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Porous glasses with sodium nitrite impregnations  [PDF]
Ewa Rysiakiewicz-Pasek,Ryszard Poprawski,Adam Urbanowicz,Miroslaw Maczka
Optica Applicata , 2005,
Abstract: The properties of sodium nitrite introduced in porous glasses have been investigated. SEM graphs indicate existence of sodium nitrite inside glass pores. It has been shown that FTIR and Raman spectra are similar for bulk sodium nitrite and sodium nitrite embedded into porous glass. The nature of FTIR and Raman bands has been determined. The size-effect of sodium nitride introduced into porous glass was observed on the basis of dielectric measurements.
Beyond Field Effect: Analysis of Shrunken Centroids in Normal Esophageal Epithelia Detects Concomitant Esophageal Adenocarcinoma
Florin M. Selaru,Suna Wang,Jing Yin,Karsten Schulmann
Bioinformatics and Biology Insights , 2007,
Abstract: Background and Aims: Because of the extremely low neoplastic progression rate in Barrett’s esophagus, it is difficult to diagnose patients with concomitant adenocarcinoma early in their disease course. If biomarkers existed in normal squamous esophageal epithelium to identify patients with concomitant esophageal adenocarcinoma, potential applications would be far-reaching. The aim of the current study was to identify global gene expression patterns in normal esophageal epithelium capable of revealing simultaneous esophageal adenocarcinoma, even located remotely in the esophagus.Methods: Tissues comprised normal esophageal epithelia from 9 patients with esophageal adenocarcinoma, 8 patients lacking esophageal adenocarcinoma or Barrett’s, and 6 patients with Barrett’s esophagus alone. cDNA microarrays were performed, and pattern recognition in each of these subgroups was achieved using shrunken nearest centroid predictors. Results: Our method accurately discriminated normal esophageal epithelia of 8/8 patients without esophageal adenocarcinoma or Barrett’s esophagus and of 6/6 patients with Barrett’s esophagus alone from normal esophageal epithelia of 9/9 patients with Barrett’s esophagus and concomitant esophageal adenocarcinoma. Moreover, we identified genes differentially expressed between the above subgroups. Thus, based on their corresponding normal esophageal epithelia alone, our method accurately diagnosed patients who had concomitant esophageal adenocarcinoma.Conclusions: These global gene expression patterns, along with individual genes culled from them, represent potential biomarkers for the early diagnosis of esophageal adenocarcinoma from normal esophageal epithelia. Genes discovered in normal esophagus that are differentially expressed in patients with vs. without esophageal adenocarcinoma merit further pursuit in molecular genetic, functional, and therapeutic interventional studies.
Does a glycine sodium nitrite crystal exist?  [PDF]
Kiran T. Dhavskar,Bikshandarkoil R. Srinivasan
Physics , 2015,
Abstract: The glycine sodium nitrite crystal reported by Khandpekar and Pati in the paper entitled, Synthesis and characterisation of glycine sodium nitrite crystals having non linear optical behaviour, Opt Commun 285, 2012 288-293 is actually gamma-glycine. In addition, we show that glycine barium ammonium nitrate, glycine sodium zinc sulfate, glycine barium calcium nitrate, glycine acetamide and glycine dimer are dubious crystals.
