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大学新生血清HBsAg、HBsAb、谷丙转氨酶检测分析  [PDF]
朱琳
中国公共卫生 , 2005, DOI: 10.11847/zgggws2005-21-05-35
Abstract: ?为了解我校新生HBsAg、HBsAb的阳性率及转氨酶异常情况,为采取相应防治措施提供依据,2000~2003年连续4年,我们对入学新生进行HBsAg、HBsAb检测。现将结果报告如下。对象和方法(1)调查对象:2000~2003年共计新生5161名(校本部),其中,男生2941人,女生2220人,平均年龄(18±2)岁,学生来源主要为广东省内。(2)方法:空腹静脉采血3~4ml,分离血清用ELISA法检测。谷丙转氨酶(GPT)采用速率法、半自动化生化分析仪检测,试剂由上海复星长征医学科学有限公司生产。
绵阳市医务人员HBsAg与HBsAb的血清学检测结果分析
Analysis of serological detection results of HBsAg and HBsAb among health care workers in Mianyang city
 [PDF]

余双彬,俞梦璐,陈曦,孙圆圆,张璇,王娟,任涛,王丽萍,袁萍
- , 2018,
Abstract: 目的 分析四川省绵阳市医务人员HBsAg与HBsAb血清学检测结果,了解其乙型肝炎疫苗接种现况及乙型肝炎易感状态,为制定职业高危人群乙型肝炎疫苗接种策略提供参考依据。方法 采取多阶段分层随机抽样的方法,于2014年11月 - 2015年8月,抽取绵阳市2 437名医务人员为研究对象进行现况研究。采用问卷调查的方式面访,采用酶联免疫吸附试验(ELISA)对血清中HBsAg和HBsAb进行检测。结果 调查对象中,HBsAg、HBsAb双阴性率为27.99%(682/2 437),HBsAb阳性率为69.39%(1 691/2 437),HBsAg阳性率为2.67%(65/2 437)。HBsAg、HBsAb双阴性率:男性(32.84%)高于女性(25.55%);≥55岁者(36.14%)最高,25~34岁者(23.08%)最低;初中及以下文化程度者(33.21%)最高,大学及以上文化程度者(26.23%)最低;有乙肝疫苗接种史者(25.40%)低于无乙肝疫苗接种史者(31.21%);安州区(51.87%)最高,江油市(24.40%)最低。乙肝疫苗接种率为60.89%(1 484/2 437),其中女性高于男性,随年龄的增高疫苗接种率呈下降趋势,随文化程度增高疫苗接种率呈上升趋势。差异均有统计学意义(P<0.05)。结论 绵阳市医务人员乙型肝炎易感性仍较高,亟待完善医务人员乙肝疫苗接种策略,及时监测乙肝表面抗体水平,完善疫苗漏补种措施。
Prevalence of Hepatitis B Cab with or Without Anti Hbsab in Hbsag Seronegative Blood Donors
H Salman Roughani
Journal of Shahid Sadoughi University of Medical Sciences , 2005,
Abstract: Introduction: There are multiple reports of Acute Hepatitis B after blood transfusion inspite of good screening for Hepatitis B before transfusion. Therefore, occult hepatitis B is a serious concern for Blood transfusion. There is a lot of evidence that positive HBCAb in seronegative HBSAg blood donors is associated with occult Hepatitis B. Aim: Evaluation of the prevalence of HBCAb in seronegative HBSAg blood donors. Method: In a cross sectional descriptive study, we evaluated the serum of 1230 Blood donors for HBCAb, HCVAb and Aminotranferase levels. HBSAg or AntiHIV Ab positive cases were excluded from the study. Detection of Anti HBSAb was done in HBCAb positive patients and liver biopsy was performed in all HCVAb positive cases. Results: 15.1% of blood donors were positive for HBCAb and 51.6% of them had Anti HBSAb. Aminotranferase levels were normal in all people who were positive for HBCAb ,but about 50% of HCVAb positive persons had elevated aminotransferase levels and liver biopsy of all these patients showed inflammation Conclusion: Prevalence of HBCAb is high in our seronegative HBSAg Blood donors and biomolecular studies such as PCR for HBV DNA is indicated in HBCAb positive people, especially in people with isolated HBCAb .
