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Antibacterial effect of borage (Echium amoenum) on Staphylococcus aureus
Abolhassani, Mohsen;
Brazilian Journal of Infectious Diseases , 2004, DOI: 10.1590/S1413-86702004000500008
Abstract: borage (echium amoenum) is a large annual plant of the boraginaceae family, which grows in most of europe and in northern iran. the borage flower is used as a medicinal herb in france and other countries. iranian borage is used in traditional medicine for infectious diseases, flu and as an anti-febrile. we tested the aqueous extract of borage dried flowers in vitro for its antibacterial activity. the extract showed concentration-dependent antibacterial activity against staphylococcus aureus 8327. this activity was heat resistant, but the activity of freeze-dried extract gradually diminished during a 90-day period. the traditional use of iranian borage flowers for infectious diseases and for controlling fever appears to be justified.
Antibacterial Activity of Long-Chain Fatty Alcohols against Staphylococcus aureus  [PDF]
Naoko Togashi,Akiko Shiraishi,Miki Nishizaka,Keisuke Matsuoka,Kazutoyo Endo,Hajime Hamashima,Yoshihiro Inoue
Molecules , 2007, DOI: 10.3390/12020139
Abstract: The antibacterial activity against Staphylococcus aureus of long-chain fatty alcohols was investigated, with a focus on normal alcohols. The antibacterial activity varied with the length of the aliphatic carbon chain and not with the water/octanol partition coefficient. 1-Nonanol, 1-decanol and 1-undecanol had bactericidal activity and membrane-damaging activity. 1-Dodecanol and 1-tridecanol had the highest antibacterial activity among the long-chain fatty alcohols tested, but had no membrane-damaging activity. Consequently, it appears that not only the antibacterial activity but also the mode of action of long-chain fatty alcohols might be determined by the length of the aliphatic carbon chain.
Antibacterial and Antifungal Activity of Iranian Propolis Against Staphylococcus aureus and Candida albicans
Yousef-Beigi Ghasem,Ownagh Abdolghaffar,M. Hasanloei
Pakistan Journal of Biological Sciences , 2007,
Abstract: Propolis samples from West North region of Iran were studied for their antibacterial (against Staphylococcus aureus) and antifungal (against Candida albicans) activities. In this article, yield of extracts and their pH values were measured. Antibacterial and antifungal activities of Ethanol- Extracted Propolis (EEP) were investigated by Petri dish bioassay method. Dilutions of EPP in agar with serial concentrations ranging from 0/04 to 10% (W/V) were prepared and antimicrobial activities were determined as Minimal Inhibitory Concentrations (MIC). All samples were active against the fungal and bacterial test strains. MIC values for different propolis samples against Staphylococcus aureus were, respectively 4, 3 and 1.5% (W/V) and against Candida albicans were, respectively 2, 4 and 3% (W/V).
Antibacterial Effect of Garlic (Allium sativum L.) on Staphylococcus aureus  [PDF]
M. Shokrzadeh,A.G. Ebadi
Pakistan Journal of Biological Sciences , 2006,
Abstract: Garlic (Allium sativum L.) has an important dietary and medicinal role for centuries. It is a large annual plant of the Liliaceae family, which grows in most of Europe and in northern Iran. Iranian garlic is used in traditional medicine for infectious diseases, flu and as an anti-febrile. The present study tested the aqueous extract of garlic in vitro for its antibacterial activity. The extract showed concentration-dependent antibacterial activity against Staphylococcus aureus 8327. This activity was heat resistant, but the activity of freeze-dried extract gradually diminished during a 90 days period. The traditional use of Iranian garlic for infectious diseases and for controlling fever appears to be justified.
