oalib
Search Results: 1 - 10 of 100 matches for " "
All listed articles are free for downloading (OA Articles)
Page 1 /100
Display every page Item
Antibacterial activity of Pterocarpus santalinus  [cached]
Manjunatha B
Indian Journal of Pharmaceutical Sciences , 2006,
Abstract: Antibacterial activity of leaf and stem bark of Pterocarpus santalinus (Fabaceae) was investigated. The antibacterial activity was tested against both Gram-positive and Gram-negative organisms. Among the two extracts tested, stem bark extract exhibited broad-spectrum antibacterial activity against the tested organisms. The stem bark extract showed maximum activity against Enterobacter aerogenes, Alcaligenes faecalis, Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus . The leaf extract showed maximum activity against Escherichia coli, Alcaligenes faecalis, Enterobacter aerogenes and Pseudomonas aeruginosa . Both extracts exhibited concentration dependent activity.
Investigation of the antibacterial activity of pioglitazone
Masadeh MM, Mhaidat NM, Al-Azzam SI, Alzoubi KH
Drug Design, Development and Therapy , 2011, DOI: http://dx.doi.org/10.2147/DDDT.S24126
Abstract: vestigation of the antibacterial activity of pioglitazone Original Research (4334) Total Article Views Authors: Masadeh MM, Mhaidat NM, Al-Azzam SI, Alzoubi KH Published Date September 2011 Volume 2011:5 Pages 421 - 425 DOI: http://dx.doi.org/10.2147/DDDT.S24126 Majed M Masadeh1, Nizar M Mhaidat2, Sayer I Al-Azzam2, Karem H Alzoubi2 1Department of Pharmaceutical Technology; 2Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan Purpose: To evaluate the antibacterial potential of pioglitazone, a member of the thiazolidinediones class of drugs, against Gram-positive (Streptococcus pneumoniae) and Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria. Methods: Susceptibility testing was done using the antibiotic disk diffusion method and the minimal inhibitory concentration (MIC) of pioglitazone was measured according to the broth micro incubation standard method. Results: Pioglitazone induced a dose-dependent antibacterial activity in which the optimal concentration was 80 μM. Furthermore, results indicated that while E. coli was sensitive (MIC = 31.25 ± 3.87 mg/L) to pioglitazone-induced cytotoxicity, S. pneumoniae and K. pneumoniae were resistant (MIC = 62.5 ± 3.77 mg/L and MIC = 62.5 ± 4.14 mg/L, respectively). Moreover, pretreatment of bacteria with a suboptimal concentration of pioglitazone (40 μM) before adding amoxicillin, cephalexin, co-trimoxazole, or ciprofloxacin enhanced the antibacterial activity of all agents except co-trimoxazole. This enhancing effect was particularly seen against K. pneumoniae. Conclusion: These results indicate the possibility of a new and potentially important pioglitazone effect and the authors’ ongoing studies aim to illustrate the mechanism(s) by which this antibacterial effect is induced.
ANTIBACTERIAL ACTIVITY OF ARACEAE: AN OVERVIEW  [PDF]
Roy Saswati,Dutta Choudhury M.,Paul S.B.
International Journal of Research in Ayurveda and Pharmacy , 2013,
Abstract: Infectious diseases account for approximately one-half of all deaths in tropical countries. In industrialized nations, despite the progress made in the understanding of microbiology and their control, incidents of epidemics due to drug resistant microorganisms and the emergence of hitherto unknown disease-causing microbes, pose enormous public health concerns. Historically, plants have provided a good source of antiinfective agents and remain highly effective instruments in the fight against microbial infections. The Araceae is a large family comprising some hundred genera and more than fifteen hundred species. Most of the aroids prefer to grow in moist or shady habitats. Some are terrestrial while others are vines, creepers or climbers. Many species of the aroids are also epiphytes. Many plants of family Araceae have been reported to have antibacterial activities and huge number of researches are going on with the different plants of Araceae for screening of pure compounds responsible for this antibacterial activity. Present article will highlight the antibacterial activity of different plants of Araceae family.
