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Helicobacter pylori eradication induce platelet recovery in idiopathic thrombocytopenic purpura  [cached]
G. Emilia,G. Longo,M. Luppi,G. Gandini
Reumatismo , 2011, DOI: 10.4081/reumatismo.2001.330
Abstract: Recent reports have suggested an association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura (1TP). The prevalence of H pylori infection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 patients (43.33%) by 13C urea breath test and confirmed by histologic examination. Bacterium eradication with antibiotics, obtained in 12 of 13 infected patients (92.3%), led to a complete response in 4 (33.33%) and to a partial response (platelets 90 x IO^L-120 x IO’VL) in 2 (16.66%). The response was maintained for a median of 8.33 months, but 1 patient relapsed 7 months after eradication. Search for H pylori infection seems appropriate in ITP patients at diagnosis. Bacterium eradication provides a new good option for a non immunosuppressive treatment in some ITP patients. (Blood 2001; 97: 812-814)
Frequency of Helicobacter pylori in patients underwent endoscopy  [PDF]
Ahmet Uyan?ko?lu,Muharrem Co?kun,Do?an Nas?r Binici,?iir U?ar
Dicle Medical Journal , 2012,
Abstract: Objectives: The aim of this study was to investigate thefrequency of Helicobacter pylori in patients underwent endoscopyeastern Anatolia.Materials and methods: The patients whose endoscopicantral biopsies were taken for any reason in our endoscopyunit in February-June 2010 period were includedand retrospectively investigated. The frequency of Helicobacterpylori was determined as separating the patientsaccording to general, sex and the age groups. Antral biopsieswere stained with hematoxylin-eosin and modified giemsamethod and examined under light microscope andreported as (+) mild, (++) moderate, (+++) severe positiveaccording to their intensities.Results: Biopsy specimens of 1298 patients were includedinto the study. The mean age was 47.5 ± 17.5 years(range 14-88) and 607 of these patients (47%) were male.Histopathological evaluation revealed that, 918 of the patientswere (71%) positive and 379 (29%) were negativefor Helicobacter pylori. Approximately 60% of our patientshad mild, 29% had moderate and 11% had severe positivityfor Helicobacter pylori. No significant difference wasfound in the frequency of Helicobacter pylori betweenwomen and men. The frequencies of Helicobacter pyloriwere 73.2%, 71.5%, 68.6% and 70.4%, respectively, inthe age groups of 14-30 years, 31-45 years, 46-60 yearsand 61-88 years.Conclusion: The frequency of Helicobacter pylori was71% in Eastern Anatolia Region. No statistically significantdifference was found between genders and agegroups in term of the frequency of Helicobacter pylori.
PLATELET COUNT RESPONSE TO HELICOBACTER PYLORI ERADICATION IN IRANIAN PATIENTS WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA  [cached]
Mohammad Erfan Zare
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: Idiopathic thrombocytopenic purpura (ITP) is an autoimmune hematological disordercharacterized by auto antibody-mediated platelet destruction. Although the main cause of ITPremains unclear, but its relationship with some infection was demonstrated. In recent years, many studies have demonstrated improvement of platelet counts in ITP patients after treating Helicobacter pylori infection. The aim of this study was to investigate the effects of H. pylori eradication on platelet count response in Iranian ITP patients.A total of 26 patients diagnosed with both ITP and H. pylori infection. ITP were diagnosed whose platelet counts were less than 100×103/μL. These patients were tested for H. pylori infection by Urea Breath Test and serum H. pylori antibody. All patients received triple therapy for 7 or 14 days to eradicate
La relación de Helicobacter pylori con la displasia y el cáncer gástrico en Costa Rica
Miranda,M.; Cháves,M.; Orozco,L.; San Román,M. A.; S. Durán,G.; Vargas,G; Jiménez,E; Pe?a,L.; Rodríguez,L.; Barrantes,E.;
Revista de Biología Tropical , 1998,
Abstract: occurrence of the bacterium helicobacter pylori was compared for two costa rican sites with contrasting levels of gastric cancer incidence, poás (incidence 15. 13%) and puriscal (83. 53%). a sample of 185 adults of similar age and sex proportions was studied in each site, using both h. pylori antiserum tests and gastroscopy to collect two biopsies per case. no clear association between h. pylori and gastric cancer was found.
