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Search Results: 1 - 10 of 401943 matches for " Marvin Lester M. Cuaresma "
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Assessing the Managerial Skills and Decision-Making Ability of the Local Chief Executives: The Case of the Third District of Nueva Ecija  [PDF]
Kim Fe Pauleen A. Villanueva, Aileen A. Villanueva, Dennis U. Lasig, Ryan B. Esteban, Marvin Lester M. Cuaresma
Open Access Library Journal (OALib Journal) , 2019, DOI: 10.4236/oalib.1105899
Abstract:
The research is about the assessment of the Managerial Skills and Deci-sion-Making Ability of the Local Chief Executives of the Third District of Nueva Ecija, Philippines. The study argued that Managerial Skills and “De-cision-making Ability” must go together to effect change in the local gov-ernance and as an important domain of leadership. The leadership of the Local Chief Executives of the Third District of Nueva Ecija could be measured in terms of managerial skills and decision-making ability. This must go together to effect change in local governance. The study used the Descriptive Survey Method. This method involves the collection of data in order to test hypotheses or answer questions. With devolved powers from the national government, the local government officers specifically local chief executives such as mayor and barangay chairmen, together with the public administrators of their respective units, are expected to manage their work, people, and environment effectively, efficiently lead them towards the achievement of their goals and be able to relate these with local governance buzzwords like transparency, accountability, participation, equity, efficiency, effectiveness, and development. Data were collected by means of a survey questionnaire. The study confirmed that managerial skills and decision making ability are essential qualifications in good governance. The offshoot of the two domains is the essence of effective leadership which stems from the fact that leaders have the capacity to translate visions into actions. Central to this is their ability to make sound decisions and manage with efficiency the work of a civil servant.
The politics of governing cities, infrastructures and resource flows: spaces of reproduction or reconfiguration?
M. Hodson ,S. Marvin
Geographica Helvetica (GH) , 2012,
Abstract: No abstract available.
Observations of nightside auroral plasma upflows in the F-region and topside ionosphere
C. Foster,M. Lester
Annales Geophysicae (ANGEO) , 2003,
Abstract: Observations from the special UK EISCAT program UFIS are presented. UFIS is a joint UHF-VHF experiment, designed to make simultaneous measurements of enhanced vertical plasma flows in the F-region and topside ionospheres. Three distinct intervals of upward ion flow were observed. During the first event, upward ion fluxes in excess of 1013 m–2 s–1 were detected, with vertical ion velocities reaching 300 m s–1 at 800 km. The upflow was associated with the passage of an auroral arc through the radar field of view. In the F-region, an enhanced and sheared convection electric field on the leading edge of the arc resulted in heating of the ions, whilst at higher altitudes, above the precipitation region, strongly enhanced electron temperatures were observed; such features are commonly associated with the generation of plasma upflows. These observations demonstrate some of the acceleration mechanisms which can exist within the small-scale structure of an auroral arc. A later upflow event was associated with enhanced electron temperatures and only a moderate convection electric field, with no indication of significantly elevated ion tem- peratures. There was again some evidence of F-region particle precipitation at the time of the upflow, which exhibited vertical ion velocities of similar magnitude to the earlier upflow, suggesting that the behaviour of the electrons might be the dominant factor in this type of event. A third upflow was detected at altitudes above the observing range of the UHF radar, but which was evident in the VHF data from 600 km upwards. Smaller vertical velocities were observed in this event, which was apparently uncorrelated with any features observed at lower altitudes. Limitations imposed by the experimental conditions inhibit the interpretation of this event, although the upflow was again likely related to topside plasma heating.
