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维医沙疗对兔膝骨关节炎血液流变学和血液动力学影响  [PDF]
卫荣,迪丽娜尔·马合木提,杨少玲,哈木拉提·吾甫尔
科技导报 , 2009,
Abstract: 探讨维医沙疗对兔膝骨关节炎动物模型血液流变及血液动力学的影响,为维医沙疗的研究提供科学依据。选用20只模型新西兰兔,用右后肢固定的方法建立兔膝骨性关节炎动物模型,随机分为2组A组为自由活动组,10只,解除石膏固定后,让其自由活动;B组为沙疗组,10只,解除石膏固定后让其自由活动,同时进行沙疗。待沙疗结束,检测血液流变学及血液动力学指标。结果表明,①与自由活动组比较,沙疗组在干预后全血黏度低切、中切、高切,红细胞电泳指数,红细胞压积均降低(P<0.05);血浆黏度,全血还原黏度低切降低明显(P<0.01),均具有统计学意义;沙疗组沙疗前后比较,全血黏度低切、中切、高切,血浆黏度,全血还原黏度低切均明显有降低(P<0.01);全血还原黏度高切,红细胞压积也有降低(P<0.05),均具有统计学意义。②与自由活动组比较,沙疗组在干预后右下肢的PS、ED数值均升高,差异均具有统计学意义(P<0.01);沙疗组沙疗前后,右下肢股动脉收缩期血流峰值(PS)、舒张期血流峰值(ED)数值明显增加并具有统计学意义(P<0.01)、阻力指数(RI)的数值降低具有统计学意义(P<0.05)。由此得出结论维医沙疗可改善模型动物的全血黏度指标;同时使其埋沙部位下肢股动脉血流速度加快,并减轻血管阻力。这可能是其抗炎作用的机制之一。
射频热疗对膝骨关节炎实验兔血液中白细胞介素-1β及肿瘤坏死因子-α表达的影响  [PDF]
傅照华,赵娇娇,曹青青,孔娇,武永飞,张飞
- , 2018,
Abstract: 目的 探讨射频热疗对兔膝骨关节炎形成过程中关节软骨组织形态学及血清中白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)的影响。 方法 选取雄性家兔54只,采用改良Hulth造模法将其右后肢制成实验性膝关节骨关节炎模型。待造模成功后,将上述实验兔随机分为模型组、鹿瓜多肽组及射频热疗组。鹿瓜多肽组于制模后给予鹿瓜多肽肌肉注射,射频热疗组于制模后给予射频热疗干预,模型组制模后未给予特殊处理。于治疗7d、13d及19d时每组分别取6只实验兔处死,取右侧股骨内侧髁软骨,采用改良Mankins标准对其进行形态学评分,同时采用ELISA法检测各组实验兔血清中IL-1β及TNF-α含量。 结果 经相同时间治疗后,发现模型组、鹿瓜多肽组及射频热疗组右侧股骨内侧髁软骨Mankins评分及血清中IL-1β、TNF-α含量均依次降低,组间差异均具有统计学意义(P<0.05)。射频热疗组随着治疗时间延长,其右侧股骨内侧髁软骨Mankins评分及血清中IL-1β、TNF-α含量均逐渐降低,各观察时间点间差异均具有统计学意义(P<0.05)。 结论 射频热疗治疗兔膝骨关节炎的疗效明显优于鹿瓜多肽,其治疗机制可能与调控血清中IL-1β、TNF-α含量有关。
Objective To explore the effect of radiofrequency-induced hyperthermia on the morphology of articular cartilage and any changes in serum-1 interleukin-1 (IL-1β) and tumor necrosis factor-alpha (TNF-α) in the process of knee osteoarthritis in rabbits. Methods Fifty-four male rabbits were selected and knee osteoarthritis was introduced to their right hind limbs using the modified Hulth model. They were then randomly divided into a model group, a cervus and cucumis polypeptide (CCP) group and a radiofrequency thermotherapy (RT) group, each of 18. The CCP group was injected with deer melon peptide intramuscularly. The RT group was given radiofrequency hyperthermia treatment. The model group was not provided with any special treatment. On the 7th, 13th and 19th day of the treatment, 6 rabbits in each group were sacrificed to resect the right medial femoral condyle cartilage. The morphological characteristics of the cartilage were evaluated using the modified Mankins score, while the content of IL-1βand TNF-α in the serum were detected using enzyme-linked immuno-sorbent assays (ELISAs). Results At the same time points, the average Mankins score and the average content of IL-1βand TNF-α in the serum of the model group were significantly higher than in the CCP group, with the values in the latter group significantly higher than in the RT group. In the RT group, the average Mankins score, as well as the IL-1 beta and TNF-alpha levels in the serum, decreased significantly with longer treatment. Conclusion Radiofrequency-induced hyperthermia is superior to deer melon polypeptide in treating knee osteoarthritis, at least in rabbits. Its therapeutic mechanism may be related to the control of serum IL-1 beta and TNF-alpha levels
