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Essential oil in the taxonomy of Ocimum selloi benth
Martins, Ernane R.;Casali, Vicente W. D.;Barbosa, Luiz C. A.;Carazza, Fernando;
Journal of the Brazilian Chemical Society , 1997, DOI: 10.1590/S0103-50531997000100006
Abstract: chemical composition analysis of the essential oil from the leaves and flowers of two accessions of ocimum selloi benth, cultivated at the federal university of vi?osa was carried out. for accession a the major component was identified as estragole and represented 94,95% and 92,54% of the oil from the leaves and flowers respectively. for accession b, the oil from the leaves and flowers was constituted by 65,49% and 66,18% of methyleugenol, respectively. for both accessions several minor constituents were also identified. the phenotypic and chemical differences observed between these two accessions suggest the existence of two chemicaly distinct varieties for ocimum selloi benth.
Phytochemical screening and anticonvulsant property of Ocimum basilicum leaf essential oil  [cached]
Juliana S OLIVEIRA,Lívia A. PORTO,Charles S. ESTEVAM,Rosana S. SIQUEIRA
Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas , 2009,
Abstract: Ocimum basilicum (Lamiaceae) y otras especies del mismo género son usadas como medicamentos en el tratamiento de enfermedades del sistema nervioso central (SNC). En este reporte, hemos investigado los posibles efectos anticonvulsivantes y depresivos del SNC del aceite esencial (EO) de las hojas de Ocimum basilicum (conocida como "Maria Bonita") en diferentes modelos experimentales. Los análisis por GC-MS y GC-FID del aceite esencial permitieron la identificación de 7 compuestos constituyendo el 98.8% del aceite total. Los principales componentes fueron 1.8-cineol, linalol y geraniol que comprendieron el 92.9% del aceite. EO, a todas las dosis, mostró actividad depresora del SNC revelado en el tamizaje farmacológico general: decrecimiento de la actividad espontánea, ptosis, ataxia y sedación. Además, todas las dosis de EO indujeron un incremento significativo del tiempo de sue o (p<0.05) y disminuyeron la latencia de sue o (p<0.01). EO también incrementó la latencia para el desarrollo de convulsiones en las pruebas de pentilenetetrazol (PTZ) y picrotoxina (p<0.05). Para PTZ, los efectos de EO fueron revertidos por flumazenil. EO no interfirió con las convulsiones inducidas por estricnina (p>0.05). Nuestros datos sugieren que EO posee propiedades anticonvulsivantes y depresoras del SNC lo que podría estar mediado por una interacción con los receptores GABAérgicos centrales.
Chemical composition and antimicrobial activity of essential oils of Ocimum canum Sims. and Ocimum selloi Benth.
Nascimento, Jeferson C.;Barbosa, Luiz C.A.;Paula, Vanderlucia F.;David, Jorge M.;Fontana, Renato;Silva, Luiz A.M.;Fran?a, Robson S.;
Anais da Academia Brasileira de Ciências , 2011, DOI: 10.1590/S0001-37652011005000019
Abstract: this work describes the chemical composition and antimicrobial activity of the volatile oils of ocimum canum and ocimum selloi, both occurring in jequié/ba, northeastern brazil. the plants were collected in the winter/2005 andsummer/2006, the oils extracted by steam distillation and further analyzed by gc-ms. a total of 30 and 31 compounds was identified from the oils of o. selloi and o. canum, respectively. it was observed that the oil content of o. canum showed variation during the seasons, while the oils of o. selloi did not. methylchavicol and linalool were the main chemical components found in the aerial parts and leaves of o. canum. this finding permitted to characterize this specimen as a new chemotype of o. canum. regarding the aerial parts of o. selloi, eugenol, 1,8-cineole, transcaryophyllene and linalool were identified as their major components. all extracted oils from the aerial parts showed biological activity against gram-positive cocci - staphylococcus aureus atcc 25923 - but only the o. canum one showed activity against gram-negative bacilli - escherichia coli atcc 25922.
