Abstract: UCP1是唯一在褐色脂肪组织(BAT)中表达的解偶联蛋白质。有别于解偶联蛋白家族其他成员的功能,UCP1的主要功能是参与BAT的产热调节和能量代谢来维持机体的能量代谢平衡。陆续有研究阐明调控UCP1参与BAT产热调节和能量代谢的分子机制,逐渐揭示了UCP1BAT能量代谢过程中涉及的信号通路与转录调控。这不仅让我们更好地理解UCP1BAT能量代谢调控中的重要作用,而且为基于褐色脂肪组织的肥胖治疗提供了理论依据。本文阐述了近年来研究发现的UCP1BAT能量代谢过程中发挥重要作用的信号通路与转录调控,并讨论了多种基于针对褐色脂肪组织的肥胖治疗手段的有效性与可行性。
UCP1 is the only one expression of uncoupling protein in the brown adipose tissue (BAT). Different from the uncoupling protein family other member functions, UCP1’s main function is to participate thermogenic regulation and energy metabolism in BAT to maintain the body’s energy metabolic balance. In
懒猴的头骨形态及其比较研究
吴介云,
动物学杂志 , 1991,
Abstract:
大绒鼠被毛的季节性变化
Seasonal Variations of Hair in Eothenomys miletus
 [PDF]

付家豪, 杨涛, 张麟, 陈金龙, , 朱万龙
Bioprocess (BP) , 2015, DOI: 10.12677/BP.2015.54006
Abstract: 为阐明大绒鼠被毛的季节性变化及其在体重调节和体温调节中的作用,本研究测定了季节性变化条件下大绒鼠的体温、被毛重量和非颤抖性产热。结果表明:冬季大绒鼠的体温显著降低,冬季被毛重量和非颤抖性产热显著高于夏季。其中冬季被毛重量较夏季高35.48%。所有结果暗示被毛的适应性变化是野生小型哺乳动物应对环境温度季节性波动的主要适应策略之一,在其体重调节和体温调节中具有重要作用和意义。
The role of seasonal change of hair in the regulation of body mass regulation and thermoregulation was examined in Eothenomys miletus in the present study. Mass of hair, body temperature and nonshivering thermogenesis (NST) were measured in E. miletus that were wild-captured over four seasons. The results showed that body temperature was significantly lower in winter, and mass of hair and NST were also higher than those in summer, mass of hair was 35.48% higher in winter compared with that in summer. These findings suggest that seasonal changes in the hair are em-ployed by the wild small mammals in response to seasonal environment fluctuations, and thus play important roles in the regulations of body mass regulation and thermoregulation.
中缅树鼩的生理生态和行为学研究进展
Progress and Prospect of Studies on Physiological and Behavioral Ecology in Tree Shrews, Tupaia belangeri
 [PDF]

侯东敏, 朱万龙, 高文荣, 张浩,
Bioprocess (BP) , 2016, DOI: 10.12677/BP.2016.63006
Abstract: 中缅树鼩(Tupaia belangeri)作为东洋界特有的小型哺乳动物以及人类代谢性疾病动物模型,对其进行生理生态学研究有助于了解其对季节性环境变化的适应策略及其体内产热机制等生态学和进化生物学问题,具有十分重要的意义。通过对中缅树鼩行为方面的研究,可为其作为实验动物的驯化饲养和行为生态研究奠定基础。本文阐述了关于中缅树鼩的生理生态和行为学特征的研究进展,以期对未来可能的发展方向进行展望。
As a typical small mammal in the oriental realm and an animal model for the metabolic disease of human, it is significative to do physiological and ecological research on Tupaia belangeri, which helps to believe its adaptive strategy of seasonal climate change and its body thermogenesis me-chanism problems in ecology and evolutionary biology. Meanwhile, research on the behavior of Tupaia belangeri can lay the foundation to domesticate them as an experimental animal and do behavioral ecological research. The article expounds the research progress on the physiological and behavioral characteristics of the tree shrew, attempting to point out the development direction of future.