射频热疗对兔膝骨关节炎形成过程中Ⅱ型胶原表达的影响
The effects of radiofrequency heating on type II collagen formation in the osteoarthritic knee
 [PDF]

傅照华,赵娇娇,张飞,武永飞,曹青青,孔娇,周春娟
- , 2018,
Abstract: 目的 探讨射频热疗对兔膝骨关节炎形成过程中Ⅱ型胶原表达的影响。 方法 选取雄性家兔54只,采用改良Hulth造模法将其右后肢制成实验性膝关节骨关节炎模型。待造模成功后,将上述实验兔随机分为模型组、鹿瓜多肽组及射频热疗组。鹿瓜多肽组于制模后给予鹿瓜多肽肌肉注射,射频热疗组于制模后给予射频热疗治疗,模型组制模后未给予特殊处理。于治疗7d、13d及19d时每组分别取6只实验兔处死,取右侧股骨内侧髁软骨,采用改良Mankins评分对其进行形态学评分;同时采用实时定量PCR技术检测各组实验兔右侧股骨内侧髁软骨组织Ⅱ型胶原含量。 结果 经相同天数治疗后,发现模型组、鹿瓜多肽组及射频热疗组右侧股骨内侧髁软骨Mankins评分依次降低,软骨组织Ⅱ型胶原含量依次增高,组间差异均具有统计学意义(P<0.05)。射频热疗组随着治疗时间延长,其Mankins评分逐渐降低,软骨组织中Ⅱ型胶原含量逐渐增高,各时间点间差异均具有统计学意义(P<0.05)。 结论 射频热疗治疗兔膝骨关节炎的疗效明显优于鹿瓜多肽,其治疗机制可能与显著增加软骨中Ⅱ型胶原含量有关。
Objective To explore the effect of radiofrequency heating on type II collagen expression in a rabbit model of osteoarthritis. Methods Knee osteoarthritis was induced in the right hind legs of 54 male rabbits using modified Hulth modeling. The rabbits were randomly divided into a model group which was not given any special treatment, a Lugua polypeptide group and a radiofrequency hyperthermia group. The Lugua polypeptide group was injected with Lugua polypeptide; the radiofrequency hyperthermia group was treated with radiofrequency irradiation. Six, 12 and 18 days after the treatment, the morphological condition of the rats′ right femoral medial condyle cartilages were evaluated using modified Mankins scoring and the type II collagen content of the cartilage was detected using a quantitative PCR technique. Results At the same time points after treatment, the average Mankins scores were decreased in all the 3 groups, with that of the model group was significantly higher than those of both of the other groups, and the radiofrequency hyperthermia group′s average score was significantly better than that of the Lugua polypeptide group. The average type II collagen content was significantly increased in all the 3 groups to various extent (the radiofrequency hyperthermia group > Lugua polypeptide group > model group) . For the radiofrequency hyperthermia group, the average Mankins score decreased significantly and the average type II collagen content increased significantly as the treatment continued. Conclusion Radiofrequency hyperthermia is superior to Lugua polypeptide for treating knee osteoarthritis, at least in rabbits. Its therapeutic effectiveness may be related to a significant increase of type II collagen in the cartilage
沙疗下不同月龄兔膝骨关节炎股骨的骨质骨量及生物力学性能变化
Change of Volume and Mechanical Properties of Femoral Bone in Rabbits at Different Ages with Knee Osteoarthritis under Sand-therapy
 [PDF]

胡小鑫,居来提·买提肉孜,黄少君,木合塔尔·克力木,迪丽娜尔·马合木提,张春广,阿布力米提·买买提,张锐,艾尔西丁·阿不来提
- , 2015, DOI: 10.7507/1001-5515.20150184
