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Study of the Effect of α-Tochopherol and Propyl Gallate on Autoxidation, Physical and Chemical Properties of German Sausages During Storage in Different Packaging  [cached]
E. Khosravi,Sh. Dokhani,G. H. Kabir
Journal of Science and Technology of Agriculture and Natural Resources , 2005,
Abstract: The meat productions are the most popular among different food products. On of the serious problems of this kind of products may be the change of the physical and chemical properties. The Restriction of the use of synthetic antioxidants have prompted the extensive research on the effect of the natural antioxidant and replacement of synthetic antioxidant with the natural ones. In this study, the effect of α-tochopherol (vitamin E) and propyl gallate on German sausage was evaluated. Four different German sausages were formulated and prepared in 30 Kg batches as follows: control without antioxidant, sausages plus α- tochopherol (200 or 500 ppm) and sausages plus propyl gallate (200 ppm). Twelve Kg of the samples were filled into cellulosic casings and the other 18 Kg in polyamidic casings. All samples were cooked. One third of the packed samples were stored at (4 C ± 1) for 10 days and the rest were stored at (– 18 C ± 1) for 6 months. The extent of autoxidation for samples were determind by peroxid and TBA values. During the storage period, autoxidation rates of control samples were more than other treatments. Propyl gallate was more effective in reduction of autoxidation than α- tochopherol treatments. Addition of 500 ppm vitamin E was more effective than 200 ppm. Significant differences were observed among treatments (P< 0.05). The study of the shear strength of the stored susages at the (4 oC ±1) for the 10 days indicated that the most shear strength is seen in the cellulosic casing samples. The same results obtained for the stored samples at the (-18 oC ±1) for the 6 months.

生物物理学报 , 1987,
Abstract: The effects of propyl gallate and iso-butyl gallate on the fluidity, phase transition and Na + -K+ ATP ase activity of human erythrocyte membranes have been studied using ANS, NPN and DPH probes as used. Results show that both compounds give rise to (1) a decrease of the fluorescence but no change in ANS partition from the aqueous medium to the bilayer; (2) a decrease of the phase transition temperature and an increase of fluidity of membranes; (3) a decrease of the Na + -K+ ATP ase activity of membranes; (4) a decrease of the fluorescence polarization of DPH labelled on the ghost and an increase of fluidity of membranes, as the concentration of both compounds increases. In the given region of concentration, the effect of propyl gallate and iso-butyl gallate shows quantitative-effective and structural-effective relationships.
Nephroprotective effect of Bauhinia variegata (linn.) whole stem extract against cisplatin-induced nephropathy in rats  [cached]
Pani Saumya,Mishra Satyaranjan,Sahoo Sabuj,Panda Prasana
Indian Journal of Pharmacology , 2011,
Abstract: The nephroprotective activity of the ethanolic extract of Bauhinia variegata (Linn.) whole stem against cisplatin-induced nephropathy was investigated by an in vivo method in rats. Acute nephrotoxicity was induced by i.p. injection of cisplatin (7 mg/kg of body weight (b.w.)). Administration of ethanol extract at dose levels of 400 and 200 mg/kg (b.w.) to cisplatin-intoxicated rats for 14 days attenuated the biochemical and histological signs of nephrotoxicity of cisplatin in a dose-dependent fashion. Ethanol extract at 400 mg/kg decreased the serum level of creatinine (0.65 ± 0.09; P<0.001) and urea (32.86 ± 5.88; P<0.001) associated with a significant increase in body weight (7.16 ± 1.10; P<0.001) and urine volume output (11.95 ± 0.79; P<0.05) as compared to the toxic control group. The ethanol extract of B. variegata at 400 mg/kg (b.w.) exhibited significant and comparable nephroprotective potential to that of the standard polyherbal drug cystone. The statistically (one-way-ANOVA followed by Tukey-Kramer multiple comparison) processed results suggested the protective action of B. variegate whole stem against cisplatin-induced nephropathy.
