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C3 POLYMORPHISM IN HYPERLIPOPROTEINEMIA (HLP)
D.D. FARHUD
Iranian Journal of Public Health , 1989,
Abstract: C3 typing was performed, by agarose gel electrophorisis, in 147 German patients suffering from hyperlipoproteinemia. The control group consisted of 322 healthy Germans. High frequencies of non-typeable sera, varying between 16.66 and 35.71% in different HLP types, found in the present investigation are notable and are a clue for chemical denaturation of C3 protein in HLP patients. Statistical analysis showed significant results (P.0.001) in all five HLP types, as well as in the total, in comparison with the control group.
Glucocerebrosidase L444P mutation confers genetic risk for Parkinson’s disease in central China  [cached]
Wang Youpei,Liu Ling,Xiong Jing,Zhang Xiaowei
Behavioral and Brain Functions , 2012, DOI: 10.1186/1744-9081-8-57
Abstract: Background Mutations of the glucocerebrosidase (GBA) gene have reportedly been associated with Parkinson disease (PD) in various ethnic populations such as Singaporean, Japanese, Formosan, Canadian, American, Portuguese, Greek, Brazilian, British, Italian, Ashkenazi Jewish, southern and southwestern Chinese. The purpose of this study is to determine in central China whether or not the reported GBA mutations remain associated with PD. Methods In this project, we conducted a controlled study in a cohort of 208 central Chinese PD patients and 298 controls for three known GBA mutations (L444P, N370S and R120W). Results Our data reveals a significantly higher frequency of L444P mutation in GBA gene of PD cases (3.4%) compared with the controls (0.3%) (P = 0.007, OR = 10.34, 95% CI = 1.26 - 84.71). Specifically, the frequency of L444P mutation was higher in the late onset PD (LOPD) cases compared with that in control subjects. The N370S and R120W mutations were detected in neither the PD group nor the control subjects. Conclusions Our observations demonstrated that the GBA L444P mutation confers genetic risk for PD, especially LOPD, among the population in the central China area.
Double Mutation in Tomato Ribosomal Protein L3 cDNA Confers Tolerance to Deoxynivalenol (DON) in Transgenic Tobacco  [PDF]
Akbar Safipoor Afshar,Amir Mousavi,Ahmad Majd,Renu
Pakistan Journal of Biological Sciences , 2007,
Abstract: The contamination of mycotoxins associated with head blight of wheat and other grains caused by Fusarium graminearum is chronic threat to crop, human and animal health throughout the world. Deoxinevalenol (DON), produced by the fungus, belonging to class trichothecene is believed to act as a virulence factor in fungal pathogenesis by inhibiting eukaryotic protein synthesis, thereby blocking or delaying the expression of defense related proteins induced by host plant. The putative site of action of DON is 60s ribosomal protein L3 (RPL3). In order to reduce the effects of DON in the host plants, we modified tomato RPL3 (LeRPL3) to introduce W258R/H259Y mutations so that amino acid residue 258 is changed from tryptophan to arginine and 259 from histidine to tyrosine. Transgenic tobacco plants expressing these modified LeRPL3 cDNAs were tested for growth pattern of T1 seedlings in presence of DON. When seedling of these transgenic tobacco plants were compared for growth in the presence of DON, a significant difference in growth rate and the ability to undergo differentiation was observed among those plants expressing the modified version of the Rpl3 gene, compared to those expressing the wild-type Rpl3 gene. Expression of the tagged gene product indicates that is was not due to somaclonal variation. These results indicate a possible mechanism of host plant resistance to the fungal pathogen F. graminearum among the susceptible cereal species based on the expression of modified Rpl3 genes.
Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp
Michelle I Portugal, Adriane R Todeschini, Cristiana S de Lima, Carlos AM Silva, Ronaldo Mohana-Borges, Tom HM Ottenhoff, Lucia Mendon?a-Previato, Jose O Previato, Maria CV Pessolani
BMC Microbiology , 2008, DOI: 10.1186/1471-2180-8-75
Abstract: The capacity of a panel of 30 mer synthetic peptides covering the full length of Hlp to bind to heparin/heparan sulfate was analyzed by solid phase assays, NMR, and affinity chromatography. An additional active region between the residues Gly46 and Ala60 was defined at the N-terminal domain of Hlp, expanding the previously defined heparin-binding site between Thr31 and Phe50. Additionally, the C-terminus, rich in Lys residues, was confirmed as another heparan sulfate binding region. The amino acids in Hlp identified as mediators in the interaction with heparan sulfate were Arg, Val, Ile, Lys, Phe, and Thr.Our data indicate that Hlp interacts with heparan sulfate through two distinct regions of the protein. Both heparan sulfate-binding regions here defined are preserved in all mycobacterial Hlp homologues that have been sequenced, suggesting important but possibly divergent roles for this surface-exposed protein in both pathogenic and saprophic species.Leprosy and tuberculosis constitute age-old infectious diseases that have affected human beings for millennium. Leprosy, caused by Mycobacterium leprae, continues to be a significant public health problem in several developing countries, including Brazil, and is responsible for the legacy of millions of individuals with permanent physical deformities [1]. On the other hand, tuberculosis, caused by Mycobacterium tuberculosis has most likely killed more human beings than any other disease in history, at an average of 4 individuals per minute worldwide [2]. One major reason for the failure to eradicate these diseases may be closely related to the absence of effective vaccines since BCG, the only one available against both leprosy and tuberculosis, has displayed highly variable protection rates around the world [3]. Mycobacteria are intracellular pathogens that preferentially infect mononuclear phagocytes although other cell types such as epithelial and endothelial cells are also colonized during disease dissemination [4].
