oalib
匹配条件: “” ,找到相关结果约100条。
列表显示的所有文章,均可免费获取
第1页/共100条
每页显示
安宫牛黄丸联合中药治疗高胆红素血症临床观察  [PDF]
郑宋明,郑晶晶
中国中药杂志 , 2007,
Abstract: 安宫牛黄丸作为治疗高热惊厥和瘟热病昏迷等急救药物已被广泛应用,但作为常规治疗高胆红素血症尚未见报道。为探索中西医结合治疗高胆红素血症的有效方法,用安宫牛黄丸联合中药清营凉血汤治疗高胆红素血症进行了分组对照初步观察研究,结果显示疗效显著。1临床资料1.1一般资料共选择2001年10月至2004年12月本院门诊及住院患者121例,所有患者TBil≥171μmol·L-1,诊断符合2000年9月(西安)中华医学会修订的《病毒性肝炎防治方案》....
安宫宁胶囊中子宫松弛成分的研究  [PDF]
韩定献,余子川,苏明武,苏桂香,王菊英
中国中药杂志 , 1995,
Abstract: 安宫宁胶囊中子宫松弛成分的研究韩定献,余子川,苏明武,苏桂香(湖北中医学院武汉430061)王菊英(同济医科大学武汉430000)安宫宁胶囊系中药黄芩单味药材经精制加工而成。具有清热解毒、泻火止血、安胎等功效。临床用于胎动不安、痛经和子宫收缩不协调等症。《本草图经》、《本草纲目》、《丹溪心法》和《主治秘诀》均载有黄芩具有安胎作用。关于黄芩中具有安胎作用的有效成分,国内外杂志尚无报道。我们对黄芩中具有安胎作用的有?...
缩宫药物研究述评  [PDF]
王明军,高金有
中国中医药信息杂志 , 2000,
Abstract: 在产科疾病中,产后出血一自困扰着广大的产妇患者和医务工作者.其病因大多是山于子宫收缩乏力、胎盘滞留或粘连、第三产程延长等引起的.其中,产后宫缩乏力使子宫小能正常收缩和缩复(即子宫复旧小全),从而小能关闭胎盘附着部子宫壁血窦而致过多流血,为产后出血的主要原因’.根据中医学理论,产后血疲证的一个重要原因也是山于产后宫缩乏力、血被寒凝、疲阻胞脉而导致的产后恶露淋漓小爽2.针对这一病症,加强宫缩成为治疗宫缩乏力最迅速有效的治疗方法.山于缩宫药物具有自接兴奋子宫平滑肌,加强子宫收缩力的功效,从而改善并治愈产后出血,所以缩宫药愈来愈成为治疗产后出血的关键药物.本文就近年来缩宫药物(包括中西药品)的临床应用及研究工作进行综介评述,n在探讨其应用价值及发展趋向.
胶艾汤对动物离、在体子宫活动的影响  [PDF]
李祥华王文英
中国中药杂志 , 2005,
Abstract: 胶艾汤出自《金匮要略》,为妇科要方,临床上常用于妇女月经过多、或妊娠腹痛、或产后出血等症。有补血、止血、调经安胎之功。笔者以催产药缩宫素作为对照,比较了胶艾汤对子宫的作用强弱,研究其对动物离体子宫和产后在体子宫收缩的影响,以证实其对子宫的直接作用,从而阐明其止血的机制1 实验材料11 药物及试剂胶艾汤按传统剂量配比,全方由川芎60g,阿胶60g,艾叶90g,甘草60g,当归90g,白芍120g,生地黄180g组成。购自
绝经后妇女宫腔积脓9例分析  [PDF]
田霞,袁世珍
宁夏医科大学学报 , 2012,
Abstract: 目的探讨绝经后妇女宫腔积脓的临床特点及治疗方法。方法回顾性分析我院2006年1月至2010年12月5年间收治的9例绝经后妇女宫腔积脓的临床资料。结果宫腔积脓症状、体征不典型,2例误诊为盆腔包块,2例以急腹症收住普外科,4例均行全子宫双侧附件切除术。术后均放置盆腔引流管,并进行全身大剂量抗感染治疗。余5例患者入院时均已确诊,则行经阴道宫腔冲洗术。9例患者均痊愈出院。结论绝经后妇女宫腔积脓症状、体征不典型,误诊率高,可发生子宫穿孔、弥漫性腹膜炎等严重并发症,及时诊治者预后良好。
Structural insights into the binding of MMP9 inhibitors  [cached]
Arpit Tandon,Siddharth Sinha
Bioinformation , 2011,
Abstract: Matrix Metalloproteinase are family of enzymes responsible for degradation of extracellular matrix. MMP9 (gelatinase B) is one of the common matrix metalloproteinase that is associated with tissue destruction in a number of disease states such as rheumatoid arthiritis, fibrotic lung disease, dilated cardiomyopathy, as well as cancer invasion and metastasis. Recent study demonstrates that increased expression of MMP9 results in augmentation of myopathy with increased inflammation and fibernecrosis. Previous studies do not provide any conclusive information related to structural specificity of MMP9 inhibitors towards its active site, but with the availability of experimental structures it is now possible to study the structural specificity of MMP9 inhibitors. In light of availability of this information, we have applied docking and molecular dynamics approach to study the binding of inhibitors to the active site of MMP9. Three categories of inhibitor consisting of sulfonamide hydroxamate, thioester, and carboxylic moieties as zinc binding groups (ZBG) were chosen in the present study. Our docking results demonstrate that thioester based zinc binding group gives favourable docking scores as compared to other two groups. Molecular Dynamics simulations further reveal that tight binding conformation for thioester group has high specificity for MMP9 active site. Our study provides valuable insights on inhibitor specificity of MMP9 which provides valuable hints for future design of potent inhibitors and drugs.
