oalib
Search Results: 1 - 10 of 100 matches for " "
All listed articles are free for downloading (OA Articles)
Page 1 /100
Display every page Item
Use of Preputial Skin as Cutaneous Graft after Nevus Excision  [PDF]
A. D'Alessio,E. Piro,M. Brugnoni,L. Abati
International Journal of Pediatrics , 2010, DOI: 10.1155/2010/951270
Abstract: We report a four-year-old boy with a nevus covering all the plantar side of his second finger on the left foot. He was also affected by congenital phimosis. Surgical excision of the nevus was indicated, but the skin defect would have been too large to be directly closed. The foreskin was taken as a full-thickness skin graft to cover the cutaneous defect of the finger. The graft intake was favourable and provided a functional repair with good aesthetic characteristic.
Use of Preputial Skin as Cutaneous Graft after Nevus Excision  [PDF]
A. D'Alessio,E. Piro,M. Brugnoni,L. Abati
International Journal of Pediatrics , 2010, DOI: 10.1155/2010/951270
Abstract: We report a four-year-old boy with a nevus covering all the plantar side of his second finger on the left foot. He was also affected by congenital phimosis. Surgical excision of the nevus was indicated, but the skin defect would have been too large to be directly closed. The foreskin was taken as a full-thickness skin graft to cover the cutaneous defect of the finger. The graft intake was favourable and provided a functional repair with good aesthetic characteristic. 1. Introduction In order to prevent melanoma, selective removal of suspicious nevi is indicated. Furthermore, the site of lesion could indicate surgical excision to prevent continuous microtraumas [1–3]. Surgical excision could determine loss of substance due to the dimension of the nevus that could not be easily directly repaired. The foreskin is a good autologous full-thickness skin graft in several conditions [4]. The authors report the use of foreskin as skin graft to repair a loss of substance due to excision of an interdigital nevus of the foot. 2. Case Presentation A four-year-old boy presented a 2?cm 1.5?cm congenital compound nevus entirely covering the plantar surface of the second finger of his left foot (Figure 1). Paediatric dermatologist’s indication was a radical excision because of the site and the dimension of this melanocytic lesion. Primary closure of the skin defect secondary to radical excision of the lesion was not indicated because of the large loss of substance and the risk of retractive scar. A skin graft was necessary to perform the repair. Figure 1: Site and features of the congenital compound nevus. The boy was also affected by congenital phimosis which required circumcision. So we decided to take foreskin as an autologous full-thickness skin graft. Then we performed circumcision and a radical excision of the nevus (Figure 3(a)); foreskin, trimmed in a rectangular shape (Figure 2), was sutured into the residual defect (Figure 3(b)). An occlusive medication was placed and removed ten days after. Figure 2: Foreskin trimmed in a rectangular shape. Figure 3: Residual open area after excision of the nevus (a) and foreskin graft sutured to cover the cutaneous defect (b). Postoperatively the skin graft healed well. Today, one year after the operation, the patient has normal use of the foot finger with no evidence of contracture (Figure 4). Figure 4: Delayed postoperative result (1 year after intervention). 3. Discussion Congenital melanocytic nevus is a frequent condition in childhood (0,2–1%) [1, 2]. The role of these lesions in increasing incidence of cutaneous
Purulent Cutaneous Fistula: As the First Symptom of the Late Aortic Stent-Graft Infection—A Case Report and Review of the Literature  [PDF]
Damian Ziaja,Grzegorz Biolik,Jerzy Chudek,Krzysztof Ziaja
Case Reports in Surgery , 2013, DOI: 10.1155/2013/421780