Nephroprotective Role of Resveratrol and Ursolic Acid in Aristolochic Acid Intoxicated Zebrafish  [PDF]
Yu-Ju Ding,Chiao-Yin Sun,Chi-Chung Wen,Yau-Hung Chen
Toxins , 2015, DOI: 10.3390/toxins7010097
Abstract: The nephrotoxicity of aristolochic acid (AA) is well known, but information regarding the attenuation of AA-induced toxicity is limited. The aim of the present study was to study the nephroprotective effects of resveratrol (Resv) and ursolic acid (UA) in a zebrafish model. We used two transgenic lines, Tg(wt1b:EGFP) and Tg(gata1:DsRed), to evaluate the nephroprotective effects of Resv and UA by recording subtle changes in the kidney and red blood cell circulation. Our results demonstrated that both Resv and UA treatment can attenuate AA-induced kidney malformations and improve blood circulation. Glomerular filtration rate assays revealed that both Resv and UA treatment can restore renal function (100% for Mock; 56.1% ± 17.3% for AA-treated; 80.2% ± 11.3% for Resv+AA; and 83.1% ± 8.1% for UA+AA, n = 15). Furthermore, real-time RT-PCR experiments showed that pre-treatment with either Resv or UA suppresses expression of pro-inflammatory genes. In conclusion, our findings reveal that AA-induced nephrotoxicities can be attenuated by pre-treatment with either Resv or UA. Therefore, we believe that zebrafish represent an efficient model for screening AA-protective natural compounds.
R. Naga Kishore*, N. Anjaneyulu, M. Naga Ganesh, K. Pruthviraj and N. Sravya
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Diuretic activity and nephroprotective activity of different extracts of fruits of fragaria vesca in rat was studied. The study suggested that the extracts have good diuretic property. Diuretic study was carried out as per Lipschitz method. Where successive aqueous, ethonolic and petroleum extracts were studied for diuretic activity. The 6 hrs acute study of successive aqueous, ethonolic extracts showed increase in urine volume and K+ ion excretion as compared to control. However, advanced toxicological studies remain to be performed in rodents. Fruit extracts have shown moderate nephroprotective effect against gentamicin induced nephrotoxicity.
K. Gaikwad et al
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Nephrotoxicity is one of the most common kidney problems and occurs when body is exposed to a drug or toxin. A number of therapeutic agents can adversely affect the kidney resulting in acute renal failure, chronic interstitial nephritis and nephritic syndrome because increasing number of potent therapeutic drugs like aminoglycoside antibiotics, chemotherapeutic agents and NSAIDS. Nephroprotective agents are the substances which possess protective activity against nephrotoxicity. Medicinal plants have curative properties due to the presence of various complex chemical substances. The present review is about the some of the medicinal plants possessing nephroprotective activity on Cisplatin and Gentamicin induced nephrotoxicity.
Nephroprotective effect of ethanolic extract of roots and oleanolic acid isolated from roots of Lantana camara  [PDF]
Narendra Vyas,Ameeta Argal
International Journal of Pharmacology and Clinical Sciences , 2012,
Abstract: Background: It is estimated that about 12% of men and 55% of women have at least one episode of kidney stone during their life time. The incident in general population is about 1 in 1000 adults per year. Objectives: The present study was done to evaluate the nephroprotective effect of ethanolic extract of roots and oleanolic acid (OA) isolated from roots of Lantana camara (L. camara)Materials and methods: The nephroprotective effect of different concentrations of oleanolic acid (60 mg/kg, 80 mg/kg and100 mg/kg) and ethanolic extracts of roots of L. camara (ELC) at a dose of 200 mg/kg was assessed in albino Wistar male rats using gentamicin induced nephrotoxicity model. The parameters studied were urine volume, serum creatinine, urine creatinine, serum albumin, urine albumin, serum blood urea nitrogen, serum urea, urine blood urea nitrogen, urine urea, weight of kidney, body weight and glomerular filtration rate (GFR). Statistical analysis was performed by Dunnett’s Multiple Comparison test. All values were represented as Mean ± SEM. A p value < 0.05 was considered as statistically significant. Results: Urine creatinine, serum creatinine, blood urea, blood urea nitrogen, serum albumin, urine albumin and weight of rat kidneys were found to be increased in rats treated with gentamicin, but these indicators of nephrotoxicity were normalized in OA (p < 0.001) and ELC (p < 0.05) treated rats in a dose dependent manner. Reduced level of GFR in gentamicin treated group was also normalized by OA and ELC treated groups in a dose dependent manner. Conclusion: The result of the above study concludes that the OA showed promising nephroprotective activity in dose dependent manner. These results suggest the therapeutic utility of OA in renal injury.
