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Anticariogenic effect of fluoride-releasing elastomers in orthodontic patients
Miura, Karina Katsue;Ito, Izabel Yoko;Enoki, Carla;Elias, Ana Maria;Matsumoto, Mírian Aiko Nakane;
Brazilian Oral Research , 2007, DOI: 10.1590/S1806-83242007000300007
Abstract: this in vivo experimental study evaluated the efficacy of fluoride-releasing elastomers in the control of streptococcus mutans levels in the oral cavity. forty orthodontic patients were recruited and divided into two groups of 20. fluoride-releasing elastomeric ligature ties (fluor-i-ties, ortho arch co. inc., usa) were used in the experimental group, and conventional elastomeric ligature ties (d. morelli, brazil), in the control group. two initial samples of saliva were collected at a 14-day interval to determine the number of colony forming units (cfu) of streptococcus mutans. immediately after collecting the second sample, fluoride-releasing elastomeric ligature ties were placed in the patients of the experimental group, and conventional ligature ties, in the patients of the control group. seven, 14 and 28 days after placement of the elastomeric ligature ties, saliva and plaque surrounding the orthodontic appliance were collected for microbiologic analysis. there were no significant differences in the number of streptococcus mutans cfus in saliva or plaque in the area surrounding the fluoride-releasing or conventional elastomeric ligature ties. thus, fluoride-releasing elastomeric ligature ties should not be indicated to reduce the incidence of enamel decalcification in orthodontic patients. since there was no significant reduction in s. mutans in saliva or plaque, other means of prevention against enamel decalcification should be indicated for these patients.
Analysis of fluoride concentration in solutions prepared at dispensing pharmacies
Eduardo Pizzatto,Estela Maris Losso,Melina Carolina Miranda,Vivian Danielle de Souza
RSBO , 2011,
Abstract: Introduction: Fluoride plays an important role in oral health promotion and is considered important in dental caries prevention both in children and adults. Fluoride is widely used at high-risk conditions of caries, when the use of fluoride-containing mouthwashes is recommended, considering that fluoride itself reduces the risk of dental caries. Objective: To evaluate the fluoride concentration in solutions prepared at different dispensing pharmacies in the city of Curitiba – PR, Brazil. Material and methods: The analysis of fluoride concentration was preformed through Ion Chromatography method (DIONEX). Results: The results obtained through this analysis showed that all solutions presented fluoride concentration above that required in the dentist’s prescription, varying between 5.48% and 24.02% more fluoride, at absolute concentration. Conclusion: This finding highlights the increasing risk of fluoride acute intoxication in cases of accidental ingestion of the solution.
In vitro assessment of an experimental coat applied over fluoride varnishes
Delbem, Alberto Carlos Botazzo;Brighenti, Fernanda Louren??o;Oliveira, Felipe Alberto Lino;Pessan, Juliano Pelin;Buzalaf, Marília Afonso Rabelo;Sassaki, Kikue Takebayashi;
Journal of Applied Oral Science , 2009, DOI: 10.1590/S1678-77572009000400003
Abstract: objective: the time of contact between the product and enamel surface is important in ensuring the efficacy of fluoride varnishes. thus, some alternatives could avoid fluoride loss to saliva and improve the anticariogenic action of the product. this study evaluated the effect of an experimental coat on the anticariogenic action of fluoride varnishes. material and methods: enamel bovine blocks were selected by evaluating surface microhardness and randomized into five groups (n=24): placebo, duraphattm, duraphattm with coat, duofluoridtm and duofluoridtm with coat. twelve blocks from each group were used to analyze calcium fluoride (caf2) formed on enamel after treatment. the other 12 blocks were subjected to ph cycling for 7 days. the varnishes were kept on enamel for 6 h. next, the percentage change of surface microhardness (%smhc) and mineral loss (δz) were calculated. caf2 retained and fluoride present in the ph-cycled solutions were also measured. results: the use of the coat did not decrease %smhc and δz, but all fluoride varnishes had better results when compared to the placebo (anova and kruskal-wallis, respectively). the values from caf2 formed were higher compared to the values of caf2 retained (non-paired t test, p<0.05). there was a trend to decrease the amount of f in the solutions at the end of ph cycling (kruskal-wallis, p<0.05). conclusions: although the experimental coat increased the formation of caf2 on the enamel surface, it did not significantly improve the anticariogenic action of fluoride varnishes.
