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Spindle cell carcinoma of the oropharynx: a rare variant of squamous cell carcinoma
Fuente-Ca?ibano R, Ala?ón-Fernández MA, Murillo-Lázaro CR, Ruiz-González M, Crespo-Hierro J, Morales-Puebla M, García-Castillo E, Crespo-Serrano J.
Revista de la Sociedad Otorrinolaringológica de Castilla y León, Cantabria y La Rioja , 2012,
Abstract: Spindle cell carcinoma is a malignant and rare squamous cell carcinoma. It's a double examination showed a cell proliferation: a cell sarcomatous spindle cell and a carcinomatous epithelial cells.Although it can affect any part of the body, is found more commonly in the upper aerodigestive tract.It occurs more frequently in males between the 6th and 7th decades of life.Its behavior is aggressive with a tendency to relapse. Alcohol and smoking have been identified as the most important risk factors.The histological diagnosis is difficult and is often necessary to use immunohistochemistry and electron microscopy. At present, it is believed that origin is epithelial.
Spindle cell carcinoma of the nasal cavity  [cached]
Sachin Gupta,Dominick Santoriello,Rosemary Wieczorek,Mark D DeLacure
Rare Tumors , 2013, DOI: 10.4081/rt.2013.e10
Abstract: Spindle cell carcinoma (SpCC) is a unique variant of squamous cell carcinoma (SCC). SpCC confined to the nasal cavity is extremely rare, with only one case having been previously reported. We present a case report of nasal cavity SpCC and review the literature on this rare entity. A 29-year-old male presented with intermittent epistaxis from the left nasal cavity. On physical examination, the patient had an ulcerated mass in the left nasal vestibule and a biopsy showed a proliferation of spindle and epitheliod cells. The patient underwent wide local excision of the mass via a lateral alotomy approach and reconstruction with a composite conchal bowl skin and cartilage graft. Histologically, the mass had dyplastic squamous epithelium and spindle-shaped cells admixed with epitheliod cells. Immunohistochemistry was only positive for pancytokeratin AE1/AE3 and vimentin. Six months after surgery, the patient continues to have no evidence of disease. On literature review, only one previous case of SpCC confined to the nasal cavity was identified. We present a rare case of nasal cavity SpCC. No definite treatment protocol exists for this unique entity, but we believe that this tumor should primarily be treated with aggressive, wide local excision. Adjuvant radiation and/or chemotherapy have also been used anecdotally.
Spindle Cell Carcinoma of the Tongue: A Rare Tumor in an Unusual Location  [PDF]
Murat Oktay,Tuba Dilay Kokenek-Unal,Bulent Ocal,Guleser Saylam,Mehmet Hakan Korkmaz,Murat Alper
Pathology Research International , 2011, DOI: 10.4061/2011/572381
Abstract: Spindle cell carcinoma is a rare biphasic tumor consisting of epithelial and mesenchymal components. Presence of this tumor type in the tongue has rarely been reported. Herein, a case of 55-year-old woman who presented with a polypoid lesion at her tongue has been reported. Surgery was performed and pathologic examination revealed a spindle cell carcinoma. We present this rare tumor with an unusual location to contribute in part to the better understanding and awareness of this rare malignancy. 1. Introduction Spindle cell carcinoma (SpCC) is a relatively rare malignancy affecting the upper aerodigestive tract. The most common site of origin in head and neck region is larynx (particularly vocal cords) and hypopharynx. Usually, oral cavity is not affected. SpCC occurs commonly in 6-7th decades of life and represents a male predominance. Smoking, alcohol consumption, and previous irradiation of the head and neck region are the predisposing factors. It is a poorly differentiated variant of squamous cell carcinoma (SCC) [1] with a more aggressive behavior [2–4]. This biphasic tumor is composed of both malignant epithelial and malignant mesenchymal components. Despite several immunohistochemical, electron microscopic, and genetic studies, precise histogenesis of SpCC is quite controversial. This contraversy has reflected itself with a wide spectrum of nomenclature on this tumor type such as carcinosarcoma, pseudosarcoma, sarcomatoid carcinoma, collision tumor, and pseudosarcomatous carcinoma. There is limited literature on SpCC arising in the aerodigestive tract. Moreover, there is only a handful of literature reporting the tongue localization of these tumors. We report here a case of SpCC arising from the tongue in a patient who has been previously operated for SCC and treated with radiotherapy (RT). 2. Case Report A 55-year-old woman was admitted to the department of otorhinolaryngology with a painless polypoid lesion located in the tongue (Figure 1(a)). Clinical history revealed that she had an unhealing lesion in the right lateral border of the tongue diagnosed with SCC and had been operated twice in 2000 and 2002. She had no metastatic lymph node in performed neck dissection. After the last surgery, she had received postoperative RT. Figure 1: Macroscopic features and radiological imaging of SpCC. (a) Photographic view of the tumor just before operation. (b) Polypoid tumor mass in oral cavity on CT imaging. (c) The cut surfaces of the tumor. On physical examination, a polypoid, exophytic mass was observed in the previously operated region which was 5 ×
Primary mucinous carcinoma of eyelid: A rare clinical entity  [cached]
Chauhan Ashutosh,Ganguly Manomoy,Takkar Puneet,Dutta Vibha
Indian Journal of Ophthalmology , 2009,
Abstract: Primary cutaneous mucinous carcinoma of the eyelid, a rare pathologic entity, is an adenocarcinoma of the eccrine glands. Though it has low metastatic potential, it does have a significant recurrence rate. We present the occurrence, clinical and histological features, and management of this tumor in a 62-year-old male who presented with a recurrent, firm, nodular left lower lid lesion. He underwent excision with a 5 mm margin and the defect was repaired with a Mustarde′s cheek rotation flap. A full oncological screening, including whole-body Positron Emission Tomography scan, excluded the presence of primary mucinous carcinoma elsewhere and any metastatic spread. This case underscores the importance of considering this tumor in recalcitrant eyelid lesions and highlights the pathology of this tumor.