A comparison on HBsAg and HBsAb prevalence in patients with Down syndrome and other mentally retarded patients living in retarded children institutes in Tehran
Sahebjamei M. Associate Professor,Nik Bin B. Professor?,?Razavi Armaghanni N. Dentist
Journal of Dental Medicine , 2003,
Abstract: Statement of Problem: The Prevalence of HBsAg, among patients with Down Syndrome (DS) has been"nreported higher than normal population. Living in institutes, comparing to home, leads to higher"nprobability of HBsAg prevalence."nAim: The purpose of the present study was to determine HBsAg prevalence in patients with DS and"ncompare it with other mentally retarded patients with similar conditions, and also with healthy population"nin Iran."nMaterials and Methods: One hundred patients, with average age of 12 years, living in five institutes in"nTehran, were chosen. Children with DS and other mentally retarded children were considered as the first"nand second groups, respectively (50 members in each group). Blood samples were taken and tested"n(ELLSA) to determine HBsAg and HBsAb titre. For statistical analysis, Chi- Square test was used."nResults: HBsAg was positive in 8% and 4% of DS and MR groups, respectively. HBsAb was seen in"n25% of DS, comparing to 32% of MR. The prevalence of HBsAg in retarded patients living in institutes"nwas higher than normal population of Iran (less than 3%), which was not statistically significant."nConclusion: Consideration of sterilization principles and infection control upon dental operations, in"nthese centers, are necessary. It is also suggested that these children, as a high- risk population, should be"nvaccinated against hepatitis B.
2015年晴隆县健康人群乙肝HBsAg、抗-HBs血清学监测分析
Serological monitoring analysis of Hepatitis B HBsAg and HBsAb in healthy people in Qinglong County in 2015
 [PDF]

郑云,孙启刚,蒋万权,张六阳
- , 2017,
Abstract: 目的 了解晴隆县健康人群病毒性乙型肝炎(简称乙肝)表面抗原、表面抗体水平及表面抗原抗体同时阳性率,探讨乙肝感染情况,为防控策略和措施提供科学依据。方法 采用随机抽样方法,从全县14个乡镇中每个乡镇随机抽取一个行政村,每个行政村随机抽取8个年龄组共30人采静脉血分离血清,采用酶联免疫吸附法(ELISA)检测乙肝表面抗原(HBsAg)、乙肝表面抗体(抗-HBs)。结果 2015年晴隆县健康人群HBsAg、抗-HBs、HBsAg和抗-HBs同时阳性率分别为4.52%、49.23%、1.73%;各年龄段之间、各乡镇之间差异均有统计学意义(P<0.01);定点接种抗-HBs阳性率为52.73%,大于逐户上门接种的42.39%,差异有统计学意义(P<0.01)。8~12月龄组和5~6岁组HBsAg、HBsAg和抗-HBs同时阳性率呈现2个高峰,8~12月龄组抗-HBs阳性率最高,以后随着年龄的增长逐渐降低,特别是5~6岁组后降幅明显;城乡结合部、边远少数民族乡镇呈现HBsAg、HBsAg和抗-HBs同时阳性率偏高,抗-HBs阳性率偏低的现象。结论 提高乙肝疫苗免疫及时率及基础免疫全程接种率,加强边远少数民族乡镇、城乡结合部人群乙肝疫苗查漏补种和5岁以上人群每3~5年一次乙肝疫苗加强免疫以及加强乙肝防控措施宣传教育,是预防和控制乙肝疫情的关键。
慢性HBV感染者经核苷(酸)类似物治疗获血清HBsAg 转阴后的长期预后
