oalib
Search Results: 1 - 10 of 100 matches for " "
All listed articles are free for downloading (OA Articles)
Page 1 /100
Display every page Item
Myasthenia gravis and thymoma: evaluation of 41 patients
ASSIS, JOSé LAMARTINE DE;ZAMBON, ANTONIO ALBERTO;SOUZA, PATRICIA S.;MARCHIORI, PAULO EURIPEDES;
Arquivos de Neuro-Psiquiatria , 1999, DOI: 10.1590/S0004-282X1999000100002
Abstract: we evaluated the epidemiological, clinical, laboratory and therapeutical aspects of 41 patients with thymomatous myasthenia gravis. thirty five patients (85.36%) were submitted to thymectomy. follow-up ranged from two to 18 years. diagnosis of thymoma was based upon clinical investigations and ct scan of the anterior mediastinum and in 11 patients supported by immunological tests of anti-striated muscle antibodies with a positive result in more than 80% of cases. histopathologic examination of all thymomectomized patients confirmed the diagnosis of thymoma. there was a significant predominance of benign over malignant thymoma. occurred higher prevalence of male patients and of patients over 40 years of age. the therapeutical strategy to control myasthenic clinical findings was the same as that for non-thymomatous myasthenia gravis. the corticosteroids associated to cytotoxic drugs were less often used. radiotherapy of the anterior mediastinum was more often used in patients having invasive tumors submitted to surgery or not. with regard to survival and control of myasthenia gravis, especially in younger patients and in those submitted to early surgery, results of treatment were surprisingly favorable.
Myasthenia gravis and thymoma: evaluation of 41 patients  [cached]
ASSIS JOSé LAMARTINE DE,ZAMBON ANTONIO ALBERTO,SOUZA PATRICIA S.,MARCHIORI PAULO EURIPEDES
Arquivos de Neuro-Psiquiatria , 1999,
Abstract: We evaluated the epidemiological, clinical, laboratory and therapeutical aspects of 41 patients with thymomatous myasthenia gravis. Thirty five patients (85.36%) were submitted to thymectomy. Follow-up ranged from two to 18 years. Diagnosis of thymoma was based upon clinical investigations and CT scan of the anterior mediastinum and in 11 patients supported by immunological tests of anti-striated muscle antibodies with a positive result in more than 80% of cases. Histopathologic examination of all thymomectomized patients confirmed the diagnosis of thymoma. There was a significant predominance of benign over malignant thymoma. Occurred higher prevalence of male patients and of patients over 40 years of age. The therapeutical strategy to control myasthenic clinical findings was the same as that for non-thymomatous myasthenia gravis. The corticosteroids associated to cytotoxic drugs were less often used. Radiotherapy of the anterior mediastinum was more often used in patients having invasive tumors submitted to surgery or not. With regard to survival and control of myasthenia gravis, especially in younger patients and in those submitted to early surgery, results of treatment were surprisingly favorable.
Levamisole Aids in Treatment of Refractory Oral Candidiasis in Two Patients with Thymoma Associated with Myasthenia Gravis: Report of Two Cases  [PDF]
Wei-Hao Lai,Shin-Yu Lu,Hock-Liew Eng
Chang Gung Medical Journal , 2002,
Abstract: Oral candidiasis is associated with defects in cell-mediated immunity and is commonamong patients undergoing cytotoxic chemotherapy, or corticosteroid or antibiotic therapy,and those patients seropositive for AIDS and HIV (human immunodeficiency virus). Thispaper demonstrates the important role of cell-mediated immunity in oral candidiasis in 2cases of thymoma associated with myasthenia gravis. Both suffered from recurrent oral candidiasisafter a thymectomy, radiotherapy, and chemotherapy. There was an initial goodresponse to conventional antifungal therapy, which later became refractory. Lymphocytesubset quantitation showed a T cell deficiency and a decreased CD4/CD8 ratio. Levamisole,an immunomodulator, or an immunopotentiating drug was added as adjunctive therapy incombination with oral nystatin treatment. Oral candidiasis responded favorably, and substantialrelief was obtained with a concurrent increase in T cells and the CD4/CD8 ratio.These findings clearly demonstrate a significant role of cell-mediated immunity in oral candidiasis,and that eradication of infection is dependent on the host defense mechanism.
