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This paper aims to analysis the comprehensive influence of regulation policy such as, Tobacco Hazards Prevention Act, Tobacco Health and Welfare Tax, on demand for cigarette inTaiwan. Annual data through 1971 to 2009 are used to estimate the demand for cigarettes by applying SUR model. The impacts of deregulation of foreign cigarettes imports, anti-smoking campaigns on cigarette case, the implementation of Tobacco Hazards Prevention Act, and levy of Tobacco Health and Welfare Tax are taken into account by using dummy variables. The empirical results indicate that the price elasticities for domestic and imported cigarettes are ？0.88 and ？0.47, respectively. The income elasticities are 0.06 for domestic and 0.18 for imported cigarettes and the cross-price elasticities are 0.40 for domestic and 0.63 for imported cigarettes. The regulation policies of revelation of cigarette health information, anti-smoking campaigns on cigarette case, and the Tobacco Health and Welfare Tax have significantly negative effects on both domestic and imported cigarette consumption. In addition, opening the markets to imported cigarettes has had a significantly negative effect on domestic cigarette consumption, but had a significantly positive effect on imported cigarette consumption. Finally, Tobacco Hazards Prevention Act has a significantly negative effect on domestic cigarette consumption, but had an insignificantly effect on imported cigarette consumption. In conclusions, the effects of regulation policy on domestic cigarettes are more significant than on imported cigarettes. Taiwan Government should increase the amount of the Tobacco Health and Welfare Tax, and transform it from unit tax into ad valorem tax in order to effectively reduce the demand on imported cigarettes.