Rare case of Helicobacter pylori-related gastric ulcer: Malignancy or pseudomorphism?  [cached]
Ting-Ting Li,Feng Qiu,Zhi-Qiang Wang,Lu Sun
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i12.2000
Abstract: Helicobacter pylori (H. pylori) is a pathogen and the most frequent cause of gastric ulcers. There is also a close correlation between the prevalence of H. pylori infection and the incidence of gastric cancer. We present the case of a 38-year-old woman referred by her primary care physician for screening positron emission tomography-computed tomography (PET-CT), which showed a nodular strong accumulation point with standardized uptake value 5.6 in the gastric fundus. Gastroscopy was then performed, and a single arched ulcer, 12 mm in size, was found in the gastric fundus. Histopathological examination of the lesion revealed chronic mucosal inflammation with acute inflammation and H. pylori infection. There was an obvious mitotic phase with widespread lymphoma. Formal anti-H. pylori treatment was carried out. One month later, a gastroscopy showed a single arched ulcer, measuring 10 mm in size in the gastric fundus. Histopathological examination revealed chronic mucosal inflammation with acute inflammation and a very small amount of H. pylori infection. The mitotic phase was 4/10 high power field, with some heterotypes and an obvious nucleolus. Follow-up gastroscopy 2 mo later showed the gastric ulcer in stage S2. The mucosal swelling had markedly improved. The patient remained asymptomatic, and a follow-up PET-CT was performed 6 mo later. The nodular strong accumulation point had disappeared. Follow-up gastroscopy showed no evidence of malignant cancer. H. pylori-associated severe inflammation can lead to neoplastic changes in histiocytes. This underscores the importance of eradicating H. pylori, especially in those with mucosal lesions, and ensuring proper follow-up to prevent or even reverse early gastric cancer.
Doen?a de Ménétrier: Regress?o Completa após Erradica??o do Helicobacter Pylori
Ramos,R.; Herrera,M.; Hervias,D.; Duarte,P.; Vicente,C.; Casteleiro,C.;
Jornal Português de Gastrenterologia , 2008,
Abstract: ménétrier disease is a rare disease with an unknown ethiology. a 43-year-old man presented at our emergency department with vomiting and oedema of the legs. diagnosis of ménétrier disease was based on clinical, laboratory and histological examination of biopsies performed on gastroscopy. after erradication of helicobacter pylori there was a regression of all clinical complaints and histological abnormalities.
Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura?
Maryam Maghbool,Masood Maghbool,Mehdi Shahriari,Mehran Karimi
Pediatric Reports , 2009, DOI: 10.4081/pr.2009.e2
Abstract: Idiopathic thrombocytopenic purpura (ITP) is an acute self-limited bleeding disorder that can progress to chronic form in 10-15% of the cases. Helicobacter pylori (H. pylori) infection is a possible cause of chronic ITP. We studied 30 children with resistant chronic ITP for H. pylori infection based on the detection of H. pylori fecal antigen. This retrospective study was based on data obtained from medical records of 30 children aged between five and 17 years (median age at ITP diagnosis was ten years). A specially-designed data sheet was used to record information on age, sex, duration of disease, family history of bleeding disorders, previous treatments and median platelet count. In patients with H. pylori infection, antimicrobial treatment consisted of amoxicillin, metronidazol and omeprazol. Response was assessed every month for one year and defined as complete (platelet count >150x109/L) or partial (platelet count between 50 and 150x109/L). We detected H. pylori infection in 5 patients. In 4 of them increased platelet count was seen during one year of follow-up and in one patient the platelet count was acceptable during six months. Although the pathological mechanism of H. pylori-induced thrombocytopenia was unclear in our patient sample, the assessment of H. pylori infection and use of eradication therapy should be attempted in chronic and resistant ITP patients.
