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Paraoxonase and Arylesterase activities of human serum paraoxonase in coronary artery disease
Abdolkarim Mahrooz,Mohammad Nouri,Mohammad Reza Rashidi,Naser Aslanabadi
Koomesh , 2008,
Abstract: Introduction: Considering the importance of serum paraoxonase (PON1) in preventing fromproduction of oxidized low-density lipoprotein (LDL), and consequently, its role in prohibiting fromdevelopment of atherosclerosis, we investigated paraoxonase and arylesterase activities of PON1 inpatients with coronary artery disease (CAD) and with different coronary stenosis.Materials and Methods: In the present study, 120 patients with CAD were examined and theirstenosis documented by coronary angiography. Then, the patients were divided into two groups: 60patients with less than 50% of stenosis and 60 patients with more than 70% of stenosis. Paraoxonaseand arylesterase activity was measured with substrates of paraoxon and phenylacetate, respectively.The effects of eight drugs, which are prescribed in cardiovascular diseases, were assayed onparaoxonase activity.Results: There were no significant differences in LDL-C, total cholesterol and triglyceride levelsbetween two groups, but HDL levels in patients with >70% of stenosis were significantly decreased ascompared with those of patients who had <50% of stenosis (P<0.03). Both paraoxonase andarylesterase activity in patients with >70% of stenosis were significantly lower (P<0.05) than patientswith<50% of stenosis.Conclusion: Paraoxonase and arylesterase activities of PON1 and HDL levels in patients with>70% of stenosis were lower than patients with <50% of stenosis. In other words, the PON1 activitiesand HDL levels decrease with progression of atheroma. Therefore, the study might support theimportant role of HDL-bound PON1 in preventing from formation of ox-LDL and its anti-atherogenicactivity.
Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population
Emin T Elkiran, Nefsal Mar, Bilge Aygen, Ferit Gursu, Aziz Karaoglu, Suleyman Koca
BMC Cancer , 2007, DOI: 10.1186/1471-2407-7-48
Abstract: This case control study involved a total of 39 patients with newly diagnosed LC (untreated) and same number of age- and sex-matched healthy individuals. Serum PON1 and ARE activities in addition to lipid parameters were measured in both groups.Serum PON1 and ARE activities were found to be lower in patients with LC compared to the controls (p = 0.001 and p = 0.018, respectively). The ratio of PON1/high density lipoprotein (HDL) was significantly lower in the LC group compared to the control one (p = 0.009). There were positive correlations between the serum levels of HDL and PON1 in both the control (r = 0.415, p = 0.009) and the LC groups (r = 0.496, p = 0.001), respectively. PON1 enzyme activity was calculated as three different phenotypes in both groups. In regard to lipid parameters, total cholesterol levels were significantly lower (p = 0.014) in the LC group whereas the other lipid parameters such as HDL, LDL, and triglyceride levels were not significantly different among groups.Serum PON1 activity is significantly low in the LC group compared with the healthy controls. Metastasis status and cigarette smoking do not affect serum PON1 activity in the LC patients.Lung cancer (LC) is among the most common malignancies in the Western World and is the leading cause of cancer deaths in both men and women. It is one of the few tumors with a known carcinogen, namely tobacco, contributing to its etiology. Since cigarette smoking was noted in 80% to 90% of patients with LC, the leading cause of LC is accepted to be smoking [1,2].An elevated oxidative status has been found in many types of cancer cells, and the introduction of chemical and enzymatic antioxidants can inhibit tumour cell proliferation [3]. High doses and/or inadequate removal of reactive oxygen species (ROS) result in oxidative stress, which may cause severe metabolic malfunctions and damage to biological molecules including DNA [4]. It is well known that oxidative stress induced by environmental carcinoge
Review: REVIEW ON: ANKYLOSING SPONDYLITIS  [PDF]
Priyanka Lokwani*,Yozana Upadhyay,Pramod Kumar,Stuti Gupta
Pharmacie Globale : International Journal of Comprehensive Pharmacy , 2011,
Abstract: Ankylosing spondylitis (AS) is a chronic, progressive, connective tissue disorder that is characterized by inflammation of the joints of the spine (vertebral joints), hipbones, and sacrum (sacroiliac joints). There is no cure for ankylosing spondylitis, but treatments can decrease pain and lessen symptoms. Treatment includes pain relieving drugs, DMARDs and TNFα blockers; herbal and homeopathic medications are also available.
Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers
Suleyman Aydin, Suna Aydin, Gerry A. Croteau, íbrahim Sahin, , Cihan Citil
Journal of Medical Biochemistry , 2010, DOI: 10.2478/v10011-010-0009-8
Abstract: Occupational cement dust exposure has been associated with an increased risk of liver abnormalities, pulmonary disorders, and carcinogenesis. Decreased antioxidant capacity and increased plasma lipid peroxidation have been posed as possible causal mechanisms of disease. Accordingly, this study examined the serum paraoxonase (PON1) arylesterase (AE), ghrelin, HDL-C, LDL-C and serum nitrite (NOx) levels in cement dust exposed workers. Twenty-eight volunteer male cement plant workers and 30 volunteer control male workers, aged 29-54 years, participated. The concentrations of serum PON1, AE, NOx, ghrelin, and HDL-cholesterol and LDL-cholesterol were measured in both groups. PON-1, AE, ghrelin and HDL-cholesterol were lower in the cement plant workers than in controls. Serum nitrite (NOx), and LDL-C levels in cement plant workers were higher (p<0.05) than in the control group workers. No correlation was observed between the serum levels of HDL-cholesterol and PON1 and between HDL-cholesterol and ghrelin. A weak negative correlation was detected between the serum ghrelin and NOx. The study results strongly suggest that HDL-paraoxonase, AE, ghrelin, HDL-C, and high NOx, and LDL-C levels may have a role in disease involving oxidative damage. However, some studies are necessary to address the association between occupational dust exposure and respiratory symptoms.
Andersson Lesion in Ankylosing Spondylitis
Manimegalai N, KrishnanKutty K, Panchapakesa Rajendran C, Rukmangatharajan S, Rajeswari S
JK Science : Journal of Medical Education & Research , 2004,
Abstract: Andersson lesions are destructive foci that appear at the discovertebral junction in ankylosingspondylitis. We report three cases of ankylosing spondylitis with such lesions. These lesions simulatean infection and in our country, mimic spinal tuberculosis.
The Association of Acromegaly and Ankylosing Spondylitis
Alpaslan Tuzcu,Ayse Dicle Turhanoglu,Mithat Bah?eci,Hatice ?ztürkmen Akay
Dicle Medical Journal , 2004,
Abstract: Coexistence of acromegaly and anklosing spondylitis had been rarelyreported. Only two case reports were described coexistence of two diseasesin literature. These two diseases have some similar clinical andradiographic features. Calcaneal epin formation, enteshopathy and caudeequina syndrome can be seen both acromegaly and ankylosing spondylitis.Our case had clinical and radiological features of both acromegaly andankylosing spondylitis. Acral enlargement, coarsening of feature,malocclusion, non-suppressed growth hormone levels with oral glucosetolerance test and evidence of pituitary adenoma were support diagnose ofacromegaly. Morning stiffness, positive Schober and Moll test, elevatederythrocyte sedimentation rate and grade 4 sacroiletis of the patient lead usto diagnose ankylosing spondylitis at the same time. In this case report, weaim to discuss interesting coexistence of two disease
Cardiopulmonary Manifestations of Ankylosing Spondylitis  [PDF]
Mahnaz Momeni,Nora Taylor,Mahsa Tehrani
International Journal of Rheumatology , 2011, DOI: 10.1155/2011/728471
Abstract: Ankylosing spondylitis is a chronic inflammatory condition that usually affects young men. Cardiac dysfunction and pulmonary disease are well-known and commonly reported extra-articular manifestation, associated with ankylosing spondylitis (AS). AS has also been reported to be specifically associated with aortitis, aortic valve diseases, conduction disturbances, cardiomyopathy and ischemic heart disease. The pulmonary manifestations of the disease include fibrosis of the upper lobes, interstitial lung disease, ventilatory impairment due to chest wall restriction, sleep apnea, and spontaneous pneumothorax. They are many reports detailing pathophysiology, hypothesized mechanisms leading to these derangements, and estimated prevalence of such findings in the AS populations. At this time, there are no clear guidelines regarding a stepwise approach to screen these patients for cardiovascular and pulmonary complications. 