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Experimental antithrombotic effect of potatoes harvested in the autumn  [PDF]
Junichiro Yamamoto, Megumi Masuda, Kanae Hyodo, Masahiro Iwasaki
Health (Health) , 2012, DOI: 10.4236/health.2012.42017
Abstract: Prevention of arterial thrombotic diseases has a high priority in developed countries. While an inappropriate diet is known to enhance the risk for acute thrombotic events, a regular diet with proven antithrombotic effects might be beneficial in the prevention of such diseases. The present study is part of a series of investigations aimed to assess the possible antithrombotic activity of various fruits and vegetables. Previously we demonstrated antithrombotic effect of specific potato varieties harvested in the spring. The present study aimed to test seven varieties of potatoes, which were harvested in the autumn. The in vitro Global Thrombosis Test (GTT) was used for selection, which was then followed by the He-Ne laser-induced in vivo thrombosis test in mice treated with potato filtrates orally. We have shown that all seven potato varieties showed some antithrombotic effect and the heat-resistant effect of four varieties was highly significant. Our present findings add further components to a diet containing fruits and vegetables with antithrombotic effect.
Effect of Onion (Allium cepa. Linn) Aqueous Extract on Serum Concentration of LH, FSH and Testosterone Compared with Zinc Sulfate Supplementation in the Rats
Jamshid Ghiasi Ghalehkandi,Ahmad Asghari,Rahim Beheshti,Mohammadreza Valilu,Abdolreaz Yeghaneh
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2012.3346.3349
Abstract: The onion (Allium cepa) has long been used in traditional medicine is one of the important Allium species commonly used in the daily diet and has recently been the source of much interest because of its antithrombotic, hypolipidaemic, hypotensive, diaphoretic, antibiotic, antidiabetic, antiatherogenic and anticancer medicinal properties. Zinc deficiency causes primary testicular failure and altered testicular steroidogenesis. The aim of present study was to evaluation of onion (Allium cepa. Linn) aqueous extract on serum concentration of LH, FSH and testosterone compared with Zn sulfate supplementation in the rats. In this experiment, 162 mature male rats (250 g on the average) were acquired from Razi Serum-Producing Institute of Karaj and transferred to keeping place. This design is performed as a factorial experiment 3x3 (3 level of onion extract and 3 level of zinc sulfate complement) in the form of totally random design with 9 groups per 3 replications each containing 6 rats. All of keeping cages were disinfected before performing the experiment. Data showed that the effect of different levels of zinc supplementation and onion extract was significant on the concentrations of these hormones, p<0.05. The combined use of onion and Zn was more significant on LH and FSH and no significant on testosterone, p<0.01. Treatment group 9 has highest increase in the amount of LH and FSH. The reason of this fact that contrary, the concentration of testosterone showed no increase in the experimental groups treated with onion and Zn supplementation probably can be attribute to the negative feedback effect of this hormone versus LH and FSH.
Anti-Obesity Effects of Onion Extract in Zucker Diabetic Fatty Rats  [PDF]
Orie Yoshinari,Yoshiaki Shiojima,Kiharu Igarashi
Nutrients , 2012, DOI: 10.3390/nu4101518
Abstract: Anti-obesity effects of onion extract were determined in obesity and diabetes-prone Zucker diabetic fatty rats by measuring the efficacy of markers concerned with diabetes and obesity. Body and adipose tissue weights in 5% of onion extract-fed group were found to be significantly lower than the control group without onion extract. Fasting blood glucose and HOMA-IR levels were also improved, although the serum insulin and leptin levels did not show any remarkable difference. Serum triglyceride and free fatty acid levels in both the 3% and 5%-fed group were found to be reduced compared to the control group. Additionally the feeding of the onion extract increased the glucose tolerance. These results suggest that dietary onion extract is beneficial for improving diabetes by decreasing lipid levels. We also examined differentiation ability of rat white preadipocyte cells using the onion extract and its sulfur-containing components. Cycloalliin, S-methyl-l-cysteine, S-propyl-l-cysteine sulfoxide, dimethyl trisulfide, especially S-methyl-l-cysteine sulfoxide were reported to be effective in inhibiting formation of oil drop in the cells, suggesting that these compounds may be involved in the anti-obesity effect of the onion extract.
