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New composites of popcorn to Brazil / Novos compostos de milho-pipoca para o Brasil  [cached]
Carlos Alberto Scapim,Ant？nio Teixeira do Amaral Júnior,Rafael Augusto Vieira,Lia Mara Moterle
Semina : Ciências Agrárias , 2010,
Abstract: Although advances are obtained, the number of varieties and hybrids from inbred lines of popcorn are reduced. The objective of this work was to evaluate new composites developed in Brazil and to indicate those which present better potential to initiate an intrapopulation breeding program. Trials were carried out during 2005/2006 cropping season. Treatments included 21 genotypes (hybrid from inbred lines, composites and synthetic) cultivated in two locations (Umuarama and Cidade Gaúcha), both located in Northwest of Paraná State. Grain yield (GY) and popping expansion (PE) were evaluated by individual and joint analyses of variance. Composites UEM 5, UEM 6 and UEM 7 obtained the highest quality of the PE, with similar values to the check treatments in both locations. GY of genotypes ranged more than popping expansion over locations. Composites UEM 5, UEM 6 and UEM 7 revealed satisfactory potential both PE and GY when evaluated in Umuarama, Paraná State, Brazil. Apesar dos avan os, o número de variedades e híbridos comerciais de linhagens de milho-pipoca é reduzido. Assim, o objetivo deste trabalho foi avaliar novos compostos desenvolvidos no Brasil e indicar os de maior potencial genético para iniciar um trabalho de melhoramento intrapopulacional. A pesquisa foi desenvolvida no ano agrícola 2005/2006. Os tratamentos constaram de 21 genótipos (híbridos de linhagens, compostos e sintéticos) cultivados em dois municípios, Umuarama e Cidade Gaúcha, ambos no Noroeste do Estado do Paraná. As características avaliadas por meio de análises de variancia individuais e conjunta foram rendimento de gr os (RG) e capacidade de expans o (CE). Os compostos UEM 5, UEM 6 e UEM 7 expressaram alta qualidade da pipoca (CE), com valores semelhantes às testemunhas em ambos os locais. O rendimento dos genótipos foi mais instável do que a capacidade de expans o entre os locais avaliados. Os compostos UEM 5, UEM 6 e UEM 7 revelaram potencial satisfatório tanto para CE quanto para RG quando avaliados em Umuarama, PR.
Synthesis and evaluation of anti-leishmania activity of analogs isoxazoles derivatives of grandisin and veraguensin neolignans Síntese e avalia o da atividade anti-Leishmania de análogos isoxazólicos derivados das neolignanas grandisina e veraguensina  [cached]
Ozildéia Soares,Maria Letícia . F. Silva,Jo？o Vitor D. Martins,Gabriela R. Hurtado
Orbital : the Electronic Journal of Chemistry , 2012,
Abstract: Using the concept of bioisosterismo, the new analogs isoxazole were designed from the molecular modification of grandisin and veraguensin neolignans, which have a grouping that is a furan ring bioisóstero isoxazole. In order to obtain more potent compounds, and better physical and chemical characteristics, our research group synthesized six analogues isoxazole neolignans. These reactions were performed of 1,3-dipolar cycloaddition between oximes chlorine and terminal acetylenes previously synthesized. The reaction system CuSO4.5H2O/Ascorbate Sodium / KHCO3, CH2Cl2/THF was used, and under this condition were obtained isoxazole six analogues with yields ranging from 71% To 90%. The compounds were sent for testing anti-Leishmania activity and anti-trypanosome. Utilizando o conceito de bioisosterismo, novos análogos isoxazólicos foram planejados a partir da modifica o molecular das neolignanas grandisina e veraguensina as quais possuem um grupamento furanico que é um bioisóstero de anéis isoxazólicos. Visando a obten o de compostos mais potentes, e melhores características físico-químicas, nosso grupo de pesquisa sintetizou seis análogos isoxazólicos neolignanicos. Foram realizadas rea es de cicloadi o 1,3-dipolar entre cloro oximas e acetilenos terminais previamente sintetizados. O sistema reacional CuSO4.5H2O/Ascorbato de Sódio/ KHCO3, CH2Cl2/THF foi utilizado e, sob esta condi o foram obtidos seis análogos isoxazólicos com rendimentos que variaram de 71 % a 90 %. Os compostos foram encaminhados para teste de atividade anti-Leishmania e anti-tripanossoma.