Antibacterial activity of Ocimum gratissimum L. essential oil
Nakamura, Celso Vataru;Ueda-Nakamura, Tania;Bando, Erika;Melo, Abrah?o Fernandes Negr?o;Cortez, Díogenes Aparício Garcia;Dias Filho, Benedito Prado;
Memórias do Instituto Oswaldo Cruz , 1999, DOI: 10.1590/S0074-02761999000500022
Abstract: the essential oil (eo) of ocimum gratissimum inhibited staphylococcus aureus at a concentration of 0.75 mg/ml. the minimal inhibitory concentrations (mics) for shigella flexineri, salmonella enteritidis, escherichia coli, klebsiella sp., and proteus mirabilis were at concentrations ranging from 3 to 12 mg/ml. the endpoint was not reached for pseudomonas aeruginosa (>=24 mg/ml). the mics of the reference drugs used in this study were similar to those presented in other reports. the minimum bactericidal concentration of eo was within a twofold dilution of the mic for this organism. the compound that showed antibacterial activity in the eo of o. gratissimum was identified as eugenol and structural findings were further supported by gas chromatography/mass spectra retention time data. the structure was supported by spectroscopic methods.
Antibacterial activity of Ocimum gratissimum L. essential oil
Nakamura Celso Vataru,Ueda-Nakamura Tania,Bando Erika,Melo Abrah?o Fernandes Negr?o
Memórias do Instituto Oswaldo Cruz , 1999,
Abstract: The essential oil (EO) of Ocimum gratissimum inhibited Staphylococcus aureus at a concentration of 0.75 mg/ml. The minimal inhibitory concentrations (MICs) for Shigella flexineri, Salmonella enteritidis, Escherichia coli, Klebsiella sp., and Proteus mirabilis were at concentrations ranging from 3 to 12 mg/ml. The endpoint was not reached for Pseudomonas aeruginosa (>=24 mg/ml). The MICs of the reference drugs used in this study were similar to those presented in other reports. The minimum bactericidal concentration of EO was within a twofold dilution of the MIC for this organism. The compound that showed antibacterial activity in the EO of O. gratissimum was identified as eugenol and structural findings were further supported by gas chromatography/mass spectra retention time data. The structure was supported by spectroscopic methods.
Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice
Rabelo, M.;Souza, E.P.;Soares, P.M.G.;Miranda, A.V.;Matos, F.J.A.;Criddle, D.N.;
Brazilian Journal of Medical and Biological Research , 2003, DOI: 10.1590/S0100-879X2003000400016
Abstract: we have investigated the antinociceptive effects of the essential oil of ocimum gratissimum l. (labiatae) (eoog) in two classical models of pain in male swiss mice (25-35 g), the writhing test and the formalin test. at doses of 30, 100 and 300 mg/kg (po), eoog produced a dose-dependent inhibition (from 58.3 ± 4.4 to 40.7 ± 6.3, 36.4 ± 3.6 and 24.6 ± 3.6, respectively; n = 8-10, p<0.05) of acetic acid-induced writhing, causing up to a ~60% inhibition at the highest dose used, comparable to that obtained with indomethacin (10 mg/kg, po). at the same doses, eoog predominantly inhibited the late (inflammatory) phase of the formalin-induced pain response (from 59.3 ± 8.3 to 40.4 ± 4.8, 23.2 ± 2.8 and 25.3 ± 5.5, respectively; n = 6, p<0.05), with a maximal reduction of ~60% of the control, although a significant reduction of the initial (neurogenic) phase was also observed at 300 mg/kg (from 62.5 ± 6.07 to 37 ± 5.9; p<0.05). on the basis of these data, we conclude that eoog possesses interesting antinociceptive properties in the writhing and formalin tests. due to the relatively low toxicity of eoog, further detailed examination is strongly indicated for a better characterization of its pharmacological properties and its potential therapeutic value.
Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice  [cached]
Rabelo M.,Souza E.P.,Soares P.M.G.,Miranda A.V.
Brazilian Journal of Medical and Biological Research , 2003,
Abstract: We have investigated the antinociceptive effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) in two classical models of pain in male Swiss mice (25-35 g), the writhing test and the formalin test. At doses of 30, 100 and 300 mg/kg (po), EOOG produced a dose-dependent inhibition (from 58.3 ± 4.4 to 40.7 ± 6.3, 36.4 ± 3.6 and 24.6 ± 3.6, respectively; N = 8-10, P<0.05) of acetic acid-induced writhing, causing up to a ~60% inhibition at the highest dose used, comparable to that obtained with indomethacin (10 mg/kg, po). At the same doses, EOOG predominantly inhibited the late (inflammatory) phase of the formalin-induced pain response (from 59.3 ± 8.3 to 40.4 ± 4.8, 23.2 ± 2.8 and 25.3 ± 5.5, respectively; N = 6, P<0.05), with a maximal reduction of ~60% of the control, although a significant reduction of the initial (neurogenic) phase was also observed at 300 mg/kg (from 62.5 ± 6.07 to 37 ± 5.9; P<0.05). On the basis of these data, we conclude that EOOG possesses interesting antinociceptive properties in the writhing and formalin tests. Due to the relatively low toxicity of EOOG, further detailed examination is strongly indicated for a better characterization of its pharmacological properties and its potential therapeutic value.
