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Henoch Sch nlein Purpuran  [cached]
O?uz S?ylemezo?lu,Kibriya Fidan
Turk Pediatri Ar?ivi , 2008,
Abstract: Henoch Sch nlein Purpura (HSP) is the most common vasculitis of children and defined as IgA immune complex-mediated small vessel vasculitis. HSP usually presents with the triad of palpable purpura, colicky abdominal pain and arthritis. The major cause of the morbidity is renal involvement and it may progress to chronic renal failure. Symptomatic involvement of other organs is not common. A wide variety of infective organisms predominantly group A streptococcus may trigger HSP. Skin involvement of HSP may begin as urticaria, but it progresses to purple, nonblanching lesions predominantly on the lower legs and buttocks. The arthritis is usually transient and it does not cause chronic joint lesions. Renal involvement occurs in the 30-50 % of the patients. In general, long-term outcomes in HSP are good. The major exception is patients with severe renal involvement. Therapy of HSP is primarily supportive, aiming at the symptomatic relief of arthritis and abdominal pain.Immunosuppressive agents are the choice of therapy for the glomerulonephritis of HSP. (Turk Arch Ped 2008; 43: Suppl: 4-8)
Henoch-Scho nlein purpura that wasn’t!
Daniel P. Hawley,Ruth Murphy,Liz Stretton,Satyapal Rangaraj
Rheumatology Reports , 2012, DOI: 10.4081/rr.2012.e8
Abstract: We present an interesting case of a 13 year old girl with Wegener’s granulomatosis/granulomatosis with polyangiitis, who was misdiagnosed with Henoch-Scho nlein purpura. The case highlights several important learning points for paediatric practice.
Protein-losing enteropathy associated with Henoch-Sch nlein purpura  [cached]
Ayako Nakamura,Tatsuo Fuchigami,Yasuji Inamo
Pediatric Reports , 2010, DOI: 10.4081/pr.2010.e20
Abstract: The gastrointestinal manifestations of Henoch-Sch nlein purpura include abdominal pain, gastrointestinal bleeding, intussusception, and perforation. Protein-losing enteropathy is rarely associated with Henoch-Sch nlein purpura. Two pediatric patients with Henoch-Sch nlein purpura who developed protein-losing enteropathy are reported. Tc-99m human serum albumin scintigraphy is useful in the detection of protein-losing enteropathy.
Spontaneous Coronary Artery Dissection in a Patient with Henoch -Sch nlein Purpura  [PDF]
Zeki ?im?ek,G?ksel Acar,Elnur Alizade,Mustafa Ak?akoyun
Ko?uyolu Kalp Dergisi , 2009,
Abstract: Henoch-Sch nlein purpura is a small vessel vasculitis that affects mainly the skin, joints, gastrointestinal tract and kidneys. The cardiovascular system is also rarely affected . We describe a 47-year-old man with Henoch-Sch nlein purpura who developed anteroseptal myocardial infarction. The coronary angiography revealed coronary dissection at the level of second diagonal branch of left anterior desending artery as the culprit lesion. The region of dissection and the proximal lesion was successfully treated by stenting. The myocardial infarction on the basis of spontaneous coronary dissection in the present case with established Henoch-Sch nlein purpura, may be the first to be described.
