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COEXISTENCE OF TUBERCULOSIS AND CARCINOMA IN UTERINE CERVIX - A CASE REPORT  [cached]
Surekha Tayade,Madhuri Bagde
International Journal of Biomedical and Advance Research , 2012, DOI: 10.7439/ijbar.v3i7.521
Abstract: Coexistence of carcinoma and tuberculosis of uterine cervix is rare. As the clinical presentation of both the entities is same, proper histo - pathological evaluation is needed to diagnose a simultaneous occurrence or a mere resemblance of one to the other. Immunosuppressive states may propagate the existence of the two together. However, whether tuberculosis, a chronic inflammatory condition facilitates carcinogenesis is yet to be determined.
Primary Uterine Cervix Schwannoma: A Case Report and Review of the Literature  [PDF]
Maryam Tahmasbi,Johnny Nguyen,Masoumeh Ghayouri,Yuan Shan,Ardeshir Hakam
Case Reports in Pathology , 2012, DOI: 10.1155/2012/353049
Abstract: Schwannoma (neurilemmoma) is a benign peripheral nerve sheath tumor that occurs in a wide variety of locations; however, its finding in the uterine cervix is extremely rare. We report a case of an incidental primary benign cervical schwannoma in a 48-year-old woman. In the English literature, a few cases of primary schwannoma of the cervix have been reported, which include seven cases of primary malignant cervical schwannoma and only two that are benign. These cases are reviewed in the following discussion. 1. Introduction Cervical schwannoma is a very rare entity in the field of gynecologic pathology. In this paper, we describe an incidental benign cervical schwannoma in a 48-year-old woman. 2. Case Presentation A 48-year-old woman presented to the emergency department with a sharp, severe left lower quadrant pain. Ultrasound imaging of the abdomen and pelvis demonstrated an enlarged uterus with multiple masses (highly suggestive of leiomyoma), an 8.7?cm left adnexal complex mass, and minimal fluid in the pelvis. Subsequent computed tomography (CT) scan of the abdomen and pelvis confirmed the above findings. Pelvic examination revealed a posterior cervix with an enlarged, boggy uterus, but no tenderness. The cervix could not be visualized on speculum exam due to a distorted uterus. No palpable inguinal lymph nodes were identified. The remainder of the physical exam was unremarkable. Laboratory workup was notable for an elevated CA-125 level (125.9?U/mL). The patient’s past medical history was significant for breast cancer status after lumpectomy, radiation therapy, and Tamoxifen therapy. Her past gynecologic history was remarkable for laparoscopic myomectomy (12 years prior to this encounter). She resumed having regular cycles every 30 days and denied any recent abnormal bleeding, weight loss, and gastrointestinal or genitourinary symptoms. The patient was advised that the best approach would be to remove the uterus and ovaries and send them for intraoperative consultation during the surgery. Subsequently, the patient underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH/BSO). Exploration of the pelvis at the time of surgery revealed a large multilobated uterus that was about 16 weeks in size, as well as hemorrhagic cysts on both ovaries. The left ovary was no longer 8 to 9?cm, but was instead around 4 to 5?cm. Additionally, there was also some blood in the pelvis. Pelvic washings were obtained, and a representative section from the left ovary was submitted for frozen section examination. The diagnosis was reported as a
Embryonal Rhabdomyosarcoma of the Uterine Cervix: Two Cases Report and Literature Review  [PDF]
Khlifi Abdeljalil, Boukadida Asma, Mouna Kouira, Hachani Faten, Meddeb Sawssen, Hidar Samir, Bibi Mohamed, Essaidi Habib, Khairi Hedi
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.414122
Abstract: Introduction: Embryonal rhabdomyosarcoma (RMS) of the uterine cervix is a rare and extremely aggressive malignant entity. However, prognosis seems to be improved with the use of multimodality approach treatment. Cases: We report the cases of 50- and 51-year-old women, presenting with vaginal bleeding and mass. The two patients underwent radical surgery. Histological examination revealed RMS of uterine cervix. Treatment was effective in the first case but despite the chemotherapy, the second patient died two months later. Discussion and Conclusions: The prognosis of the cervical embryonal RMS depends on clinical and histological features. The current treatment protocols are based on trials done on pediatric patients. Studies on embryonal RMS treatment and outcomes are limited in women over forty years. In patients with unfavorable prognosis characteristics, the multimodality approach including surgery, adjuvant chemo and radiotherapy can be effective. Otherwise, surgery alone can effectively be proposed.