Effect Of Essential Leaf Oil Of Ocimum Gratissimum On Clinical Isolates Of Pseudomonas aeruginosa
BA Iwalokun, IG Owuh, SA Ronke
African Journal of Clinical and Experimental Microbiology , 2004,
Abstract: Ocimum gratissimum leaf oil, which has been reported to possess in vitro and in vivo efficacy against enteric bacteria was tested against forty six clinical isolates of Pseudomonas aeruginosa in Lagos, Nigeria. The effect of the essential oil (EO) on pyocyanin production among these strains was also investigated. Agar well diffusion assay revealed susceptibility in 40 (87%) of the 46 tested strains with inhibition zone diameter (20-36 mm) comparable with the effect of tobramycin. Of the 40 susceptible isolates, 34 strains were quantitatively demonstrated to show susceptibility when further tested with the essential oil in broth and on agar yielding MIC and MBC values of 36 – 54 mg/ml and 42 – 66 mg/ml respectively. The values were higher than the 12 mg/ml (MIC) and 24 mg/ml (MBC) observed in Escherichia coli ATCC 25922. Compared with the control, the essential oil was found to reduce pyocyanin production significantly (p < 0.01) at 15 mg/ml (30.1 – 30.5 vs 259.2 – 276. 7 μg/ml) and 75 mg/ml (2.5 – 3.5 vs. 259.2 – 276.7 μg/ml) in both sensitive and resistant strains, suggesting that Ocimum gratissimum leaf oil may inhibit expression of virulence factors and progression of Pseudomonas infections caused by the tested strains. Key Words: Ocimum gratissimum leaf oil, Pseudomonas aeruginosa, Nigeria Afr. J. Clin. Exper. Microbiol. 2004; 5 (3): 265-271
Light intensity on growth, leaf micromorphology and essential oil production of Ocimum gratissimum  [cached]
Valéria Ferreira Fernandes,Laís B. de Almeida,Emily V. R. da S. Feijó,Delmira da C. Silva
Revista Brasileira de Farmacognosia , 2013,
Abstract: Light conditions can promote the growth and development of plants and contribute to increase the essential oil production of commercially cultivated medicinal and aromatic species. In view of the great importance of Ocimum gratissimum L., Lamiaceae, as an aromatic plant, the objective of this work was to determine the effect of light intensities (approximately 4, 7, 11 and 20 mol m-2 d-1) on growth, foliar micromorphology, essential oil content, yield and chemical composition of O. gratissimum. Biomass production of different organs, root:shoot ratio and leaf mass per area were found to linearly increase with increased light availability, whereas stem dry matter fraction, number of leaves, leaf area and plant height have increased up to 10 mol m-2 d-1 and decreased from this value. The tector trichomes density increased with increased light availability, but there was no effect of light treatments on the glandular trichomes density and essential oil content. Regardless of the light level, the major component of the essential oil was eugenol. The essential oil yield per plant increased linearly with light intensity as a direct effect of increased leaf biomass under similar conditions.
Essential oil of Ocimum grattissimum (Labiatae) as Sitophilus zeamais (Coleoptera: Curculionidae) protectant
EF Asawalam, SO Emosairue, A Hassanali
African Journal of Biotechnology , 2008,
Abstract: Ocimum grattissimum L. (Labiatae) leaves are widely eaten as a vegetable in Nigeria, and in the eastern parts, are traditionally used in post-harvest protection and relieving stomach aches. The effect of the essential oil of O. grattissimum leaves on Sitophilus zeamais (Motschulsky) (Coleoptera: Curculionidae) was assessed for repellency, mortality, progeny emergence and maize damage in the laboratory. The oil was found to be moderately repellent to the maize weevil and induced high mortality in the weevils. In addition, grains treated with the essential oil showed significant reduction in the number of progeny derived from surviving S. zeamais. There was no observable feeding damage on grains treated with the highest dosage of the essential oil extract. Gas chromatography-linked mass spectrometry (GC-MS) and GC co-injections with authentic samples showed the presence of the following major constituents: thymol (32.7%), paracymene (25.4%), -terpinene (10.8%), -selinene (4.5%), phellandrene (3.9%) and - myrcene (3.1%). The results provide a scientific rationale for the use of the plant in post-harvest protection.
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