Harnessing the potential clinical use of medicinal plants as anti-diabetic agents
Campbell-Tofte JI, M lgaard P, Winther K
Botanics: Targets and Therapy , 2012, DOI: http://dx.doi.org/10.2147/BTAT.S17302
Abstract: rnessing the potential clinical use of medicinal plants as anti-diabetic agents Review (1726) Total Article Views Authors: Campbell-Tofte JI, M lgaard P, Winther K Published Date August 2012 Volume 2012:2 Pages 7 - 19 DOI: http://dx.doi.org/10.2147/BTAT.S17302 Received: 24 January 2012 Accepted: 23 April 2012 Published: 22 August 2012 Joan IA Campbell-Tofte,1 Per M lgaard,2 Kaj Winther1 1Department of Clinical Biochemistry, Frederiksberg University Hospital, Frederiksberg, Denmark; 2Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark Abstract: Diabetes is a metabolic disorder arising from complex interactions between multiple genetic and/or environmental factors. The characteristic high blood sugar levels result from either lack of the hormone insulin (type 1 diabetes, T1D), or because body tissues do not respond to the hormone (type 2 diabetes, T2D). T1D patients currently need exogenous insulin for life, while for T2D patients who do not respond to diet and exercise regimes, oral anti-diabetic drugs (OADs) and sometimes insulin are administered to help keep their blood glucose as normal as possible. As neither the administration of insulin nor OADs is curative, many patients develop tissue degenerative processes that result in life-threatening diabetes comorbidities. Several surveys of medicinal plants used as anti-diabetic agents amongst different peoples have been published. Some of this interest is driven by the ongoing diabetes pandemic coupled with the inadequacies associated with the current state of-the-art care and management of the syndrome. However, there is a huge cleft between traditional medicine and modern (Western) medicine, with the latter understandably demanding meaningful and scientific validation of anecdotal evidence for acceptance of the former. The main problems for clinical evaluation of medicinal plants with promising anti-diabetic properties reside both with the complexity of components of the plant materials and with the lack of full understanding of the diabetes disease etiology. This review is therefore focused on why research activities involving an integration of Systems Biology-based technologies of pharmacogenomics, metabolomics, and bioinformatics with standard clinical data, should be used for cost-effective validation of the safety and anti-diabetic efficacy of promising medicinal plants. The application of such approaches to studying entire mixtures of plant materials will ensure proper elucidation of novel therapies with improved mechanisms of action, as well as facilitate a personalized clinical use of medicinal plants as anti-diabetic agents.
ANTI-MICROBIAL SCREENING OF SOME MEDICINAL PLANT EXTRACTS
Mansoor Shazia,Mohd. Ali Saadia,Fatima Jasmine,Jamal Mohammad Arif
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: Medicinal plants are the best source to obtain a variety of herbal drugs. The use of plant extracts and photochemical both with known anti-microbial properties can be of great importance in therapeutic treatments. The plants have provided a good source of anti-infective agents and many of them remain highly effective in the fight against microbial infections. Therefore in the present study seven medicinal plants that are Emblica officinalis, Ficus bengalensis, Myristica fragrans, Acacia arabica, Aloe barbadensis, Ricinus communis and Zizyphus jujuba were screened for potential anti-bacterial activity against medically important bacterial strains, such as Pseudomonas aurogenosa, Proteus vulgaris, Staphylococcus aureus and Streptococcus cereviceae. The anti-microbial activity was determined in methanolic extracts using agar well diffusion method. Streptococcus cereviceae showed resistance against the plant extracts. Emblica officinalis and Aloe barbadensis showed strong anti-bacterial activity against all the tested bacterial strains. Hence, this plant extract can be used to evaluate any bioactive natural products that may serve as leads in the development of new pharmaceuticals that can address the unmet therapeutic needs.
In vitro studies on anti asthmatic, analgesic and anti convulsant activities of the medicinal plant Bryonia laciniosa.Linn
Jayarama Reddy,Gnanasekaran D.,Vijay D.,Ranganathan T.V.