Abstract: 研究维医沙疗对不同月龄兔骨性关节炎(OA)股骨的骨质骨量变化及生物力学性能的影响。实验选用新西兰大白兔成熟期组16只,生长期组16只,对其右后股骨膝关节腔注射木瓜蛋白酶建OA模型,成熟期组随机分2组:对照组(不沙疗)8只,沙疗组8只;生长期组随机分2组:对照组(不沙疗)8只,沙疗组8只;采用CT扫描4次(建模前1 d、建模第13、27、41 d),MIMICS软件获取股骨模型、各骨质的骨体积和骨体积比的变化;最后进行股骨三点弯曲试验,获得弹性载荷和弹性挠度并计算截面惯性矩、最大弯曲正应力、弯曲弹性模量和结构刚度。实验结果表明:①成熟期兔股骨OA建模前1d与第13d相比较,松质骨量增多而皮质骨量减少(P<0.05);而各自相比对照组,沙疗组在沙疗作用下OA兔股骨松质骨量减少和皮质骨量增多(P<0.05)。②各自相比对照组,沙疗组OA兔股骨挠度和横截面惯性矩无统计学差异(P>0.05),而截面面积、最大弯曲正应力、最大载荷、弹性模量和结构刚度变大(P<0.05)。本研究显示:①维医沙疗对不同月龄兔OA股骨的各骨质骨量变化都有良性影响。②维医沙疗能改善不同月龄兔OA股骨的力学性能。
The present paper is aimed to study the effect of sand-therapy with Uyghur medicine on biomechanical properties and femoral bone volume of the femur of osteoarthritis (OA) rabbits at two different ages. In the experiments, we injected Papain through the joint space of right knees into the bodies of New Zealand rabbits (16 in the growing group, and 16 in the mature group), and established an OA model. The 16 rabbits in the mature group were divided randomly into 2 sub-groups: 8 in control group (no sand therapy), and 8 sand-therapy group. The 16 rabbits in the growing group were divided randomly into 2 groups as well: 8 in the control group (no sand therapy), and 8 in the sand-therapy group. We carried out CT scanning four times (1 day before, 13th, 27th and 41st days after the establishment of the model, respectively). After importing the CT data to MIMICS, the different volumes of each sclerotin were recorded and change of the percentage of each sclerotins in total femur bone volume were analyzed. Finally the rabbit femurs were given three-point bending test, the elastic load and the elastic deflection were obtained and the inertia of the section, the maximum bending stresses, the bending modulus of elasticity and the structural rigidity were calculated. The experimental results showed that ① Compared with 1 day before and 13th day after establishment of model at maturity, the cancellous bone volume increased and cortical bone volume decreased (P<0.05), but compared with those in the control group, the cancellous bone volume of femurs decrease and cortical bone volume increased under sand-therapy (P<0.05). Compared with those in the control group, there were no significant changes in the deflection and cross-sectional moment of inertia in the sand-therapy group (P>0.05), but the maximum bending normal stress, maximum load, elastic modulus, and structural stiffness (P<0.05) in the sand therapy group were larger than those in the control group. The study showed that sand-therapy in Uyghur medicine has benign effect on bone volume of the OA rabbit
虎膝的鉴别  [PDF]
许华,杨曾让
中国中药杂志 , 1986,
Abstract: <正>常发现以豹(Pantherapardus)、熊(Selenarctosthibetanus)、黄牛(Bostaurusdomesticus)、猪(Susscrofadomestica)的膝盖骨(膑骨)充虎(Pantheratigris)的膝盖骨(参考照片一、二)。现将虎膝与它们的性状比较鉴别介绍如下。1.虎膝:呈长圆形,略扁。长4.7~5.2cm,短径2.7~3.3cm。上端(基部)较宽厚,下端(尖部)稍窄,微向上翘。中部前面向两侧横凹。关节面(后面)光滑,显光泽,黄
肿瘤治疗的绿色疗法——热疗  [PDF]
科技导报 , 2014,
Abstract: 热疗是一门古老的科学.古希腊著名医生希波克拉底即认为“药物不能治的可用手术治,手术不能治的可用热来治疗,热不能治的就无法治了.”这在一定程度上预言了热疗在肿瘤治疗中的重要作用.
