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Traumatic Hemothorax: Analysis of 282 Patients  [cached]
Fuat Say?r,Ufuk ?obano?lu,Abidin ?ehito?ullar?
Turk Toraks Dergisi , 2012,
Abstract: Objective: The approaches and results of the treatment were evaluated in the cases treated on admission to our clinic because of traumatic hemothorax. Materials and Methods: Of the cases admitted after trauma between 2002-2011, 282 patients treated in our clinic due to hemothorax were included. The cases were retrospectively analyzed in terms of age, gender, cause of trauma, treatment methods, indications of thoracotomy, the location of coexisting trauma in addition to thoracic trauma and treatment outcomes. Results: Motor-vehicle accidents were the most important cause of hemothorax (168 cases, 59.5%). penetrating injury in 58 cases (20.5%) and gunshot wounds in 32 cases (11.3%). Effective and adequate treatments were provided with tube thoracostomy in 165 cases (58.5%). The number of patients under 15 years was 22 (7.8%). Emergency thoracotomy was applied to 35 (12.4%) cases. The mean duration of stay of the cases at the hospital was 8.3 days. Mortality occurred in 9 cases (3.1%) and morbidity in 43 cases (15.2%). Conclusion: Tube thoracostomy was sufficient to treat the vast majority of the cases. Benefit can be obtained from video thoracoscopy as the first step of treatment in cases with isolated hemothorax who are hemodynamically stable because of traumatic hemothorax. Thoracotomy has been less necessary than the tube thoracostomy. However, thoracotomy should not be avoided even in the emergency department when necessary.
$α$-Decay Lifetime in Superheavy Nuclei With $A>282$  [PDF]
Madhubrata Bhattacharya,G. Gangopadhyay
Physics , 2008, DOI: 10.1103/PhysRevC.77.047302
Abstract: Nuclei with $A>282$ have been studied in the Relativistic Mean Field approach using the force FSU Gold and a zero range pairing interaction. The Euler-Lagrange equations have been solved in the co-ordinate space. Alpha nucleus potential has been constructed with the DDM3Y1 interaction, which has an exponential density dependence, in the double folding model using the nucleon densities in the daughter nucleus and the $\alpha$ particle. Half lives of $\alpha$ decay have been calculated for tunneling of the $\alpha$ particle through the potential barrier in the WKB approximation and assuming a constant preformation probability. The resulting values agree well with experimental measurements.
海洋石油281/282平台防腐蚀涂装  [PDF]
程龙,李剑石,曹士峰,王鋆,潘煜怡
涂料工业 , 2009,
Abstract: ?介绍了海洋石油281/282平台涂装的主要配套体系以及涂装过程控制。
Compound Heterozygous C282Y/H63D Mutation in Hemochromatosis: A Case Report  [PDF]
Zazour Abdelkrim, Wafaa Khannoussi, Amine El Mekkaoui, Ghizlane Kharrasse, Zahi Ismaili
Open Journal of Clinical Diagnostics (OJCD) , 2016, DOI: 10.4236/ojcd.2016.63006
Abstract: Hereditary hemochromatosis is a condition characterized by iron overload, which is both treatable and preventable. It’s mainly related to hepcidin deficiency related to mutations in genes involved in hepcidin regulation. Iron overload increases the risk of disease such as liver cirrhosis, heart disease and diabetes. Two HFE genotypes have been commonly described in cases of iron overload, C282Y homozygosity and C282Y/H63D compound heterozygoty. The diagnosis of this rare disease now can be explored by biological and imaging tools. We report a case of compound heterozygous C282Y/H63D discovered by family screening for elevated serum ferritin.
Analysis of HLA-A antigens and C282Y and H63D mutations of the HFE gene in Brazilian patients with hemochromatosis
Bittencourt, P.L.;Palácios, S.A.;Couto, C.A.;Can?ado, E.L.R.;Carrilho, F.J.;Laudanna, A.A.;Kalil, J.;Gayotto, L.C.C.;Goldberg, A.C.;
Brazilian Journal of Medical and Biological Research , 2002, DOI: 10.1590/S0100-879X2002000300007
Abstract: the hemochromatosis gene, hfe, is located on chromosome 6 in close proximity to the hla-a locus. most caucasian patients with hereditary hemochromatosis (hh) are homozygous for hla-a3 and for the c282y mutation of the hfe gene, while a minority are compound heterozygotes for c282y and h63d. the prevalence of these mutations in non-caucasian patients with hh is lower than expected. the objective of the present study was to evaluate the frequencies of hla-a antigens and the c282y and h63d mutations of the hfe gene in brazilian patients with hh and to compare clinical and laboratory profiles of c282y-positive and -negative patients with hh. the frequencies of hla-a and c282y and h63d mutations were determined by pcr-based methods in 15 male patients (median age 44 (20-72) years) with hh. eight patients (53%) were homozygous and one (7%) was heterozygous for the c282y mutation. none had compound heterozygosity for c282y and h63d mutations. all but three c282y homozygotes were positive for hla-a3 and three other patients without c282y were shown to be either heterozygous (n = 2) or homozygous (n = 1) for hla-a3. patients homozygous for the c282y mutation had higher ferritin levels and lower age at onset, but the difference was not significant. the presence of c282y homozygosity in roughly half of the brazilian patients with hh, together with the findings of hla-a homozygosity in c282y-negative subjects, suggest that other mutations in the hfe gene or in other genes involved in iron homeostasis might also be linked to hh in brazil.
