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小波滤噪用于示波计时电位信号处理的研究  [PDF]
顾文良,张书玲,张红权,郑建斌
分析化学 , 1999,
Abstract: 根据信号(S)和噪声(N)在小波变换下表现出的截然不同的性质,提出了一种新的滤噪方法.研究了噪音在不同细节的性质、滤噪阈值的确定及平滑与滤噪的特点.对不同S/N的示波计时电位信号进行处理的实验结果表明:小波滤噪在大大提高S/N的同时,信号强度基本不损失,优于传统的滤噪方法.
Patient-perceived value of Medication Therapy Management (MTM) services: a series of focus groups  [PDF]
Heidi Schultz, PharmD,Sarah M. Westberg, PharmD, BCPS,Djenane Ramalho de Oliveira, PhD,Amanda Brummel, PharmD
INNOVATIONS in Pharmacy , 2012,
Abstract: Objective: To determine the patient-perceived value of MTM services and non-financial barriers preventing patients with insurance coverage from receiving MTM services. Design: Focus groups. Setting: Fairview Pharmacy Services, Minneapolis, MN.Participants: Three focus groups, each with five to nine participants, consisting of different participant populations: (i) patients who paid out-of-pocket to receive MTM services; (ii) insurance beneficiaries, under which MTM is a covered benefit and participants may have received incentives for receiving MTM services; (iii) patients with an insurance plan which covers MTM services who were recruited to receive MTM services but declined. Intervention: MTM services. Main Outcome Measure: Patient-perceived value of MTM services and non-financial barriers. Results: Seven themes were identified relating to the patient-perceived value of MTM services: collaboration of the health care team, MTM pharmacist as a supporter/advocate/confidant, MTM pharmacist as a resource for questions and education, accessibility to the MTM pharmacist, financial incentives for participation in MTM services, MTM pharmacy as a specialty field, and the MTM pharmacist as a coordinator. Three themes were identified regarding patient-perceived non-financial barriers to receiving MTM services, including: availability of the MTM pharmacist, patient/physician lack of knowledge of MTM services, patient’s belief that MTM services are not needed. Conclusion: MTM is a service which patients identify as valuable. Patients are able to identify non-financial barriers that may prevent some patients from receiving MTM services. This study provides preliminary evidence of both the value and barriers perceived by patients.
基于最小二乘法的hdr图像快速滤噪算法  [PDF]
孙德全,张军,李晓峰,李辉
计算机应用 , 2009,
Abstract: ?提出一种针对高动态范围(hdr)图像滤噪的新方法,通过对用于合成hdr的一组图像进行滤噪来实现。在亮度空间中,通过求解加权最小二乘问题拟合l-t直线,并用该直线修正亮度值,从而到达滤噪目的。实验表明该算法运算量小,能有效去除椒盐型噪声,对高斯型噪声抑制效果明显,优于a.&e.(ahmet&erit)的加权求和滤噪算法。
钻井井喷关井期间井筒压力变化特征  [PDF]
任美鹏,李相方,刘书杰,王元娇
- , 2015, DOI: 10.3969/j.issn.1673-5005.2015.03.015
Abstract: 针对目前钻井井喷关井期间井筒压力计算值与实际关井压力差别较大的问题,将关井期间井筒压力变化分为两部分:关井初期地层流体继续侵入井筒的续流部分和气液密度差导致气体滑脱上升部分,从渗流理论和试井理论出发,考虑关井期间井筒内气体和钻井液的压缩性以及井筒的弹性,建立关井期间井筒续流模型;从气液两相流理论出发,考虑关井气体滑脱上升期间气体的膨胀、气体和钻井液压缩性、井筒弹性以及钻井液滤失等因素,建立关井期间气体滑脱模型;然后考虑关井期间井筒续流和气体滑脱综合影响,建立关井期间井筒压力计算模型,并给出基于本模型的气侵关井井筒压力读取方法。结果表明:关井初期井底压力呈指数增加,井底压力大于地层压力之后井底压力呈线性增加;关井初期井筒续流起主导作用,井底压力大于地层压力之后气体滑脱效应起主导作用。
Key words: drilling drilling blowout shut in wellbore pressure wellbore afterflow gas slippag
Caenorhabditis elegans Myotubularin MTM-1 Negatively Regulates the Engulfment of Apoptotic Cells  [PDF]
Wei Zou equal contributor,Qun Lu equal contributor,Dongfeng Zhao,Weida Li,James Mapes,Yuting Xie,Xiaochen Wang
PLOS Genetics , 2009, DOI: 10.1371/journal.pgen.1000679
Abstract: During programmed cell death, apoptotic cells are recognized and rapidly engulfed by phagocytes. Although a number of genes have been identified that promote cell corpse engulfment, it is not well understood how phagocytosis of apoptotic cells is negatively regulated. Here we have identified Caenorhabditis elegans myotubularin MTM-1 as a negative regulator of cell corpse engulfment. Myotubularins (MTMs) constitute a large, highly conserved family of lipid phosphatases. MTM gene mutations are associated with various human diseases, but the cellular functions of MTM proteins are not clearly defined. We found that inactivation of MTM-1 caused significant reduction in cell corpses in strong loss-of-function mutants of ced-1, ced-6, ced-7, and ced-2, but not in animals deficient in the ced-5, ced-12, or ced-10 genes. In contrast, overexpression of MTM-1 resulted in accumulation of cell corpses. This effect is dependent on the lipid phosphatase activity of MTM-1. We show that loss of mtm-1 function accelerates the clearance of cell corpses by promoting their internalization. Importantly, the reduction of cell corpses caused by mtm-1 RNAi not only requires the activities of CED-5, CED-12, and CED-10, but also needs the functions of the phosphatidylinositol 3-kinases (PI3Ks) VPS-34 and PIKI-1. We found that MTM-1 localizes to the plasma membrane in several known engulfing cell types and may modulate the level of phosphatidylinositol 3-phosphate (PtdIns(3)P) in vivo. We propose that MTM-1 negatively regulates cell corpse engulfment through the CED-5/CED-12/CED-10 module by dephosphorylating PtdIns(3)P on the plasma membrane.