超声热疗的现状与应用  [PDF]
菅喜岐,丁鑫
科技导报 , 2014, DOI: 10.3981/j.issn.1000-7857.2014.30.003
Abstract: 超声热疗是利用生物组织吸收超声波能量使自身温度升高的特性,通过高温致死病变组织或低温促使病变组织康复的热疗技术.该热疗具有微创、安全、高效等特点.利用高温致死病变组织的高强度聚焦超声已应用于子宫肌瘤、乳腺肿瘤、前列腺肿瘤、肝肿瘤等的临床治疗,在脑肿瘤及神经系统疾病方面尚处于临床应用研究阶段.低强度超声的低温升热疗对于产后出血治疗和神经组织愈合等有较好疗效.本文综述高强度聚焦超声和低强度超声热疗技术的发展、现状及应用.
综合康复治疗对轻中度膝骨关节炎骨髓水肿的疗效
 [PDF]

欧阳辉,宋秀豹,王玉苹,朱丽花,史长征
- , 2015, DOI: 10.11778/j.jdxb.2015.02.017
Abstract: 摘要  目的:探讨综合康复治疗对轻中度膝骨关节炎骨髓水肿(BME)的疗效.方法:选择核磁共振(MRI)诊断为BME的膝骨关节炎患者60例,按随机数字表随机分为综合康复治疗组和药物对照组,综合康复治疗组:在药物治疗的同时根据美国运动医学学会(ACSM)指导原则进行规范化的综合康复治疗,采用布洛芬胶囊(0.3g,一日两次)+氨基葡萄糖(750mg,一日两次)+综合康复治疗(体外高频热疗+肌力训练),共12周;对照组:布洛芬胶囊(0.3g,一日两次)+氨基葡萄糖(750mg,一日两次),共12周.两组患者治疗前及治疗结束后采用视觉模拟评分法(VAS)和西安大略与麦克马斯特大学骨关节炎指数(WOMAC)问卷调查进行疼痛和关节功能评分.BME评估利用MRI技术采用Felson等方法进行评分.结果:综合康复治疗在缓解疼痛和改善功能方面的疗效优于药物组,两组BME评分与治疗前比较均有明显减少,差异有统计学意义(P<0.01);治疗组的BME评分低于对照组,差异有统计学意义(P<0.05),提示两组方法均能有效减少BME,且综合康复疗法优于单纯药物治疗.结论:通过MRI观察,综合康复治疗(体外高频热疗+肌力训练+药物)能够减轻膝骨关节炎的骨髓水肿,具有消炎、消肿、止痛、延缓软骨退变、改善关节功能的作用.
化学疗剂的作用机制
钱存柔,黄仪秀
微生物学通报 , 1983,
Abstract: 使用某些化学药品以达到抑制或杀死病原微生物的方法,称为化学治疗。而用于化学治疗的药物则称为化学疗剂。不同化学疗剂的作用机制各不相同,有的是作为微生物正常代谢物的结构类似物而与正常代谢物争夺酶,有的则是特异地抑制微生物某些大分子的生物合成过程。本文介绍某些化学疗剂如抗代谢物、抗生素、干扰素等的抗微生物作用机制。
膝褶、膝褶带、共轭膝褶带——一种可能的新型油气构造样式  [PDF]
张波,李生福,张进江,郑亚东,张仲培
天然气工业 , 2010,
Abstract: ?受控于最大有效力矩准则的共轭膝褶带,是各向异性岩石中较为常见的构造变形样式,依据大量国、内外学者的研究资料及勘探实践成果,结合膝褶带几何学、形成机制以及地球物理资料解释成果等综合分析认为,大型膝褶带和共轭膝褶带可能被误解释为“两断夹一隆”的构造形态,原先一些构造样式被解释为高角度逆冲断层的地方更可能是膝褶的枢纽带。研究结果认为,膝褶带具备形成油气构造圈闭的物质条件,可形成有利油气聚集区;膝褶带和共扼膝褶带作为非主造山期构造在油气勘探和构造解释上应引起石油地质学家和地球物理学家的重视;结合野外地质构造观测,利用地球物理资料准确识别和区分膝褶带构造与断裂构造是寻找油气构造圈闭的新思路和新方法。
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