再评宫体诗  [PDF]
沈元林?
天府新论 , 2000,
Abstract: 本文对宫体诗作了客观的认识和重新评价,指出宫体虽格调不高,但也拓展了诗歌的描写领域,并对乐府民歌有所师承,不宜一概否定
绿茶提取物表没食子儿茶素没食子酸酯对酸蚀症牙本质胶原降解作用的初步研究  [PDF]
陈黄琴,黄彬
华西口腔医学杂志 , 2012, DOI: 10.3969/j.issn.1000-1182.2012.05.023
Abstract: 目的观察绿茶提取物表没食子儿茶素没食子酸酯(EGCG)对酸蚀症暴露的牙本质胶原降解作用的影响。方法选取酸蚀症志愿者64名,随机分成两组。制作个别托盘,托盘内注入羧甲基纤维素钠(CMC)凝胶(对照组)或添加了EGCG的CMC凝胶(试验组)。要求志愿者于夜间睡时佩戴,清晨取下。试验前1d,以及试验后第1、2、3、4周收集培养液,用放射免疫试剂盒法测量Ⅰ型胶原羧基端肽(ICTP)的质量浓度。结果凝胶种类和使用时间对ICTP的质量浓度均有影响;EGCG能快速、有效地降低ICTP的表达水平,与对照组相比,差异有统计学意义(P<0.05)。结论EGCG能有效地减少脱矿牙本质胶原的降解,可以提高牙本质抗酸蚀的能力。
用子波变换的能量最大准则分析婴儿痉挛症脑干诱发电位  [PDF]
崔林阳?,姜楠?,陈世畯?
生物化学与生物物理进展 , 2003,
Abstract: 借鉴流体力学中用子波变换识别湍流相干结构的能量最大准则,解释婴儿痉挛症发病的三联征,尤其想说明智能迟滞的原因.从电生理的角度来说明,为什么脑干是婴儿痉挛症的责任病灶——这个生化及病理已经做出的推测.研究发现婴儿痉挛症患儿的脑干通道对外界刺激的反应能力和信息的传递能力与正常儿童有明显差异,借用能量最大准则在湍流中的解释,认为是因为信息传导阻滞引起患儿智能发育的迟滞,并试着提出评价最理想治疗效果的标准.
Increased expression of MMP9 is correlated with poor prognosis of nasopharyngeal carcinoma
Zhen Liu, Lixia Li, Zhixiong Yang, Weiren Luo, Xin Li, Huiling Yang, Kaitai Yao, Bin Wu, Weiyi Fang
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-270
Abstract: Using real-time PCR, we detected the mRNA expression of MMP9 in normal nasopharyngeal tissues and nasopharyngeal carcinoma (NPC) tissues. Using immunohistochemistry analysis, we analyzed MMP9 protein expression in clinicopathologically characterized 164 NPC cases (116 male and 48 female) with age ranging from 17 to 80 years (median = 48.4 years) and 32 normal nasopharyngeal tissues. Cases with greater than or equal to 6 and less than 6 of the score value of cytoplasmic MMP9 immunostaining were regarded as high expression and low expression, respectively. The relationship between the expression levels of MMP9 and clinical features was analyzed.The expression level of MMP9 mRNA was markedly greater in NPC tissues than that in the nasopharyngeal tissues. Immunohistochemical analysis revealed that the protein expression of MMP9 detected in NPC tissues was higher than that in the nasopharyngeal tissues (P = 0.004). In addition, high levels of MMP9 protein were positively correlated with the status of lymph node metastasis (N classification) (P = 0.002) and clinical stage (P < 0.001) of NPC patients. Patients with higher MMP9 expression had a significantly shorter overall survival time than did patients with low MMP9 expression. Multivariate analysis suggested that the level of MMP9 expression was an independent prognostic indicator (P = 0.008) for the survival of patients with NPC.High level of MMP9 expression is a potential unfavorable prognostic factor for patients with NPC.Nasopharyngeal carcinoma (NPC) is one of the most common malignant diseases in the Chinese and other south-east Asians. Unfortunately, most NPC patients tend to present a more advanced stage of disease when first diagnosed due to its deep location and vague symptoms. Therefore, it is of great interest to search valuable factors for early diagnosis, prognosis prediction, and novel therapeutic strategies.The formation and metastasis of NPC is a complex and continuous process with the participation of
第1页/共100条
每页显示


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.