Antibacterial Effect of Component of Terminalia muelleri Benth. against Staphylococcus aureus  [PDF]
K. Anam,A.G. Suganda,E.Y. Sukandar,L. Broto S. Kardono
International Journal of Pharmacology , 2010,
Abstract: A component of ethylacetate extract of Terminalia muelleri Benth. leaves, was found to inhibit Staphyloccoccus aureus and Methicillin-resistant Staphylococcus aureus growth therefore, the aims of this study were to investigate the effect of the active components on morphology of bacteria cell which was observed by Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM). Tetracycline HCl, penicillin G and vancomycin HCl were used as reference antibiotic. The active component at twice of the MIC caused shrinkage and thinning of the cell wall. The cell damage pattern which is caused by the active compound was similar to the damage caused by vancomycin HCl. It was explained that the antibacterial target of action of the active compound was inhibit the synthesis of the cell wall.
Antibacterial Activity of Eucalyptus Extracts on Methicillin Resistance Staphylococcus aureus
Fatemeh Mohsen Nezhad,Habib Zeigham,Ali Mota,Morteza Sattari,Abbas Yadegar
Research Journal of Biological Sciences , 2012,
Abstract: Methicillin-resistant S. aureus is a major cause of community and hospital acquired infections. There is an urgent need to develop anti-MRSA agents with novel mechanisms of action. Eucalyptus is a tall and evergreen tree, which is cultivated in many countries. Essential oil of Eucalyptus and their major constituents possess toxicity against a wide range of microbes including bacteria and fungi. In the present study, antibacterial activity of Eucalyptus alcoholic and aquatic extracts were investigated against a battery of clinically important MRSA strains. The alcoholic extract of Eucalyptus leaves was obtained by 95% ethanol and aquatic extract by boiling from the fresh leaves. Different concentrations of extracts were prepared and used for the antibacterial assay by agar well diffusion method. Bacterial DNA extracted by lysostaphin and boiling method was used to detect mecA gene from standard and clinical strains using a PCR amplification assay. Result of this study show that alcoholic and aquatic extract of Eucalyptus have antibacterial effects. In mecA negative Staphylococcus aureus the maximum zone of alcoholic extract was 18 mm at 30 μL volume, whereas in mecA positive Staphylococcus aureus the maximum zone of alcoholic extract was 14 mm at 30 μL volume. Among the various components of Eucalyptus oil, 1,8-cineole is the most important and is largely responsible for a variety of its antibacterial properties. According to the results, alcoholic extract of Eucalyptus has higher antibacterial effect than aquatic extract. Due to various chemical components of Eucalyptus more attention must be taken for the clinical application of this plant.
Antibacterial Activity of THAM Trisphenylguanide against Methicillin-Resistant Staphylococcus aureus  [PDF]
Alan J. Weaver, Joyce B. Shepard, Royce A. Wilkinson, Robert L. Watkins, Sarah K. Walton, Amanda R. Radke, Thomas J. Wright, Milat B. Awel, Catherine Cooper, Elizabeth Erikson, Mohamed E. Labib, Jovanka M. Voyich, Martin Teintze
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097742
Abstract: This study investigated the potential antibacterial activity of three series of compounds synthesized from 12 linear and branched polyamines with 2–8 amino groups, which were substituted to produce the corresponding guanides, biguanides, or phenylguanides, against Acinetobacter baumannii, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Antibacterial activity was measured for each compound by determining the minimum inhibitory concentration against the bacteria, and the toxicity towards mammalian cells was determined. The most effective compound, THAM trisphenylguanide, was studied in time-to-kill and cytoplasmic leakage assays against methicillin-resistant Staphylococcus aureus (MRSA, USA300) in comparison to chlorhexidine. Preliminary toxicity and MRSA challenge studies in mice were also conducted on this compound. THAM trisphenylguanide showed significant antibacterial activity (MIC ~1 mg/L) and selectivity against MRSA relative to all the other bacteria examined. In time-to-kill assays it showed increased antimicrobial activity against MRSA versus chlorhexidine. It induced leakage of cytoplasmic content at concentrations that did not reduce cell viability, suggesting the mechanism of action may involve membrane disruption. Using an intraperitoneal mouse model of invasive MRSA disease, THAM trisphenylguanide reduced bacterial burden locally and in deeper tissues. This study has identified a novel guanide compound with selective microbicidal activity against Staphylococcus aureus, including a methicillin-resistant (MRSA) strain.