Following Inhibition of BCL-2 by Antisense Oligonucleotides Compensatory Suppression of Apoptosis Involves the Direct Signal Transduction Pathway of LNCaP Cells  [PDF]
Marvin Rubenstein, Courtney M. P. Hollowell, Patrick Guinan
Open Journal of Apoptosis (OJApo) , 2015, DOI: 10.4236/ojapo.2015.41001
Abstract: Previously we have shown that when LNCaP cells are treated with antisense oligonucleotides (oligos) directed against BCL-2, compensatory changes in non-targeted genes take place in attempts to restore apoptosis and promote tumor aggressiveness. In addition to the inhibition of BCL-2, we find that the apoptosis promoter caspase-3 activity is suppressed, the transcription activity of STAT-3 is enhanced, while other regulators (bax, clusterin, AKT-1) associated with mitochondrial regulated apoptosis and caspase cascade are either unchanged or undetectable. We now evaluate proteins associated with the second pathway of apoptosis activation mediated by direct signal transduction involving fas, fas-ligand (a tumor necrosis factor-like cell surface receptor aka CD95), as well as the similar programmed death cell surface receptor (PD-1) and its respective ligand (PD-1L). This study evaluates the growth inhibition of in vitro propagating LNCaP cells employing mono- and bispecific oligos directed against BCL-2 [the second binding site was directed against the epidermal growth factor receptor (EGFR)]; and employing RT-PCR. The expression of these four proteins was evaluated. Expression of fas-ligand, PD-1 and PD-L1 were all significantly enhanced, whereas fas itself was undetectable. This suggests that in addition to pathways associated with the mitochondrial pathway of apoptosis, compensatory changes occur in the direct signal transduction pathway of this process. In addition to alterations in androgen sensitivity, growth factor expression and oncogene expression, these data suggest that suppressive BCL-2 therapy involves multiple pathways, including those involved with immune targeting and cytotoxicity and must be taken into account to make gene therapy more efficacious.
Altered Oncogene Activity Contributes to Compensation for Antisense Suppression of Bcl-2 and Tumor Resistance  [PDF]
Marvin Rubenstein, Courtney M. P. Hollowell, Patrick Guinan
Open Journal of Apoptosis (OJApo) , 2015, DOI: 10.4236/ojapo.2015.43007
Abstract: Antisense oligonucleotides (oligos) have targeted growth regulatory proteins in prostate cancer models. To identify compensatory alterations in the expression of non-targeted genes we evaluate mono- and bispecific oligos targeting and equally suppressing the expression of the apoptosis inhibitory protein bcl-2. Bcl-2 is chosen because oligos directed towards it have entered clinical trials to restore apoptosis in cancer patients. Treated LNCaP cells compensate for the diminished bcl-2 by suppressing caspase-3 (an apoptosis promoter) while enhancing expression of AKT-1 (another apoptosis inhibitor), androgen receptor (AR) and its (p300 and IL-6) coactivators. Additional proteins are enhanced including PD-1, its ligand PD-L1 (immune checkpoint blockade markers) and fas-ligand, which activate apoptosis through the signal transduction, along with suppressor protein p53, polymerase transcription mediator MED-12 and signal transducer STAT-3. These alterations in expression may contribute to a greatly enhanced expression of the proliferation marker KI-67. This suggests that therapeutic approaches to restore apoptosis through suppression of bcl-2 lead to an altered expression in non-targeted genes involving apoptosis, androgen sensitivity, transcriptional activity and immune responsiveness, leads to an increase in proliferation (and a more androgen driven aggressive phenotype). In this study we evaluate the expression of two oncogenes (v-myc and K-ras) and find a large and significant enhancement of v-myc activity, which is produced by oligos targeting bcl-2 at the 5’ position. For K-ras, although significant suppression is produced by the bispecific targeting bcl-2 at the 3’ position, the percent change is relatively small compared with other compensatory alterations we have measured, and much less than in v-myc. Therefore, for the two oncogenes being evaluated, only increased v-myc activity is probably large enough to contribute to increased tumor aggressiveness in compensation for bcl-2 suppression.
Transfusion, erythropoiesis-stimulating agent therapy, and kidney transplant wait time  [PDF]
Robert M. Perkins, H. Lester Kirchner, Rajesh Govindasamy
Open Journal of Internal Medicine (OJIM) , 2012, DOI: 10.4236/ojim.2012.21001
Abstract: Aim: Anemia is highly prevalent among patients wait-listed for renal transplant, and management with blood transfusion or erythropoietin stimulating agents may impact transplant wait time. The purpose of this study was to examine the impact of blood transfusion and erythropoiesis stimulating agent therapy on renal transplant wait time. Methods: We retrospectively analyzed all adult patients listed for first deceased donor kidney transplantation at two transplant centers in Central Pennsylvania between 2004 and 2008. The exposures of interest were blood transfusion and erythropoietin stimulating agent therapy. Cox proportional hazards were used to model time to deceased donor kidney transplant. Results: Among 407 patients listed for transplant, 84 received a deceased donor kidney during a median follow-up of 26.3 months. In an adjusted Cox proportional hazards model, with erythropoiesis stimulating agent and transfusion both treated as time-dependent exposures, UNOS inactive status at listing date (hazard ratio [HR] 0.81; 95% CI 0.73 - 0.89; P < 0.001) and transfusion during the wait list period (HR 0.27; 95% CI 0.11 - 0.69; P = 0.01) independently predicted longer transplant wait time. Erythropoiesis stimulating agent use prior to or after transplant wait listing date did not independently predict wait time. Conclusion: Blood transfusion while waitlisted for kidney transplant is strongly associated with prolonged wait time.