Fluoride concentration in toothpastes of the Mexican market
Hernández-Guerrero, Juan Carlos;de la Fuente H., Javier;Ledesma-Montes, Constantino;Fontana-Uribe, Bernardo;Jiménez-Farfán1, Dolores;
Boletín médico del Hospital Infantil de México , 2005,
Abstract: introduction. the most widely used method for applying fluoride (f-) topically is the fluoridated toothpaste. its early use in large quantities is a risk factor for dental fluorosis. objective: to determine the actual concentration of f in toothpastes sold in the mexican market. material and methods. sixty-five different commercial toothpastes were analysed using the f ion-specific electrode technique. results. the range of the f content was from 0 to 2 053 ppm. of them, 16.92% were toothpastes for infant use (range= 0-1153 ppmf-). mexican toothpastes had a mean of 879 ± 599.2 ppmf and imported toothpastes have a mean of 619.7 ppmf-; 54.5% of the infantile toothpastes presented f concentrations above 730 ppm and in 40% of the analyzed products, annotation on f content was found. conclusions. our results showed a wide variation in f concentration and suggest the need to implement policies to regulate the f concentration in these products. it is important that all the manufactured dentifrices show in the label and package the total f content of the product and the recommended doses will be printed, in order to prevent dental fluorosis.
Clinical Studies of Fluoride Concentration on Human Beings  [PDF]
Gupta Pankaj,Sharma Sunil Kumar
International Journal of Research in Pharmacy and Science , 2011,
Abstract: Fluoride endemic and non endemic area were selected through ground water sample of Alwar and Dausa Districts. Three different locations containing 5.8 ppm, 9.5 ppm and 12.5 ppm fluoride were identified as fluoride endemic zone. Blood samples were collected from villagers of Alwar and Dausa Districts under supervision of medical staff. The samples were analyzed for the study of haemoglobin, TRBC and TWBC using standard techniques. The result revealed that persons residing in high fluoride endemic zone contained significantly high fluoride concentration in serum as compared to persons residing in non-endemic area. The concentration of fluoride in blood is directly proportional to the concentration of fluoride in ground water. The ascorbic acid concentration depleted significantly with increase in the concentration of fluoride in drinking water, indicative of mobilization of ascorbic acid with the increase of fluoride intake. The total Erythrocyte, packed cell volume and haemoglobin percentage declined significantly following fluoride water ingestion and decrease was found to be dose dependent. However the Leucocytes number increased to overcome from fluorosis condition in the subjects. The data suggests that the ground water of Alwar and Dausa Districts contain very high fluoride concentration which results in altered blood physiology hence not good for human health
Assement of the fluoride concentration and pH in different mouthrinses on the brazilian market
Delbem, Alberto Carlos Botazzo;Sassaki, Kikue Takebayashi;Castro, Alessandra Maia de;Pinto, Leila Maria Cesário Pereira;Bergamaschi, Maurício;
Journal of Applied Oral Science , 2003, DOI: 10.1590/S1678-77572003000400008
Abstract: in this study, the fluoride concentration and ph of 14 commercial brands of mouthrinses were assessed in order to compare them with the values expressed on the labels and with those established by the national sanitary surveillance agency. forty-two (42) products were obtained from three places, with different manufacturing batches. the fluoride concentration was determined in diluted solutions, using a combined specific electrode for fluoride ion (9609 bn orion research) and ion analyzer (290 a orion research). the results showed that 50% of the solutions had statistically significant differences, with higher fluoride concentrations than those expressed on the labels, and the ph ranged from 4.23 to 7.34, but only one of the products registered the ph value on its label.
Fluoride Concentration of Drinking Water in Babil-Iraq  [PDF]
Mohammed Hashim Matloob
Journal of Applied Sciences , 2011,
Abstract: The role of fluoride in reducing the risk of dental caries is well documented and is the basis for current intake recommendations. The aim of this study was to evaluate the fluoride content of tap and bottled water currently consumed in Babil-Iraq and to determine whether fluoride intakes by Iraqi consumers fell within the recommended ranges. Fluoride concentrations of 50 samples of tap water (originated from the Euphrates River) and forty popular brands of bottled water currently sold in Babil-Iraq were determined using an Ion-selective electrode. The mean fluoride content of tap and bottled water were 0.1840.041 and 0.0730.066 mg L-1, respectively. The average volume of water consumed by Iraqi adults daily was estimated to be 800240 mL in winter to 2000650 mL in summer. Based on these data the average daily intake of fluoride by Iraqi consumer from tap and bottled water were 0.1470.055 to 0.3680.145 mg and 0.0580.056 to 0.1460.140 mg, respectively. These levels revealed that whether tap or bottled water are used as the primary source of drinking water, then Iraqi consumers are at a higher risk of tooth decay. Water fluoridation is recommended as a relevant public health measure to increase the resistance to dental caries.
