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Iron deficiency anemia  [cached]
?nci Y?ld?z
Turk Pediatri Ar?ivi , 2009,
Abstract: Iron deficiency anemia is the most frequent and widespread anemia around the world. Its prevalence is increased in infants and adolescent girls. The etiologic factors may vary but anemia is essentially related to iron-deficient nutrition, blood loss and malabsorption. Children may have paleness, cardiovascular and neurologic impacts of anemia, pica, epithelial changes as koilonychia, glossitis, angular stomatitis. Treatment is by oral or parenteral supplementation of iron. (Turk Arch Ped 2009; 44 Suppl: 14-8)
Iron deficiency anemia and its importance in gastroenterology clinical practice  [PDF]
Vu?eli? D.,Nenadi? B.,Pe?ko P.,Bjelovi? M.
Acta Chirurgica Iugoslavica , 2007, DOI: 10.2298/aci0701091v
Abstract: Iron deficiency anemia (IDA) is a universal problem involving individuals of all ages and both sexes and is a common cause of referral to medical departments. This anemia is one of the most common types of anemia. IDA impairs growth and intellectual development in children and adolescent. In women IDA is most common in reproductive period because of menstrual and pregnancy iron losses. IDA affects roughly 10-30% of all pregnancies and, among others morbidities, may contribute of developing postpartum depression. Among other adult patient, chronic occult gastrointestinal bleeding is the leading cause of IDA. Approximately, one third of patients with anemia have iron deficiency and up to two thirds of patients with IDA have serious gastrointestinal lesions detected with esophagogastroduodenoscopy and colonoscopy, including 10-15% with malignancy. However, in practice not all anemic patients undergo appropriate diagnostic tests to detect iron deficiency. Furthermore, a substantial proportion of patients with IDA do not undergo endoscopic evaluation. The approach to its investigation and subsequent therapy depends upon a comprehensive understanding of iron metabolism and heme synthesis. Once diagnosis of iron deficiency or IDA is established, evaluation for the cause of anemia must be appropriate performed and treatment must include corrective replenishment of body stores.
Iron Deficiency Anemia
Hassan Ahari,Nayer Farzbod
Acta Medica Iranica , 1965,
Abstract: The object of this paper is to draw attention to iron deficiency anemia which is the most common nutritional disturbance in infants and children. Iron deficiency anemia constitutes the most prevalent form of anemia in this age group. The records of infants and children admitted to the Pediatric Department of Tehran University Puhlavi Hospital for various ailments during a one year period (Mnrch l!l63 - HHi-t ) were analyzed. 262 infants and children out of a total number of an5, or 7t /., showed iron deficiency anemia detect cd by blood film studies and hemoglobin determination, The majority, 123 or 4{).!t /., of these patients were infants and children between six months and two years of age. The etiology indicates that faulty feeding is the main cause. Infections, parnsitcs, and hemorrhage were among other causes observed. ,'('itll regard to treatment, parenteral iron was preferred because cf its ef., Icctivcncss in short periods of hospital stay. In conclusion, the routine study of blood films and hemoglobin determiualion, especially in the low socio _ economic group of medically less organized countries is advised
The Professional Medical Journal , 2009,
Abstract: Introduction: The adherence to treatment of iron deficiency anemia often is poor in both developed and developing countries. The current standard therapy is oral ferrous sulfate administered 3 times daily. It is possible that adherence would improve with a single-dose daily treatment regimen. Objectives: To compare single versus thrice daily ferrous sulfate for treatment of iron deficiency anemia in young children. Design: Quasi experimental study Setting: Children Department Military Hospital Rawalpindi. Period: From (01 Jan- to31 Mar 05 and 03 Jul to 02 Oct 05) Subjects and Methods: Total 250 patients of iron deficiency anemia (hemoglobin values: 7.0 to 9.9 gm/dl and serum ferritin values: 10 ng/ml or less) were identified. Children divided into two groups and matched on the basis of age; and gender. One group (n = 125) received ferrous sulfate once daily and the control group (n = 125) received ferrous sulfate thrice daily at a total dose of 6 mg/kg/day of elemental iron for 2 months. Hemoglobin and serum ferritin values were measured as baseline and at the end of the study. Results: Successful treatment of anemia (target hemoglobin > 10 gm/dl) occurred in 81.42 % of the single dose and in 79.83 % of thrice daily dose groups and the side effects were minimal between the two groups. Conclusion: A single versus a 3 times daily dose of ferrous sulfate resulted in a similar rate of successful treatment of iron deficiency anemia, without significant side effects.
The Professional Medical Journal , 2007,
Abstract: Objective: To evaluate the safety and efficacy of intra venous iron sucrose(venofer) as comparedto oral iron in treatment of iron deficiency anaemia during pregnancy. Study Design: Prospective study. Pregnantwomen with iron deficiency anaemia were selected from ante natal clinic. Patients were divided into two groups. GroupA: These patients were given oral iron. Group B: These patients were given intravenous sucrose. All patients wereevaluated for adverse effects, clinical and laboratory response >. Results: Intravenous group achieved a higher Hblevel in a shorter period. Group B showed no major side effects while (80%) of patients in Group A developedgastrointestinal symptoms. Conclusion: Intravenous iron sucrose is safe and effective in treatment of iron deficiencyanemia during pregnancy.
M. Ghavamian
Acta Medica Iranica , 1969,
Abstract: In 6 patients with iron deficiency anemia the proliferation of epi, thelial cells of glomeruli were prominent associated with edema and adherence of Bowman's capsule in kidney biopsy, the cause of proliferation is not known.
