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Effect of Lovastatin on Lipid peroxidation and total antioxidant concentrations in hemodialysis patients
Hassan Argani, Amir Ghorbani, Nadereh Rashtchizade, Mohammad Rahbaninobar
Lipids in Health and Disease , 2004, DOI: 10.1186/1476-511x-3-6
Abstract: We tested lipid peroxidation and total antioxidant levels in forty five stable hyperlipidemic HD males (age range 40–60 years) before, after 45 and 90 days of prescription of 20 mg/day Lovastatin for three months. Malondialdehyde (MDA), as prototype of lipid peroxidation, and total antioxidants (TA) were measured by flourimetric and spectrophotometric assays, respectively.Serum triglyceride (Tg) (213.7 ± 112.4 mg/dl vs. 153.4 ± 54.8 mg/dl p = 0.003), serum cholesterol (C) (185.8 ± 48.3 mg/dl vs. 149.3 ± 37.8 mg/dl, p = 0.014), LDL-C (120.1 mg/dl ± 48.9 vs. 84.8 ± 43.7 mg/d, p = 0.001), VLDL-C (40.7 ± 18.9 mg/dl vs. 30.7 ± 10.9 mg/dl, p = 0.025), MDA (13.1 ± 3.5 nmol/ml vs. 1.27 ± 1 nmol/ml, p = 0.00), TA (0.98 ± 0.17 mmol/l vs. 1.28 ± 0.27 mmol/l, p = 0.001) and HDL (24.9+11.1 mg/dl vs. 31.4 ± 7.7 mg/dl, p = 0.007) significantly were changed by 3 months of Lovastatin therapy. These changes for HDL, VLDL and Tg after the 3 months were more obvious than 45 days of Lovastatin therapy.In HD patients serum lipids and their oxidations are increased. Both of them, quantitatively and qualitatively, are improved by using of Lovastatin. The later would be due to enhance of TA activity.End stage renal diseases (ESRD), despite of the different etiologies, show a common hyperatherogenic state [1]. This may be due to existence of classic and nonclassic risk factors. Hypertension, hyperlipidemia, diabetes mellitus and cardiovascular hypertrophy as the first group, and hyperhemocycteinemia, increased Lpa, inflammation, hyperfibrinogenemia and oxidative stresses, as the later, are usually seen in ESRD. Higher levels of triglyceride (Tg) and cholesterol (C) are observed in 33%–70% and 20%, respectively [2]. Higher melvalonate level (due to its retention in ESRD) [3], lower serum albumin concentration [4], lower lipoprotein lipase enzyme [5] and lower Lecithin cholesterol acetyl transferase (LCAT) enzyme [6] are responsible for dyslipidemia. Although hyperlipidemia due to the above ca
Efficacy of piperine, an alkaloidal constituent of pepper on nitric oxide, antioxidants and lipid peroxidation markers in L-NAME induced hypertensive rats
Kumar S, Saravana Kumar M, Raja B
International Journal of Research in Pharmaceutical Sciences , 2010,
Abstract: A pharmacological inhibition of nitric oxide synthase (NOS) in rats produces vasoconstriction which causes hypertension. We have investigated that whether piperine ameliorates Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) - induced hypertension. Treatment of rats with L-NAME (40 mg/kg in drinking water for 4 weeks) caused a sustained decrease in the nitrite/nitrate concentrations (NOx) in plasma compared with control rats. Piperine restored the plasma NO metabolites concentration in L-NAME-treated hypertensive rats. Moreover, piperine significantly restored enzymatic (superoxide dismutase, catalase, glutathione peroxidase), non-enzymatic antioxidants (vitamin C, vitamin E and reduced glutathione) and decreased the levels of lipid peroxidation markers, compared to the L-NAME-treated group. Histopathological findings of piperine treated hypertensive rat heart confirmed the biochemical findings of this study. Taken together, these results suggest that L-NAME-induced hypertension is associated with decreased release of NO, an imbalance in antioxidant status and increased lipid peroxidation. Our results indicate that piperine attenuates hypertension on NO-deficient rats and that oxidative stress participates in the established phase of this type of hypertension.
Changes in Antioxidants and Lipid Peroxidation in Workers of A Pesticide Production Factory
H.R Joshaghani,A.R Ahmadi
Journal of School of Public Health and Institute of Public Health Research , 2008,
Abstract: Background and Aim: Organophosphate compoounds are cholinesterase activity inhibitors. Contact with them cause changes in the blood antioxidant enzyme levels and lipid peroxidation. The aim of this research was to investigate the simultaneous changes in cholinesterase, total serum antioxidant levels, and activities of some of the erythrocyte antioxidant enzymes and find possible correlations among these variables in pesticide factory workers. Materials and Methods: This research was a cohort study carried out, during 2006, on the employees of a pesticide factory in Golestan Province, Iran. Blood samples were taken at the beginning (n=81 subjects) and after 3 months (n=63, of the initial 81). Erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant levels were determined enzymatically (Randox, UK) and serum SOD was measured by the ELISA method (IBL, Germany). For the determination of malondialdehyde (MDA) a chemical method (based on thiobarbituric acid) was used. Confidence interval was 95% for all statistical tests.Results: Levels of serum and erythrocyte SOD, serum MDA, and both serum and eryhthrocyte GPx significantly increased (paired t-test, p<0.05), while the serum total antioxidant level decreased (paired t-test, p<0.05). No statistically significnt correlation was seen between cholinesterase and changes in the other variables. Conclusion: Contact with organophosphorus compounds will cause increases in lipid peroxidation and decreases in total antioxidants. It is suggested that, while more severe physical protective measures are taken, nutritional supplements be taken by the personnel to increase protection against hazardous materials.