Analysis of HLA-A antigens and C282Y and H63D mutations of the HFE gene in Brazilian patients with hemochromatosis  [cached]
Bittencourt P.L.,Palácios S.A.,Couto C.A.,Can?ado E.L.R.
Brazilian Journal of Medical and Biological Research , 2002,
Abstract: The hemochromatosis gene, HFE, is located on chromosome 6 in close proximity to the HLA-A locus. Most Caucasian patients with hereditary hemochromatosis (HH) are homozygous for HLA-A3 and for the C282Y mutation of the HFE gene, while a minority are compound heterozygotes for C282Y and H63D. The prevalence of these mutations in non-Caucasian patients with HH is lower than expected. The objective of the present study was to evaluate the frequencies of HLA-A antigens and the C282Y and H63D mutations of the HFE gene in Brazilian patients with HH and to compare clinical and laboratory profiles of C282Y-positive and -negative patients with HH. The frequencies of HLA-A and C282Y and H63D mutations were determined by PCR-based methods in 15 male patients (median age 44 (20-72) years) with HH. Eight patients (53%) were homozygous and one (7%) was heterozygous for the C282Y mutation. None had compound heterozygosity for C282Y and H63D mutations. All but three C282Y homozygotes were positive for HLA-A3 and three other patients without C282Y were shown to be either heterozygous (N = 2) or homozygous (N = 1) for HLA-A3. Patients homozygous for the C282Y mutation had higher ferritin levels and lower age at onset, but the difference was not significant. The presence of C282Y homozygosity in roughly half of the Brazilian patients with HH, together with the findings of HLA-A homozygosity in C282Y-negative subjects, suggest that other mutations in the HFE gene or in other genes involved in iron homeostasis might also be linked to HH in Brazil.
Hepatocellular carcinoma and the penetrance of HFE C282Y mutations: a cross sectional study
Gavin Willis, Vicky Bardsley, Ian W Fellows, Ray Lonsdale, Jennie Z Wimperis, Barbara A Jennings
BMC Gastroenterology , 2005, DOI: 10.1186/1471-230x-5-17
Abstract: Tissue biopsies were analysed from 144 cases of hepatocellular carcinoma for HFE C282Y mutations; the data produced were compared with the frequency of HFE mutations in a large sample of the local population. Data were also retrieved from the East Anglian Cancer Intelligence Unit to determine the annual incidence of hepatocellular carcinoma; and from appropriate life tables.Eight out of 144 of the cases were homozygous for the HFE C282Y mutation, all 8 cases were male. 6 of these 8 cases had a previous diagnosis of hereditary haemochromatosis. Male HFE C282Y homozygotes were more likely to be diagnosed with hepatocellular carcinoma (odds ratio [OR] = 14, 95% confidence interval [CI] = 5–37). For this population, we estimate that the penetrance of the HFE C282Y homozygous genotype, with respect to hepatocellular carcinoma, was between 1.31 % and 2.1% for males and was zero for females.In this population, we found that only a very small proportion of homozygotes for the HFE C282Y mutation developed hepatocellular carcinoma. However, individuals with this genotype have a significantly increased risk of this rare disease relative to those who do not carry the mutations.Hereditary haemochromatosis is an autosomal recessive genetic condition in which excess iron is absorbed by the intestine. Individuals with the clinical manifestations of the disease (which include liver cirrhosis, hepatocellular carcinoma, diabetes mellitus, cardiomyopathy and arthropathy) will have accumulated iron over many years of adult life resulting in progressive tissue damage. Liver disease is the commonest cause of death of patients with hereditary haemochromatosis [1,2]. A recent cohort study of patients diagnosed with haemochromatosis in Sweden found that at ten years follow-up, the absolute risk of liver cancer was 6% among men and 1.5% among women [3]. This patient cohort is likely to be at higher risk of liver cancer than those HFE C282Y homozygotes who do not display the signs and symptoms
C282Y-HFE Gene Variant Affects Cholesterol Metabolism in Human Neuroblastoma Cells  [PDF]
Fatima Ali-Rahmani, Michael A. Huang, C.-L. Schengrund, James R. Connor, Sang Y. Lee
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088724
