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Search Results: 1 - 10 of 130 matches for " ágnes Zvara "
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Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats
Márta Sárk?zy, ágnes Zvara, Nóra Gyémánt, Veronika Fekete, Gabriella F Kocsis, Judit Pipis, Gerg? Sz?cs, Csaba Csonka, László G Puskás, Péter Ferdinandy, Tamás Csont
Cardiovascular Diabetology , 2013, DOI: 10.1186/1475-2840-12-16
Abstract: Fasting blood glucose, serum insulin, cholesterol and triglyceride levels were measured at 6, 16, and 25 wk of age in male ZDF and lean control rats. Oral glucose tolerance test was performed at 16 and 25 wk of age. At week 25, total RNA was isolated from the myocardium and assayed by rat oligonucleotide microarray for 14921 genes. Expression of selected genes was confirmed by qRT-PCR.Fasting blood glucose, serum insulin, cholesterol and triglyceride levels were significantly increased, glucose tolerance and insulin sensitivity were impaired in ZDF rats compared to leans. In hearts of ZDF rats, 36 genes showed significant up-regulation and 49 genes showed down-regulation as compared to lean controls. Genes with significantly altered expression in the heart due to metabolic syndrome includes functional clusters of metabolism (e.g. 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2; argininosuccinate synthetase; 2-amino-3-ketobutyrate-coenzyme A ligase), structural proteins (e.g. myosin IXA; aggrecan1), signal transduction (e.g. activating transcription factor 3; phospholipase A2; insulin responsive sequence DNA binding protein-1) stress response (e.g. heat shock 70kD protein 1A; heat shock protein 60; glutathione S-transferase Yc2 subunit), ion channels and receptors (e.g. ATPase, (Na+)/K+ transporting, beta 4 polypeptide; ATPase, H+/K+ transporting, nongastric, alpha polypeptide). Moreover some other genes with no definite functional clusters were also changed such as e.g. S100 calcium binding protein A3; ubiquitin carboxy-terminal hydrolase L1; interleukin 18. Gene ontology analysis revealed several significantly enriched functional inter-relationships between genes influenced by metabolic syndrome.Metabolic syndrome significantly alters cardiac gene expression profile which may be involved in development of cardiac pathologies in the presence of metabolic syndrome.
Exogenous overexpression of nerve growth factor in the urinary bladder produces bladder overactivity and altered micturition circuitry in the lumbosacral spinal cord
Peter Zvara, Margaret A Vizzard
BMC Physiology , 2007, DOI: 10.1186/1472-6793-7-9
Abstract: An osmotic pump infused 0.9% NaCl (n = 6) or NGF (n = 6)(2.5 μg/μl solution; 0.5 μl/hr) for two weeks into the bladder wall. NGF bladder content was determined by enzyme-linked immunoassays. Bladder function was assessed with conscious cystometry. Immunohistochemical and imaging techniques were used to determine the distribution of Fos-IR cells and CGRP expression in the L5-S1 spinal cord in saline and NGF-treated rats two hours after intravesical saline distention. Fos expression and CGRP-IR in NGF-treated rats with bladder distention was compared to that observed in cyclophosphamide (CYP; 75 mg/kg; i.p.) treated rats with bladder distention.Two-week infusion of NGF into the bladder wall increased bladder weight, reduced bladder capacity (60%), reduced the intercontraction interval (60%) and increased the amplitude of non-voiding contractions. NGF treatment and intravesical saline distention (2 hr) increased expression of Fos protein in L6-S1 spinal cord and altered the distribution pattern of Fos-IR cells. CGRP-IR in the lumbosacral spinal cord was also increased after NGF treatment.These data suggest that NGF infusion into the bladder wall induces bladder overactivity, can reveal a "nociceptive" Fos expression pattern in the spinal cord in response to a non-noxious bladder stimulus and increases CGRP-IR in the lumbosacral spinal cord.The exact contribution of nerve growth factor (NGF) to bladder function is not known but a correlation between bladder overactivity and elevated urinary bladder NGF has been suggested. Experimentally-induced cystitis induces bladder overactivity and increases bladder NGF protein and transcript. In the spontaneously hypertensive rat model, increased expression of bladder NGF is associated with hyperactive voiding [1]. Bladder outlet obstruction is associated with increased expression of bladder NGF [2-4]. Intrathecal [5], intravesical delivery of NGF [6] or adenovirus-mediated NGF overexpression [7] in the bladder induces bladder over
A multimodal analysis of the sequential organization of verbal and nonverbal interaction
Abuczki, ágnes
Argumentum , 2011,
Abstract: The paper addresses the study of the formal features of conversation from both a theoretical and an empirical perspective. In particular, following the framework and terminology of Sacks, Schlegoff and Jefferson (1974), turn-taking and sequencing are designated ‘formal’ features of interaction. Furthermore, the study adopts and fits into the framework of the theoretical modelling of human–computer interaction (HCI), as outlined in Hunyadi (2011). After reviewing the theoretical background of the multimodal analysis of conversation, a communicative act-based pragmatic annotation system will be outlined which is to contribute to a better understanding of the sequential organization of interaction. Finally, a case study on the sequential organization of nonverbal cues for turn regulation as well as their alignment with verbal content will be described.
