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儿茶酚胺抑素对急性心梗大鼠室性心律失常的影响
Effect of catestatin on ventricular arrhythmia in acute myocardial infarction in rats
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,,,,,,曹瑜梦
- , 2018, DOI: 10.7652/jdyxb201805007
Abstract: 摘要:目的 探讨儿茶酚胺抑素(CST)和急性心梗室性心律失常之间的关系。方法 雄性SD大鼠60只,随机分为假手术组(n=20)和心梗组(n=40),结扎冠状动脉制备心梗模型,心梗组存活36只。测量大鼠血浆CST水平,使用程序性电刺激法评估急性心肌梗死时心肌室性心律失常的易患率,同时测定在不同频率和强度的电刺激下,鼠心室肌的易损期时间窗和有效不应期的变化。了解CST对急性心梗大鼠室性心律失常的影响。结果 与假手术组相比,心梗组左室射血分数(LVEF)明显减小(P<0.01),而左室舒张末内径(LVEDD)和左室收缩末内径(LVESD)则明显增大(P<0.01) ,CST明显升高(P<0.01);程序性电刺激后, 假手术组未能诱发室性心律失常,心肌梗死组共31只(86.1%)大鼠诱发出室性心律失常(P<0.01);心梗组大鼠固定强度心室易损期时间窗延长、有效不应期缩短(P<0.01)。Logistic回归分析显示,LVEF降低和CST升高均为急性心梗室性心律失常的独立危险因素(P<0.05,P<0.01)。结论 CST升高是急性心肌梗死室性心律失常发生的独立危险因素,是可用于预测急性心梗的预后指标之一。
ABSTRACT: Objective To explore the correlation between the catestatin (CST) level and ventricular arrhythmia (VA) in acute myocardial infarction (AMI). Methods Sixty male rats were randomly divided into sham group (n=20) and AMI group (n=40). Myocardial infarction was produced by ligation of the left anterior descending coronary artery. Thirty-six rats in AMI groupsurvived. Both groups were detected for plasma CST level, ventricular arrhythmia susceptibility, ventricular vulnerable period and effective refractory period so as to evaluate the effect of CST on VA in AMI. Results Compared with that in sham group, LVEF reduced significantly in AMI group (P<0.01), while LVEDD, LVESD and CST increased (P<0.01). After programmed electrical stimulation, in AMI group VA was induced in 31 rats (86.1%) (P<0.01), ventricular vulnerable period extended, and effective refractory period shortened (P<0.01). Logistic regression analysis showed that decreased LVEF and increased CST were the independent risk factors of VA in AMI rats (P<0.01 to P<0.05). Conclusion The CST level is an independent risk factor for VA in AMI; therefore, it can be used to evaluate the prognosis of AMI
Clinical study on Fufang Sishen Decoction in treating arrhythmia after virus myocarditis  [cached]
WEI Qiang-Hua
Zhong Xi Yi Jie He Xue Bao , 2004,
Abstract: Objective: To observe the effect of Fufang Sishen Decoction (FFSSD) on arrhythmia after virus myocarditis. Methods: One hundred and two cases of arrhythmia after virus myocarditis were randomly divided into two groups. The treatment group was treated with FFSSD, 6 g, b.i.d.; and the control group with propafenone, 150 mg, q 8 h. The therapeutic effects were observed in 4 weeks.Results: The total anti-arrhythmia effects of FFSSD and propafenone were 71.9 % and 78.9 % respectively (P>0.05). FFSSD took effects relatively slowly with mild and lasting effect. Conclusion: The curative effect of FFSSD in treating arrhythmia after virus myocarditis is confirmed. FFSSD has no obvious side effects.