Analysis of fluoride concentration in mother's milk substitutes
Pagliari, Ana Valéria;Moimaz, Suzely Adas Saliba;Saliba, Orlando;Delbem, Alberto Carlos Botazzo;Sassaki, Kikue Takebayashi;
Brazilian Oral Research , 2006, DOI: 10.1590/S1806-83242006000300016
Abstract: the aim of the present study was to determine the fluoride concentration in some brands of mother's milk substitutes and evaluate the possibility of developing dental fluorosis by consuming these products. the products, all powdered, were divided into 3 groups: infant formulae (group i, n = 7), milk-based (group m, n = 8) and soy-based (group s, n = 3). samples from 3 cans of different batches of each brand were reconstituted in deionized water and analyzed using the specific electrode method, after hexamethyldisiloxane (hmds) facilitated diffusion. the fluoride content (mg f/l) of the products ranged from 0.044 to 0.326 (i), 0.014 to 0.045 (m) and 0.253 to 0.702 (s). there was significant difference in the fluoride content of cans from distinct batches (p < 0.05) in most of the brands. the reconstitution of all products in water with optimal fluoride concentration for consumption during the mineralization phase of the primary teeth could result in daily fluoride intake above 0.07 mg f/kg body weight/day. therefore, the consumption of these products, especially when reconstituted with optimally fluoridated water, could increase the risk of developing dental fluorosis.
Concentration and bioavailability of fluoride in mouthrinses prepared in dispensing pharmacies
Tabchoury, Cínthia Pereira Machado;Pierobon, Carla Noujain;Cury, Jaime Aparecido;
Journal of Applied Oral Science , 2005, DOI: 10.1590/S1678-77572005000100009
Abstract: considering the importance of medication quality control and that mouthrinses for dental caries prevention have commonly been prepared in dispensing pharmacies, this study assessed formulations containing 0.05% naf acquired from 6 dispensing pharmacies in the city of piracicaba, s.p. the mouthrinse formulations were purchased in 3 separate periods and coded from a to f. fluoride ion (f-) concentration was determined in all formulations in the 3 periods, and in those acquired in the 3rd period, the bioavailability of fluoride with dental enamel with caries-like lesions and the ph of products were evaluated. a solution of 0.05% naf and distilled deionized water were used, respectively, as positive and negative controls. in the bioavailability analysis, fluoride present in dental enamel was determined removing, by acid etching, two layers of enamel; fluoride in the acid extract was determined with a specific electrode. the mouthrinses prepared in 5 pharmacies presented a f- concentration close to the expected value, except for the product prepared in one of them, in which a mean of 0.01% naf was found. all products were more efficient than the negative control (p<0.05) in terms of reactivity with dental enamel, but differences among them were observed with regard to the positive control (p<0.05). the data suggest that a quality control program should be implemented in dispensing pharmacies to guarantee the quality of fluoridated mouthrinses formulated.
Effect of high fluoride concentration in drinking water on children’s intelligence
Seraj B,Shahrabi M,Falahzade M,Falahzade F
Journal of Dental Medicine , 2006,
Abstract: Background and Aim: Human and animal studies linking fluoride with diminished intelligence have been published. Although adverse effects of high intake of fluoride on intelligence and mental acuity continue to be reported, they are still controversial. The aim of this research was to investigate the relationship between fluoride in drinking water and children's intelligence. Materials and Methods: In this cross sectional study, 41 children were selected from the high fluoride area with 2.5mg/l (ppm) fluoride in the drinking water and 85 children were selected from low fluoride area with 0.4mg/l (ppm) fluoride in the drinking water. The intelligence quotient (IQ) of each child was measured by the Raven's test. The history of illnesses affecting the nervous system, head trauma, birth weight ( 2.5kg or 2.5kg), residental history, age and sex of children were investigated by questionnaires completed by the children's parents. Data were analyzed by Chi-Square test with p<0.05 as the limit of significance. Results: In the high fluoride area the mean IQ of children (87.9 11) was significantly lower than in the low fluoride area (98.9 12.9) (P=0.025). Conclusion: Based on the findings of this study, exposure of children to high levels of fluoride may carry the risk of impaired development of intelligence.
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