Henoch Sch?nlein purpura associated with pulmonary adenocarcinoma
Daiki Mifune, Satoshi Watanabe, Rie Kondo, Yoko Wada, Hiroshi Moriyama, Hiroshi Kagamu, Hirohisa Yoshizawa, Takafumi Tetsuka, Asako Matsuyama, Kaoru Ito, Ichiei Narita
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-226
Abstract: We report the case of a 61-year-old Japanese man who presented for examination after an abnormal shadow was detected by chest radiography. He received a diagnosis of pulmonary adenocarcinoma, stage IV. Purpura on the legs, abdominal pain, diarrhea, hematuria and proteinuria developed at this time. Henoch-Sch?nlein purpura was diagnosed, base on the clinical symptoms and histological findings of biopsy specimens of the skin, which showed vasculitis with immunoglobulin A deposits. Our patient received chemotherapy with gemcitabine after successful steroid therapy for the Henoch-Sch?nlein purpura.Although hematological malignancies are well-known causes of vasculitides, cases of Henoch-Sch?nlein purpura associated with lung adenocarcinoma are rare. Our patient was treated with corticosteroid therapy, which cleared the purpura and cytotoxic chemotherapy for the non-small cell lung cancer. However, he died from heart failure due to cardiac tamponade.Henoch-Sch?nlein Purpura (HSP) is a systemic vasculitis that involves the small vessels, most notably those in the skin, gastrointestinal tract and glomeruli, and is accompanied by arthralgia or arthritis [1]. HSP occurs commonly in children but can also affect adults [2]. Although the exact cause of HSP remains unknown, malignancy has been reported as a causative factor [3-5]. This report illustrates a rare case of HSP associated with pulmonary adenocarcinoma.A 61-year-old Japanese man presented for examination after an abnormal lung shadow was detected during population-based radiological screening. He was a current smoker with a 41 pack-year smoking history. Chest computed tomography (CT) showed a mass measuring 60 × 50 mm in the left upper lobe, with small nodules in both lung fields and left pleura, and mediastinal and subclavicular lymphadenopathy (Figure 1). Bronchoscopy revealed stenosis of the left B3 bronchus with mucosal abnormalities at points from which biopsy specimens were obtained. Cerebral magnetic resonance
Cerebral Vasculitis in Henoch-Sch nlein Purpura  [cached]
Tuba BAYKAL,Kaz?m ?ENEL,Ak?n LEVENT,Sibel OKUR
Türkiye Fiziksel Tip ve Rehabilitasyon Dergisi , 2012,
Abstract: Henoch-Sch nlein purpura (HSP) is the most common systemic vasculitis of childhood, affecting the small blood vessels. The disease is a clinical syndrome characterized by multiple organ involvement including the skin, joints, gastrointestinal tract, and the kidneys. Headache and behavioral changes can be frequently seen during the course of the disease, but severe neurological signs such as seizures, focal neurologic deficits, intracerebral hematoma, mononeuropathies, and polyradiculoneuropathies are the rare complications of HSP. In this report, we described a 17-year-old girl with HSP who presented with seizures and disturbance of consciousness. The subsequent magnetic resonance imaging of the brain demonstrated findings consistent with cerebral vasculitis. The pulse steroid therapy was performed immediately after the diagnosis and clinical improvement was achieved rapidly. In conclusion, we suggest that cerebral vasculitis should be considered in all HSP patients with neurological symptoms and signs. Turk J Phys Med Re-hab 2012;58:329-31.
Historia de la púrpura de Henoch-Sch nlein History of Henoch-Sch nlein purpura
Jorge de Jesús Cantillo Turbay,Antonio Iglesias Gamarra
Acta Medica Colombiana , 2007,
Abstract: La púrpura de Henoch-Sch nlein (PHS) define una vasculitis sistémica primaria de peque os vasos caracterizada por el depósito de complejos inmunes con el predominio de la IgA en las paredes de los capilares, vénulas o arteriolas. Típicamente compromete piel, intestino, glomérulos y está asociada con artralgias o artritis. Las descripciones clínicas de las vasculitis se iniciaron con claridad y significación con el trabajo de Robert Willan (1757-1812), el fundador de la dermatología moderna. Este artículo analiza los fundamentos históricos de la PHS. Henoch-Schonlein purpura (HSP) is defined as a primary systemic vasculitis of small vessels characterized by predominantly IgA immune deposits on the walls of the capillaries, venules, and arteriales. It typically involves skin, intestines, and glomeruli and is associated with arthritis and arthralgia. Robert Willan (1757-1812), the founder of modern dermatology, was the first to clearly describe vasculitis and its significance. This article analyzes the fundamental history of HPS.