Malignant Mixed Mullerian Tumours (Carcinosarcoma of Uterine Cervix) (MMMT): Case Report and Review of Literature  [PDF]
Oguntayo O. Adekunle, Avideme Solomon, Kolawole O. Abimbola, Adesiyun G. Adebiyi, Samaila O. Modupeola, Adewuyi A. Sunday
Open Journal of Clinical Diagnostics (OJCD) , 2018, DOI: 10.4236/ojcd.2018.81001
Abstract: Carcinosarcoma of the uterine cervix are very rare malignancy of the female reproductive tract with poor prognosis. Only fifty cases have been reported in literature until 2013. We report a 49 years old Para 7 + 3 presenting with vaginal bleeding, offensive discharge with intermittent abdominal pain. On examination an impression of a cervical polyp was made. She had total abdominal hysterectomy and bilateral salpingoophorectomy. The histological diagnosis of carcinosarcoma of the uterine cervix was made. She had chemoradiation therapy as adjuvant therapy in view of the diagnosis. Although cancer of the cervix is the second commonest cancer worldwide and the leading cause of cancer death in women, this particular histological variant is very rare, as such no standard protocol of management developed for it yet and it carries a very poor prognosis.
Metastatic Carcinoma of the Uterine Cervix from Rectal Carcinoma: A Case Report and Review of the Literature  [PDF]
Motoki Matsuura, Masato Tamate, Masahiro Suzuki, Tasuku Mariya, Sakura Takada, Yuta Tabuchi, Mizue Teramoto, Seiro Satohisa, Ryoichi Tanaka, Masahiro Iwasaki, Kaori Fukunaka, Noriyoshi Fukunaka, Satoshi Tanaka, Tsuyoshi Saito
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.410085
Abstract:

Primary adenocarcinomas of the uterine cervix account for 5% - 15% of all cervical malignancies, but secondary adenocarcinomas from extragenital cancers are rare. Only 35 cases have been reported in the literature since 1941. We report a 52-year-old Japanese woman who had been treated for rectal adenocarcinoma (Dukes C, stage IIIb) and who was diagnosed with primary uterine cervical carcinoma (FIGO stage Ib2) two years later. A radical hysterectomy was performed and the surgical specimen showed metastatic adenocarcinoma of the uterine cervix from rectal cancer without direct extension. Immunohistochemical staining was positive for cytokeratin 20 and CDX2, and negative for cytokeratin 7. Immunohistochemical staining is important for distinguishing between primary and secondary adenocarcinomas of the cervix, but histologic findings alone are not always adequate to establish the site of the primary lesion. The distinction between primary and secondary adenocarcinomas of the cervix is important for patient management and prognosis. Therefore, the possibility of metastatic adenocarcinoma should be considered whenever a diagnosis of adenocarcinoma of the cervix is received.

Bony Calvarium as the Sole Site ofMetastases in Squamous Cell Carcinomaof the Uterine Cervix  [cached]
Niloofar Ahmadloo,Farzad Bidouei,Shapour Omidvari,Mansour Ansari
Middle East Journal of Cancer , 2010,
Abstract: Isolated skeletal metastasis to the bony calvarium is extremely rare in patients with squamous cell carcinoma of the uterine cervix. We describe the clinical and imaging findings in a case of squamous cell carcinoma of the uterine cervix with metastases tothe bony calvarium as the sole site of metastasis. The patient was a 65-year-old woman with squamous cell carcinoma of the uterine cervix, FIGO stage IIIb, whose initial treatement was chemoradiation therapy. After 22 sessions of external-beam radiation,she developed headaches. On physical examination she had skull bone tenderness. On plain skull X-ray, there were osteolytic bony lesions. Brain MRI showed multiple enhancing skull bone metatstses. Eventually, a whole body bone scintigraphy revealed isolated diffuse increased activity in the bony calvarium. In the literature review, wefound only three similar cases of cervical cancer with scalp metastases and involvement of the bony calvarium.