Lipid peroxidation and antioxidants in different stages of cervical cancer: Prognostic significance  [cached]
Srivastava S,Natu S,Gupta A,Pal K
Indian Journal of Cancer , 2009,
Abstract: Background: Free radical Injury is associated with cancer, but how the extent of oxidative stress correlates with the FIGO (International Federation of Gynecology and Obstetrics) stage in Carcinoma Cervix (Ca Cx), and its significance as a prognostic marker, is not clear and needs an in-depth study. Aim: To correlate the blood levels of Lipid Peroxidation (LPO), Reduced Glutathione (GSH), Superoxide Dismutase (SOD), and Vitamin A and E levels with the clinical stage in Ca Cx. Settings and Design: This is a Prospective Case Control Study. Materials and Methods: LPO, SOD, reduced GSH were estimated by Bio Chemical Assays and Vitamins by High Performance Liquid Chromatography (HPLC). Statistical Analysis: The cases and controls were compared using One Way ANOVA and different stages over different time periods were individually compared by Repeated Measure Analysis of Variance. Results: The results indicated a statistically significant increase of LPO vis-a-vis the FIGO stage of Ca Cx and control, while the antioxidant status as depicted by GSH and SOD decreased. Vitamin A and E levels were significantly lower in cancer cases as compared to the control. Conclusion: Increased LPO and reduced antioxidant levels may be taken as associated predictive markers, thus suggesting that Ca Cx cases should get nutritive supplements to contain the blood LPO level and maintain a positive balance of antioxidants for a better outcome in terms of delayed recurrence and better Quality of Life (QOL).
Effect of Ascorbic Acid on Lipid Peroxidation Induced by Ceftazidime  [PDF]
Devbhuti P*,1,Devbhuti D2,Saha A3,Sengupta C4
Journal of PharmaSciTech , 2011,
Abstract: Lipid peroxidation is the oxidative deterioration of polyunsaturated lipids which is a free radical related process and responsible for thedevelopment of many diseases and disorders like diabetes mellitus, hypertension, cancer etc. End products of lipid peroxidation aremalondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE), etc. which are the ultimate mediator of toxicity. Antioxidants have the capability toinhibit lipid peroxidation. Keeping in mind this fact, the present in vitro study was carried out to evaluate lipid peroxidation induction potential of ceftazidime, a cephalosporin antibiotic and its suppression with ascorbic acid considering some laboratory markers of lipid peroxidation like MDA, 4-HNE and reduced glutathione (GSH). Goat liver was used as the lipid source. After treatment of the liver homogenate with drug and/or antioxidant the levels of 4-HNE, MDA and GSH were estimated in different samples at different hours of incubation. The results showed that the drug ceftazidime could significantly induce lipid peroxidation and the antioxidant ascorbic acid has the capability to inhibit ceftazidime-inducedlipid peroxidation.
Natural Antioxidants, Lipid Profile, Lipid Peroxidation, Antioxidant Enzymes of Different Vegetable Oils
Eqbal M.A. Dauqan,Aminah Abdullah,Halimah Abdullah Sani
Advance Journal of Food Science and Technology , 2011,
Abstract: Antioxidant plays a very important role in the body defense system against Reactive Oxygen Species (ROS). The free radicals also play an important role in combustion, atmospheric chemistry, biochemistry and biotechnology including human physiology. Fats and oils are energy sources that are composed mostly of triacylglycerols. Lipid ptofile are risk indicators of coronary heart disease. Various types of lipoproteins exist, but the two most abundant are Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL). Lipid peroxidation is the introduction of a functional group containing two catenated oxygyen atomsinto unsturated fatty acids in a free radical reaction. Life in oxygen has led to the evolution of biochemical adaptations that exploit the reactivity of Active Oxygen Species (AOS). Antioxidant enzymes are an important protective mechanism ROS. This paper highlight the functions of antioxidants in the blood and selected organs associated with health.
P.Vinoth kumar*
International Journal of Pharmacy and Technology , 2010,
Abstract: The purpose of this study was to investigate the possible antioxidant effect of metformin in high fructose fed diet-induced diabetic rats. The increased level of lipidperoxidation and altered levels ofenzymatic and non enzymatic antioxidants were seen in high fructose fed consumed animals. The administration of metformin significantly normalized the altered levels of lipid peroxidation and antioxidantstatus. In conclusion, this study indicates that the administration of metformin improves antioxidant status by reducing lipidperoxidation and enhancing the antioxidant enzymes activities in liver of diabetic rats.