酿酒酵母全基因组范围内筛选mtm1基因的抑制基因  [PDF]
王娟?,张玟洁?,曾雅雪?,蔡颖?,周兵?
生物化学与生物物理进展 , 2010,
Abstract: mtm1基因对于维持锰超氧化物歧化酶的活性和线粒体正常功能十分重要,mtm1基因的缺失会严重影响酵母锰超氧化物歧化酶活性,并损伤线粒体功能,因此在非发酵培养基上不能生长.利用mtm1基因缺失的突变体在非发酵培养基上的生长缺陷,转入酵母基因组文库筛选mtm1抑制基因,发现mtm1基因缺失造成的损伤一旦形成不可逆转,重新引入mtm1基因也无法挽救,直接筛选无法得到抑制基因.为了避免mtm1缺失造成的不可逆损伤,在野生型酵母中先转入带有mtm1基因的质粒,再敲除染色体上的mtm1基因,随后转入基因组文库,再利用药物5-氟乳清酸(5-foa)迫使细胞丢失表达mtm1基因的外源质粒,再筛选能在非发酵培养基上生长的转化子,通过这种方法筛选发现,por2等5个基因的过表达可以挽救mtm1基因缺失造成的非发酵培养基上的生长缺陷,为深入了解mtm1基因的功能提供了线索,对筛选其他造成不可逆损伤的突变基因的抑制基因提供了一条可行的研究思路.
Medication adherence and its relationship to the therapeutic alliance: Results from an innovative pilot study within a community pharmacy MTM practice  [PDF]
Janice Pringle, PhD.,Michael Melczak, PhD,Arnie Aldridge, MS,Margie Snyder, PharmD, MPH
INNOVATIONS in Pharmacy , 2011,
Abstract: Objectives: To determine whether patients who received Medication Therapy Management (MTM) from community pharmacists using a brief scale to measure Therapeutic Alliance (i.e., MTM + TA) would show better medication adherence than patients whoreceived MTM without use of the TA scale (MTM only). Design: Quasi-experimental, using a direct intervention group (MTM + TA) and a comparison group of randomly selected claims records from patients who received only the MTM service (MTM only). We used a doubly robust propensity score approach to estimate the average effect of therapeutic alliance on medication adherence. The analysis was limited to the following broad medication categories: antihypertensives, antidiabetic agents, and antihyperlipidemics. Setting: The direct intervention group included patients receiving MTM services from pharmacists in a community pharmacy chain setting. Participants: After matching with claims data, the direct intervention group was n=117, with an average age of 76.4. The comparison group was n=146, with an average age of 76.2. Intervention: Administration of two brief scales designed to measure general health outcomes and TA within the context of MTM (with focus on TA scale administration). Main Outcome MeasuresProportion of Days Covered (PDC) and PDC80. Results: Using the therapeutic alliance scales in the context of community pharmacistprovided MTM was associated with a 3.1 percentage point increase in patients’ overall PDC (p<.001) and an increase of 4.6 percentage points in PDC80 (p=.02) as compared to patients receiving MTM without use of the therapeutic alliance scales. Conclusion: Measuring therapeutic alliance in the context of MTM is associated with improved medication adherence and represents one strategy for enhancing the effectiveness of MTM encounters. Furthermore, administration of the therapeutic alliance scales used very little time; therefore it is likely feasible for pharmacists to routinely use the scales in their practice.
三层滤料滤床的合理选定  [PDF]
李镜明
武汉理工大学学报 , 1981,
Abstract: ?本文旨在阐明三层滤料滤床结构特点的基础上,首先讨论滤床的规格(即滤床材料、级配和厚度),其中包括一般要求,选定方法和实例。其次分析影响滤床规格的几个因素,然后根据实情况怎样调整滤床规格。最后提出了控制三层滤料分层的原理,可作为滤床设计的参考。
Two Depth Fusion, from “Manufacture” to “Intellectual Creation” —Based on Qingdao Hong Ling Group Innovative MTM Mode  [PDF]
Yu Ma, Chenggang Li
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.63024
Abstract:
Promoting the deep integration of informationization and industrialization is an inevitable choice for the transformation and upgrading of traditional industries. Based on information technology and based on smart manufacturing, Hong Ling Group actively develops MTM business targeting high-end consumer groups, achieves deep integration of the two industries, and en-hances the company’s core competitiveness and brand influence. This article combines the current trend of deep integration, using case studies, analyzing the MTM business model of the Hong Ling Group, and exploring its innovations in business models, technologies, production, and operations, and bringing new opportunities to the Chinese textile and apparel industry and other industries. Industrial roads, promote the integration of the two deep integration, refine the theoretical value and reference significance.
安德烈·关纳  [PDF]
林天健
力学与实践 , 1996, DOI: 10.6052/1000-0992-1996-128
Abstract: 安德烈·关纳林天健(珠江水利委员会勘测设计研究院,广州510611)1959年12月2日,当时世界上最薄的拱坝(坝高66.5m)马尔帕塞双曲拱坝溃决,全世界为之震惊.尽管失事后法国农业部曾两次组织专门委员会进行调查并提出报告,认为该坝的设计是正确的,...
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