Rare association of thymoma, myasthenia gravis and sarcoidosis : a case report
Mohankumar Kurukumbi, Roger L Weir, Janaki Kalyanam, Mansoor Nasim, Annapurni Jayam-Trouth
Journal of Medical Case Reports , 2008, DOI: 10.1186/1752-1947-2-245
Abstract: A 59-year-old female patient with a history of sarcoidosis was admitted to the hospital with a one-day history of sudden onset of right-sided partial ptosis and diplopia. Neurosarcoidosis with cranial nerve involvement was considered, but was ruled out by the clinical findings, and MG was confirmed by the positive tensilon test, electrophysiological findings and positive acetylcholine receptor binding antibodies. On further evaluation, a CT chest scan showed a left anterior mediastinal mass and bilateral lymphadenopathy. Post surgical diagnosis confirmed the thymoma and sarcoidosis in the lymph nodes.When two or more diseases of undetermined origin are found together, several interesting questions are raised. It is important to first confirm the diagnoses individually. Immunologic mechanisms triggering the occurrence of these diagnoses together, are difficult to address. Although the coexistence of thymoma, MG and sarcoidosis may be coincidental, it is noteworthy to report this case because of the multiple interesting features observed as well as the rarity of occurrence.The association of thymoma with myasthenia gravis (MG) is well known and amply quoted [1,2]. Thymoma with sarcoidosis however, is very rare [3]. Presented here is an interesting case with coexisting thymoma, MG and sarcoidosis.A 59-year-old female patient was admitted to the hospital with a one-day history of sudden onset of right-sided partial ptosis and diplopia on right lateral gaze. The patient had generalized fatigue for over a year. At the age of 30, the patient had symptoms of dyspnoea and painful nodular swellings over her legs. During that time, sarcoidosis was suspected and was confirmed by lung biopsy. For the fear of adverse effects, she had declined steroid treatment. The patient had occasional flares since then until a year later, when she suffered from exacerbation of sarcoidosis in the form of polyarthritis, generalized fatigue, dyspnoea, fever and nodular swelling over legs. The pat
Thymoma with Myasthenia Gravis in Adolescent  [cached]
Prasad K Shetty,,Balaiah K,,Ganesh Nayak,,Prasanna K Shetty
Online Journal of Health & Allied Sciences , 2011,
Abstract: Thymomas are exceedingly rare in the first 20 years of life, Thymic lesions comprise approximately 2–3% of all pediatric mediastinal tumors and include thymic cysts, hyperplasia, carcinoma, and thymomas. Fewer than 30 cases in children have been described in the literature. Thymomas in adults are commonly associated with other diseases, the most frequent being myasthenia gravis. However, this association has been rarely reported in childhood. These tumors are typically aggressive, with poor outcomes. We report a case of thymoma associated with myasthenia gravis in a 16-year-old girl and review the literature.
Autoimmune Hepatitis-Primary Biliary Cirrhosis: Overlap Syndrome Concomitant with Unexpected Myasthenia and Thymoma  [PDF]
Mahfoudhi Madiha, Mamlouk Habiba, Turki Sami, Kheder Adel
Open Journal of Clinical Diagnostics (OJCD) , 2015, DOI: 10.4236/ojcd.2015.51004
Abstract: The myasthenia gravis is an autoimmune disease which can be associated frequently with a thymoma and also with autoimmune pathologies. We report the case of a 64-year-old man affected an overlap syndrome corresponding to the association of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). He also presented concomitant myasthenia gravis and thymoma. The physical examination notes only a disturbed voice. The liver tests showed: alkaline phosphatase 600 U/l, alanine aminotransferase 1280 U/l, and aspartate aminotransferase 985 U/l. Viral serologies of hepatitis were all negative, as well as antinuclear, antimitochondrial and antismooth muscle antibodies. The diagnosis of an overlap syndrome was posed according to the biological and hepatic histhological results. An associated myasthenia was confirmed by the results of the EMG and the positivity of the anti-acetylcholine receptor antibody. A chest CT revealed a thymoma. The treatment consisted of ursodeoxycholic acid, prednisone, azathioprine and pyridostigmine. And the patient improved his voice and the liver function. Thymectomy was practiced without incidents.
A study of myasthenia gravis in patients with and without thymoma.
Roy A,Kalita J,Misra U,Kar D
Neurology India , 2000,
Abstract: This study was undertaken to compare the clinical, neurophysiological, radiological and prognostic features of myasthenia gravis with and without thymoma. 37 patients with myasthenia gravis (27 males, 10 females), with age range of 4.5 to 72 (mean 39) years, were managed at a tertiary care centre in India. Four patients were below 15 years of age and 6 above 55 years. Most of the patients were in stage II (34). There were 2 patients in stage III and 1 in stage I. 27 patients underwent thymectomy. Thymoma was detected in 10 cases. The decrement in patients with thymoma ranged between 11 and 62% (mean 27.9%) and nonthymoma group 10-75% (mean 28%). CT scan of thorax revealed mediastinal mass in 5 out of 10 cases of thymoma and 2 out of 27 patients without thymoma. Outcome of myasthenia gravis with thymoma was worse than without thymoma at 1 year followup. Severity of illness, extent of decrement, lack of facilitation, duration of illness and age of the patients were not related to the outcome. It is concluded the clinical and neurophysiological changes in myasthenia gravis with and without thymoma do not differ. However, patients with thymoma have a worse outcome.