Abstract: Purpose. Aortic stent-graft infection with fistula formation is a rare complication with high mortality rate when treated surgically by stent-graft removal. We report a case of a patient with aortic stent-graft infection, prosthetic-duodenal, and prosthetic-cutaneous fistulas operated without the removal of an infected prosthesis and ineffectively tailored antibiotic therapy. Case Report. A 66-year-old patient with high cardiovascular risk and endovascular stent-graft implantation developed a symptomatic infection of the aortic stent graft 42 months after procedure. It was manifested by iliolumbar muscle abscess and two fistulas: prosthetic cutaneous and prosthetic duodenal. The prosthetic-duodenal fistula was excised and separated from the prosthesis. The perforation within the duodenum was closed in layers. Iliolumbar abscess was removed and drainage was effected .The stent graft was left. The patient received tailored antibiotic therapy. He was readmitted to hospital after 4 weeks with symptoms of infection and leakage of pus discharge in the lumbar area. Despite the antibiotic therapy, the total parenteral nutrition of the patient’s clinical status and malnutrition deteriorated and he died of cardiac arrest. Conclusion. The presented case confirms that leaving off of the infected stent graft in the patient with severe comorbidity and treated with a tailored antibiotic therapy may not be effective. 1. Introduction The massive gastrointestinal haemorrhage form prosthetic-duodenal fistula is a well-known surgical complication that is rarely observed after endovascular stent-graft implantation [1]. In the case of such sargical complication, the closure of the duodenal fistula and the removal of the infected stent graft and its replacement with silver prosthesis, homograft, homogeneous vein, or extra-anatomic bypass are usually carried out; however, the outcome is usually bad [2]. A series of cases of closing the fistula without removing the stent graft, followed by prolonged antibiotic therapy with good 1-year outcomes, were reported [2, 3]. The small number of these complications prevents the development of evidence-based clinical guidelines on how to manage such a patient. We report a case of a patient with two fistulas (prosthetic-duodenal and prosthetic-cutaneous fistulas without massive gastrointestinal bleeding) diagnosed four years after a stent-graft implantation for having symptomatic abdominal aortic aneurysm and severe comorbidities. The first symptoms of stent-graft infection were lumbar pain and purulent cutaneous fistula. 2. Case Report In
Experimental model in hamster (Mesocricetus auratus) to study heterologous graft of scars and cutaneous diseases in plastic surgery
Hochman, Bernardo;Ferreira, Lydia Masako;B?as, Flaviane Cássia Vilas;Mariano, Mario;
Acta Cirurgica Brasileira , 2004, DOI: 10.1590/S0102-86502004000700013
Abstract: syrian golden hamster (mesocricetus auratus) has in its cheek pouches sub-epithelium an "immunologically privileged site" which allows the integration of homo- and heterologous graft. this paper describes some anatomical and histological characteristics of that site, as well as analyzes aspects related with its immune properties. it also focuses the advantages of this experimental model over other models which are natural or induced carriers of immunodeficiency. based on both these advantages and literature, this study aims to establish this model, through the performance of heterologous graft, as another option for the investigation of scar disturbances, as keloids and other diseases which may interest plastic surgery, as benign cutaneous lesions, and malignant neoplasias such as skin carcinomas and melanomas. the work also addresses perspectives for using this model, which still is a source scarcely known by brazilian medical class.