Microinvasive carcinoma of the uterine cervix in a 14-year-old adolescent: case report and literature review
Gon?alves, Carla Vitola;Quintana, Silvana Maria;Marcolin, Alessandra Cristina;Duarte, Geraldo;Costa, Juvenal Soares Dias da;Karam, Fabine;Bianchi, M?nia Steigleder;
Sao Paulo Medical Journal , 2009, DOI: 10.1590/S1516-31802009000200010
Abstract: context: cancer of the uterine cervix is rare during adolescence. the reported rates are 0/100,000 adolescents aged 10 to 19 years and 1.7/100,000 women aged 20 to 24 years. however, several studies have shown increasing incidence of preneoplastic lesions at increasingly early ages. case report: this paper reports a case of microinvasive carcinoma of the uterine cervix in a 14-year-old patient with menarche at 10 years of age and first coitus at 12 years of age. the objective of the present report was to alert gynecologists and pediatricians regarding the need for cervical carcinoma prevention among sexually active adolescents, based on educational programs that explain the purpose of colpocytological examinations and encourage their use, along with condom use and limitation of the number of sexual partners.
Conservative Treatment of Stage IA1 Adenocarcinoma of the Uterine Cervix during Pregnancy: Case Report and Review of the Literature  [PDF]
Francesco Sopracordevole,Diego Rossi,Jacopo Di Giuseppe,Marta Angelini,Pierino Boschian-Bailo,Monica Buttignol,Andrea Ciavattini
Case Reports in Obstetrics and Gynecology , 2014, DOI: 10.1155/2014/296253
Abstract: Microinvasive adenocarcinoma (MIAC) of the uterine cervix is rare in pregnancy. Published data on conservative treatment of MIAC both in pregnant and nonpregnant women are scarce. A conservatively treated case of MIAC in a 13-week-pregnant woman after a diagnosis of atypical glandular cells (AGC) on pap smear at the 6th week of pregnancy is presented. The problems of suspected adenocarcinoma in situ (AIS) on biopsy and MIAC on cone biopsy in pregnancy, as well as the risks and benefits of a conservative treatment are discussed. After colposcopic guide laser cervical conization and expression of informed consent the patient underwent followup and vaginal delivery at 40 weeks plus 3 days of gestation. In this case, no obstetric complication has been recorded after the cervical conization, and after a followup of 18 months the patient was alive and free of disease, with negative results as far as pap smear, colposcopy, HPV status, and cervical curettage are concerned. In a stage Ia1 disease of endocervical type, with clear margins and without lymph-vascular space invasion, cervical conization performed during the second trimester may be considered a definitive and safe treatment, at least up to delivery, after expression of informed consent by the woman. 1. Introduction Microinvasive adenocarcinoma of the cervix (MIAC) is occasionally found in the definitive histology in the specimens of conization performed because of squamous or glandular intraepithelial cervical neoplasia or suspicious for adenocarcinoma in situ (AIS). MIAC corresponds to FIGO stages Ia1 and Ia2, and its frequency, compared to all microinvasive cervical cancers (MICC), is about 12% [1]. The large presence of cytological-based screening programs in developed countries led to an increasing number of diagnoses in younger women [2], often in childbearing age. There are enough data on the safety of fertility-sparing treatment of squamous microinvasive cancers (MISC) [3–5] but few on fertility sparing treatment of MIAC [6, 7], in particular, with long-term followup [8, 9]. The occurrence of cervical cancer during pregnancy involves ethical and technical problems, related to the survival of the woman and fetal viability. Although the conservative treatment of MISC [10, 11] and small stage IB1 squamous cancer during pregnancy [12, 13] seems to be safe, scarce data are available for MIAC conservative treatment in pregnancy [2]. This case report is an addition to the few published cases of conservatively treated MIACs during pregnancy. 2. Case Presentation A 32-year-old pregnant woman, PARA 0000,
Cisplatin chemotherapy (without erythropoietin) and risk of life-threatening thromboembolic events in carcinoma of the uterine cervix: the tip of the iceberg? A review of the literature
Jon C Anders, Perry W Grigsby, Anurag K Singh
Radiation Oncology , 2006, DOI: 10.1186/1748-717x-1-14