Myasthenia Gravis with Thymoma: Histopathologic Examination and Rate of Complication After Surgery  [PDF]
Ay?e ?evik,Kutsal Turhan,Alpaslan ?akan,Ali ?zdil
Journal of Clinical and Analytical Medicine , 2011, DOI: 10.4328
Abstract: Aim: It is known that thymus and thymoma have a role in the etiopathogenesis of myasthenia gravis (MG). These associations and their effects on the survival have investigated in several studies since 17th century. The incidence of MG in patients with thymoma was reported to be 20-50% in different studies. The aim of this study is to investigate the relationship between thymoma and MG and to evaluate the rates of postoperative complications. Material and Methods: The study included 25 patients (13 female and 12 male) and the mean age of patients was 42.3 years (range 24 to 70 years). 11 (44%) of patients had been treated with the diagnosis of MG. Eight (57%) of 14 (56%) patients without the diagnosis of MG had no symptoms and thymoma was detected accidentaly. The common symptom of the other 6 (43%) patients was cough. 9 (36%) patients were staged according to WHO classification. The other patients could not be staged according to WHO classification; because they were operated before the year of 2001. Four of patients were stage B1, 2 were stage B2, 2 were stage B3 and 1 was stage AB. Postoperative complication occured in 4 (16%) patients. Results: MG was seen with a higher rate in cortical thymoma when compared with medullary thymoma, in immunohistochemical investigations. MG had been thought as a negative prognostic factor for thymoma but in the last years it had been reported as a positive prognostic factor due to the development of postoperative intensive care conditions, medical therapy and follow up.
Clinical Study on the Prognosis of Patients with Thymoma with Myasthenia Gravis  [PDF]
Dongfeng YUAN, Zhitao GU, Guanghui LIANG, Wentao FANG, Yin LI, Chinese Alliance for Research of Thymoma Database
- , 2018, DOI: : 10.3779/j.issn.1009-3419.2018.01.01
Abstract: Background and objective Thymoma is frequently associated with myasthenia gravis (MG). However, whether MG is a factor for the outcome of patients with thymoma following complete thymectomy remains unknown. The aim of this study is to investigate the effect of thymoma with MG prognostic factors. Methods A retrospective analysis of The Chinese Alliance for Research in Thymomas (ChART) database within 1992-2012 complete cases 875 cases, 20 years follow-up data analysis thymic tumor tissue type credits and MG, Masaoka staging and prognosis, postoperative adjuvant therapy and relationship with the prognosis of surgical removal of the way. Results Thymic tumor tissue type credit has correlation with MG, difference was statistically significant (χ2=24.908, P<0.001). MG: incidence of B2 type (58/178, 32.58%) > B3 type (65/239, 27.20%) > B1 (27/132, 20.45%) > AB (43/267, 16.10%) > type A, 10.17% (6/59), Masaoka stage has no correlation with MG (χ2=0.365, P=1.365). Survival analysis showed that the WHO classification, Masaoka stage associated with prognosis (P<0.05), and whether the merger MG (χ2=0.113, P=0.736), postoperative adjuvant radiotherapy (χ2=0.380, P=0.538) has nothing to do with the prognosis, postoperative adjuvant chemotherapy is associated with poor prognosis (χ2=14.417, P<0.001). Whether has nothing to do with the prognosis of the thymus resection (χ2=1.548, P=1.548), whether the whole correlated with the curative effect of thymus excision with MG (χ2=24.695, P<0.001). Conclusion Thymoma patients with MG and extended thymectomy have no correlation with prognosis. Extended thymectomy can improve the effect of MG patients.
Invasive medullary thymoma associated with myasthenia gravis: an unusual case
REIS FILHO, JORGE S.;MILANEZI, MARIA FERNANDA;MOREIRA, CHRISTIANO G.;WERNECK, LINEU C.;BOSCARDIN, PAULO;IOSHII, SERGIO OSSAMU;SCHMITT, FERNANDO C.;
Arquivos de Neuro-Psiquiatria , 2000, DOI: 10.1590/S0004-282X2000000600020
Abstract: thymomas are tumors characterized by a remarkable morphological heterogeneity and variable clinical behavior. this tumor has unique clinical associations, most notably with hematological abnormalities and myasthenia gravis. according with the müller-hermelink criteria, there are significant differences between the histological types of thymomas and the association with myasthenia gravis. among the different histological types, medullary thymoma is the least frequent variant associated with this autoimmune disease. in this report we describe a case of medullary thymoma presenting in a 71-year- old woman with a myasthenic syndrome.
Page 1 /100
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.