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Application of 2-octyl-cyanoacrylate for corneal perforation and glaucoma filtering bleb leak  [cached]
Okabe M,Kitagawa K,Yoshida T,Koike C
Clinical Ophthalmology , 2013,
Abstract: Motonori Okabe,1 Kiyotaka Kitagawa,2 Toshiko Yoshida,1 Chika Koike,1 Takeshi Katsumoto,2 Etsuko Fujihara,2 Toshio Nikaido1 1Department of Regenerative Medicine, University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Toyama, 2Division of Ophthalmology, Matsue Red Cross Hospital, Japanese Red Cross Society, Shimane, Japan Background: This paper reports on the efficacy of a tissue adhesive, 2-octyl-cyanoacrylate, in the treatment of corneal perforation and glaucoma filtering bleb leak. Methods: Two eyes from two patients with corneal perforation or laceration and two eyes from two patients with bleb leak were included. The patients underwent application of 2-octyl-cyanoacrylate onto the perforated or leaking site, and a hydrogel contact lens was applied as a bandage. We also evaluated the in vitro cell toxicity of 2-octyl-cyanoacrylate in HeLa cells. Results: The two cases of corneal perforation were repaired within 22 days with one application of the tissue adhesive. The two cases of bleb leak were repaired with 2–4 applications of the tissue adhesive over 134 (range 17–134) days). There were no recurrences or adverse effects during a mean follow-up period of 12.7 months. In vitro testing revealed that 2-octyl-cyanoacrylate was markedly toxic to HeLa cells. Conclusion: Four patients with corneal perforation or bleb leak were successfully managed using 2-octyl-cyanoacrylate tissue adhesive. This simple and easy surgical technique may become an alternative therapeutic option for corneal perforation or bleb leak, although several applications of this tissue adhesive may be required. Although 2-octyl-cyanoacrylate was toxic to HeLa cells, no adverse clinical effects were noted using this adhesive. Keywords: corneal perforation, bleb leak, tissue adhesive, 2-octyl-cyanoacrylate
Temporary management of involutional entropion with octyl-2-cyanoacrylate liquid bandage application
Osaki, Teissy;Osaki, Midori Hentona;Osaki, Tammy Hentona;
Arquivos Brasileiros de Oftalmologia , 2010, DOI: 10.1590/S0004-27492010000200004
Abstract: purpose: to evaluate the use of octyl-2-cyanoacrylate liquid bandage (band-aid liquid?, ethicon, johnson & johnson, new jersey, usa) as a temporary treatment in patients awaiting surgical repair for involutional entropion. methods: thirteen patients (15 eyelids) with involutional entropion were evaluated while they waited for surgical intervention. the lids were repositioned by the application of octyl-2-cyanoacrylate liquid bandage in the malar fold. patients were followed-up at days 1, 7 and 15. assessment and duration of correction were recorded. results: all the patients presented successful correction at day 1, with significant improvements in signs and symptoms. the mean duration of action of the octyl2-cyanoacrylate liquid bandage was three days. no ocular or dermatological reactions were noted. conclusion: octyl-2-cyanoacrylate liquid bandage showed to be a simple, safe and effective option to temporarily treat involutional entropion, while patients waited for surgical intervention.
Medial meniscus transplantation using cyanoacrylate in rabbits
Reckers, Leandro José;Fagundes, Djalma José;Cohen, Moisés;Raymundo, José Luiz Pozo;Moreira, Márcia Bento;Paiva, Vanessa Carla;
Acta Cirurgica Brasileira , 2006, DOI: 10.1590/S0102-86502006000200007
Abstract: purpose: to evaluate meniscal transplantation using as fixation method a synthetic glue derived from cyanoacrylate acid. methods: twenty rabbits were used, of which 10 for autologous transplantation and 10 for homologous transplantation. for the autologous transplantation the meniscus was removed, and then transplanted in the same animal, using the synthetic glue. for the homologous transplantation, the study was divided into two stages: 1- removal of the meniscus which was maintained at a temperature of 73oc. 2- use of cyanoacrylate acid-derived surgical adhesive for meniscal retransplantation in a different rabbit 30 days after the transplant. results: due to complications, euthanasia had to be anticipated to the 15th day in the homologous group and to the 18th day in the autologous group. macroscopically, knees submitted to transplantation presented whitish secretions from the surgical incision up to deep planes. necrosis was observed in both groups. statistical analysis has shown that mild (p=0.043) and moderate (p=0.001) complications emerged in a significantly earlier way in the homologous group, where euthanasia was also performed earlier (p=0,005). conclusion: synthetic surgical adhesives derived from cyanoacrylate acid promoted cortical to medullary bone necrosis bone in both groups.