Radiation-induced spindle cell sarcoma: A rare case report  [cached]
Khan Mubeen,Chandramala Rupa,Sharma Ridhima,Vijayalakshmi K
Indian Journal of Dental Research , 2009,
Abstract: Ionizing radiation has been known to induce malignant transformation in human beings. Radiation-induced sarcomas are a late sequel of radiation therapy. Most sarcomas have been reported to occur after exposure to a radiation dose of 55 Gray (Gy) and above, with a dose ranging from 16 to 112 Gys. Spindle cell sarcomas, arising after radiotherapy given to treat the carcinoma of head and neck region is a very uncommon sequel. This is a rare case report of spindle cell sarcoma of left maxilla, in a 24-year-old male, occurring as a late complication of radiotherapy with Cobalt-60 given for the treatment of retinoblastoma of the left eye 21 years back.
Primary Intraparenchymal Squamous Cell Carcinoma of the Kidney: A Rare and Unique Entity  [PDF]
Prithwijit Ghosh,Kaushik Saha
Case Reports in Pathology , 2014, DOI: 10.1155/2014/256813
Abstract: Primary squamous cell carcinoma (SCC) of the renal parenchyma is a very unusual entity which needs to be differentiated from primary SCC of renal pelvis, SCC from another primary site, and urothelial carcinoma with extensive squamous differentiation. We are most probably describing the second case of primary SCC of the renal parenchyma in a 51-year-old male who presented with heaviness of right upper abdomen with intermittent pain in right flank. Contrast-enhanced computed tomography (CECT) revealed a mass in the right lower pole of the kidney and histopathology following nephrectomy displayed the features of well-differentiated squamous cell carcinoma without urothelial involvement. 1. Introduction Primary squamous cell carcinoma (SCC) of the renal pelvis is a rare but relatively known entity representing only about 0.5 to 15% of all the urothelial cancers. It is often unsuspected clinically due to its rarity and inconclusive clinical and radiological features, and hence patients present at advanced stages resulting in poor prognosis [1]. However, extensive review of the literature reveals only a single case of primary SCC of renal parenchyma reported till date [2]. We probably report the second case of primary SCC of renal parenchyma in a 51-year-old man presenting with nonspecific clinical complaints. 2. Case Report A 51-year-old male presented with heaviness of right upper abdomen for last 8 months and dull and intermittent pain in the right flank, off and on for last five months. There was no history of weight loss and hematuria during this period. History of fever with associated urinary complaints was also conspicuously absent. He was a nonsmoker and nonhypertensive. The clinical examination revealed mild pallor and mild tenderness in the right flank. There was no palpable lymph node. On routine hematological investigation, his hemoglobin level was 10.2?g/dL and RBCs displayed normocytic normochromic features on peripheral blood film examination. The erythrocyte sedimentation rate (ESR) was 40?mm after the 1st hour. Serum urea and creatinine values were within normal limits. Urine analysis revealed mild pyuria which was sterile on culture. Urine dip-stick test was negative for blood and urinary RBC count was within normal limit. However, mild proteinuria was detected. A solitary heterogeneously enhancing relatively well-delineated mass situated in the lower pole of right kidney was detected on contrast-enhanced computed tomography (CECT) scan without any noticeable infiltration of adjacent organs (Figure 1(a)). Retroperitoneal lymph nodes did not
Hyalinizing clear cell carcinoma of the base of tongue: A distinct and rare entity  [cached]
Masilamani Suresh,Rao Shalinee,Chirakkal Pramod,Kumar A
Indian Journal of Pathology and Microbiology , 2011,
Abstract: Hyalinizing clear cell carcinoma (HCCC) of tongue is a rare neoplasm originating from minor salivary glands. We present a case of HCCC involving the base of tongue, in a 73-year-old male, clinically diagnosed as fibroma. Laser excision of the mass was done. Histopathological examination showed an infiltrating lesion composed predominantly of clear cells. The differential diagnosis included other salivary gland lesions having a clear cell component and metastatic clear cell renal carcinoma. Immunohistochemistry was useful in ruling out these lesions exhibiting clear cell component from clear cell carcinoma. Imaging studies revealed no lesion in either kidney. Since, HCCC has a better prognosis and the adequate treatment is wide excision, it needs to be differentiated from other carcinomas with clear cells. No further therapy was given to the patient. One year after the surgery, the patient is symptom free without local recurrence and on regular follow up.
