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 Indian Pacing and Electrophysiology Journal , 2008, Abstract: A 44-year old lady underwent electrophysiology study for recurrent palpitations and documented narrow QRS regular tachycardia. The baseline ECG showed subtle preexcitation that was easily manifest on atrial pacing. The retrograde atrial activation sequence during ventricular pacing was eccentric suggesting retrograde conduction over the accessory pathway. A regular narrow QRS tachycardia with cycle length 280 ms was easily inducible on programmed atrial stimulation. The earliest ventricular activation during sinus rhythm & atrial pacing, and the retrograde atrial activation during ventricular pacing & tachycardia were diagnostic of left free wall accessory pathway and orthodromic atrioventricular reciprocating tachycardia (AVRT). During an episode of tachycardia, an ablation catheter was placed in the region of the lateral mitral annulus using retrograde trans-aortic approach. Once the ablation catheter was stabilized in that region, an interesting change in the AVRT was seen with appearance of wide QRS complexes of right bundle branch block (RBBB) morphology and left axis deviation in the alternate beats (Figure 1). The atrial activation sequence during both narrow and wide QRS beats was same with earliest activation in the distal coronary sinus. What is the mechanism of the alternate wide QRS beats during the AVRT?
 VLSI Design , 2001, DOI: 10.1155/2001/90464 Abstract: A semicustom ASIC design methodology is used to develop a low power DSP core for mobile (battery powered) applications. Different low power design techniques are used, including dual voltage, low power library elements, accurate power reporting, pseudomicrocode, transition-once logic, clock gating, and others.
 Prof Sandip Nemade Mr Mohd Ahmed International Journal of Electronics Communication and Computer Engineering , 2011, Abstract: FPGA devices are an important component in many modern devices. This means that it is important that VLSI designers have a thorough knowledge of how to optimize designs for FPGAs. While the design flows for ASICs and FPGAs are similar, there are many differences as well due to the limitations inherent in FPGA devices. To be able to use an FPGA efficiently it is important to be aware of both the strengths and weaknesses of FPGAs. If an FPGA design should be ported to an ASIC at a later stage it is also important to take this into account early in the design cycle so that the ASIC port will be efficient. This paper investigates as how to optimize a design for an FPGA and what steps should be taken in the design to enable seamless porting from FPGA to ASICS for volume production
 Indian Pacing and Electrophysiology Journal , 2009, Abstract: There are several stigmas on the resting surface electrocardiogram that are indicators of past myocardial injury. Broad QRS pattern with bundle branch block, Q waves, persistent ST elevation are some of those facsimiles which may at times even be considered as definitive signs of left ventricular impairment.
 International Journal of Engineering and Advanced Technology , 2012, Abstract: — The paper has been inspired by the need to findan efficient method for QRS detection which is simple and hasgood accuracy and less computation time. Our heart acts as therepresentative of the physiological changes of our body.Electrocardiography (ECG) is the electrical signature of the heartand thus one of the important indicators of our pathologicalcondition. In this paper the Discrete Wavelet Transform is used todetect QRS complex. The DWT approach is found to be better andmore accurate than the other common methods when evaluatedon MIT/BIH ECG database and the database borrowed from NITJalandhar.
 Physics , 2009, Abstract: We develop the vertex detector for the international linear collider (ILC) using the FPCCD (Fine Pixel CCD), whose pixel size is 5 x 5 um2. Together with the FPCCD sensor, a prototype of the readout ASIC was developed in 2008. The readout ASIC was confirmed to work correctly at slow readout speed (1.5 Mpix/sec). In this letter, we describe the status of the performance study for the readout ASIC.
 Elmaddin Guliyev Physics , 2012, Abstract: The next generation experiment in high energy particle physics will be International Linear Collider of electron and positron at the TeV scale. The experiment is aim to search the Higgs particle and to measure its properties. The physics program required the detector with high performance. One of the central detector is a Electromagnetic calorimeter, is going to measure the energy and position of high energy photons. Fine granularity and compactness brings to utilize the Si-W sampling detector. Due to high granularity the electromagnetic calorimeter will comprise of the order of $10^8$ readout cells. The recent developed prototype ASIC chip with 36 channels will be used readout of Si-W ECAL. The performance study will discuss of developed ASIC readout with ECAL prototype, use of pulse generator.
 Physics , 2012, Abstract: One of candidates for the International Linear Collider(ILC)'s vertex detector is the Fine Pixel CCD (FPCCD) with a pixel size of 5 \times 5 (\mum^2). Sensor and readout systems are currently being studied and prototypes have been developed. In this paper we will report on the performance of latest developed readout ASIC prototype as well as the outline of the design strategy for the next ASIC prototype.
 Indian Pacing and Electrophysiology Journal , 2010, Abstract: A 70-year-old man with history of previous myocardial infarction was referred for cardiac resynchronization therapy (CRT) implantation. Echocardiography showed global wall motion abnormality and non-viable myocardium with ejection fraction of 15% and large apical aneurysm. Electrocardiography (ECG) revealed sinus rhythm with wide QRS (200 ms). Of note is the finding of marked fragmentation of QRS in limb leads and V4 - V6.
 PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035225 Abstract: Three observations have suggested that acid-sensing ion channels (ASICs) might be mammalian cutaneous mechanoreceptors; they are structurally related to Caenorhabditis elegans mechanoreceptors, they are localized in specialized cutaneous mechanosensory structures, and mechanical displacement generates an ASIC-dependent depolarization in some neurons. However, previous studies of mice bearing a single disrupted ASIC gene showed only subtle or no alterations in cutaneous mechanosensitivity. Because functional redundancy of ASIC subunits might explain limited phenotypic alterations, we hypothesized that disrupting multiple ASIC genes would markedly impair cutaneous mechanosensation. We found the opposite. In behavioral studies, mice with simultaneous disruptions of ASIC1a, -2 and -3 genes (triple-knockouts, TKOs) showed increased paw withdrawal frequencies when mechanically stimulated with von Frey filaments. Moreover, in single-fiber nerve recordings of cutaneous afferents, mechanical stimulation generated enhanced activity in A-mechanonociceptors of ASIC TKOs compared to wild-type mice. Responses of all other fiber types did not differ between the two genotypes. These data indicate that ASIC subunits influence cutaneous mechanosensitivity. However, it is unlikely that ASICs directly transduce mechanical stimuli. We speculate that physical and/or functional association of ASICs with other components of the mechanosensory transduction apparatus contributes to normal cutaneous mechanosensation.
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