冷驯化条件下高山姬鼠能量对策的初步研究
姜文秀,,,
动物学杂志 , 2009,
Abstract: 为进一步了解横断山区小型哺乳动物的能量代谢对策,本文主要研究了横断山的外来物种——高山姬鼠(Apodemuschevrieri)持续冷暴露28d的能量变化。结果表明,随着冷驯化时间延长,体重和体温降低;摄入能、消化能和可代谢能增加,至21d后这3项指标又下降;BMR和NST增加,并且28d后它们分别是对照组的187.19%和155.97%;(NST-BMR)/BMR比值7d时增加到1.02,21d后下降至0.53,并保持稳定。因此,在持续冷暴露下,高山姬鼠采取适当降低体重和体温、增加能量摄入、增加BMR和NST产热等途径来维持能量代谢平衡,但是NST在产热中的作用逐渐降低。这种能量模式很可能代表了一种外来小型啮齿动物对于在横断山生存独特的能量适应策略。
横断山区高山姬鼠身体能值的适应性调节
,刘春燕,练硝,
动物学杂志 , 2008,
Abstract: 为探讨栖息于横断山地区高山姬鼠(Apodemuschevrieri)身体状况与环境之间的适应关系,对野外和实验室条件下高山姬鼠的身体能值进行了测定。结果表明,高山姬鼠身体能值存在季节性变化,6月最高,9月次之,11月开始下降,到次年3月达到最低。冷驯化条件下,其身体能值显著降低。高山姬鼠的身体能值在不同季节和冷驯化条件下表现出的变化模式,与其低纬度高海拔、年平均温度较低的生存环境有关,反映了横断山区小型哺乳动物在季节性环境中的生存机制和适应对策。
冷暴露对中缅树鼩肝脏、膈肌和心肌线粒体呼吸的影响
谢静,,练销,
兽类学报 , 2008,
Abstract: ?:在4℃急性冷暴露(1h,4h,8h,24h)和持续冷暴露(7d,14d,28d)条件下,测定中缅树鼩膈肌、心肌和肝脏的线粒体状态ⅲ呼吸、状态ⅳ呼吸、呼吸控制率(rcr)、线粒体蛋白含量以及肝脏线粒体p/o值的变化。结果表明:肝脏线粒体状态ⅲ、状态ⅳ呼吸随着低温处理时间的延长,呼吸速率均极显著增加,在28d后分别增加了132.9%、124.4%(p<0.01),rcr与对照比较,在8h和7d组分别显著增加了35.8%和48.4%(p<0.05),线粒体蛋白含量也极显著增加,在28d后增加了104.7%(p<0.01),p/o值在整个低温处理过程中呈下降趋势,在28d后降低了40.2%,达到极显著水平(p<0.01);膈肌线粒体状态ⅲ呼吸在整个低温处理期间没有显著变化,状态ⅳ呼吸在28d达到极显著增加(p<0.01,64.9%),rcr在28d后显著降低(p<0.05,42.1%),线粒体蛋白只有4h组有极显著增加(p<0.01,45.2%);心肌的状态ⅲ呼吸在8h组有着极显著的增加(p<0.01,54.7%),状态ⅳ呼吸随着低温处理时间的增加而显著增加,28d后增加了94.7%(p<0.01),rcr在28d后降低37.8%(p<0.01),线粒体蛋白表现出先下降再上升的趋势,8h组下降37.8%(p<0.01),28d增加25.2%(p<0.05)。说明中缅树鼩在冷胁迫的条件下肝脏线粒体呼吸能力显著增强,主要表现为状态ⅳ呼吸即质子漏产热的显著增强,膈肌和心肌的线粒体呼吸也具有一定的适应性变化,补偿了冷胁迫条件下中缅树鼩增加的能量需求,是中缅树鼩在冷胁迫中重要的适应对策。
横断山区高山姬鼠消化道形态的季节动态
蓓?,朱万龙?,练硝?,*?
生态学报 , 2009,
Abstract: 为探讨栖息于横断山地区高山姬鼠的消化道特征与环境之间的适应关系,对野外条件下高山姬鼠消化道各项指标进行了测定。实验分别测定了不同季节高山姬鼠胃、小肠、大肠、盲肠的长度、含内容物重、去内容物重、干组织重。结果表明:高山姬鼠消化道特征存在季节性变化,胃、小肠、大肠的各项指标及盲肠去内容物重、干重均于食物质量较好的6月、9月份较高;盲肠长度和含内容物重于3月、11月份较高。高山姬鼠在低温、食物质量下降、繁殖等胁迫因子影响下,通过增加食物摄入、调节消化道形态来满足能量需求的增加,维持正常的生理机能。高山姬鼠的消化道在不同季节中表现出的变化模式说明其有能力适应低纬度高海拔,年平均温度较低的生存环境。
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