Medial meniscus transplantation using cyanoacrylate in rabbits  [cached]
Reckers Leandro José,Fagundes Djalma José,Cohen Moisés,Raymundo José Luiz Pozo
Acta Cirurgica Brasileira , 2006,
Abstract: PURPOSE: To evaluate meniscal transplantation using as fixation method a synthetic glue derived from cyanoacrylate acid. METHODS: Twenty rabbits were used, of which 10 for autologous transplantation and 10 for homologous transplantation. For the autologous transplantation the meniscus was removed, and then transplanted in the same animal, using the synthetic glue. For the homologous transplantation, the study was divided into two stages: 1- Removal of the meniscus which was maintained at a temperature of 73oC. 2- Use of cyanoacrylate acid-derived surgical adhesive for meniscal retransplantation in a different rabbit 30 days after the transplant. RESULTS: Due to complications, euthanasia had to be anticipated to the 15th day in the homologous group and to the 18th day in the autologous group. Macroscopically, knees submitted to transplantation presented whitish secretions from the surgical incision up to deep planes. Necrosis was observed in both groups. Statistical analysis has shown that mild (p=0.043) and moderate (p=0.001) complications emerged in a significantly earlier way in the homologous group, where euthanasia was also performed earlier (p=0,005). CONCLUSION: Synthetic surgical adhesives derived from cyanoacrylate acid promoted cortical to medullary bone necrosis bone in both groups.
2-Octyl-Cyanoacrylate Skin Adhesive Used as a Splinting Material in Auricular Surgery  [PDF]
Naoto Yamamoto, Satoshi Yanagibayashi, Ryuichi Yoshida, Hiroyuki Ogi, Megumi Takikawa, Akio Nishijima, Eri Maruyama
Modern Plastic Surgery (MPS) , 2016, DOI: 10.4236/mps.2016.64004
Abstract: In cases of auricular surgery, postoperative dressings are thought to be important for keeping auricular contour and in helping to prevent from dressing failures due to edema or subcutaneous hematoma, which may result in fibrous or cartilaginous proliferation. However, it is often difficult to achieve success with standard dressings because of the complicated shape of the auricle. We used 2-octyl-cyanoacrylate skin adhesive to dress the auricle after different types of auricular procedures (five cases of cryptotia, two of prominent ear, two of severe auricular laceration, two of skin grafting and one of flap repair of the partial auricle defect). The 2-octyl-cyanoacrlaate skin adhesive was applied to the suture line and the operated and peripheral areas for wider coverage. No dressing materials were placed over the surface. In all cases, the desired outcome was achieved, without subcutaneous hematoma, wound dehiscence, and wound infection. Contact dermatitis caused by the skin adhesive was not observed in any of the cases. Dressing and splinting after auricular surgery can be simply and successfully achieved using 2-octyl-cyanoacrylate skin adhesive. There is no need for more complicated dressings and post-surgical dressing changes, resulting in higher patient satisfaction.
Histologic evaluation of pulpotomy performed with ethyl-cyanoacrylate and calcium hydroxide
Albuquerque, Diana Santana de;Gominho, Luciana Ferraz;Santos, Roberto Alves dos;
Brazilian Oral Research , 2006, DOI: 10.1590/S1806-83242006000300008
Abstract: the aim of this study was to evaluate histological aspects of the pulp-dentin complex of dogs submitted to pulpotomy and capped with ethyl-cyanoacrylate and calcium hydroxide. thirty dog teeth were divided into 2 groups of 15 as follows: group 1 - ethyl-cyanoacrylate; group 2 - calcium hydroxide. the pulpotomies were carried out following all of the treatment precautions recommended for dogs. after 30 days the specimens were submitted to histological preparation and were then blindly evaluated by a histologist. data were analyzed statistically by the fisher exact test, comparing the two groups. after 30 days, the presence of a hard tissue barrier was observed in 83.3% of group 1, and in 100% of group 2 (p = 0.478). a continuous hard tissue barrier was observed in 50% of the ethyl-cyanoacrylate group and 75% of the calcium hydroxide group (p = 0.652). it can be concluded that both materials induced hard tissue barrier formation, but group 2 had a higher percentage than group 1, with no significant statistical differences; the differences observed between the different barriers (continuous/non-continuous) were not significant between groups and there was no pulpal necrosis in either group.