Antibacterial Effect of Essential Vegetal Extracts on Staphylococcus aureus Compared to Antibiotics  [cached]
Iosif Nicodim FIT,Gheorghe RAPUNTEAN,Sorin RAPUNTEAN,Flore CHIRILA
Notulae Botanicae Horti Agrobotanici Cluj-Napoca , 2009,
Abstract: This study is aiming to evaluate the antimicrobial activity of ten essential vegetal extracts on strains of Staphylococcus aureus isolated from animal lesions. The comparative effect of some antibiotics on these strains isolated from animals was also tested and estimated. The extracts were represented by Albies alba, Aloe barbadensis, Calendula officinalis, Cocos nucifera, Eucalyptus globulus, Hypericum perforatum, Lavandula angustifolia, Satureja hortensis, Mentha piperita, Pinus silvestris essential oils, in three amounts (30 μl, 3 μl and 0,3 μl) and comparatively eight antibiotics frequently utilized in staphylococci infections treatment in animals were used. Animal origin S. aureus strains were identified using API staph tests (BioMerieux, France). The tests were realized by diffusion method using Muller Hilton agar while the antibacterial effect was interpreted depending on the inhibition area diameter. The obtained results revealed that Satureja hortensis and Albies alba extracts inhibit the develop of the most staphylococci tested strains. The highest inhibition areas were observed for the amounts of 30 μl and 3 μl essential extract. Most of the staphylococci strains were resistant to antibiotics, the most efficient being Ceftiofur and Methicillin. The results are suggesting that savory and fir has antibacterial effect on S. aureus similar to the best antibiotics proving to be an alternative as natural antibiotics utilization in infectious diseases.
Antibacterial Activity in Marine algae Eucheuma denticulatum Against Staphylococcus aureus and Streptococcus pyogenes
Nagi A. Al-Haj,Nurmas I. Mashan,Mariana N. Shamsudin,Habsah Mohamad,Charles S. Vairappan,Zamberi Sekawi
Research Journal of Biological Sciences , 2012,
Abstract: The in vitro antibacterial activities of seaweed belong to Euchema denticulatum extract showed inhibitory activity only on gram positive organisms tested including Staphylococcus aureus and Streptococcus pyogenes, which were expressed in terms of minimum inhibitory concentration and minimum bactericidal concentration test. Thus, gram negative pathogens tested including Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa showed resistant phenotypic pattern to both extracts. Results of the present study confirmed the potential use of seaweed extract as a source of antibacterial compounds.
In-vitro Antibacterial Activity of Anogeissus leiocarpus Dc (Stem Bark) Extracts against Escherichia coli and Staphylococcus aureus
HD Sani, BS Aliyu
Bayero Journal of Pure and Applied Sciences , 2011,
Abstract: Antibacterial secreening of ethanolic, aqueous and chloroform extracts of Anogeissus leiocarpus was carried out against Escherichia coli and Staphylococcus aureus. The result shows that all the extract exhibited antibacterial activity against the test organisms with the exception of the lowest concentration of aqueous and chloroform extract. Ethanolic extracts at concentration of 300ug/ml showed greater activity against E. coli (16mm) and Staphylococcus aureus (15mm) than the remaining extracts. Activity was greater against E.coli in response to all fractions (16mm, 15mm, and 12mm respectively at the highest concentrations than the Staphylococcus aureus (14mm, 11mm, and 9mm). Results showed that, antibacterial activity of the extracts was dose - dependant. Augmentin and gentamicine were the antibiotics used as the positive control discs against the test organisms. These antibiotics showed greater activity than the crude extracts respectively. The bioactive compounds detected in the extracts were alkaloids, tannins, flavonoids, glycosides and saponins. As there is growing interest in obtaining sample of plant materials with a view to explore the possibilities for medicinal products and in addition the current global upsurge of bacterial resistance to antibacterial drugs, the plant may be used as promising candidate for drug development.
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