International Journal of Drug Discovery , 2010,
Abstract: The study was carried out to ascertain anti asthmatic, analgesic and anti convulsant activities ofthe medicinal plant Bryonia Laciniosa. The anti asthmatic activity was estimated by mesenteric mast cellcount by Atopic allergy method. Eddy's hot plate and Analgesiometer tests were used to assess theanalgesic activity of Bryonia Laciniosa. Anticonvulsant activity was evaluated by Maximum electroshockinducedseizure test. The results indicated that 70% alcoholic extract of Bryonia laciniosa increased theantiasmatic activity, analgestic activity and also anticonvulsant activity.
Anti-Hemorrhoidal Medicinal Plants of the Department of Issia: Inventory and Cytotoxicity on HFF Cells of the Ethanolic Extract 70% of Landolphia utilis A. Chev. (Apocynaceae)  [PDF]
Coulibaly Kiyinlma, Etien Dibié Théodore, Orso Bosson Arobia Marie Bernadine, Kanga Yao, Zirihi Guédé No？l
Journal of Biosciences and Medicines (JBM) , 2019, DOI: 10.4236/jbm.2019.711009
Abstract: Objective: To identify the anti-hemorrhoidal medicinal plants of the Department of Issia and evaluate the cytotoxic activity of the most requested species. Methods: The plants used in hemorrhoid recipes in the Department of Issia (C？te d’Ivoire) were obtained using a semi-structured survey based on a questionnaire sheet. To assess the use of plants on the disease, Informant Consensus Factors (ICF) for each species were calculated. The harvested species were identified at the Centre National de Floristique (CNF) of the Félix Houphou？t Boigny University (C？te d’Ivoire). Cytotoxicity tests were performed on HFF cells with the 70% ethanolic extract, prepared from the aqueous extract of the most cited species. Results: A total of twenty four medicinal species in eighteen families were recorded. Among these taxa are ten woody and fourteen herbaceous. Only three species gave an ICF greater than 0.5. The ethanolic extract 70% of the frequently requested medicinal plant did not reveal any toxicity on HFF cells. Conclusion: These results revealed that the flora of the Department of Issia is rich in anti-hemorrhoidal medicinal plant species. Their use without side effects is revealed by the absence of toxicity in one of the most solicited plants.
Anti epileptic activity of some medicinal plants  [PDF]
Saba HASAN,Vibhash DWIVEDI,Manisha MISRA,Prashant K SINGH
International Journal of Medicinal and Aromatic Plants , 2012,
Abstract: Epilepsy is a neuropsychological disorder, caused due to discharge of neurotransmitter. From time immemorial, plants have been used for their healing and therapeutic abilities, thus healing action. The aim of the present study was to highlight the anti epileptic activity of some medicinally important plants like Withania somnifera (amhar), Ocimum sanctum, Brahmi grihta (bacopa), Catharanthus roseus, Caesalpinia crista, Citrus sinensis, Datura stramonium, Ricinus communis, Terminalia glaucescens, Tetrapleura tetraptera, Senna singuena, Jatropha gossypiifolia, Mentha cardifolia. The role of such plants, with specific properties of their parts has been demonstrated and proved in earlier studies. This paper reviews the potential of such plants that can be explored to ascertain anti epileptic activity.