Efficacy of percutaneous transhepatic variceal embolization with 2-Octyl-cyanoacrylate in patients with severe recurrent hepatic encephalopathy  [cached]
WANG Guangchuan
Journal of Clinical Hepatology , 2013,
Abstract: ObjectiveTo investigate the efficacy and safety of percutaneous transhepatic variceal embolization (PTVE) performed with 2-Octyl-cyanoacrylate (2-OCA) tissue adhesive for treating recurrent hepatic encephalopathy (HE) involving large portosystemic shunts. MethodsTwelve cirrhotic patients (8 males, 4 females; mean age: 62 years old) with recurrent HE (≥3 episodes/year, despite drug therapy) were treated by PTVE with 2-OCA. The surgery was performed under local anesthesia with B ultrasound- or X-ray-guided percutaneous needle injection of the adhesive into the hepatic portal vein with balloon dilation to occlude the portosystemic shunts. Preoperative and postoperative clinical and laboratory parameters, including HE episodes, with or without gastrointestinal bleeding, markers of liver and renal function and coagulation indicators, were recorded. Significance of surgery-induced change in portal vein pressure was assessed by paired t-test. ResultsThe PTVE was performed successfully in all 12 patients. The average injected volume of 2-OCA was 8.6 ml (range: 4-16 ml). The most frequent postoperative complications were pyrexia (6/12, 50.0%) and abdominal pain (5/12, 41.7%). The mean follow-up period was 22.7±9.8 months (range: 6-37 months). During the follow-up period, two patients (16.7%) developed transient ascites and two (16.7%) patients developed upper gastrointestinal bleeding (due to esophageal varices and portal hypertensive gastropathy, respectively). In addition, three patients (25.0%) experienced HE recurrence (at postoperative months 16, 19, and 30, respectively). Two patients (16.7%) died, one from progression of hepatic failure and the other from liver cancer. In general, the PTVE procedure significantly increased the portal pressure (preoperative: (21.9±1.8) mm Hg vs. postoperative: (26.3±3.2) mm Hg; P=000). ConclusionPTVE with 2-OCA is an effective and safe procedure for managing recurrent HE with large portosystemic shunts.
2-Octyl Cyanoacrylate Skin Adhesive for Topical Skin Incision Closure in Female Pelvic Surgery  [PDF]
Rebecca L. James, Marilyn Alejandro-Rodriquez, Elba Adriana Perez, Jeffrey Mangel
Open Journal of Obstetrics and Gynecology (OJOG) , 2015, DOI: 10.4236/ojog.2015.55041
Abstract: Background: 2-octyl cyanoacrylate (2OCA) high viscosity tissue adhesive (Medline Industries, Inc., Mundelein, IL) is a liquid topical skin adhesive. 2OCA offers the same design features and clinical utility in terms of flexibility, strength, and low complication rate as the commercially available 2OCA tissue adhesives. Additionally, 2OCA features high viscosity allowing for better control during the application process, polymerization without the use of an external activator, and a distinctive violet color for ease of application visualization. Objective: The aim of this prospective case series is to descriptively report clinical data with the application of 2OCA as a topical incision closure system in female pelvic surgery. The primary outcomes included: incisional pain, incisional dehiscence, and post-operative bleeding. The secondary outcome included drying times of the adhesive with regard to incision length. Methods: A prospective open-label observational case series study was conducted to evaluate the use of 2OCA in surgical wound closure of the topical skin in adult patients undergoing gynecologic surgical procedures. A total of 50 adult women undergoing gynecologic surgery were enrolled. 2OCA was applied only by surgeons who had undergone product training to the incisions in a standardized, protocol-defined fashion. Drying times for the adhesive and photography were recorded intraoperatively. Post treatment follow-up was conducted with queries of pain level, incisional dehiscence, and incisional bleeding immediately post-operatively, 48 hours, 5 - 10 days and 14 days post-treatment. Adverse events were documented. Results: 2OCA was applied to a total of 154 incisions from the 50 patients enrolled to the study. The procedures included: 16 laparoscopic total hysterectomies, 4 diagnostic laparoscopies, 2 laparoscopic myomectomies, 2 laparoscopic bilateral or unilateral salpingo-oophorectomies, 5 total robotic-assisted laparoscopic surgeries (2 total hysterectomies, 1 supracervical hysterectomy, 1 sacrocolpopexy, and one excision of endometriosis), 7 sacral neuromodulation procedures, and 18 midurethral slings. The overall rate of incisional dehiscence was 3% (4/154). The rate of reported incisional bleeding was 3% (4/154). There was 1 incisional infection. The pain reports based on a 10-point scale had a mean of 4.96 immediately post-operatively, which decreased to a mean score < 1 (0.2) by post-op day (POD) 14. The mean drying times for the various lengths of incisions included the following: 1.28 minutes for incisions ≤ 5 mm, 1.53 minutes for