Bootstrap Approximations in Contractor Renormalization
M. Stewart Siu,Marvin Weinstein
Physics , 2007, DOI: 10.1103/PhysRevB.77.155116
Abstract: We propose a bootstrap method for approximating the long-range terms in the Contractor Renormalization (CORE) method. The idea is tested on the 2-D Heisenberg antiferromagnet and the frustrated J_2-J_1 model. We obtain renormalization group flows that directly reveal the Neel phase of the unfrustrated HAF and the existence of a phase transition in the J_2-J_1 model for weak frustration. However, we find that this bootstrap method is dependent on blocking and truncation schemes. For this reason, we discuss these dependencies and unresolved issues that researchers who use this approach must consider.
Exploring Contractor Renormalization: Tests on the 2-D Heisenberg Antiferromagnet and Some New Perspectives
M. Stewart Siu,Marvin Weinstein
Physics , 2006, DOI: 10.1103/PhysRevB.75.184403
Abstract: Contractor Renormalization (CORE) is a numerical renormalization method for Hamiltonian systems that has found applications in particle and condensed matter physics. There have been few studies, however, on further understanding of what exactly it does and its convergence properties. The current work has two main objectives. First, we wish to investigate the convergence of the cluster expansion for a two-dimensional Heisenberg Antiferromagnet(HAF). This is important because the linked cluster expansion used to evaluate this formula non-perturbatively is not controlled by a small parameter. Here we present a study of three different blocking schemes which reveals some surprises and in particular, leads us to suggest a scheme for defining successive terms in the cluster expansion. Our second goal is to present some new perspectives on CORE in light of recent developments to make it accessible to more researchers, including those in Quantum Information Science. We make some comparison to entanglement-based approaches and discuss how it may be possible to improve or generalize the method.
A classification of spectral populations observed in HF radar backscatter from the E region auroral electrojets
S. E. Milan ,M. Lester
Annales Geophysicae (ANGEO) , 2001,
Abstract: Observations of HF radar backscatter from the auroral electrojet E region indicate the presence of five major spectral populations, as opposed to the two predominant spectral populations, types I and II, observed in the VHF regime. The Doppler shift, spectral width, backscatter power, and flow angle dependencies of these five populations are investigated and described. Two of these populations are identified with type I and type II spectral classes, and hence, are thought to be generated by the two-stream and gradient drift instabilities, respectively. The remaining three populations occur over a range of velocities which can greatly exceed the ion acoustic speed, the usual limiting velocity in VHF radar observations of the E region. The generation of these spectral populations is discussed in terms of electron density gradients in the electrojet region and recent non-linear theories of E region irregularity generation. Key words. Ionosphere (ionospheric irregularities)
Simultaneous observations at different altitudes of ionospheric backscatter in the eastward electrojet
S. E. Milan,M. Lester
Annales Geophysicae (ANGEO) , 2003,
Abstract: A common feature of evening near-range ionospheric backscatter in the CUTLASS Iceland radar field of view is two parallel, approximately L-shell-aligned regions of westward flow which are attributed to irregularities in the auroral eastward electrojet region of the ionosphere. These backscatter channels are separated by approximately 100–200 km in range. The orientation of the CUTLASS Iceland radar beams and the zonally aligned nature of the flow allows an approximate determination of flow angle to be made without the necessity of bistatic measurements. The two flow channels have different azimuthal variations in flow velocity and spectral width. The nearer of the two regions has two distinct spectral signatures. The eastern beams detect spectra with velocities which saturate at or near the ion-acoustic speed, and have low spectral widths (less than 100 m s–1), while the western beams detect lower velocities and higher spectral widths (above 200 m s–1). The more distant of the two channels has only one spectral signature with velocities above the ion-acoustic speed and high spectral widths. The spectral characteristics of the backscatter are consistent with E-region scatter in the nearer channel and upper-E-region or F-region scatter in the further channel. Temporal variations in the characteristics of both channels support current theories of E-region turbulent heating and previous observations of velocity-dependent backscatter cross-section. In future, observations of this nature will provide a powerful tool for the investigation of simultaneous E- and F-region irregularity generation under similar (nearly co-located or magnetically conjugate) electric field conditions. Key words. Auroral ionosphere · Ionospheric irregularities · Plasma convection
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