Embryonal Rhabdomyosarcoma of the Uterine Cervix: Two Cases Report and Literature Review
Open Journal of Obstetrics and Gynecology (OJOG)
Embryonal rhabdomyosarcoma (RMS) of
the uterine cervix is a rare and extremely aggressive malignant entity.
However, prognosis seems to be improved with the use of multimodality approach
treatment. Cases: We report the cases of 50- and 51-year-old women, presenting
with vaginal bleeding and mass. The two patients underwent radical surgery.
Histological examination revealed RMS of uterine cervix. Treatment was
effective in the first case but despite the chemotherapy, the second patient
died two months later. Discussion and Conclusions: The prognosis of the
cervical embryonal RMS depends on clinical and histological features. The
current treatment protocols are based on trials done on pediatric patients.
Studies on embryonal RMS treatment and outcomes are limited in women over forty
years. In patients with unfavorable prognosis characteristics, the
multimodality approach including surgery, adjuvant chemo and radiotherapy can
be effective. Otherwise, surgery alone can effectively be proposed.