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Trend report on international and Japanese standardization activities for bioceramics and tissue engineered medical products  [cached]
Sadami Tsutsumi
Science and Technology of Advanced Materials , 2010,
Abstract: Since porous and injectable bioceramics have recently been utilized often as scaffolds for bone regenerative medicine, the need for their standardization has increased. One of the standard proposals in ISO/TC150 and JIS has been a draft for characterization of the porous bioceramic scaffolds in both micro- and macro-scopic aspects. ISO/TC150/SC7 (Tissue engineered medical products) has been co-chaired by Professor J E Lemons, Department of Surgery, University of Alabama at Birmingham and Dr R Nakaoka, Division of Medical Devices, National Institute of Health Sciences, Japan. The scope of SC7 has been specified as 'Standardization for the general requirements and performance of tissue engineered medical products with the exclusion of gene therapy, transplantation and transfusion'.
Tissue Engineered Human Skin Equivalents  [PDF]
Zheng Zhang,Bozena B. Michniak-Kohn
Pharmaceutics , 2012, DOI: 10.3390/pharmaceutics4010026
Abstract: Human skin not only serves as an important barrier against the penetration of exogenous substances into the body, but also provides a potential avenue for the transport of functional active drugs/reagents/ingredients into the skin (topical delivery) and/or the body (transdermal delivery). In the past three decades, research and development in human skin equivalents have advanced in parallel with those in tissue engineering and regenerative medicine. The human skin equivalents are used commercially as clinical skin substitutes and as models for permeation and toxicity screening. Several academic laboratories have developed their own human skin equivalent models and applied these models for studying skin permeation, corrosivity and irritation, compound toxicity, biochemistry, metabolism and cellular pharmacology. Various aspects of the state of the art of human skin equivalents are reviewed and discussed.
Regenerative Medicine from Protocol to Patient  [cached]
Gustav Steinhoff
Journal of Stem Cells and Regenerative Medicine , 2011,
Abstract: The essentials of the upcoming and rapidly changing specialty of regenerative medicine, which has kindled high hopes among the clinical and scientific community as well as the society, are presented concisely in this book. Considering the multivariate sub-specialties within regenerative medicine, starting with cell biology and allied basic sciences through translational research to clinical application in various specialties of medicine, enormous efforts are mandatory to bring a comprehensive text book of this nature. The authors deserve kudos for this. This book comprehensively describes and reviews the current progress in stem cell research and regenerative medicine, in five main parts: (I) Biology of Tissue Regeneration; (II) Stem Cell Science and Technology; (III) Tissue Engineering, Biomaterials and Nanotechnology; (IV) Regenerative Therapies; and (V) Regulation and Ethics. It fully covers all the major components in the field. Each chapter, written by the experts in the respective areas of work, throws light on the intricacies in detail, making this book immensely useful for students, clinicians and scientists interested in regenerative medicine. However, there is still scope for further refinement of some chapters. In Part II Stem Cell Science and Technology, three important stem cell types- muscle stem cells (satellite cells), stem cells from the skin and hair follicles, and stem cells from the gut epithelium-may be added as three individual chapters which probably the authors could consider for the next edition, as these cell types represent unique stem cells that have distinct properties and replenish specifically muscle, skin, hair, and gut epithelium respectively. In the chapter on cardiac stem cells, a table summarizing the properties of the four different types of cardiac stem cells described in the text may give readers more clear comparison of the pros and cons on these cells and know their properties better. The future direction (section 12.5) discussed the quality of cells and efficiency of the in vivo viability of transplantation. It would be great to add additional discussions on some other directions, such as improving the integration of the cardiac stem cells with host and combining with tissue engineering to improve transplantation. A new chapter to include the clinical trials of various stem cell therapies: both successful ones and otherwise, as well, the inclusion of the perspectives for some promising cell therapies, which have not been applied in clinic, probably would have done more justice from the perspectives of clinicians
Regenerative medicine: a review
Porcellini, Adolfo;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009000800017
Abstract: regenerative medicine is a technique to replace or repair defective or diseased tissue or organs by in vitro design with in vivo usage. it can be considered a relatively new branch of medicine born in 1997 when whithman dh et al. proposed to integrate platelet enriched plasma (prp) in fibrin glue. in 1998 marx et al. demonstrated that prp was able to induce bone regeneration of the jaw. in the same period it was discovered that a fraction of stem cells of bone marrow origin was able to repair several mesenchymal tissues or organs.
Study of regenerative medicine in China: demands and clinical translation  [cached]
Xiao-bing FU
Medical Journal of Chinese People's Liberation Army , 2012,
Abstract: The repair and regeneration of tissue is a well-discussed topic. Over the past 20 years, with the development of genetics, auxology, stem cell biology, and tissue engineering, tissue repair and regeneration have rapidly developed as emerging "Regenerative Medicine". Regenerative medicine has significant market demand in China. Based on national statistics, injury and poisoning patients rank third in afflictions in city hospitals (accounting for 9.13%) and rank second in afflictions in county hospitals (accounting for 14.07%). Totally, approximately one hundred million patients suffered from traumatic, genetic and metabolic diseases in China and demand reparative and regenerative medical treatment each year. The Chinese government and its related departments have always attached great importance and support to the development of regenerative medicine, and the Chinese academic circle is involved in a very wide range of diseases and injuries including regenerative medical theory and technology. Stem cell biology, organ engineering and duplication, tissue engineering research and production have developed rapidly, and great portion of these studies have started to appear in applications, which have aroused extensive concerns in international professional circle. In the next 10 years, the Chinese regenerative medical system will be further improved, in both statute and rules, clinical translation will be further accelerated. Breakthroughs are expected in induced differentiation of stem cells and synchronous repair and regeneration of multiple organs, construction of major organs by tissue engineering, large-scale applications of tissue engineering products, and other aspects.
