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Effect of Dieckol, a Component of Ecklonia cava, on the Promotion of Hair Growth  [PDF]
Jung-Il Kang,Sang-Cheol Kim,Min-Kyoung Kim,Hye-Jin Boo,You-Jin Jeon,Young-Sang Koh,Eun-Sook Yoo,Sung-Myung Kang,Hee-Kyoung Kang
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13056407
Abstract: This study was conducted to evaluate the effect of Ecklonia cava, a marine alga native to Jeju Island in Korea, on the promotion of hair growth. When vibrissa follicles were cultured in the presence of E. cava enzymatic extract (which contains more than 35% of dieckol) for 21 days, E. cava enzymatic extract increased hair-fiber length. In addition, after topical application of the 0.5% E. cava enzymatic extract onto the back of C57BL/6 mice, anagen progression of the hair-shaft was induced. The treatment with E. cava enzymatic extract resulted in the proliferation of immortalized vibrissa dermal papilla cells (DPC). Especially, dieckol, among the isolated compounds from the E. cava enzymatic extract, showed activity that increased the proliferation of DPC. When NIH3T3 fibroblasts were treated with the E. cava enzymatic extract and the isolated compounds from the E.?cava enzymatic extract, the E. cava enzymatic extract increased the proliferation of NIH3T3 fibroblasts, but the isolated compounds such as eckol, dieckol, phloroglucinol and triphlorethol-A did not affect the proliferation of NIH3T3 fibroblasts. On the other hand, the E. cava enzymatic extract and dieckol significantly inhibited 5α-reductase activity. These results suggest that dieckol from E. cava can stimulate hair growth by the proliferation of DPC and/or the inhibition of 5α-reductase activity.
Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice
Hye Kyung Kim
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/439294
Abstract: Aims of study. Present study investigated the effect of Ecklonia cava (EC) on intestinal glucose uptake and insulin secretion. Materials and methods. Intestinal Na
Isolation and Structural Determination of Two Novel Phlorotannins from the Brown Alga Ecklonia kurome Okamura, and Their Radical Scavenging Activities  [PDF]
Mari Yotsu-Yamashita,Sawako Kondo,Shinya Segawa,Yi-Chin Lin,Haruhiko Toyohara,Hisatomi Ito,Keiichi Konoki,Yuko Cho,Takafumi Uchida
Marine Drugs , 2013, DOI: 10.3390/md11010165
Abstract: Two novel phlorotannins with a molecular weight of 974, temporarily named 974-A and 974-B, were isolated from the polyphenol powder prepared from the edible marine brown alga Ecklonia kurome Okamura , and their chemical structures were determined by spectroscopic method . The isolated yield of the total of 974-A and 974-B was approximately 4% (w/w) from the polyphenol powder. In 974-A, the carbon at the C2′ position in the A ring of phlorofucofuroeckol-A forms a C–C bond with the carbon at the C2″ position of the C ring of triphloretol-B, while in 974-B, phlorofucofuroeckol-B and triphloretol-B form a C–C bond in the same manner as in 974-A. These structures were supported by high resolution-MS/MS data. To evaluate the antioxidant activities, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and intracellular radical scavenging assay, using 2′,7′-dichlorofluorescin diacetate (DCFH-DA), were performed for 974-A, 974-B, and four known phlorotannins. The results of the DPPH assay showed that the IC 50 values of 974-A, 974-B, phlorofucofuroeckol-A, and dieckol were significantly smaller than those of phlorofucofuroeckol-B, phloroglucinol, α-tocopherol, and ascorbic acid. Furthermore, the DCFH-DA assay suggested that 974-A, 974-B, and dieckol reduce intracellular reactive oxygen species most strongly among the tested compounds.
Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway  [PDF]
Chen Zhang,Yong Li,Zhong-Ji Qian,Sang-Hoon Lee,Yong-Xin Li,Se-kwon Kim
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/140462
Abstract: The matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, as well as in the disease processes such as arthritis and cancer metastasis. In the present study, dieckol was obtained with high yield from marine brown alga Ecklonia cava (EC), and its effect was assessed on the expression of MMP-2 and -9 and morphological changes in human fibrosarcoma cell line (HT1080). Dieckol inhibited the expression of MMP-2 and -9 in a dose-dependent manner and also suppressed the cell invasion and the cytomorphology in 3D culture system on HT1080 cells. Moreover, dieckol may influence nuclear factor kappa B (NF-κB) pathway without obvious influence on activator protein-1 (AP-1) pathway and tissue inhibitor of metalloproteinases (TIMPs). In conclusion, dieckol could significantly suppress MMP-2 and -9 expression and alter cytomorphology of HT1080 cell line via NF-κB pathway. 1. Introduction The past few decades of cancer research has revealed that matrix metalloproteinases (MMPs) play a significant role in a variety of pathologic conditions. Especially in malignant tumors, the activities of MMPs are deregulated and their expressions are often associated with poor prognosis. Among all the MMPs, MMP-2 and -9 have demonstrated to play a major role in the establishment of metastasis, which substantially increases in majority of malignant tumors. Therefore, inhibition of MMP-2 and -9 is thought to have a therapeutic benefit for cancer [1–8]. Recently, significant achievements have been made in synthetic bioactive applications. However, natural compounds and their derivatives are still known as the richest source of bioactive compounds with huge pharmaceutical application potential [9]. Dieckol (Figure 1) is a phloroglucinal derivative isolated from marine brown alga Ecklonia cava (EC) with a variety of biological functions in vitro and in vivo, for example, antioxidant, antitumor, antihuman immunodeficiency virus (-HIV), and anti-inflammatory activities. For instance, dieckol is a novel safe phloroglucinal derivative which inhibited the cytopathic effects of HIV-1 including HIV-1-induced syncytia formation, lytic effects, and viral p24 antigen production, as well as exhibited reverse transcriptase enzymes inhibitory and HIV-1 entry activity in addition to its other biological properties [10, 11]. Figure 1: Chemical structure of dieckol. In the present study, effect of dieckol on the expression of MMP-2 and -9, cytotoxicity, and cellular invasiveness was evaluated in HT1080 cells. The selectivity of this
Inhibitory Effects of Ecklonia cava Extract on High Glucose-Induced Hepatic Stellate Cell Activation  [PDF]
Kumiko Yokogawa,Isao Matsui-Yuasa,Akiko Tamura,Masaki Terada,Akiko Kojima-Yuasa
Marine Drugs , 2011, DOI: 10.3390/md9122793
Abstract: Nonalcoholic steatohepatitis (NASH) is a disease closely associated with obesity and diabetes. A prevalence of type 2 diabetes and a high body mass index in cryptogenic cirrhosis may imply that obesity leads to cirrhosis. Here, we examined the effects of an extract of Ecklonia cava, a brown algae, on the activation of high glucose-induced hepatic stellate cells (HSCs), key players in hepatic fibrosis. Isolated HSCs were incubated with or without a high glucose concentration. Ecklonia cava extract (ECE) was added to the culture simultaneously with the high glucose. Treatment with high glucose stimulated expression of type I collagen and α -smooth muscle actin, which are markers of activation in HSCs, in a dose-dependent manner. The activation of high glucose-treated HSCs was suppressed by the ECE. An increase in the formation of intracellular reactive oxygen species (ROS) and a decrease in intracellular glutathione levels were observed soon after treatment with high glucose, and these changes were suppressed by the simultaneous addition of ECE. High glucose levels stimulated the secretion of bioactive transforming growth factor-β (TGF-β) from the cells, and the stimulation was also suppressed by treating the HSCs with ECE. These results suggest that the suppression of high glucose-induced HSC activation by ECE is mediated through the inhibition of ROS and/or GSH and the downregulation of TGF-β secretion. ECE is useful for preventing the development of diabetic liver fibrosis.
Polyphenol Contents and Polyphenol Oxidase Activities of Some Nigerian Kolanuts  [PDF]
T.P. Prohp,K.E. Ekpo,E.V. Osagie,A. Osagie
Pakistan Journal of Nutrition , 2009,
Abstract: The levels of polyphenol and activities of polyphenol oxidases in some Nigerian kolanuts were investigated. Garcina cola had the least polyphenol content of 15.60±1.70 (mg/g), while Cola nitida (red) recorded the highest value of 33.50±2.51mg/g. Polyphenol oxidase from Garcina cola had its optimum pH of activity in the acidic region (pH 3), but the white and red species of Cola nitida had a neutral (pH 7) optimum pH. With catechol as substrate, polyphenol oxidase activity was highest in Cola nitida (white) (55.70±2.60) and lowest in Garcina cola (2.22 ± 0.04). Whilst the values of polyphenol obtained may explain the high incidence of enzymatic browning in some Nigeria kolanuts, the white cultivar of Cola nitida could be further explored as a good source of polyphenol oxidase.