Abstract: A review of several prospective trials demonstrates no treatment related grade 4 cardiovascular toxicities and only two grade 5 toxicities in 1424 (0.1%) collective patients. A recent publication and our own unpublished experience finds 6 of 128 (4.7%) patients developed grade 4 to 5 cardiovascular (thrombosis/embolism) toxicity. The differenc in incidence of severe or life threatening cardiovascular toxicity of 0.1 versus 4.7% is highly statistically significant (p < 0.00001.)This dramatic difference in incidence of cardiovascular toxicity raises the possibility that cardiovascular toxicities were inadequately reported on the listed prospective trials. For those patients enrolled in prospective trials, we suggest that thromboses should be diligently documented and reported. Only after the true incidence of thromboses is established can we implement appropriate levels of early screening and intervention that may prevent life threatening complications.A retrospective, case control study of 147 with carcinoma of the cervix or vagina treated with chemoradiotherapy with or without erythropoietin showed a 23 versus 3% incidence of TE. [1] Such recent findings of an elevated risk of cardiovascular toxicity, specifically thromboembolic events (TE), in patients receiving concurrent irradiation, cisplatin chemotherapy and erythropoietin have spurred interest in the true incidence of TE in patients receiving concurrent irradiation and cisplatin chemotherapy in the absence of erythropoietin.The use of cisplatin, either alone or in combination with other chemotherapeutic agents, has become the standard of care for the treatment of various solid tumors. Specifically, the routine use of cisplatin in the treatment of cancers of the uterine cervix has been cemented with the publication of several recent prospective randomized trials [2-8].When reporting the results of these prospective trials, the scoring of treatment related toxicity is site specific. For example, TE are scored as
Papillary Serous Carcinoma of the Uterine Cervix with Lung Metastasis  [PDF]
Maliha Khan,Alan D. Gilman,Sobia Nizami,Aram Barbaryan,Alaa M. Ali,Aibek E. Mirrakhimov
Case Reports in Oncological Medicine , 2014, DOI: 10.1155/2014/683103
Abstract: Papillary serous carcinoma of the uterine cervix is a rare histological variant of cervical adenocarcinoma, with a very small number of cases reported. It is an aggressive tumor and is usually diagnosed at advanced stages by the time of diagnosis. Early-stage tumors can be treated with surgery and/or radiotherapy, while late-stage tumors have been treated with chemotherapy plus radical surgery with intermittent success. Here we report a case of metastatic papillary serous carcinoma observed at our hospital, which has been treated with debulking surgery and combination chemotherapy with carboplatin and paclitaxel. 1. Introduction Cervical adenocarcinoma accounts for 10–20% of invasive cervical cancers and has a poor radiosensitivity and chemosensitivity [1, 2]. Papillary serous carcinoma of the uterine cervix (PSCC) is a very rare variant of cervical adenocarcinoma, which histologically resembles the same tumor occurring more commonly in the ovary, fallopian tube, endometrium, and peritoneum [3]. It is recognized as an aggressive neoplasm that can be pure or mixed with other adenocarcinoma subtypes [3]. PSCC is staged similarly to other types of cervical cancer and is presented in Table 1 [4]. It is usually found with lymph node metastases and occasionally in Stage III or IV (staging is presented in Table 1) [2]. The diagnosis of PSCC should be made after metastasis from other sites, particularly the endometrium, has been excluded [5]. There is a paucity of the literature on PSCC with only 46 cases being reported to date [2]. Here we describe a recent case of primary PSCC with pulmonary metastases diagnosed at our hospital. Table 1: Carcinoma of the cervix uteri: Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) staging system (adapted from Reference [ 4]). 2. Case Presentation A 64-year-old African American female, gravida (G) 0 with menopause at age 52, presented with a four-week history of vaginal bleeding in July 2013. The bleeding occurred daily, ranging in severity from spotting to moderate bleeding. Her review of systems was otherwise negative, and she had no documented past medical history. She reported that her last Pap smear was performed several years ago and was normal. The vital signs were unremarkable. On pelvic examination, cervical ulceration of 2-3?cm with friability was found. The physical examination was otherwise unremarkable. Laboratory investigations showed only microcytic anemia with a hemoglobin level of 11.3?g/dL (normal range: 14.0–18.0?gm/dL) and CA-125 of 343 (normal range: 0–35?U/mL). On transabdominal
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