基于近邻保持嵌入算法的心律失常心拍分类
Arrhythmia heartbeats classification based on neighborhood preserving embedding algorithm
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高兴姣,李智,陈珊珊,李健
- , 2017, DOI: 10.7507/1001-5515.201605045
Abstract: 心律失常是一种极其常见的心电活动异常症状,基于心电图(ECG)的心拍分类对心律失常的临床诊断具有十分重要的意义。本文提出一种基于流形学习的特征提取方法——近邻保持嵌入(NPE)算法,实现心律失常心拍的自动分类。分类系统利用NPE算法获取高维心电节拍信号的低维流形结构特征,然后将特征向量输入支持向量机(SVM)分类器进行心拍的分类诊断。实验基于 MIT-BIH 心律失常数据库提供的 ECG 数据,对 14 种类型的心律失常心拍进行分类,总体分类准确率高达 98.51%。实验结果表明,所提方法是一种有效的心律失常心拍分类方法。
Arrhythmia is a kind of common cardiac electrical activity abnormalities. Heartbeats classification based on electrocardiogram (ECG) is of great significance for clinical diagnosis of arrhythmia. This paper proposes a feature extraction method based on manifold learning, neighborhood preserving embedding (NPE) algorithm, to achieve the automatic classification of arrhythmia heartbeats. With classification system, we obtained low dimensional manifold structure features of high dimensional ECG signals by NPE algorithm, then we inputted the feature vectors into support vector machine (SVM) classifier for heartbeats diagnosis. Based on MIT-BIH arrhythmia database, we clustered 14 classes of arrhythmia heartbeats in the experiment, which yielded a high overall classification accuracy of 98.51%. Experimental result showed that the proposed method was an effective classification method for arrhythmia heartbeats.
应用遗传算法优化神经网络的致死性心电节律辨识算法研究
Research on malignant arrhythmia detection algorithm using neural network optimized by genetic algorithm
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余明,陈锋,张广,李良喆,王春晨,詹宁波,顾彪,韦婧,吴太虎
- , 2017, DOI: 10.7507/1001-5515.201612066
Abstract: 致死性心电节律的辨识和分类是自动体外除颤仪的关键任务。本文对已存在的心电节律辨识算法提取出的 21 个特征值进行了回顾性研究,并基于这些特征值构建了一个遗传算法优化的反向传播神经网络。以数据库提供的 1 343 例心电信号样本用于实验。实验结果表明,本文构建的神经网络在对窦性节律、心室颤动、室性心动过速、心脏停搏 4 类心电信号的辨识分类上有很好的表现,在测试集上的平衡准确性高达 99.06%;相较已存在的算法,辨识性能更好。将该算法应用在自动体外除颤仪上,将进一步提高除颤前节律分析的可靠性,最终提高心脏骤停的存活率。
Detection and classification of malignant arrhythmia are key tasks of automated external defibrillators. In this paper, 21 metrics extracted from existing algorithms were studied by retrospective analysis. Based on these metrics, a back propagation neural network optimized by genetic algorithm was constructed. A total of 1,343 electrocardiogram samples were included in the analysis. The results of the experiments indicated that this network had a good performance in classification of sinus rhythm, ventricular fibrillation, ventricular tachycardia and asystole. The balanced accuracy on test dataset reached up to 99.06%. It illustrates that our proposed detection algorithm is obviously superior to existing algorithms. The application of the algorithm in the automated external defibrillators will further improve the reliability of rhythm analysis before defibrillation and ultimately improve the survival rate of cardiac arrest.