Pre-endoscopic screening for Helicobacter pylori and celiac disease in young anemic women  [cached]
Lucy Vannella, Debora Gianni, Edith Lahner, Antonio Amato, Enzo Grossi, Gianfranco Delle Fave, Bruno Annibale
World Journal of Gastroenterology , 2009,
Abstract: AIM: To evaluate the usefulness of pre-endoscopic serological screening for Helicobacter pylori (H pylori) infection and celiac disease in women aged < 50 years affected by iron-deficiency anemia (IDA).METHODS: One hundred and fifteen women aged < 50 years with IDA were tested by human recombinant tissue transglutaminase IgA antibodies (tTG) and anti-H pylori IgG antibodies. tTG and H pylori IgG antibody were assessed using an enzyme-linked immunosorbent assay (ELISA). All women were invited to undergo upper GI endoscopy. During gastroscopy, biopsies were collected from antrum (n = 3), gastric body (n = 3) and duodenum (n = 4) in all patients, irrespective of test results. The assessment of gastritis was performed according to the Sydney system and celiac disease was classified by Marsh’s System.RESULTS: 45.2% women were test-positive: 41 patients positive for H pylori antibodies, 9 patients for tTG and 2 patients for both. The gastroscopy compliance rate of test-positive women was significantly increased with respect to those test-negative (65.4% vs 42.8%; Fisher test P = 0.0239). The serological results were confirmed by gastroscopy in 100% of those with positive H pylori antibodies, in 50% of those with positive tTG and in 81.5% of test-negative patient. Sensitivity and specificity were 84.8% and 100%, respectively for H pylori infection and, 80% and 92.8% for tTG. Twenty-eight patients had positive H pylori antibodies and in all the patients, an active H pylori infection was found. In particular, in 23 out of 28 (82%) patients with positive H pylori antibodies, a likely cause of IDA was found because of the active inflammation involving the gastric body.CONCLUSION: Anti-H pylori IgG antibody and tTG IgA antibody testing is able to select women with IDA to submit for gastroscopy to identify H pylori pangastritis and/or celiac disease, likely causes of IDA.
La relación de Helicobacter pylori con la displasia y el cáncer gástrico en Costa Rica  [cached]
M. Miranda,M. Cháves,L. Orozco,M. A. San Román
Revista de Biología Tropical , 1998,
Abstract: Se comparó la incidencia de la bacteria Helicobacter pylori en un lugar de baja incidencia de cáncer gástrico, Poás (15. 13%) y otro de incidencia muy alta, Puriscal (83. 53%) Se eligió a 185 adultos de cada cantón, similares en edad y sexo y se practicó un estudio serológico para buscar anticuerpos IgG para H. pylori, y una gastroscopía para tomar dos biopsias por caso. Los resultados no apoyan la existencia de una fuerte relación entre H. pylori y cáncer gástrico. Occurrence of the bacterium Helicobacter pylori was compared for two Costa Rican sites with contrasting levels of gastric cancer incidence, Poás (incidence 15. 13%) and Puriscal (83. 53%). A sample of 185 adults of similar age and sex proportions was studied in each site, using both H. pylori antiserum tests and gastroscopy to collect two biopsies per case. No clear association between H. pylori and gastric cancer was found.
The association between Helicobacter pylori infection and lymphoid reaction in patients suffering from dyspepsia in Bahrain  [cached]
Fakhro Abdul Rahman,Fateha Bahaa El Din,Amin Farid Iman,Jamsheer Huda
Saudi Journal of Gastroenterology , 1999,
Abstract: Lymphoid reaction to Helicobacter pylori (H. pylori ) infection varies from simple aggregates to primary gastric lymphoma. This study analyzes various lymphoid reaction to H. pylori infection among 102 patients with dyspepsia in Bahrain during 1994-1995. Cases underwent gastroscopy for gastrointestinal complaints and at least four biopsies were taken from each patient. The prevalence of H. pylori among the study group was 79.4%. Males constituted 63.7%. Lymphoid reaction in the form of lymphoid follicles and lymphoid aggregates were found in 31.4% and 24.5% respectively. The Odds Ratio (OR) of developing lymphoid reaction among H. pylori infected cases, compared to non- H. pylori subjects was 20.1:1, and the relative risk (RR) was 7.13. The OR of developing lymphoid follicles among H. pylori cases compared to non-H. pylon subjects was 11:1 and the RR was 5.63.
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