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Study on the Ecotourism Development in Dazhou  [PDF]
Xiaomei Pu, Lin Tian, Zibiao Cheng
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.65002
Abstract: After comprehensive discussion of the origin of ecotourism, the concept of ecotourism and the theoretical basis for ecotourism development, the paper carried out the SWOT analysis on ecotourism development in Dazhou City, and then proposed development strategies. The strategies were to: enhance the ecological awareness of the entire people and create a good atmosphere for ecotourism development; break the talent bottleneck of ecotourism development by adopting the policy of “combination boxing”; make scientific and feasible master plan for Dazhou’s ecotourism development; develop quality ecotourism products; innovate marketing strategies for ecotourism in Dazhou.
Assessment of the feasibility of exon 45–55 multiexon skipping for duchenne muscular dystrophy
Laura van Vliet, Christa L de Winter, Judith CT van Deutekom, Gert-Jan B van Ommen, Annemieke Aartsma-Rus
BMC Medical Genetics , 2008, DOI: 10.1186/1471-2350-9-105
Abstract: We here tested the feasibility of inducing multiexon 45–55 in control and patient muscle cell cultures using various AON cocktails.In all experiments, the exon 45–55 skip frequencies were minimal and comparable to those observed in untreated cells.We conclude that current state of the art does not sufficiently support clinical development of multiexon skipping for DMD.Antisense-mediated exon skipping is emerging as a very promising therapeutic approach for Duchenne muscular dystrophy (DMD) [1]. The aim of this approach is to restore the disrupted reading frame of DMD transcripts, and allow synthesis of partly functional, internally deleted Becker-like dystrophins, rather than prematurely truncated non-functional Duchenne dystrophins. This can be achieved by antisense oligonucleotides (AONs) that target specific exons and hide them from the splicing machinery during pre-mRNA splicing, resulting in the skipping of said exons [2]. Proof of concept of this strategy has been obtained in numerous patient-derived cell cultures with different types of mutations, the mdx mouse model and recently in a first clinical trial where AONs were injected locally in the tibialis anterior muscle of 4 Duchenne patients [1,3-9]. One of the disadvantages of this therapy is its mutation specificity: different exons have to be skipped to restore the reading frame for different mutations [10]. Fortunately, most mutations involve deletions of one or more exons between exon 45 and 53 or between exon 2–20 (50% and 15% of all mutations, respectively) [11]. Therefore, restoration of the reading frame for over 50% of all patients (75% of deletion patients) is theoretically feasible using a strategically selected set of only 10 exons [12]. Skipping of exon 51 is beneficial for the largest group of patients (19% of all deletions, or 13% of all Duchenne patients, (Aartsma-Rus et al. accepted manuscript).Nevertheless, it would be more straightforward if a single formulation of AONs would be applicable
Challenges and Response to the Development of Sharing Economy in Dazhou  [PDF]
Yan Ding
Open Journal of Business and Management (OJBM) , 2019, DOI: 10.4236/ojbm.2019.74111
Abstract: The development of sharing economy activates the stock resources of Dazhou, improves the employment rate of Dazhou, and protects the environment of Dazhou. To promote the healthy development of sharing economy in Dazhou, we should further popularize the concept of sharing economy, strengthen industry supervision and guidance, innovate the supervision thinking, increase the government support for sharing economy, provide support for the development of sharing economy platforms in policies and funds, and create a good environment for the development of sharing economy.
Research on Side Reform Strategies of Service Supply in Dazhou  [PDF]
Zibiao Cheng, Chengduan Wang, Xiaoyi Liu
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.612021
Abstract: Dazhou is a large industrial and agricultural city with a huge population. The proportion of service industry in GDP is lower than the secondary industry. Compared with the overall level of the whole country, there is a big gap, and the development potential of service industry is huge. There are three major obstacles to the supply-side reform of the service industry in Dazhou: unsuitable institutional supply and transformational development, uncoordinated consumption supply and market demand, and unbalanced talent supply and development needs. In order to solve these problems, it is required to strengthen the supply of the system, accumulate the power of transformation, improve the quality of supply, guide the return of consumption, strengthen the supply of talents, and create a dynamic state of Dazhou to promote the transformation and upgrading of the service industry. While maintaining the growth rate of the service industry, it must integrate with agriculture and industry, and provide services for the development of agriculture and industry and a platform to foster the new vitality of Dazhou’s economic development.
中国短胖孢菌  [PDF]
菌物学报 , 1982,
Abstract: 短胖孢菌属(Cercosporidium)是半知菌类中暗丛梗孢菌类的一个小属,仅有30多个种,都是植物的寄生菌。本文报告我国短胖孢菌属共18个种,其中9个是新组合,一个是新种——千斤拔短胖孢(CercosporidumflemingiaeLiuetGuosp.Nov)。
Research on Modern Agricultural Management System of Dazhou City
Zibiao Cheng, Xiaoyi Liu
Open Access Library Journal (OALib Journal) , 2019, DOI: 10.4236/oalib.1105523
On the basis of summarizing the achievements of modern agriculture de-velopment in Dazhou city, this paper analyzes the challenges faced by the construction of modern agricultural management system in Dazhou city: poor modern agricultural management environment; shortage of modern agricultural technology talents; hindered rural land transfer and modern agricultural management service guarantee policy needed to be improved. It puts forward the strategy of constructing modern agricultural management system in Dazhou city: creating a sound environment for modern agricultural management; building modern think-tanks for agricultural management by the joint efforts of both bringing and developing, standardizing land transfer procedures and improving rural market transfer mechanisms together with improving the guarantee system for modern agricultural management.