1. Cardiac Manifestations of Ankylosing Spondylitis Introduction Ankylosing spondylitis is a chronic and inflammatory condition, affecting the spine, sacroiliac, and peripheral joints. This entity most often affects young men and may lead to spinal vertebral fusion. Human leukocyte antigen (HLA)-B27 is present in the majority of patients with AS and is reported to contribute to the pathophysiologic manifestations of this condition [1]. It has been estimated that cardiac manifestations in patients with AS are found in 2–10% of patients. It was initially in the 1930s when aortitis found in a group of patients with spondylitis. It is widely accepted today that not only is aortic pathology linked to AS, but there is also risk for conduction defects, valvular regurgitation, and cardiomyopathy, associated with this entity [1]. This is especially important, given that in many patients, cardiac changes may begin prior to the onset of clinical symptoms [2, 3]. 1.1. Valvular Disease The presence of aortic root and valve disease in ankylosing spondylitis is related to the duration of the underlying disease. Aortic disease and aortic regurgitation may, however, predate the onset of any joint symptoms, and the presence of ankylosing spondylitis as an underlying cause may not be initially appreciated [1]. One of the first pathophysiologic descriptions of valvular disease in AS was put forward by Bulkley and Roberts, who studied autopsy findings in eight patients with AS. They noted aortic root dilatation along with fibrous proliferation along the intima [4]. Further examination demonstrated a cellular inflammatory process coupled with platelet aggregation
ESTABLISHMENT OF PARAOXONASE AND ARYLESTERASE ACTIVITY OF PARAOXONASE 1 (PON1) IN DEPENDENCE ON 55(L/M) AND 192(Q/R) DNA POLYMORPHISM IN ADULT PEOPLE WITH DOWN SYNDROME  [PDF]
Pavel SYKORA,Vanda REPISKá,Mária SHUSTROVá,Lukách HALCHáK
Journal of Special Education and Rehabilitation , 2010,
Abstract: Human serum paraoxonase 1 is a calcium-dependent esterase located on high density lipoproteins (HDL). It inhibits LDL peroxidation and hydrolysis of oxide forms of phospholipides and therefore significantly affects the development of ateroscletosis. The aim of this study was to establish the paraoxonase and arylesterase activity of PON1 in adult people with Down syndrome (DS). Adults with DS (10 men and 10 women ages 16 to 37 years) participated and were compared to a control group (10 men and 10 women age ranging from 17 to 45 years). The 55(L/M) and 192(Q/R) DNA polymorphism (PCR-RFLP method) and paraoxonase and arylesterase activity was investigated in every patient. The results showed the reduction of PON1 activity in people with DS, in contrast to the decreased development of atherosclerosis in DS. Therefore it can be concluded, that PON1 does not have a direct effect on the lower prevalence of atherosclerosis in people with DS.
Serum Paraoxonase (Arylesterase) activity in chronic renal failure
Gayathri Balasubramaniam,Mohana Priya,Usha Anand,Viyaya Duraiswamy
International Journal of Students' Research , 2011, DOI: 10.5549/ijsr.1.1.32-33
Abstract:
Relationship of Serum Paraoxonase Enzyme Activity and Thermal Burn Injury  [cached]
Serap Yildirim,Songul Doganay,Abdulkadir Yildirim,Osman Enver Aydin
Eurasian Journal of Medicine , 2012,
Abstract: Objective: This study investigated changes in serum oxidative stress parameters in burn cases compared to healthy controls. Materials and Methods: This study was performed in 41 burn patients with mild to severe thermal burn injuries and 38 healthy volunteers. The burn cases were selected from patients who were hospitalized in the burn unit for the treatment of second- and third-degree burns. Malondialdehyde (MDA) levels and PON-1 paraoxonase and arylesterase activities were measured in patient serum samples.Results: PON-1 paraoxonase activity and MDA levels in patients with major thermal burn injury were significantly higher than healthy controls, but PON-1 arylesterase activities were lower. A significant negative correlation was observed between the burn percentage of the total body surface area and the PON-1 arylesterase activities in patients.Conclusion: Human thermal burn injury was associated with an increase in MDA production and a decrease in PON-1 arylesterase activity, which was proportional to the percentage of total burned surface area.
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