Cutaneous Manifestations at Saphenous Vein Harvest Site among Iraqi Patients with Coronary Artery Bypass Graft  [PDF]
Khalifa E. Sharquie, Adil A. Noaimi, Ali S. Alaboudi
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2012, DOI: 10.4236/jcdsa.2012.21008
Abstract: Background: Coronary artery bypass grafting (CABG) has become a common surgical procedure and increasingly done in Iraq. The greater saphenous vein (GSV) is the most veins often used as the conduit and its complications include a variety of cutaneous manifestations. Objective: To report the cutaneous manifestations at the saphenous vein harvesting site in Iraqi patients who undergone CABG. Methods: A total of 100 (82 males, 18 females) patients who had undergone CABG using the saphenous vein (SV) harvested by longitudinal incision open technique at the legs and/ or thighs were included in this case descriptive study. All cases were seen at least two months after the time of the operation in the outpatient clinic of the Cardiac Surgery Department in the Ibn-Albitar Hospital during October 2009 - October 2010. A detailed history and close dermatological examination were done including all related points to their problems. Results: The cutaneous changes on and around the saphenous vein (SV) graft donor scars were noticed in 60 out of 100 patients, 49 (81.66%) males and 11 (18.33%) females, their ages ranged from 32 - 74 (59.38±8.3221) years, with body mass index (BMI)ranged from 21.8746 - 26.9057 (23.875±8.5378). The duration interval between the time of CABG and presentation ranged from 2-180 months with a median of 5 months, 36 (60%) patients presented at less than 6 months and 24 (40%) patients presented at more than 6 months. Anesthesia was the predominant presenting symptom in 49 (81.6%), followed by neurolgic pain 8 (13.3%) and pruritus 2 (3.3%), while the cutaneous signs recorded at the site of SVG were: Xerosis in 17 (28.3%) patients, followed by residual hyperpigmentation 11(18.3%), depigmentation 11(18%), recent hair loss 11 (16.6%), hypertrophic scar 8 (13.3%), non-healing ulcer 7 (11.6%), lymphedema 7 (11.6%) and neuropathy dermatitis 6 (10%). Conclusions: Cutaneous manifestations following coronary artery bypass surgery are not uncommon problem in Iraqi patients that are seen at area of saphenous vein harvesting but the most interesting thing is to report the neuropathy dermatitis.
Condensation Induced by Rarefaction Waves and Reflected Rarefaction Waves
Fu Yunfei,Han Zhaoyuan,Gong Minwei,
Fu Yunfei
,Han Zhaoyuan,Gong Minwei

大气科学进展 , 1995,
Abstract: In this paper, homogeneous condensation induced by unsteady rarefaction waves and reflected rarefaction waves in vapor-gas mixture was investigated experimentally. It is shown that the temperature of condensation onset during very fast unsteady expansion in vapor-gas mixture is much lower than that during equilibrium process in the atmosphere. It is of interest to indicate that the size of droplets approximates a constant, but the number density and the mass density of droplets change rapidly in the region of static flow.
Local hyperhemia to heating is impaired in secondary Raynaud's phenomenon
Aude Boignard, Muriel Salvat-Melis, Patrick H Carpentier, Christopher T Minson, Laurent Grange, Catherine Duc, Fran?oise Sarrot-Reynauld, Jean-Luc Cracowski
Arthritis Research & Therapy , 2005, DOI: 10.1186/ar1785
Abstract: Vascular dysfunction is a key element of the systemic sclerosis (SSc) disease process, and involves both the micro and macrovasculature [1]. The microcirculation undergoes structural and functional changes that are interdependent. This microangiopathy is characterized by capillary rarefaction, development of megacapillaries and vascular obliteration [2], which are associated with functional abnormalities mainly related to an endothelial dysfunction. Endothelial cells seem to play a pivotal role in SSc pathogenesis via the impairment of endothelium-dependent vasodilation and an increased transendothelial migration of T lymphocytes [3,4]. Endothelium-dependent vasodilation is impaired in patients with SSc mainly through an impaired ability to release nitric oxide (NO), and is an early event in the disease process [1,5]. Furthermore, patients with SSc have fewer endothelial progenitor cells than controls, and those present are often dysfunctional as well [6].Accurate and sensitive measurement techniques are a key issue in the quantification of this vascular dysfunction, especially endothelial dysfunction. Different techniques have been used to quantify the microvascular dysfunction in SSc, such