An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect
Fraga-Silva, Rodrigo Araujo;Costa-Fraga, Fabiana P.;Sousa, Frederico B. De;Alenina, Natalia;Bader, Michael;Sinisterra, Ruben D.;Santos, Robson A. S.;
Clinics , 2011, DOI: 10.1590/S1807-59322011000500021
Abstract: introduction and objective: the heptapeptide angiotensin-(1-7) is a component of the renin-angiotensin system, which promotes many beneficial cardiovascular effects, including antithrombotic activity. we have recently shown that the antithrombotic effect of angiotensin-(1-7) involves receptor mas-mediated no-release from platelets. here, we describe an orally active formulation based on angiotensin-(1-7) inclusion in cyclodextrin [ang-(1-7)- cyd] as an antithrombotic agent. cyclodextrins are pharmaceutical tools that are used to enhance drug stability, absorption across biological barriers and gastric protection. method: to test the antithrombotic effect of ang-(1-7)-cyd, thrombus formation was induced in the abdominal vena cava of spontaneously hypertensive rats that were pretreated either acutely or chronically with ang-(1-7)-cyd. male mas-knockout and wild-type mice were used to verify the role of the mas receptor on the effect of ang-(1-7)-cyd. results: acute or chronic oral treatment with ang-(1-7)-cyd promoted an antithrombotic effect (measured by thrombus weight; all values are, respectively, untreated vs. treated animals) in spontaneously hypertensive rats (acute: 2.86 + 0.43 mg vs. 1.14 + 0.40 mg; chronic: 4.27 + 1.03 mg vs. 1.39 + 0.68 mg). this effect was abolished in mas-knockout mice (thrombus weight in mas wild-type: 0.76 + 0.10 mg vs. 0.37 + 0.02 mg; thrombus weight in mas-knockout: 0.96 + 0.11 mg vs. 0.87 + 0.14 mg). furthermore, the antithrombotic effect of ang-(1-7)-cyd was associated with an increase in the plasma level of angiotensin-(1-7). conclusion: these results show for the first time that the oral formulation ang-(1-7)-cyd has biological activity and produces a mas-dependent antithrombotic effect.
Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats  [PDF]
Marcela Alejandra Vazquez-Prieto,Cecilia Rodriguez Lanzi,Carina Lembo,Claudio Rómulo Galmarini,Roberto Miguel Miatello
Journal of Nutrition and Metabolism , 2011, DOI: 10.1155/2011/475216
Abstract: This study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F
Effects of Onion on Serum Uric Acid Levels and Hepatic Xanthine Dehydrogenase/Xanthine Oxidase Activities in Hyperuricemic Rats  [PDF]
Fatemeh Haidari,Mohammad Reza Rashidi,Seid Ali Keshavarz,Soltan Ali Mahboob
Pakistan Journal of Biological Sciences , 2008,
Abstract: The aim of this study was to investigate the effects of onion on serum uric acid levels and hepatic Xanthine Dehydrogenase/Xanthine Oxidase activities in normal and hyperuricemic rats. Hyperuricemia was induced by intraperitoneal injection of 250 mg kg-1 potassium oxonate in rats. Oral administration of onion at 3.5 and 7.0 mg kg-1 day-1 for 7 days was able to reduce serum uric acid levels in hyperuricemic rats with no significant effects on the level of this compound in the normal animals. In addition, onion when tested in vivo on rat liver homogeneities elicited significant inhibitory actions on the Xanthine Dehydrogenase (XDH) and Xanthine Oxidase (XO) activities. This effect resulted less potent than that of allopurinol. However, the hypouricemic effect observed in the experimental animal did not seem to parallel the change in XDH and XO activities, implying that the onion might be acting via other mechanisms apart from simple inhibition of enzyme activities. Such hypouricemic action and enzyme inhibitory activity of onion makes it a possible alternative for allopurinol, or at least in combination therapy to minimize the side-effects of allopurinol, in particular in long-term application.
Gastric Cytoprotective Activity of Ilicic Aldehyde in Rats and Mice  [PDF]
O. J. Donadel,A. María,G. Wendel,E. Guerreiro,O. Giordano
Molecules , 2000, DOI: 10.3390/50300462
Abstract: Ilicic alcohol, a natural sesquiterpene, was converted into an aldehyde by using Jones’ oxidation. The gastroprotective activity of ilicic aldehyde was evaluated in mice and rats.