Investigation of the antibacterial activity of pioglitazone  [cached]
Masadeh MM,Mhaidat NM,Al-Azzam SI,Alzoubi KH
Drug Design, Development and Therapy , 2011,
Abstract: Majed M Masadeh1, Nizar M Mhaidat2, Sayer I Al-Azzam2, Karem H Alzoubi21Department of Pharmaceutical Technology; 2Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, JordanPurpose: To evaluate the antibacterial potential of pioglitazone, a member of the thiazolidinediones class of drugs, against Gram-positive (Streptococcus pneumoniae) and Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria.Methods: Susceptibility testing was done using the antibiotic disk diffusion method and the minimal inhibitory concentration (MIC) of pioglitazone was measured according to the broth micro incubation standard method.Results: Pioglitazone induced a dose-dependent antibacterial activity in which the optimal concentration was 80 μM. Furthermore, results indicated that while E. coli was sensitive (MIC = 31.25 ± 3.87 mg/L) to pioglitazone-induced cytotoxicity, S. pneumoniae and K. pneumoniae were resistant (MIC = 62.5 ± 3.77 mg/L and MIC = 62.5 ± 4.14 mg/L, respectively). Moreover, pretreatment of bacteria with a suboptimal concentration of pioglitazone (40 μM) before adding amoxicillin, cephalexin, co-trimoxazole, or ciprofloxacin enhanced the antibacterial activity of all agents except co-trimoxazole. This enhancing effect was particularly seen against K. pneumoniae.Conclusion: These results indicate the possibility of a new and potentially important pioglitazone effect and the authors’ ongoing studies aim to illustrate the mechanism(s) by which this antibacterial effect is induced.Keywords: pioglitazone, susceptibility testing, antibiotics, diabetes
Antibacterial activity of Ficus capensis
SB Oyeleke, BEN Dauda, OA Boye
African Journal of Biotechnology , 2008,
Abstract: The leaves and stem bark of Ficus capensis were investigated for antibacterial activity against some selected organisms at a concentration of 2000 ìg/ml using agar diffusion method. The crude leaf extract inhibited the growth of Escherichia coli and Shigella sp. but no activity against Salmonella typhi. The stem bark extracts also had activity against E. coli and Shigella sp. but no activity against S. typhi. The phytochemical screening of the extracts reveals the presence of alkaloids, balsams, taninins, carbohydrates, resins, flavonoids, Sterols and terpenes. Glycosides were absent in the leaf extract while the stem bark extract had glycosides. Both extracts did not posses free arthraquinones and saponins. The Minimum inhibitory concentration (MIC) of the extracts range from 500-2000 ìg/ml. The fractions obtained from the thin layer chromatography had no activity on the test organisms. The results from the activity of the crude extracts suggest that F. capensis could be used in treatment of diseases caused by these bacteria except S. typhi.
EVALUATION OF ANTIBACTERIAL ACTIVITY OF HERBS  [PDF]
Pesaramelli Karteek,Vellanki Jahnavi,D.V. Keerthi,K. Chaitanya Sravanthi
International Research Journal of Pharmacy , 2012,
Abstract: Medicinal plants have been used for centuries as remedies for human diseases because they contain components of therapeutic value. The acceptance of traditional medicine as an alternative form of health care and the development of microbial resistance to the available antibiotics has led researchers to investigate the antimicrobial activity of medicinal plants. Wild plants have been reported to have antimicrobial and antioxidant properties for centuries, and indigenous plants have been used in herbal medicine for curing various diseases. The development of bacterial resistance to currently available antibiotics has necessitated the search for new antibacterial agents. In lieu of the above justification, present study aimed at evaluating the In vitro antibacterial studies on the extracts of three herbs namely Punica Granatum, Ricinus communis and Zingiber officinalis carried out on five medically important bacterial strains (Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa and Proteus vulgaris). Based on the present investigation results, extracts has great potential against different microorganisms tested and has inhibitory effect. It can be concluded that these plants can be used as therapeutic natural agents that may serve as lead for the development of new pharmaceuticals addressing the major therapeutic needs.