as microinjection [7], video microscopy [8], iontophoresis [9] or venous occlusion plethysmography [3], whereas endothelial function of conductance arteries can be monitored using ultrasonography of the brachial artery [10]. An easier non-invasive technique for monitoring cutaneous vascular function is the response to a given physiological challenge using cutaneous laser Doppler flowmetry. Using cold tests, the response of skin cutaneous blood flow does not significantly differ between primary Raynaud's phenomenon (RP) and SSc [11-13]. The response to brachial artery occlusion, however, gives more interesting results. Indeed, several authors showed a dramatic alteration of the amplitude and kinetics of post-occlusive hyperhemia in patients with SSc in comparison with primary RP
PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma  [PDF]
Jennifer Freytag,Cynthia E. Wilkins-Port,Craig E. Higgins,J. Andrew Carlson,Agnes Noel,Jean-Michel Foidart,Stephen P. Higgins,Rohan Samarakoon,Paul J. Higgins
Journal of Oncology , 2009, DOI: 10.1155/2009/963209
Abstract: The emergence of highly aggressive subtypes of human cutaneous squamous cell carcinoma (SCC) often reflects increased autocrine/paracrine TGF- synthesis and epidermal growth factor receptor (EGFR) amplification. Cooperative TGF-/EGFR signaling promotes cell migration and induces expression of both proteases and protease inhibitors that regulate stromal remodeling resulting in the acquisition of an invasive phenotype. In one physiologically relevant model of human cutaneous SCC progression, TGF-1
Keratinocyte Growth Factor Induces Gene Expression Signature Associated with Suppression of Malignant Phenotype of Cutaneous Squamous Carcinoma Cells  [PDF]
Mervi Toriseva, Risto Ala-aho, Sirkku Peltonen, Juha Peltonen, Reidar Grénman, Veli-Matti K?h?ri
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033041
Abstract: Keratinocyte growth factor (KGF, fibroblast growth factor-7) is a fibroblast-derived mitogen, which stimulates proliferation of epithelial cells. The expression of KGF by dermal fibroblasts is induced following injury and it promotes wound repair. However, the role of KGF in cutaneous carcinogenesis and cancer progression is not known. We have examined the role of KGF in progression of squamous cell carcinoma (SCC) of the skin. The expression of KGF receptor (KGFR) mRNA was lower in cutaneous SCCs (n = 6) than in normal skin samples (n = 6). Expression of KGFR mRNA was detected in 6 out of 8 cutaneous SCC cell lines and the levels were downregulated by 24-h treatment with KGF. KGF did not stimulate SCC cell proliferation, but it reduced invasion of SCC cells through collagen. Gene expression profiling of three cutaneous SCC cell lines treated with KGF for 24 h revealed a specific gene expression signature characterized by upregulation of a set of genes specifically downregulated in SCC cells compared to normal epidermal keratinocytes, including genes with tumor suppressing properties (SPRY4, DUSP4, DUSP6, LRIG1, PHLDA1). KGF also induced downregulation of a set of genes specifically upregulated in SCC cells compared to normal keratinocytes, including genes associated with tumor progression (MMP13, MATN2, CXCL10, and IGFBP3). Downregulation of MMP-13 and KGFR expression in SCC cells and HaCaT cells was mediated via ERK1/2. Activation of ERK1/2 in HaCaT cells and tumorigenic Ha-ras-transformed HaCaT cells resulted in downregulation of MMP-13 and KGFR expression. These results provide evidence, that KGF does not promote progression of cutaneous SCC, but rather suppresses the malignant phenotype of cutaneous SCC cells by regulating the expression of several genes differentially expressed in SCC cells, as compared to normal keratinocytes.
A regionwise comparative study of the extent of post punch graft surgical repigmentation in cutaneous achromia
Lahiri Koushik,Sengupta S
Indian Journal of Dermatology, Venereology and Leprology , 1998,
Abstract: One hundred and ten cases of stable cutaneous achromia constituted the sample population, of which 67 were females and 43 males. Age ranged between 6 and 71 years. A total of 1742 grafts were placed over 177 lesions on 29 regions and the cases were followed up to a maximum period of 2 years. The extent of maximum pigment spread (MPS) was noted in different regions of the body. It was observed that exposed parts exhibited better outcome vis-a-vis covered and shadowed part. MPS ranged between 0 to 10 mm., with an overall average of approximately 5.5mm.
Page 1 /100
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.