The Clinical Analysis of Childhood Henoch-Sch nlein Purpura Patients  [PDF]
Cihangir Akgün,Sinan Akbayram,Avni Kaya,Hayrettin Temel
Turkderm , 2012,
Abstract: Background and Design: Henoch-Schonlein purpura is affected often the skin, joints, gastrointestinal tract and kidneys and common systemic vasculitis of childhood. Henoch-Schonlein purpura are many and varied symptoms, also it was followed in children policlinics and hospitalized diseases for an important role. We aimed to determination of the patients with Henoch-Sch nlein purpura by examination of their clinical analyses. Material and Method: The medical records of 212 patients with Henoch-Sch nlein purpura in our polyclinics have been retrospectively studied. These patients were analyzed age groups, diagnosed seasons, held systems, laboratory findings, the treatments, complications and prognosis. SPSS 13 statistical software package was used for data analysis. Results: The mean age of the patients was 9.33±3.20 years. The disease was more frequently demonstrated in fall and winter seasons. There was no statistically assosiation between age groups with season, joint involvement, central nerveous system involvement, gastrointestinal system involvement and scrotal involvement but there was a positive correlation between age groups and renal involvement. Conclusion: The treatment duration increases with the age of the patient and the necessity to use a combined treatment (antihistaminic, non-steroid anti-inflammatory treatment and steroids) increases.
Corticosteroid therapy in Henoch-Sch nlein gastritis
Pavlovi? Mom?ilo,Radlovi? Nedeljko,Lekovi? Zoran,Berenji Karolina
Srpski Arhiv za Celokupno Lekarstvo , 2007, DOI: 10.2298/sarh0704208p
Abstract: Introduction. Henoch-Sch nlein purpura (HSP) is the most common vascular disease of childhood. It is a multisystem disease most commonly affecting the skin, joints, gastrointestinal tract, and kidneys, but other organs may be affected, too. Gastrointestinal involvement occurs in approximately 65-90% of patients, ranging from mild symptoms such as abdominal pain, nausea, and vomiting, to more severe manifestations such as gastrointestinal bleeding and intussusception. In most cases, HSP spontaneously resolves without treatment. The use of corticosteroids is controversial and usually reserved for severe systemic manifestations. Some authors suggest that the abdominal pain and gastrointestinal hemorrhage of HSP may respond to steroids, with some suggesting that there is a benefit in their use and describing a regimen. Case outline. This is a case report of HSP in a fourteen year-old boy with abdominal pain and hematemesis. Upper endoscopy showed an edematous and erythematous change in the body of the stomach and purpuric lesions in the duodenum, while multiple erosions were found in the antral area. Parenteral corticosteroid therapy with gastric acid secretion inhibitor administration led to regression of gastrointestinal symptoms on the seventh day, with relapses on the fourth and sixth day. Peroral administration of corticosteroids and gradual decrease of daily doses started on the eighth day of abdominal symptoms. New purpuric skin rashes appeared during six weeks. Conclusion. Corticosteroid therapy with gastric acid secretion inhibitors showed a positive effect in our patient with a severe form of HSP accompanied by abdominal pain and gastrointestinal hemorrhage. .
Púrpura de Sch?nlein Henoch: Qué hay de nuevo?
Mazas,MC;
Revista argentina de dermatolog?-a , 2011,
Abstract: henoch sch?nlein purpura is the most common vasculitis in childhood, althoug it can be seen in adults. it is caharacterized by the presence of palpable purpura, abdominal or joint pain may be accompanied by hematuria. renal involvement is more common in adults. the diagnosis is clinical but biopsy may be useful to rule out other differential diagnoses. discussed in this review the changes made regarding the diagnostic criteria and developments in relation to pathophysiology.
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