Sarcoma de vena cava inferior
León álvarez,Jorge Luis; Roselló Silva,Nelson; Llorens Nú?ez,Martha; Ochoa Montes,Luis Alberto; Zarza Llorca,Yoanka; Senra Piedra,Gerardo;
Revista Cubana de Medicina , 2010,
Abstract: authors present an infrequent case of a female patient with abdominal tumor a great superficial collateral circulation type cava-cava, the abdominal ultrasound, the transthoracic and transesophageal echocardiogram and the computerized axial tomography (cat) identified a tumor of the vena cava inferior. the fine-needle aspiration cytology of lesion confirmed the presence of primary fusopleomorphous sarcoma of high degree of malignancy of vena cava inferior.
Polyphenol Uses in Seafood Conservation
M.C. Gomez-Guillen,M.P. Montero
American Journal of Food Technology , 2007,
Abstract: Oxidative reactions are the main culprits in color alterations associated with seafood spoilage. Black spot formation or melanosis is a natural post-mortem oxidative mechanism, which cause crustaceans rejection by consumers because of their appearance. The use of phenolic compounds, such as 4-hexylresorcinol, appears to be a good alternative to the conventional sulphites, allowing longer conservation periods. Lipidic oxidation is also one of the main restrictive factors in the preservation of fish products. The application of natural plant extracts to prevent oxidative rancidity has been studied in a number of fish products. However, polyphenol-protein interactions may have a masking effect on the free radical scavenging activity of polyphenols and may also have a detrimental effect on the in vivo bioavailability of both phenolics and proteins. Polyphenolic plant extracts may be included into fish gelatin-based films in order to obtain an edible film with antioxidant properties. These films applied on the surface of raw or mild processed salted or smoked fish may increase the shelf life of fish products by reduction the lipid oxidation during the chilled storage.
Analysis on Composition and Antioxidative Properties of Phlorotannins Isolated from Japanese Eisenia and Ecklonia Species  [PDF]
Toshiyuki Shibata, Kohki Nagayama, Shingo Sugiura, Saki Makino, Mitsuyoshi Ueda, Yutaka Tamaru
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.615253
Abstract: The composition and antioxidative properties of crude phlorotannins isolated from Japanese Eisenia and Ecklonia species including cultured E. kurome were analyzed. As a result of liquid chromatography mass spectrometry analysis, it was suggested that the phlorotannins were composed of compounds containing 3 - 7 phloroglucinol units for Eisenia species and 3 - 8 phloroglucinol units for Ecklonia species. The antioxidant properties of phlorotannins were evaluated using the hydrophilic oxygen radical absorbance capacity (H-ORAC) assay, the measurements of superoxide anion radical scavenging activity (SOSA) with electron spin resonance method, and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and reducing power assay. It was clarified that the phlorotannins contained H-ORAC values of 8.9 × 103 - 1.0 × 104 μmol-Trolox equivalents (TE)/g, SOSA of 1.5 × 104 - 2.9 × 104 superoxide dismutase units/g, DPPH radical scavenging activity of 4.7 × 103 - 5.5 × 103 μmol-TE/g, and reducing power of 6.5 × 102 - 7.0 × 102 mg-ascorbic acid equivalents/g, and had excellent antioxidative properties.
Plant Polyphenol Antioxidants and Oxidative Stress
URQUIAGA,INES; LEIGHTON,FEDERICO;
Biological Research , 2000, DOI: 10.4067/S0716-97602000000200004
Abstract: in recent years there has been a remarkable increment in scientific articles dealing with oxidative stress. several reasons justify this trend: knowledge about reactive oxygen and nitrogen species metabolism; definition of markers for oxidative damage; evidence linking chronic diseases and oxidative stress; identification of flavonoids and other dietary polyphenol antioxidants present in plant foods as bioactive molecules; and data supporting the idea that health benefits associated with fruits, vegetables and red wine in the diet are probably linked to the polyphenol antioxidants they contain.in this review we examine some of the evidence linking chronic diseases and oxidative stress, the distribution and basic structure of plant polyphenol antioxidants, some biological effects of polyphenols, and data related to their bioavailability and the metabolic changes they undergo in the intestinal lumen and after absorption into the organism.finally, we consider some of the challenges that research in this area currently faces, with particular emphasis on the contributions made at the international symposium "biology and pathology of free radicals: plant and wine polyphenol antioxidants" held july 29-30, 1999, at the catholic university, santiago, chile and collected in this special issue of biological research
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