msbB deletion confers acute sensitivity to CO2 in Salmonella enterica serovar Typhimurium that can be suppressed by a loss-of-function mutation in zwf
Verena Karsten, Sean R Murray, Jeremy Pike, Kimberly Troy, Martina Ittensohn, Manvel Kondradzhyan, K Brooks Low, David Bermudes
BMC Microbiology , 2009, DOI: 10.1186/1471-2180-9-170
Abstract: We report here that msbB (or msbB somA) Salmonella are highly sensitive to physiological CO2 (5%), resulting in a 3-log reduction in plating efficiency. Under these conditions, msbB Salmonella form long filaments, bulge and lyse. These bacteria are also sensitive to acidic pH and high osmolarity. Although CO2 acidifies LB broth media, buffering LB to pH 7.5 did not restore growth of msbB mutants in CO2, indicating that the CO2-induced growth defects are not due to the effect of CO2 on the pH of the media. A transposon insertion in the glucose metabolism gene zwf compensates for the CO2 sensitivity of msbB Salmonella. The msbB zwf mutants grow on agar, or in broth, in the presence of 5% CO2. In addition, msbB zwf strains show improved growth in low pH or high osmolarity media compared to the single msbB mutant.These results demonstrate that msbB confers acute sensitivity to CO2, acidic pH, and high osmolarity. Disruption of zwf in msbB mutants restores growth in 5% CO2 and results in improved growth in acidic media or in media with high osmolarity. These results add to a growing list of phenotypes caused by msbB and mutations that suppress specific growth defects.Lipopolysaccharide (LPS), the most abundant molecule on the surface of Gram-negative bacteria, acts as a permeability barrier and renders the outer-leaflet of the outer membrane (OM) relatively impermeable to hydrophobic antibiotics, detergents [1], and host complement [2]. LPS consists of three major components: lipid A, core polysaccharides and O-linked polysaccharides. Lipid A, with its fatty acid anchors [lauric, myristic and sometimes palmitic acid], is an endotoxin primarily responsible for TNFα-mediated septic shock. The addition of myristic acid to the lipid A precursor is catalyzed by the enzyme MsbB [3].It has been shown that msbB Salmonella serovar Typhimurium exhibits severe growth defects in LB and sensitivity to bile salts (MacConkey) and EGTA-containing media. However, compensatory suppressor
On string backgrounds and (logarithmic) CFT  [PDF]
Jorgen Rasmussen
Mathematics , 2004,
Abstract: We discuss the link between string backgrounds and the associated world-sheet CFTs. In the search for new backgrounds and CFTs, Penrose limits and Lie algebra contractions are important tools. The Nappi-Witten construction and the recently discovered logarithmic CFT by Bakas and Sfetsos, are considered as illustrations. We also speculate on possible extensions.
Stochastic backgrounds of gravitational waves  [PDF]
Michele Maggiore
Physics , 2000,
Abstract: We review the motivations for the search of stochastic backgrounds of gravitational waves and we compare the experimental sensitivities that can be reached in the near future with the existing bounds and with the theoretical predictions.
Flux backgrounds from Twists  [PDF]
David Andriot,Ruben Minasian,Michela Petrini
Physics , 2009, DOI: 10.1088/1126-6708/2009/12/028
Abstract: It is well known that a constant O(n,n,Z) transformation can relate different string backgrounds with n commuting isometries that have very different geometric and topological properties. Here we construct discrete families of (flux) backgrounds on internal manifolds of different topologies by performing certain coordinate dependent O(d,d) transformations, where d is the dimension of the internal manifold. Our two principal examples include respectively the family of type IIB compactifications with D5 branes and O5 planes on six-dimensional nilmanifolds, and the heterotic torsional backgrounds.
Study of Backgrounds at JLC IR  [PDF]
H. Aihara,M. Iwasaki,K. Tanabe
Physics , 2003,
Abstract: A full simulation program based on GEANT4 has been developed to study beam-induced backgrounds in the JLC beam delivery system. We report some results obtained using this program.
Cosmological String Backgrounds  [PDF]
Dieter Luest
Physics , 1993,
Abstract: Talk given at the ``4th Hellenic School on Elementary Particle Physics", Corfu, 2-20 September 1992: The propagation of strings in cosmological space-time backgrounds is reviewed. We show the relation of a special class of cosmological backgrounds to exact conformal field theory. Particular emphasis is put on the singularity structure of the cosmological space-time and on the discrete duality symmetries of the string background.
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