Long-Term Clinical Prognosis of CHB Patients with HBsAg Seroclearance after Long Term Nucleos(t)ide Analogues Antiviral Therapy
 [PDF]

盘 铮,尤 旭,崇雨田,李向永
PAN Zheng
,YOU Xu,CHONG Yu-tian,LI Xiang-yong

- , 2018, DOI: A
Abstract: 【目的】回顾性研究长期服用核苷(酸)类似物的慢性乙型肝炎病毒(CHB)患者获得血清HBsAg转 阴后的长期临床预后。【方法】选取中山大学附属第三医院长期服用核苷(酸)类似物抗病毒治疗获得血清HB? sAg转阴的127例慢乙肝患者为研究对象,失访患者23例,纳入本研究的患者104例。定期收集患者临床数据, 包括患者人口学数据、家族史、个人病史、基线及随访各时间点的生化学、病毒学、血清学、肝脾影像学指标以及 药物治疗安全性数据等。【结果】104例患者中,85.6%(89例)男性,37.7%(34例)基线时HBeAg阳性;经过平均 5.5(0.3~14.0)年核苷(酸)类似物治疗,HBsAg阴转时平均年龄为49.0(27.0~81.0)岁,ALT复常率为66.2%(48/ 68),HBVDNA不可测率为98.1%(102例),HBeAg转阴率为85.3%(29/34),HBeAg/HBeAb转换率为79.4%(27/ 34),HBsAg阴转率为100%(104例),HBsAg/HBsAb转换率7.7%(8例)。104例患者至最后1次随访时,ALT复常 率为83.8%(57/68),HBVDNA不可测率为99.1%(103),HBeAg阴转率为88.2%(30/34),HBeAg/HBeAb转换率 为79.4%(27/34),HBsAg阴转率为97.1%(101),HBsAg/HBsAb转换率为27.9%(29例), 3例患者出现HBsAg复转 阳,但血清HBsAg滴度较低,HBsAg滴度对数值波动在-0.3~0.7U/mL。1例(1.0%)患者从慢性乙型肝炎进展至 肝硬化, 2例(1.9%)肝硬化患者进展至肝癌,无1例患者死亡。【结论】服用核苷(酸)类似物抗病毒治疗的慢性 HBV感染者获得血清HBsAg转阴后的长期临床预后良好
保山市15岁以上人群乙肝HBsAg、 HBsAb血清学调查
Serological survey analysis of hepatitis B surface antigen and surface antibody among population over 15 years old in Baoshan city
 [PDF]

赵丽娟,王黎明,张腾,黄东升,李庆芳,段丽忠,王生芳,郑维斌
- , 2015,
Abstract: 摘要:目的 了解保山市15岁以上人群乙型病毒性肝炎(简称乙肝)表面抗原、表面抗体水平,探讨乙肝感染情况及防控策略和措施。方法 采用多阶段分层随机抽样的原则,在保山市5个县区随机抽取15岁以上人群2768人,调查基础数据,对抽取的血清用胶体金快速检测表面抗原(HBsAg)、表面抗体(抗-HBs)结果 2012年保山市15岁以上人群乙肝表面抗原、表面抗体阳性率分别为2.96%、23.16%;男性表面抗原、表面抗体阳性率分别为3.58%、24.72%,女性分别为2.45%、21.85%;各年龄段乙肝表面抗原阳性率、表面抗体保护率分别在2.4%~3.7%和18.6%~27.8%之间;农民表面抗原、表面抗体阳性率分别为3.03%,22.31%,非农民表面抗原、表面抗体阳性率分别为2.49%,22.57%;城区表面抗原、表面抗体阳性率分别为2.65%、23.26%,郊区表面抗原、表面抗体阳性率分别为6.54%、16.51%,山区表面抗原、表面抗体阳性率分别为1.52%、26.05%,城乡差异有统计学意义;隆阳区、腾冲县、施甸县、昌宁县、龙陵县表面抗原阳性率分别为2.42%、3.09%、2.75%、4.07%、2.50%,表面抗体阳性率分别为23.65%、34.00%、15.29%、25.18%、18.25%,差异有统计学意义。结论 保山市15岁以上人群乙肝表面抗原携带率较低,但乙肝疫苗保护率也较低。应充分发挥教育、卫生、社区、基层公共卫生服务的作用,加大对乙肝危害及接种乙肝疫苗好处的宣传力度,提高接种率。
住院新生儿首针乙肝疫苗后抗体滴度情况及影响因素分析 Analysis on the HBsAb Titers and Its Determinants After the First Immunization of Hepatitis B Vaccine Among Hospitalized Neonates  [PDF]
李维禧,谢蒙,樊盼盼,蒋勇,赵东赤
- , 2017,
Abstract: 目的:调查住院新生儿接种首针重组酵母乙型肝炎(乙肝)疫苗后HBsAb滴度情况,并探讨其相关影响因素。方法:以2012-2014年我院的1 002例新生儿为研究对象,在出生后24h内接种首针乙肝疫苗。采用化学发光微粒子免疫分析法检测HBsAb滴度,并通过问卷调查收集相关资料。通过单因素方差分析及有序多分类Logistic回归模型分析新生儿HBsAb滴度的影响因素。结果:新生儿首针乙肝疫苗免疫后,HBsAb滴度<10mIU/ml者397例,10-99mIU/ml者294例,100-999mIU/ml者252例,≥1 000mIU/ml者59例;低无抗体率为67.0%,其中无抗体率为39.6%,低抗体率为29.4%。经综合考虑单因素分析和有序多分类Logistic回归分析,胎龄、母亲HBsAb滴度和母亲HBsAg这3个因素是新生儿HBsAb滴度的影响因素,其低无抗体的OR值分别为1.179(胎龄<32周)、8.906(母亲HBsAb<10mIU/ml)、4.203(母亲HBsAb 10-99mIU/ml)和3.134(母亲HBsAg阳性)。结论:胎龄<32周、母亲HBsAb<100mIU/ml和母亲HBsAg阳性新生儿首针乙肝疫苗后HBsAb滴度较低,应加强HBsAb滴度的监测