中药反应性基因——中药抗肿瘤恶病质研究的新切入点
吴煜,杨宇飞,杨焕明
世界科学技术-中医药现代化 , 2000,
Abstract: 癌症恶病质(CancerCachexia)发生于恶性肿瘤晚期。进一步探讨中医治疗肿瘤恶病质的基础 ,从新的途径 ,用新的方法研究有效中药抗恶病质的作用机理 ,将有助于揭示中医中药治疗恶病质的实质。人类基因组研究的方法学内容与中医学的整体观、辨证观有许多相似之处。基因芯片技术记忆片技术可进行快速大量的基因表达检测 ,能够实现获得样口中大量基因序列及表达信息的目的 ,从而解决高通量基因表达平行分析问题。选择对肿瘤恶病质有确切疗效的有效中药以基因芯片技术研究其抗肿瘤恶病质的基因表达和功能调控 ,无疑对深入研究中药的抗恶病质作用机理具有深刻的理论意义。
特发性室性心律失常射频消融术治疗的疗效及安全性分析
Effectiveness and safety of radiofrequency ablation in patients with idiopathic ventricular arrhythmia
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武金娥,李国良,,,蒋永荣,孟恬宇,孙超峰
- , 2015, DOI: 10.7652/jdyxb201503027
Abstract: 摘要:目的 通过对本院经射频消融术治疗的特发性室性心律失常患者资料进行回顾性分析及随访,从而评估我院特发性室性心律失常经射频消融术治疗的疗效与安全性。方法 选取自2008年1月至2014年3月在本院接受射频消融术治疗的特发性室性心律失常患者63例,进行定期门诊或电话随访,复查Holter观察射频消融术后室性心律失常发作情况,心动超声比较左室舒张末期内径大小及射血分数变化。结果 射频消融术治疗特发性室性心律失常的即刻成功率为89.29%,远期成功率为82.14%;射频消融术前术后心动超声示左室射血分数及左室舒末内径无明显改善(P>0.05);射频消融术后Holter示室性早搏负荷较术前明显减少(P<0.05);1例患者射频消融术后合并主动脉佛氏窦瘤破裂,1例出现股动脉穿刺处血肿形成。结论 射频消融术治疗特发性室性心律失常是安全而有效的。
ABSTRACT: Objective To assess the effectiveness and safety of radiofrequency catheter ablation for idiopathic ventricular arrhythmia in patients with idiopathic ventricular arrhythmia after radiofrequency catheter ablation treated in the First Affiliated Hospital of Xi’an Jiaotong University based on the follow-up and retrospective analysis. Methods We retrospectively analyzed the clinical data of 63 patients with idiopathic ventricular arrhythmia who underwent radiofrequency catheter ablation during January 2008 and March 2014 in the First Affiliated Hospital of Xi’an Jiaotong University. In the follow-up, Holter moniterings were reviewed to evaluate ventricular arrhythmia and echocardiography to assess the ejection fractions and left ventricular end-diastolic diameters. Results The immediate success rate of catheter ablation for the treatment of idiopathic ventricular arrhythmia was 89.29% and the long-term success was 82.14%. The ejection fractions and left ventricular end-diastolic diameters were not obviously improved after radiofrequency ablation (P>0.05). The ventricular premature