COMPOSTOS BIOATIVOS EM SUB-PRODUTOS DA CASTANHA DE CAJU  [cached]
G. P. M. BARRETO,A. C. R. SOUZA,H. M. C. AZEREDO,A. Z. MERCADANTE
Alimentos e Nutri？？o , 2008,
Abstract: O processamento de suco a partir do pseudofruto (ped onculo) de caju gera como subproduto um baga §o, que constitui uma rica fonte de fen 3is, cido asc 3rbico (AA) e caroten 3ides, os quais se constituem em compostos de alto valor agregado em raz ￡o de suas fun § μes ben ficas sa ode humana. Considerando que este baga §o pode ser transformado para produzir ingredientes funcionais, este trabalho teve como objetivo determinar a composi § ￡o de caroten 3ides, teores de compostos fen 3licos totais e de AA, al m da determina § ￡o da atividade anti-radical livre de derivados do baga §o do ped onculo do caju. O baga §o de caju foi submetido a cinco ciclos de dilui § ￡o/prensagem, gerando um baga §o final (retentado) e um extrato, o qual foi filtrado (extrato bruto) e concentrado (extrato concentrado). O retentado apresentou um n -vel significativamente superior de fen 3is totais, de caroten 3ides totais e da atividade antiradical livre; al m de apresentar cor amarela mais intensa, indicada pelos maiores valores de b* e de croma (C*). Por outro lado, o extrato concentrado apresentou o maior teor de AA. Os principais caroten 3ides encontrados, tanto no retentado como nos extratos, foram all-trans- -criptoxantina e all-trans- -caroteno. Estes resultados indicam que o retentado possui compostos bioativos que podem ser utilizados como ingrediente funcional.
Anti-cancer natural products isolated from chinese medicinal herbs
Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang, Jiajie Guo, Xiuping Chen, Yitao Wang
Chinese Medicine , 2011, DOI: 10.1186/1749-8546-6-27
Abstract: Surgery, chemotherapy and radiotherapy are the main conventional cancer treatment often supplemented by other complementary and alternative therapies in China [1]. While chemotherapy is one of the most extensively studied methods in anti-cancer therapies, its efficacy and safety remain a primary concern as toxicity and other side effects of chemotherapy are severe. Moreover, multi-drug resistant cancer is even a bigger challenge. Medicinal herbs are main sources of new drugs. Newman et al. reported that more than half of the new chemicals approved between 1982 and 2002 were derived directly or indirectly from natural products [2]. Some active compounds have been isolated from Chinese medicinal herbs and tested for anti-cancer effects. For example, β-elemene, a compound isolated from Curcuma wenyujin Y. H. Chen et C. Ling (Wenyujin), is used as an anti-cancer drug in China. For this study, we searched three databases, namely PubMed, Scopus and Web of Science, using keywords "cancer", "tumor", "neoplastic" and "Chinese herbs" or "Chinese medicine". Publications including research and review papers covered in this review were dated between 1987 and 2011, the majority of which were published between 2007 and 2011. Chinese herb-derived ingredients, including flavonoids, alkaloids, terpenes, quinones and saponins, were found.GA (Figure 1A) is the principal active ingredient of gamboges which is the resin from various Garcinia species including Garcinia hanburyi Hook.f. (Tenghuang) [3]. GA has various biological effects, such as anti-inflammatory, analgesic and anti-pyretic [3] as well as anti-cancer activities [4,5]. In vitro and in vivo studies have demonstrated its potential as an excellent cytotoxicity against a variety of malignant tumors, including glioblastoma, as well as cancers of the breast, lung and liver. GA is currently investigated in clinical trials in China [6-8].GA induces apoptosis in various cancer cell types and the action mechanisms of GA remain unclea
PROFILE OF MEDICINAL PLANTS WITH ANTI-OPHIDIAN PROPERTY  [PDF]
Sandeep V. Binorkar,Dilip K. Jani
Journal of Pharmaceutical and Scientific Innovation , 2012,
Abstract: The morbidity and mortality associated with snake bite is a serious health concerned especially in developing countries. The rural communities are the worst affected and where it is considered as one of the occupational health hazards especially related to agriculture industry. About 50,000 deaths are recorded per year as a result of snakebite. The scenario may sometimes deteriorate further because of Ineffectiveness and or complications of the anti snake venom as well as untimely interventions or lack of appropriate medications in venomous snakebite cases. The common poisonous snakes found in India are Cobra (Naja naja), Krait (Bangarus Caeruleus), Russell’s viper (Daboia russelli) and saw scaled viper (Echis Carinatus). Over the years many attempts have been made for the development of snake venom antagonists from plants sources. Ethnobotanical data suggests that certain plant species are used traditionally all over the world to treat snakebite cases successfully. Randomness or the use of a variety of species in different families appears to be a feature of traditional snake bite treatments. Present article deals with the Traditional, ethno botanical and pharmacological review of certain plants utilized in the cases of snakebite.
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