HBsAg阳性母亲的婴儿接种乙肝疫苗免疫持久性9年随访观察  [PDF]
章明太,刘克洲,金建华,陈智
中国公共卫生 , 1996,
Abstract: ?提要106名HBsAg阳性母亲的耍儿,用10μg×3剂和以0、1、6月程序接种乙肝疫苗。于接种后1年检测时,对其中抗-HBsS加值>2.1的87人,及免疫接种失败者HBsAg阳性19人和未接种乙肝疫苗而HBsAg阳性要儿28人作了为期9年随访研究.在抗.HBS阳转者抗~HBS水平的动态变化观察中未发现HBsAg阳转者.至9年时仍有29人(44.600)抗一HBS水平>2.1,说明疫苗的免疫源性和9年的免疫效果是好的.HBsAg阳性19人与未接种疫苗而HBsAg阳性28名耍儿同时追踪结果,仍持续HBsAg阳性,提示这些要儿系宫内或田产期慈染所致。
Hbsab Measurement after Hepatitis B Vaccination and Introduction of Non-REsponder Persons
Montazam Seyed Hassan,Tanomand Asgar,Jelvehgari Mitra
Research Journal of Biological Sciences , 2012,
Abstract: Hepatitis is a general term meaning inflammation of the liver and can be caused by a variety of different viruses such as hepatitis A, B, C, D and E. Infection with HBV occurs worldwide and the prevalence rate is different in various areas. HBV causes one million deaths per annum. Hepatitis B vaccines have been used for reducing prevalence in many countries. The aim of this research is estimating efficacy of HBV Vaccine via HbsAb measurement in students who will be health-care workers in the future and presenting of non-responder persons. In this study, Blood samples of 288 students, who were vaccinated compactly, 1-6 month after third vaccination, were collected. After serum preparation, HbsAb were estimated by ELISA method. The antibody titer greater than 10 IU seems to be protective after the injection of Hepatitis B vaccine .In the HbsAb negative persons, vaccination was repeated. The results show the presence of HbsAb more than 10 IU in 250 individuals. Therefore the efficacy of vaccine in students is 86.8%. The average HbsAb production is 447.3 IU with 23.7 standard derivations. The lower limit was 0 and upper limit was 966 units. 25% of individuals have HbsAb less than 239, 25% of them 239-435, 25% of persons 435-653.7 and 25% of students more than 653-7 IU L 1. Also, in the second vaccination, 30 people had HbsAb more than 10 IU L 1. But 8 people (2.77%) were HbsAb negative or non-responder. The vaccine efficacy among students was same as that the other studies who reported 81-99%. In the mention of students who have HbsAb less than 10 IU L 1, Its better, storage conditions and the method of injecting vaccine and efficiency of available vaccine in Iran were studied. Also, study of serologic markers of HBV (HbcAb, HbeAg and HBeAb) for negative people is recommended.
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