Intravenous iron treatment for iron deficiency anemia in pregnancy  [cached]
Aykut Barut,Mehmet Harma
Journal of the Turkish-German Gynecological Association , 2009,
Abstract: Iron deficiency anemia in pregnancy can have serious deleterious effects for both mother and fetus. Estimates of prevalence vary widely, but those based on hemoglobin determinations are always considerably higher than those based on ferritin, emphasizing the need for a full hematological work-up in diagnosis. Intravenous therapy usually results in a more rapid increase in hemoglobin and iron stores, but unresolved concerns of possible teratogenicity mean that it should not be used in the first trimester, while cost considerations make it a second choice to oral treatment in the second trimester where this is feasible and effective, except in severe anemia where a more rapid response is desirable. On the other hand, intravenous administration is the first choice treatment in the third trimester and postpartum. All the available intravenous iron preparations are similar in molecular composition, but the exact nature of the complex determines the molecular weight and particle size, which to a large extent determine the properties of the preparation. All are effective and relatively safe, but the higher molecular weight iron dextrans are associated with a greater number of adverse events, and there are concerns about iron toxicity with ferric gluconate. It seems that a degree of expertise and experience and rigorous adherence to protocols and precautions may be required for their safe and effective use.
Diagnosis of iron deficiency anemia in children of Northeast Brazil
Carvalho,Antonio Geraldo Cidr?o; Lira,Pedro Israel Cabral de; Barros,Maria de Fátima Alcantara; Aléssio,Maria Luiza Martins; Lima,Marília de Carvalho; Carbonneau,Marie Annette; Berger,Jacques; Léger,Claude Louis;
Revista de Saúde Pública , 2010, DOI: 10.1590/S0034-89102010000300015
Abstract: objective: to diagnose iron deficiency anemia in children. methods: the study was conducted with a sample of 301 children aged six to 30 months attending public daycare centers in the city of recife, northeast brazil, in 2004. the diagnoses of anemia were based on a combination of different hematological and biochemical parameters: hemoglobin, mean corpuscular volume, ferritin, c-reactive protein, transferrin saturation and transferrin receptor. the chi-square test and anova were used in the statistical analysis. results: of all children studied, 92.4% had anemia (hb <110 g/l) and 28.9% had moderate/severe anemia (hb <90 g/l). lower levels of hemoglobin were found in children aged 6-17 months. iron deficiency was found in 51.5% of children using ferritin (<12 μg/l) as parameter. taking into consideration the combination of hemoglobin level, ferritin and transferrin receptor, 58.1% had anemia with iron deficiency, 34.2% had anemia without iron deficiency and 2.3% had iron deficiency without anemia. mean ferritin concentration was significantly higher in children with high c-reactive protein when compared with those with normal levels (22.1 vs. 14.8 μg/l). conclusions: the use of several biochemical and hematological parameters allowed to diagnosing iron deficiency anemia in two thirds of children, suggesting a need to identify other determinants of anemia without iron deficiency.
Dhatri Loha In The Management Of Iron Deficiency Anemia
Ragamala KC,Kumar T P,Shailaja U
International Journal of Ayurvedic Medicine , 2010,
Abstract: Iron deficiency anemia is currently the most widespread micronutrient deficiency affecting nearly 1.5 billion people globally i.e. around 1/3 of the whole population. About 70% of Indians are found to be anemic out of which, 95% of anemia is due to iron deficiency. Infants, preschool children and adolescents are at greatest risk of developing iron deficiency and its resultant anemia. It is mostly seen in rural areas and in communities of low socio-economic group. Because of this reason IDA was selected for this study to assess the efficacy of Dhatriloha. So to evaluate the effect of Dhatriloha in the management of Iron deficiency anemia in children aged between 1-6years the present study has been taken up. 30 patients, from Kaumarabhritya OPD and IPD of SDMCA & H, Hassan, fulfilling the inclusion and exclusion criteria were selected in to study. Dhatriloha was administered in a dose of 250mg twice daily for a period of 60 days. The cases were recorded according to the case performa and observations were recorded. Symptoms were scored and statistically analyzed for any change before and after the study. In the group statistically highly significant change (P = <0.001) was observed in the signs and symptoms of IDA. There was a statistically highly significant response in hemoglobin concentration in the group (P =<0.001).
A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases  [cached]
Fernando Bermejo, Santiago García-López
World Journal of Gastroenterology , 2009,
Abstract: Iron deficiency (ID), with or without anemia, is often caused by digestive diseases and should always be investigated, except in very specific situations, as its causes could be serious diseases, such as cancer. Diagnosis of ID is not always easy. Low serum levels of ferritin or transferrin saturation, imply a situation of absolute or functional ID. It is sometimes difficult to differentiate ID anemia from anemia of chronic diseases, which can coexist. In this case, other parameters, such as soluble transferrin receptor activity can be very useful. After an initial evaluation by clinical history, urine analysis, and serological tests for celiac disease, gastroscopy and colonoscopy are the key diagnostic tools for investigating the origin of ID, and will detect the most important and prevalent diseases. If both tests are normal and anemia is not severe, treatment with oral iron can be indicated, along with stopping any treatment with non-steroidal anti-inflammatory drugs. In the absence of response to oral iron, or if the anemia is severe or clinical suspicion of important disease persists, we must insist on diagnostic evaluation. Repeat endoscopic studies should be considered in many cases and if both still show normal results, investigating the small bowel must be considered. The main techniques in this case are capsule endoscopy, followed by enteroscopy.
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