There exists no distance-regular graph with intersection array {55,36,11;1,4,45}  [PDF]
Alexander L. Gavrilyuk
Mathematics , 2010,
Abstract: We prove that a distance-regular graph with intersection array $\{55,36,11;1,4,45\}$ does not exist. This intersection array is from the table of feasible parameters for distance-regular graphs in "Distance-regular graphs"\ by A.E. Brouwer, A.M. Cohen, A. Neumaier.
Running a marathon from -45°C to +55°C in a climate chamber: a case study
K lin K, Knechtle B, Rüst CA, Mydlak K, Rosemann T
Open Access Journal of Sports Medicine , 2012, DOI: http://dx.doi.org/10.2147/OAJSM.S36808
Abstract: nning a marathon from -45°C to +55°C in a climate chamber: a case study Case report (1119) Total Article Views Authors: K lin K, Knechtle B, Rüst CA, Mydlak K, Rosemann T Published Date October 2012 Volume 2012:3 Pages 131 - 145 DOI: http://dx.doi.org/10.2147/OAJSM.S36808 Received: 07 August 2012 Accepted: 03 September 2012 Published: 25 October 2012 Kaspar K lin,1 Beat Knechtle,1,2 Christoph Alexander Rüst,1 Karsten Mydlak,3 Thomas Rosemann1 1Institute of General Practice and Health Services Research, University of Zurich, Zurich; 2Gesundheitszentrum St Gallen, St Gallen, Switzerland; 3Gemeinschaftslabor Cottbus, Medizinisches Versorgungszentrum für Labormedizin, Mikrobiologie und Infektionsepidemiologie, Cottbus, Germany Background: We describe a runner who completed a self-paced marathon (42.195 km) in a climate chamber with a temperature difference of 100°C, starting at an ambient temperature (Tambient) of 45°C and finishing at an Tambient of +55°C. Methods: Tambient was set at 45°C at the start, and was steadily increased at a rate of 1°C at 4.5-minute intervals to +55°C. Before the start, after every 10.5 km, and at the end of the marathon, body mass, urine, and sweat production were measured and samples of venous blood and urine were collected. The runner’s temperature was recorded every 10 seconds at four sites, ie, the rectum for body core temperature (Tcore), and at the forehead, right wrist, and right ankle for surface temperatures (Tskin). Results: The subject took 6.5 hours to complete the marathon, during which Tcore varied by 0.9°C (start 37.5°C, peak 38.4°C). The largest difference (Δ) of Tskin was recorded at the ankle (Δ16°C). The calculated amount of sweat produced increased by 888% from baseline. In the blood samples, myoglobin (+250%) showed the highest change. Of the pituitary hormones, somatotropic hormone (+391%) and prolactin (+221%) increased the most. Regarding fluid regulation hormones, renin (+1145%) and aldosterone (+313%) showed the greatest increase. Conclusion: These results show that running a marathon in a climate chamber with a total ΔTambient of 100°C is possible, and that the Tambient to Tcore relationship is maintained. These results may offer insight into regulatory mechanisms to avoid hypothermia and hyperthermia. The same study is to be performed using more subjects with the same characteristics to validate the present findings.
The effect of temperature on structural changes of NI55CO45 amorphous powder  [PDF]
Spasojevi? M.,Mari?i? Aleksa M.,Rafailovi? Lidija
Science of Sintering , 2004, DOI: 10.2298/sos0402105s
Abstract: Cobalt and nickel alloy powders were obtained by electrochemical deposition on a titanium cathode from an ammonium solution of cobalt and nickel sulfate. Powders of a specific chemical structure and composition, particle shape and size were obtained by an appropriate choice of electrolysis parameters, current density, deposit growth rate and solution temperature and composition. Within the current density range of 5 - 450 mAcm-2, the current density did not significantly affect the chemical composition of the powders, but had a significant effect on the particle structure, shape and size. Crystal particles formed at a current density lower than 30 mAcm-2. Amorphous powders were obtained at a current density higher than 50 mAcm-2. Structural changes of the obtained amorphous powder of 55mol.% Ni, 45 mol.% Co, pressed under the pressure of 100 MPa, were investigated by measuring the temperature dependence of electrical resistance in isothermal and non-isothermal conditions varying from room temperature to 750°C. The process of thermal stabilization of defects that appeared during pressing occurred within the temperature range of 200-390 C. The DSC method was used to determine that the powder crystallization process occurred in two stages with peak temperatures of the exothermal maximum in the first and second stage of T1 = 438 C and T2 = 573 C, respectively. A distinct correlation between the change of electrical resistance and the crystallization process was established. The reduction of electrical resistively occurs during each crystallization stage.


物理学报 , 1987,
Abstract: The structure change of Cu55Zr45 metallic glass during natural and artificial ageing was investigated with EXAFS method. For comparison, the structure of quenched specimen was also determined. The corresponding phenomena after the specimen was aged artificially was studied with the small angle X-ray scattering and DSC, which are suitable for observing structure relaxation. Finally, according to the facts observed, a model of phase separation was suggested to explain the EXAFS of the specimens and their change during ageing.
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