Nephroprotective action of glycosaminoglycans: why the pharmacological properties of sulodexide might be reconsidered  [cached]
Antonio V Gaddi,Arrigo FG Cicero,Giovanni Gambaro
International Journal of Nephrology and Renovascular Disease , 2010,
Abstract: Antonio V Gaddi1, Arrigo FG Cicero1, Giovanni Gambaro21Atherosclerosis and Metabolic disease Research Unit, Internal Medicine, Aging and Kidney diseases Dept., University of Bologna, Italy; 2Nephrology and Dialysis Unit, Gemelli University Hospital, Sacred Heart Catholic University, Rome, ItalyAbstract: A relatively large body of evidence supports the notion that glomerular capillary wall and mesangial alterations in diabetic nephropathy involve biochemical alterations of glycoproteins in these structures. Evidence in experimental animals rendered diabetic reveals that the administration of heparin and other anionic glycoproteins can effectively prevent the biochemical alterations that promote albuminuria. Moreover, angiotensin II inhibits heparan sulfate synthesis, while heparins modulate angiotensin II signaling in glomerular cells, inhibiting aldosterone synthesis and lowering proteinuria in diabetes patients. Sulodexide, a mixture of heparin and dermatan sulfate, appears to be a promising treatment for diabetic proteinuria partially resistant to renin–angiotensin system blocking agents. Sulodexide prevents heparan sulfate degradation, thus allowing reconstruction of heparan sulfate content and restoration of glomerular basement membrane ionic permselectivity. The antiproteinuric effect appears to be mainly related to the basal proteinuria and consequently to the duration of treatment in a relatively large number of small clinical trials. On the other hand, several sulodexide pharmacodynamic properties could improve the prognosis of chronic kidney disease patients, also independently from its antiproteinuric effect. However, sulodexide development as an antiproteinuric drug needs to be continued, in order to define which kind of patients could better respond to this treatment.Keywords: glycosaminoglycans, sulodexide, albuminuria, proteinuria, diabetic nephropathy
Schistosomal glomerular disease (a review)
Andrade, Zilton A.;Van Marck, E.;
Memórias do Instituto Oswaldo Cruz , 1984, DOI: 10.1590/S0074-02761984000400017
Abstract: in this review paper schistosomal glomerulopathy is defined as an immune-complex disease. the disease appears in 12-15 per cent of the individuals with hepatosplenic schistosomiasis. portal hypertension with collateral circulation helps the by pass of the hepatic clearance process and the parasite antigens can bind to antibodies in the circulation and be trapped in the renal glomerulus. chronic membranousproliferative glomerulonephritis is the most commom lesion present and the nephrotic syndrome is the usual form of clinical presentation. the disease can be experimentally produced, and schistosomal antigens and antibodies, as well as complement, can be demonstrated in the glomerular lesions. specific treatment of schistosomiasis does not seem to alter the clinical course of schistosomal nephropathy.
Nephroprotective Effect of Fresh Leaves Extracts of Sida Cordifolia Linn in Gentamicin Induced Nephrotoxicity in Rats Bhatia Lovkesh*, Bhatia Vivek, Grover Manav  [PDF]
Bhatia Lovkesh 1 *,Bhatia Vivek 2,Grover Manav 3
International Journal of Research in Pharmacy and Science , 2012,
Abstract: The present study was aimed at evaluating the ethanolic and aqueous extracts of leaves of Sida cordifolia Linn. for nephroprotective effect in gentamicin-induced nephrotoxicity in rats. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of gentamicin 100 mg/kg/d for eight days. Effect of concurrent administration of ethanolic and aqueous extracts of leaves of Sida cordifolia Linn.at dose of 200 and 400 mg/kg b.w. respectively was given by oral route. Serum creatinine, serum urea, urine creatinine and blood urea nitrogen (BUN) were determined on day 9. Histopathological study of kidney was also done. Both the extracts produced significant(P<0.001)nephroprotective activity in Gentamicin induced nephrotoxicity models as evident by decrease in serum creatinine, serum urea, urine creatinine and BUN levels in extract treated groups which was elevated by gentamicin, which was further confirmed by histopathological study. Gentamicin induced glomerular congestion, blood vessel congestion, and epithelial desquamation, accumulation of inflammatory cells and necrosis of the kidney cells were found to be reduced in the groups receiving extracts of Sida cordifolia Linn.along with gentamicin.
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