Abstract: Although disruptions in the maintenance of iron and cholesterol metabolism have been implicated in several cancers, the association between variants in the HFE gene that is associated with cellular iron uptake and cholesterol metabolism has not been studied. The C282Y-HFE variant is a risk factor for different cancers, is known to affect sphingolipid metabolism, and to result in increased cellular iron uptake. The effect of this variant on cholesterol metabolism and its possible relevance to cancer phenotype was investigated using wild type (WT) and C282Y-HFE transfected human neuroblastoma SH-SY5Y cells. Expression of C282Y-HFE in SH-SY5Y cells resulted in a significant increase in total cholesterol as well as increased transcription of a number of genes involved in its metabolism compared to cells expressing WT-HFE. The marked increase in expression of NPC1L1 relative to that of most other genes, was accompanied by a significant increase in expression of NPC1, a protein that functions in cholesterol uptake by cells. Because inhibitors of cholesterol metabolism have been proposed to be beneficial for treating certain cancers, their effect on the viability of C282Y-HFE neuroblastoma cells was ascertained. C282Y-HFE cells were significantly more sensitive than WT-HFE cells to U18666A, an inhibitor of desmosterol Δ24-reductase the enzyme catalyzing the last step in cholesterol biosynthesis. This was not seen for simvastatin, ezetimibe, or a sphingosine kinase inhibitor. These studies indicate that cancers presenting in carriers of the C282Y-HFE allele might be responsive to treatment designed to selectively reduce cholesterol content in their tumor cells.
HFE C282Y and H63D in adults with malignancies in a community medical oncology practice
James C Barton, Luigi F Bertoli, Ronald T Acton
BMC Cancer , 2004, DOI: 10.1186/1471-2407-4-6
Abstract: Data from patients with more than one malignancy were analyzed according to each primary malignancy. For the present study, OR ≥2.0 or ≤0.5 was defined to be increased or decreased, respectively.There were 110 primary malignancies (52 hematologic neoplasms, 58 carcinomas) in the 100 adult patients. Allele frequencies were similar in patients and controls (C282Y: 0.0850 vs. 0.0896, respectively (OR = 0.9); H63D: 0.1400 vs. 0.1447, respectively (OR = 0.9)). Two patients had hemochromatosis and C282Y homozygosity. With C282Y, increased OR occurred in non-Hodgkin lymphoma, myeloproliferative disorders, and adenocarcinoma of prostate (2.0, 2.8, and 3.4, respectively); OR was decreased in myelodysplasia (0.4). With H63D, increased OR occurred in myeloproliferative disorders and adenocarcinomas of breast and prostate (2.4, 2.0, and 2.0, respectively); OR was decreased in non-Hodgkin lymphoma and B-chronic lymphocytic leukemia (0.5 and 0.4, respectively).In 100 consecutive adults with malignancy evaluated in a community medical oncology practice, frequencies of HFE C282Y or H63D were similar to those in the general population. This suggests that C282Y or H63D is not associated with an overall increase in cancer risk. However, odds ratios computed in the present study suggest that increased (or decreased) risk for developing specific types of malignancy may be associated with the inheritance of HFE C282Y or H63D. Study of more patients with these specific types of malignancies is needed to determine if trends described herein would remain and yield significant differences.An increased prevalence of certain types of malignancy has been reported in putative hemochromatosis heterozygotes characterized by iron phenotype criteria or family studies [1-4]. However, discovery of the HFE gene on Ch6p and two common hemochromatosis-associated HFE missense mutations C282Y (exon 4; nt 845G→A) and H63D (exon 2; nt 187 C→G) [5] permits definition of hemochromatosis heterozygosity using mo
Bernoulli process with 282 ky periodicity is detected in the R-N reversals of the earth's magnetic field  [PDF]
Jozsef Garai
Physics , 2004,
Abstract: Investigating the polarity time scales for the last 118 My a Bernoulli process with p=0.5 overriding with a Gaussian noise have been detected for the R-N magnetic reversals. The Bernoulli trials are separated by 282 ky. The frequency of the Bernoulli process correlates to planetary cycles and consistent with an impact triggered global cooling mechanism. The detected pattern allows calculating the probability of an upcoming R-N reversal between any time intervals.
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