Quality of Scar after Total Thyroidectomy: A Single Blinded Randomized Trial Comparing Octyl-Cyanoacrylate and Subcuticular Absorbable Suture  [PDF]
Fabrizio Consorti,Rosaria Mancuso,Annalisa Piccolo,Eugenio Pretore,Alfredo Antonaci
ISRN Surgery , 2013, DOI: 10.1155/2013/270953
Abstract: Objective. To compare the quality of resulting scar at 6 weeks after total thyroidectomy with the use of the tissue adhesive octyl-cyanoacrylate or subcuticular absorbable suture for the closure of cervicotomy. Material and Methods. There are 50 patients undergoing a cervicotomy for total thyroidectomy. Twenty-five patients were randomly assigned to closure with tissue adhesive and 25 with subcuticular absorbable suture. At week 6 the scar was evaluated by blinded assessors with the Italian version of POSAS questionnaire, a validated wound scale composed of an observer’s and a patient’s subscale. Results. Assessment of scar appearance showed a statistically significant difference ( ) in favor of subcuticular suture with respect to tissue adhesive on observer’s assessment. The difference on patients’ self-assessment was not significant. A multivariate analysis of six qualitative features of scars showed a significant influence on assessment for hyperpigmentation and relief of scar. The Italian version of POSAS proved to be reliable. Conclusion. Though tissue adhesive represents a valid method of skin closure, subcuticular absorbable suture provides a better aesthetic outcome in small cervical incisions in the early phase after thyroid surgery. 1. Background Aesthetic outcome is particularly relevant in thyroid surgery since patients are mostly women and young adults and since the incision is in a highly sensitive and visible anatomic location. Cosmetic concern about the final scar appearance contributed to motivate the development of minimally invasive approaches for thyroid surgery and parathyroid surgery over the last decade [1–3]. Minimally invasive thyroid surgery techniques (MIT) are different but all share the same goals: reduction of tissue trauma, early hospital discharge, and better neck wound cosmetic appearance, while maintaining the same surgical outcome as traditional thyroidectomy [4]. In addition to MIT, methods of skin closure contribute to the overall aesthetic outcome and patient’s satisfaction. Methods of skin closure vary in published series and are largely the results of surgeon’s choice based upon the need for a rapid, economic, and reproducible technique [5]. Skin closure techniques include the use of the tissue adhesive octyl-cyanoacrylate, introduced 15 years ago in clinical practice as an ideal system of wound closure [6]. Many studies showed that tissue adhesive is an acceptable alternative to standard wound closure since it yields similar clinical and aesthetic results, even if early wound dehiscence occurs in the 1% to 5% of
Effects of the Bovine Amniotic Membrane on Corneal Healing with Acute Alkali Burns in Rabbits
Ramazan Gonenci,Muhammed Enes Altug,Ahmet Koc,Huseyin Oksuz,Hayati Yuksel
Journal of Animal and Veterinary Advances , 2012,
Abstract: The Bovine Amniotic Membrane (BAM) was transplanted on the right cornea of 8 adult rabbits after an alkali burn was created with 2.5 N NaOH. Density and area of the corneal opacity, area of the corneal epithelial defect, vascularization and complications were clinically evaluated. Left corneas of the same animals were used as active control group. At the end of the experiment, all the eyes were extirpated and histologically examined on light microscopy. BAM has decreased density and area of the corneal opacity and increased reepithelialisation, but promoted episcleral vasodilatation more prominently in clinical examination. Histologically; the distrubition of Polymorphonuclear (PMN) leucocytes, corneal thicknesses, edema, keratinization, neovascularization and inflammation were significantly reduced by BAM compared to active control group. BAM was highly found to be effective to restore the corneal surface with acute alkali burns in the rabbit.
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