The Making of a Bewitchment Narrative
ágnes Hesz
Folklore : Electronic Journal of Folklore , 2007,
Abstract: By analysing the formation of one bewitchment narrative, the paperargues that narratives on bewitchment primarily serve as communicative devices by which one can negotiate his social position in the community, even in cases when overt social conflict is not involved. In case of misfortune the local bewitchment theories give rise to several competing interpretations in the community (a Hungarian village in Romania). The different versions also assign different roles to the bewitched: some put them into the position of the guilty while others show them as wholly innocent victims. By following the interpretational strategies applied during the construction of the bewitchment narrative of a family whose social position was shaken, the paper aims to show how the bewitched managed to reach a version which has put them into a favourable position, and how this narrative was employed to ‘save their faces’.
Intertextualité, motivation et fonction esthétique. Une étude comparative des textes du 12e, du 13e et du 14e siècles de la légende de Saint Alexis
Dancs, ágnes
Argumentum , 2007,
Abstract: The legend of Alex, a Syrian saint who lived in the 5th century A. D., was popular in Europe during the Middle Ages. The Syrian legend was translated into Greek, from Greek into Latin in the 10th century and from Latin to French and other native languages. There are French manuscripts of the 12th, 13th and 14th centuries that are preserved. I made a comparaison between these texts and I found passages in the manuscripts of the 13th and the 14th centuries that I consider thematic amplifications of the texts existing up to those times. These passages are quoted from the Bible. I collate the verses of the Vulgate and the French texts for showing the stylistic modifications and the stylitic instruments of the authors who were forming their sources while rewriting.
The Use of Metaphors in Advertising. A Case Study and Critical Discourse Analysis of Advertisements in Cosmopolitan
Abuczki, ágnes
Argumentum , 2009,
Abstract: The aim of this study is to draw attention to the ways the media use and manipulate people's thinking by applying a specific type of figure speech, namely metaphor in advertisements. I try to investigate the relationship between individual psychology, metaphor and the media by means of a case study of the metaphors contained in two issues of the Cosmopolitan magazine, the original American issue and a Hungarian version. A model is proposed in my essay whereby people's thinking is structured by metaphor. Magazines such as the Cosmopolitan have the power to influence the way that people, and therefore, societies construct abstract domains such as interpersonal relationships, health, and beauty. In the first half of this paper, I will explain the relationship between consumerism and advertising; and I will also provide a definition of metaphors, describe their component parts, observe their role from a cognitive perspective, and provide a brief historical overview of the research of metaphors. In the second part of the paper, I will present my research of a collection of metaphors – categorized according to their source domains – found in the adverts of the magazine.
Stable flows with restricted edges
ágnes Cseh
Computer Science , 2013,
Abstract: The stable marriage problem with its extensions is a widely studied subject. In this paper, we combine two topics related to it, setting up new and generalizing known results in both. The stable flow problem extends the well-known stable matching problem to network flows. Restricted edges have some special properties: forced edges must be in the stable solution, while forbidden edges may not be in it. Free edges are not able to block matchings. Here we describe a polynomial algorithm that finds a stable flow with forced and forbidden edges or proves its nonexistence. In contrast to this, we also show that determining whether a stable flow with free edges exists, is NP-complete.
Tunable terahertz oscillations in superlattices subject to an in-plane magnetic field
M. Orlita,R. Grill,L. Smrcka,M. Zvara
Physics , 2006, DOI: 10.1103/PhysRevB.74.125312
Abstract: We present a concept of terahertz oscillations in superlattices that are generated under conditions apparently different from standard Bloch oscillations. These oscillations are induced when crossed magnetic and electric fields are applied to the superlattice, both in the in-plane direction. The frequency of these oscillations is tunable by the applied fields.
Magyarországi gyógyszerészek és üzleteik a 18. század végén (Az 1786. évi patikavizitációk tanulságai) Hungarian pharmacists and stores at the end of the 18th century (The lessons of visits in pharmacy in the year of 1786)
Romhányi ágnes
Kaleidoscope History , 2012,
A népi gyógyítás és a modern orvoslás viszonya a 19. századi Magyarországon The relationship of folk and modern medicine in the 19th century Hungary
Fazekas Eszter ágnes
Kaleidoscope History , 2011,
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