contractions were significantly reduced after radiofrequency ablation (P<0.05). In postoperative care, one case was found with ruptured sinus valsalva tumor and another patient was found with the complication of hematoma in femoral artery puncture. Conclusion Radiofrequency ablation for idiopathic ventricular arrhythmia is safe and effective
双参宁心胶囊对小型猪介入性心肌缺血的保护作用  [PDF]
于震,刘建勋,李欣志,尚晓泓,闫爱国,冯新庆
中国中药杂志 , 2007,
Abstract: 目的:研究双参宁心胶囊对小型猪介入性心肌缺血的治疗作用。方法:小型猪LAD经心导管介入自体血栓制备心肌缺血模型,喂饲双参宁心胶囊6d后,观察冠状动脉造影、血流动力学、生化和病理组织学的改变。结果:造模6d后,心肌缺血小型猪冠状动脉LAD基本栓塞,心输出量(CO)、心脏指数(CI)、左心做功(LCW)和左心做功指数(LCWI)明显降低,病理组织学可见心肌变性、坏死,缺失区被纤维组织替代填充、嗜中性粒细胞浸润。各组给药6d后,双参宁心胶囊可明显减轻小型猪冠状动脉LAD自体血栓栓塞的程度,改善血流动力学,增加CO,CI,LCW,LCWI,降低外周血管阻力(SVR)和外周血管阻力指数(SVRI),抗脂质过氧化,增加血浆超氧化物歧化酶(SOD)活性,降低血浆丙二醛(MDA)含量,同时减轻心肌病理组织学变性和坏死改变。结论:双参宁心胶囊可能通过改善心肌收缩功能,增加左心做功,抑制心肌细胞膜的脂质过氧化,发挥抗心肌缺血的作用。
高原低氧环境气虚小鼠心、肺反应性变化的分子机制研究  [PDF]
骆亚莉,刘永琦,安方玉,孙丽姣,蔡路路,李欣,马彦平
中国中医药信息杂志 , 2015, DOI: 10.3969/j.issn.1005-5304.2015.12.013
Abstract: 目的探讨高原低氧环境气虚小鼠心、肺反应性变化的分子机制。方法spf级模型组小鼠置于低氧舱内进行减压低氧暴露,对照组在常氧环境中饲养,连续21d。观察小鼠体征。末次低氧暴露后检测2组小鼠心乳酸脱氢酶(ldh)、na+-k+-atp酶活性,肺功能变化,心、肺组织缺氧诱导因子-1α(hif-1α)及肺组织通道蛋白-5(aqp5)蛋白和基因表达。结果模型组小鼠出现气虚体征。与对照组比较,模型组小鼠心ldh活性增高、na+-k+-atp酶活性降低(p<0.05,p<0.01);肺功能指标检测结果显示,模型组小鼠吸气时间、呼气时间、持续时间、潮气量、呼气末端停顿均降低和频率升高(p<0.05,p<0.01);心、肺hif-1α蛋白、基因表达均增高,肺aqp-5基因表达增高(p<0.05,p<0.01)。结论较长时间的高原低氧暴露,可导致小鼠表现气虚体征并出现肺通气效率降低。心肌受损可能与心na+-k+-atp酶活性变化有关,而心、肺hif-1α表达及肺aqp-5基因表达升高,可能有利于提高心、肺的适应性代偿反应。
2-(4′-硝基苯乙烯基)苯并恶唑及其衍生物的合成与同质多晶性  [PDF]
沈永嘉,韩萍扬,任绳武
华东理工大学学报 , 1990,
Abstract: 合成了2-(4′-硝基苯乙烯基)苯并恶唑及其5位甲基、硝基、乙酰氨基和苯基取代的衍生物,利用差热分析和多晶X射线衍射测定了它们的受热行为并鉴定了它们的同质多晶性。结果表明:这些化合物都是热不稳定的,一经受热便会发生晶型的转变,主要原因在于α晶型熔点较低并且晶格能较小,受热熔融后的熔体相对β晶型是过冷液体。
心经经脉、心因性牵涉痛与心脏相关联系的机制
荣培晶,朱兵
中国科学 生命科学 , 2002,
Abstract: 采用神经示踪剂荧光素三标记法研究了上肢内侧面(心经经脉循行线)、外侧面(肺经经脉循行线)与心脏的神经联系. 结果表明, 脊神经节的小量细胞的外周轴突有双分支现象, 其一支分布于心脏, 另一支分布于上肢; 心经循行线与心脏之间的脊神经节细胞外周轴突分支支配现象更明显. 与肺经穴位相比, 刺激心经穴位引起更大的心交感神经兴奋, 心经穴位通过心交感神经对心功能起调节作用. 心交感神经刺激可引起心经穴位的最大反射性肌电反应, 表明心脏功能异常的传入活动可能在心经循行线出现肌紧张反应. 结果提示, 心经与心脏特异性联系的基础是神经节段的相同性和神经纤维分布相对密集性; 心脏传入神经与心经穴位神经支配的重叠性及反射的循经性是心因性牵涉痛的基础.
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