Syringomatous carcinoma: Case report of a rare tumor entity
B El Khannoussi, H Hechlaf, I Lalya, M Oukabli, A Al Bouzidi, N Ortonne
Pan African Medical Journal , 2012,
Abstract: Syringomatous carcinoma is a rare cutaneous neoplasm, most frequently situated on the face and scalp and histologically characterised by an infiltrative pattern of basaloid or squamous cells, a desmoplastic stromal reaction and keratin filled cysts. We report the case of a 76-year-old woman who presented an ulcerative interscapular lesion measuring 3x4cm. After resection, the histological examinations of the specimens have identified a basal cell carcinoma. However, a local recurrence was observed 18 months later; histopathological findings showed a syringomatous pattern and neoplastic epithelial cells arranged in interconnecting cords with microcystic areas. Nests, cords, and tubules of the tumour extended into the dermis and into the adjacent muscle. Sclerosis of stroma around the cords was present. Tumour cells were not connected to the epidermis. The immunohistochemical analysis showed positivity for anti-CK7, AE1/AE3 and negativity for anti CEA and anti CK20. These histological and immunohistochemical analyses were consistent with the diagnosis of syringomatous eccrine carcinoma. Syringomatous carcinoma is an extremely invasive tumor, locally destructive and slowly growing adnexal tumour, derived from eccrine sweat glands. It is often mistaken, both clinically and microscopically, for other benign and malignant entities. The tumour recurrence is high due to extensive perineural invasion, but regional or distant metastases are rare. The local aggressive nature of the tumour and the high recurrence rate may necessitate mutilating procedures. Optimal treatment consists of a complete microscopically controlled surgical excision with clear surgical margins.
Primary Epithelial Myoepithelial Carcinoma of Lung, Reporting of a Rare Entity, Its Molecular Histogenesis and Review of the Literature
Farzana Arif,Susan Wu,Shahriyour Andaz,Stewart Fox
Case Reports in Pathology , 2012, DOI: 10.1155/2012/319434
Abstract: Primary epithelial myoepithelial carcinoma of lung is a rare entity and is thought to arise from the submucosal bronchial glands distributed throughout the lower respiratory tract. Because of the rarity of this tumor, we describe one case of epithelial myoepithelial carcinoma arising in the bronchus intermedius and presenting as an endobronchial mass. A 57-year-old male patient presented with an incidental finding of an endobronchial mass located in the lumen of the right lower lobe bronchus and caused near total luminal occlusion of the bronchus. An endobronchial carcinoid tumor was entertained clinically. Subsequently the patient underwent an uneventful videothoracoscopic lobectomy of lower and middle lobes of the right lung. Morphologically and immunohistochemically the tumor was characterized by two cell populations with epithelial and myoepithelial cells forming duct-like structure. The final diagnosis of epithelial myoepithelial carcinoma of lung was rendered.
Pulmonary epidermoid carcinoma in a patient with acromegaly: a rare entity
Siham El Aziz, Asma Chadli, Atika Obbiba, Hassan El Ghomari, Ahmed Farouqi
Pan African Medical Journal , 2012,
Abstract: A 56-years-old woman was referred to our unit for partially treated acromegaly. She had a high level of insulin growth factor. She did not complain of any pulmonary symptoms and was a non-smoker. Physical examination revealed clinical features of acromegaly. She had a 13 mm pituitary adenoma and was proposed for surgical intervention. Her chest X-ray showed a right paracardiac tumor. Computed tomography scan revealed a large right-sided fowler tumor. Pituitary surgery was cancelled and lobectomy after biopsy with lymph nodes excision was performed through thoracotomy. Histological study of the tumor revealed a medium differentiated epidermoid carcinoma with positive lymph nodes and extension to pleura. She was referred to chemotherapy protocol. Association between carcinoma and acromegaly has previously been reported. Most common tumors are colorectal and thyroid neoplasia. As we see in this case report, we need to consider other carcinomas in acromegalic patients like pulmonary carcinoma, despite their rarity in women. Pan African Medical Journal 2012; 12:27
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