Effect of Haemodialysis on Plasma Lipid Peroxidation and Endogenous Non-enzymic Antioxidants in Gorgan (South East of Caspian Sea)  [PDF]
Abdoljalal Marjani
Journal of Medical Sciences , 2006,
Abstract: The aim of this study was to evaluate the effect of haemodialysis on lipid peroxidation (the level of lipid peroxidation expressed as malondialdehyde) and endogenous non-enzymic antioxidants before and after the dialysis and compared with control group. The sampling procedure was a purposive sampling. Twenty two patients with Chronic Renal Failure (CRF) disease who were haemodialysed at 5th Azar hospital of Gorgan Dialysis Center (2005). Twenty two age and sex matched healthy control were recruited for this study. Plasma level of malondialdehyde and uric acid were significantly increased and reduced in the postdialysis group when compared with predialysis and control group, respectively (p<0.001). The plasma level of albumin and total bilirubin were significantly increased in postdialysis group when compared with predialysis group (p<0.001). The increasing level of plasma lipid peroxidation and the significant difference of non-enzymic antioxidants in the haemodialyzed pateints after the process of dialysis, maybe related with the pateint uremia, the quality of consumed water in the dialysis procedure, dialysis membrane and the loss of these antioxidants through membranes and hemoconcenteration of them during the dialysis process and the dialysis process (may increase lipid peroxidation during the dialysis process). These states of affairs may play an important role in progress of cardiovascular abnormality in haemodialyzed pateints. Due to this conditions a review of haemodialysis membrane, the techniques used in the dialysis, the consumption of various oral antioxidant, the elimination of active oxygens from the dialysis surrounding are among the measures which can prevent sudden cardiovascular abnormality in the haemodialysis pateints and ultimately these important factors up- grade the pateints quality of life and prevent sudden silent myocardial infarction.
Effects of micro-ketoglutarate on antioxidants and lipid peroxidation products in rats treated with sodium valproate
Murugesan Vidya,Perumal Subramanian
Journal of Applied Biomedicine , 2006,
Abstract: Oxidative stress may cause free radical reactions to produce deleterious modifications in membranes,proteins, enzymes and DNA. Valproic acid is a major anti-epileptic drug with a broad spectrum of antiepilepticactivity. Chronic treatment with valproic acid can lead to elevated serum ammonia levels andspecific oxidative metabolites of valproic acid have been associated with the drug’s toxicity. Theinfluence of sodium valproate treatment on lipid peroxidation and lipid profiles and the detoxifyingeffects of α-ketoglutarate on sodium valproate induced toxicity were studied in rats. The levels ofthiobarbituric acid reactive substances, hydroperoxides and lipid profile variables (cholesterol,phospholipids, triglycerides and free fatty acids) were significantly increased in sodium valproate treatedrats. Further, non-enzymic antioxidants (reduced glutathione) and the activities of the enzymic(superoxide dismutase, catalase, glutathione peroxidase) antioxidants were significantly decreased insodium valproate treated rats. The levels were observed to be normal in α-KG + sodium valproate treatedrats. These biochemical alterations during α-KG treatment could be due to (i) its ubiquitous collection ofamino groups in body tissues, (ii) the participation of α-KG in non-enzymatic oxidative decarboxylationof the hydrogen peroxide decomposition process and (iii) its role in the metabolism of fats which couldsuppress oxygen radical generation and thus prevent lipid peroxidative damage.
Effect of Aegle marmelos Leaf Extract and -Tocopherol on Lipid Peroxidation and Antioxidants in Isoproterenol Induced Myocardial Infarction in Rats
Murugan Rajadurai,Mannangatti Padmanabhan,Ponnaian Stanely Mainzen Prince
The Cardiology , 2011,
Abstract: The present study investigates the effect of oral administration of an aqueous Aegle marmelos leaf extract (AMLEt) on lipid peroxidation and antioxidants in isoproterenol (ISO) treated rats. A significant increase in the activities of marker enzymes such as creatine kinase, lactate dehydrogenase, aspartate transaminase and alanine transminase in serum of isoproterenol treated rats was observed. The levels of thiobarbituric acid reactive substances and hydroperoxides increased but the levels and activities of nonenzymic (vitamin C, reduced glutathione and ceruloplasmin) and enzymic (glutathione peroxidase, superoxide dismutase and catalase) antioxidants decreased in isoproterenol administered rats. Pretreatment with aqueous AMLEt at doses of 100 and 200 mg/kg orally for a period of 35 days exerted a significant effect on isoproterenol treated rats. The effect of AMLEt at a dose of 200 mg/kg showed a similar effect as that of ?-tocopherol (60 mg/kg). Thus the results of our study show the cardioprotective activity of Aegle marmelos leaf extract in isoproterenol induced myocardial infarction in rats.
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