Antithrombotic Effects of Different Strains of Lactic Acid Bacteria  [PDF]
Hiromasa Ooe, Masaru Kato, Kanae Hyodo, Keiko Nakashima, Hiroshi Ashigai, Kyoko Kato, Toshinori Sasaki, Yuko Fukushima, John C. Giddings, Junichiro Yamamoto
Health (Health) , 2014, DOI: 10.4236/health.2014.618280
Abstract: Objective: The aim of the present study was to assess the antithrombotic properties of different strains of orally available antithrombotic lactic acid bacteria (LAB). Research Methods & Procedures: Antithrombotic activity, antiplatelet reactivity and/or thrombolytic activity, were measured in seven strains of LAB and LAB cell-free-extracts (LAB filtrates) using the shear-induced platelet reactivity/thrombolytic activity, The Global Thrombosis Test (GTT), with non-anticoagulated rat blood in vitro. Subsequently, the most potent antithrombotic strains identified in vitro were assessed in vivo after oral administration in mouse carotid arteries using a helium-neon laser-induced thrombosis model. Result: Five strains out of seven LAB (Lactobacillus paracasei KW 3100, Lactobacillus fermentum NBRC 3961, Lactobacillus pentosus JCM 8333, Leuconostoc oeni Elios 1, Pediococcus pentosaceus NK-2) promoted significant endogenous thrombolysis in vitro. In addition, one strain (Lactobacillus fermentum NBRC 3961) significantly inhibited shear-induced platelet re-activity. Three antithrombotic strains, Lactobacillus fermentum NBRC 3961, Leuconostoc oeni Elios 1, and Lactobacillus pentosus JCM 8333, were further assessed in vivo. The results demonstrated that filtrates, and the cells per se of these LAB, modulated antiplatelet activity and/or thrombolytic activity, and that the antithrombotic mechanisms were mainly influenced by protein content (60% - 70% of dry matter). Conclusion: The findings suggested that some strains of lactic acid bacteria could usefully provide the basis for the production of oral antithrombotic probiotics.
Evaluation of acute and subchronic toxicity of a non-anticoagulant, but antithrombotic algal heterofucan from the Spatoglossum schr?ederi in Wistar rats
Almeida-Lima, Jailma;Dantas-Santos, Nednaldo;Gomes, Dayanne L.;Cordeiro, Sara L.;Sabry, Diego A.;Costa, Leandro S.;Freitas, Maria de L.;Silva, Naisandra B.;Moura, Carlos E. B.;Lemos, Telma M. A. M.;Leite, Edda L.;Rocha, Hugo A. O.;
Revista Brasileira de Farmacognosia , 2011, DOI: 10.1590/S0102-695X2011005000098
Abstract: fucan is a term used to denominate a family of sulfated polysaccharides rich in l-fucose. the brown alga spatoglossum schr?ederi, dictyotaceae, synthesizes three heterofucans named a, b, and c. fucan a is a non-anticoagulant heterofucan which possesses potent antithrombotic (in vivo) and antiproliferative (in vitro) activities. however, its toxicity in vivo has not been determined. the present study examined the acute and subchronic toxicity of the fucan a in wistar rats after subcutaneous administration. after that, the animals were killed and examined. the results showed in the acute study that fucan a did not cause general adverse effects and mortality in the concentrations 0, 20, 100, 1000, and 2000 μg/g body weight per rat for seven days. regarding the subchronic study, the data showed that the fucan a did not cause any change in hematological and biochemistry parameters, as well as in the morphology, and in the size of the rat's organs analyzed at a concentration of 20 μg/g body weight per rat during a 62-day period. in conclusion, this study indicates this heterofucan is a compound with potential pharmacological value that has no toxicity in vivo.
Evaluation of acute and subchronic toxicity of a non-anticoagulant, but antithrombotic algal heterofucan from the Spatoglossum schr ederi in Wistar rats  [cached]
Jailma Almeida-Lima,Nednaldo Dantas-Santos,Dayanne L. Gomes,Sara L. Cordeiro
Revista Brasileira de Farmacognosia , 2011,
Abstract: Fucan is a term used to denominate a family of sulfated polysaccharides rich in L-fucose. The brown alga Spatoglossum schr ederi, Dictyotaceae, synthesizes three heterofucans named A, B, and C. Fucan A is a non-anticoagulant heterofucan which possesses potent antithrombotic (in vivo) and antiproliferative (in vitro) activities. However, its toxicity in vivo has not been determined. The present study examined the acute and subchronic toxicity of the fucan A in Wistar rats after subcutaneous administration. After that, the animals were killed and examined. The results showed in the acute study that fucan A did not cause general adverse effects and mortality in the concentrations 0, 20, 100, 1000, and 2000 μg/g body weight per rat for seven days. Regarding the subchronic study, the data showed that the fucan A did not cause any change in hematological and biochemistry parameters, as well as in the morphology, and in the size of the rat's organs analyzed at a concentration of 20 μg/g body weight per rat during a 62-day period. In conclusion, this study indicates this heterofucan is a compound with potential pharmacological value that has no toxicity in vivo.
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