Detection of the antibacterial activity of chitosan
Heisig, Peter,Clau?en, Tatjana,Mayer, Gerd
GMS Krankenhaushygiene Interdisziplin?r , 2007,
Abstract: Using three bacterial strains the antibacterial activity of Chitoskin , a chitosan-containing wound-dressing, was investigated by determining the viable bacterial cell count in liquid cultures in the absence and presence of Chitoskin . Results were compared to those obtained for cellulose and silver-laminated cellulose.While the pure cellulose wound-dressing had no impact on the bacterial growth, Chitoskin and, to an even greater extend, silver-laminated cellulose reduced the viable cell count over 4,5 hrs. Adding a second sample after 2 hrs of incubation resulted in a significantly increased activity of Chitoskin . In the presence of protein the activity of the silver-laminated cellulose was completely abolished, while that of Chitoskin continued for at least 3 hrs. Covering bacterial cells on an agar plate with Chitoskin reversibly inhibited their growth, but did not kill them. Instead, they could be transferred to another sterile agar plate.The results are compatible with the hypothesis that Chitoskin shows a bacteriostatic activity due to its ability to strongly adsorb the cells. From the theoretical point of view, heavily contaminated wounds would benefit from an early renewal of the wound dressing.
EVALUATION OF ANTIBACTERIAL ACTIVITY OF CAFFEINE
Pawar Pruthviraj,Bikkad Suchita,Kurhade Shital,Kadbane Shilpa
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: The present study was carried out with water soluble portion and pure solvent of the acetone, ethanol, methanol, acetonitrile, water) extracts of leaves and leaf buds of Camellia sinensis (green tea), and beans of Coffea arabica (coffee). Caffeine (3,7-dihydro-1, 3,7-trimethyl-1H-purine-2,6-dione) was isolated from both plants using a liquid-liquid extraction method, detected on thin layer chromatography (TLC) plates in comparison with standard caffeine, which served as a positive control. After performing the gross behavioral study, the Antibacterial activity was evaluated against Gram-negative bacteria included; Escherichia coli, Proteus mirabilis, Klebsiella pneumonia and Pseudomonas aeruginosa Both compounds at a concentration of 2 mg/ml showed similar antibacterial activities against all tested bacteria, except for P. mirabilis, and the highest inhibitory effect was observed against P. aeruginosa using a modified agar diffusion method. The minimal inhibitory concentration (MIC) of caffeine was determined using a broth microdilution method in 96 multi-well microtitre plates. MIC values ranged from 65.5 to 250.0 μg/ml for the caffeine isolated from coffee and 65.5 to 500.0 μg/ml for green tea caffeine. Combination results showed additive effects against most pathogenic bacteria especially for P. aeruginosa, using both antibacterial assays.
Antibacterial activity of mushroom Osmoporus odoratus  [cached]
Sivakumar R,Vetrichelvan T,Rajendran N,Devi M
Indian Journal of Pharmaceutical Sciences , 2006,
Abstract: The petroleum ether, chloroform, acetone and water extracts of mushroom Osmoporus odoratus were selected for examine the antibacterial activity against Staphylococcus aureus, Streptococcus pyogenes, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa by disc diffusion method using Muller Hinton agar media. And the extracts were compared with that of standard ampicillin (30 μg) and chloramphenicol (30 μg). The water extract alone showed antibacterial activity against the tested organisms and the results were comparable with that of ampicillin rather than chloramphenicol.
ANTIBACTERIAL ACTIVITY OF LOCAL MALAYSIAN HONEY
NURIZA TUMIN,N. ARSYIAH A. HALIM,M. SHAHJAHAN,NOOR IZANI N. J.
Malaysian Journal of Pharmaceutical Sciences , 2005,
Abstract: The antibacterial activity of five different local honey brands viz. Tualang, Hutan, Gelang, Pucuk Daun and Ee Feng Gu honey obtained from different locations in Malaysia was investigated. Honeys were tested for putative antibacterial activity by disc diffusion assay and their inhibition of growth of six pathogenic bacteria in batch culture. Minimum inhibitory concentration (MIC) was determined for each of the honey tested using standard assay procedures. In terms of physicochemical properties, it was observed that the pH of these honeys was within 3.55–4.91, their specific gravity was 1.3–1.35, moisture content was 16–23.3% and dry matter content was 76.6–84%. Marked variations were observed in the antibacterial activity of these honey samples. Two honey brands, Hutan and Gelang did not produce any substantial antibacterial activity while other brands showed a spectrum of antibacterial activity with their growth inhibitory effect against at least three-four different bacterial species including S. typhi, S. aureus, S. sonnie and E. coli.
Page 1 /100
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.