Esophagus and regenerative medicine  [cached]
Ricardo Londono,Blair A Jobe,Toshitaka Hoppo,Stephen F Badylak
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i47.6894
Abstract: In addition to squamous cell carcinoma, the incidence of Barrett’s esophagus with high-grade dysplasia and esophageal adenocarcinoma is rapidly increasing worldwide. Unfortunately, the current standard of care for esophageal pathology involves resection of the affected tissue, sometimes involving radical esophagectomy. Without exception, these procedures are associated with a high morbidity, compromised quality of life, and unacceptable mortality rates. Regenerative medicine approaches to functional tissue replacement include the use of biological and synthetic scaffolds to promote tissue remodeling and growth. In the case of esophageal repair, extracellular matrix (ECM) scaffolds have proven to be effective for the reconstruction of small patch defects, anastomosis reinforcement, and the prevention of stricture formation after endomucosal resection (EMR). More so, esophageal cancer patients treated with ECM scaffolds have shown complete restoration of a normal, functional, and disease-free epithelium after EMR. These studies provide evidence that a regenerative medicine approach may enable aggressive resection of neoplastic tissue without the need for radical esophagectomy and its associated complications.

- , 2016, DOI: 10.7507/1002-1892.20160296
Abstract: 目的分析脱细胞鱼皮基质作为新型组织工程支架材料的最新研究进展,讨论该材料用于医学临床的可行性及风险管理。 方法基于对脱细胞鱼皮基质研究最新进展的广泛调研,综合分析其研发、应用现况,提出应重点关注的关键问题。 结果脱细胞鱼皮基质作为新型细胞外基质有巨大的临床应用潜力,但我国在该领域的研究几乎空白,国外对该类产品的转化医学研究刚刚兴起,主要集中于人工皮肤、外科补片、创伤敷料等方面。 结论脱细胞鱼皮基质作为组织工程支架新产品的开发具有良好的临床可行性和必要性,但作为新策略、新产品尚需进行大量的应用基础研究。
ObjectiveTo review the recent research progress of acellular fish skin as a tissue engineered scaffold, and to analyze the feasibility and risk management in clinical application. MethodsThe research and development, application status of acellular fish skin as a tissue engineered scaffold were comprehensively analyzed, and then several key points were put forward. ResultsAcellular fish skin has a huge potential in clinical practice as novel acellular extracellular matrix, but there have been no related research reports up to now in China. As an emerging point of translational medicine, investigation of acellular fish skin is mainly focused on artificial skin, surgical patch, and wound dressings. ConclusionDevelopment of acellular fish skin-based new products is concerned to be clinical feasible and necessary, but a lot of applied basic researches should be carried out.
Functionalized Nanostructures with Application in Regenerative Medicine  [PDF]
Macarena Perán,María A. García,Elena López-Ruiz,Milán Bustamante,Gema Jiménez,Roberto Madeddu,Juan A. Marchal
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13033847
Abstract: In the last decade, both regenerative medicine and nanotechnology have been broadly developed leading important advances in biomedical research as well as in clinical practice. The manipulation on the molecular level and the use of several functionalized nanoscaled materials has application in various fields of regenerative medicine including tissue engineering, cell therapy, diagnosis and drug and gene delivery. The themes covered in this review include nanoparticle systems for tracking transplanted stem cells, self-assembling peptides, nanoparticles for gene delivery into stem cells and biomimetic scaffolds useful for 2D and 3D tissue cell cultures, transplantation and clinical application.
Cell and biomolecule delivery for regenerative medicine
Ian O Smith and Peter X Ma
Science and Technology of Advanced Materials , 2010,
Abstract: Regenerative medicine is an exciting field that aims to create regenerative alternatives to harvest tissues for transplantation. In this approach, the delivery of cells and biological molecules plays a central role. The scaffold (synthetic temporary extracellular matrix) delivers cells to the regenerative site and provides three-dimensional environments for the cells. To fulfil these functions, we design biodegradable polymer scaffolds with structural features on multiple size scales. To enhance positive cell–material interactions, we design nano-sized structural features in the scaffolds to mimic the natural extracellular matrix. We also integrate micro-sized pore networks to facilitate mass transport and neo tissue regeneration. We also design novel polymer devices and self-assembled nanospheres for biomolecule delivery to recapitulate key events in developmental and wound healing processes. Herein, we present recent work in biomedical polymer synthesis, novel processing techniques, surface engineering and biologic delivery. Examples of enhanced cellular/tissue function and regenerative outcomes of these approaches are discussed to demonstrate the excitement of the biomimetic scaffold design and biologic delivery in regenerative medicine.
How Can Nanotechnology Help to Repair the Body? Advances in Cardiac, Skin, Bone, Cartilage and Nerve Tissue Regeneration  [PDF]
Macarena Perán,María Angel García,Elena Lopez-Ruiz,Gema Jiménez,Juan Antonio Marchal
Materials , 2013, DOI: 10.3390/ma6041333
Abstract: Nanotechnologists have become involved in regenerative medicine via creation of biomaterials and nanostructures with potential clinical implications. Their aim is to develop systems that can mimic, reinforce or even create in vivo tissue repair strategies. In fact, in the last decade, important advances in the field of tissue engineering, cell therapy and cell delivery have already been achieved. In this review, we will delve into the latest research advances and discuss whether cell and/or tissue repair devices are a possibility. Focusing on the application of nanotechnology in tissue engineering research, this review highlights recent advances in the application of nano-engineered scaffolds designed to replace or restore the followed tissues: (i) skin; (ii) cartilage; (iii) bone; (iv) nerve; and (v) cardiac.
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