Effects of Urethane and Sodium Nitrite on Different Tissues of Mice
F Koohdani,F Sasani,K Mohammad,P Mehdipour
Journal of School of Public Health and Institute of Public Health Research , 2008,
Abstract: Background and Aim: To determin the most sensitive tissues to carcinogenic effect of urethane and co-carcinogenic effect of sodium nitrite by investigation of histopathological variations in different tissues of balb/c mice.Materials and Methods: An experimental study in 40 inbred balb/c mice aged 9-11 weeks was designed. The samples were classified into 4 groups: The first group was mice treated with 50 mg/l sodium nitrite in 0.9% NaCl instead drinking water SN&NaCl). The urethane group (U) was characterized by intraperitoneal injection of 3 times urethane (600 mg/ kg/day at 48 hour intervals). The third group was given 50 mg/l sodum nitrite in drinking water (U&SN) following the same intake of urethane as the second group, and the forth one was the control group. All mice were sacrificed after 20 weeks; tissues were removed and examined for histopathological changes. Data analyzed by Fisher exact test.Results: The formation of lung tumor was, significantly, increased in the urethane group as compared with the control group & (NS+Nacl) groups ( respectively P<.004 & P<.02) and in (U+NS) group as compared with the control group & (NS+Nacl) groups ( respectively P<.003 & P<.02). In females mice also The formation of lung tumor was, significantly, increased in the urethane group as compared with the control group & (NS+NaCl) groups (P<.05) and in the (U+NS) group was significantly higher than those in (C) & (NS+NaCl) groups (P<.009).The formation of lung adenocarcinomas was, significantly, increased in the (U+NS) group as compaired with the (C) & (NS+Nacl) groups (P<.003). In females mice also the formation of lung adenocarcinomas was, significantly, increased in the (U+NS) group as compaired with the (C) & (NS+Nacl) groups (P<.009) and (U) group (p<.05).The frequencies of stomach and testis hyperplasia and metaplasia in different groups did not show any significant differences. There was no histopathological variation in other tissues.Conclusion: Our results showed the tumorigenic effect of urethane in lung tissue. Sodium nitrite increases tumorogenic effect of urethan. Sodium nitrite increases carcinogenic effect of urethan (This result is the first study that suggest sodium nitrite increases carcinogenic effect of urethan).Urethan increases co-carcinogenic effect of sodium nitrite.
CYTOGENETICS EFFECTS INDUCED BY NITRITE OF SODIUM ON MITOTIC DIVISION AT ALLIUM CEPA L.  [cached]
Silvica Padureanu
Analele ?tiin?ifice Ale Universit??ii Alexandru Ioan Cuza din Ia?i,Sectiunea II A : Genetica si Biologie Moleculara , 2006,
Abstract: The paper presents the influence of nitrite of sodium upon the mitotic division of Allium cepa L. The treatment with nitrite of sodium has determined the lessening of the mitotic index and the chromosomial mutations.. The experiment prowed that nitrite of sodium, known as a polluting agent has a mutagenic potential on the plants.
Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction
Bakytbek Egemnazarov, Ralph T Schermuly, Bhola K Dahal, Garry T Elliott, Niel C Hoglen, Mark W Surber, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Hossein A Ghofrani
Respiratory Research , 2010, DOI: 10.1186/1465-9921-11-81
Abstract: Ex vivo isolated rabbit lungs perfused with erythrocytes in Krebs-Henseleit buffer (adjusted to 10% hematocrit) and in vivo anesthetized catheterized rabbits were challenged with periods of hypoxic ventilation alternating with periods of normoxic ventilation. After baseline hypoxic challenges, vehicle, sodium nitrite or acidified sodium nitrite was delivered via nebulization. In the ex vivo model, pulmonary arterial pressure and nitric oxide concentrations in exhaled gas were monitored. Nitrite and nitrite/nitrate were measured in samples of perfusion buffer. Pulmonary arterial pressure, systemic arterial pressure, cardiac output and blood gases were monitored in the in vivo model.In the ex vivo model, nitrite nebulization attenuated HPV and increased nitric oxide concentrations in exhaled gas and nitrite concentrations in the perfusate. The acidified forms of sodium nitrite induced higher levels of nitric oxide in exhaled gas and had longer vasodilating effects compared to nitrite alone. All nitrite formulations increased concentrations of circulating nitrite to the same degree. In the in vivo model, inhaled nitrite inhibited HPV, while pulmonary arterial pressure, cardiac output and blood gases were not affected. All nitrite formulations had similar potency to inhibit HPV. The tested concentration of appeared tolerable.Nitrite alone and in acidified forms effectively and similarly attenuates HPV. However, acidified nitrite formulations induce a more pronounced increase in nitric oxide exhalation.Hypoxia-induced pulmonary arterial vasoconstriction is an important physiologic mechanism leading to redistribution of blood flow from poorly ventilated areas of the lung to better ventilated ones in an attempt to optimize ventilation-perfusion matching [1]. Generalized HPV, which occurs during exposure to hypoxia or at high altitudes, is a pathophysiologic process resulting in an acute increase in pulmonary vascular resistance, right ventricular overload, and restriction
The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury  [PDF]
Wei Li,Zihui Meng,Yuliang Liu,Rakesh P. Patel,John D. Lang
Journal of Transplantation , 2012, DOI: 10.1155/2012/635179
Abstract: Liver ischemia-reperfusion injury is a major cause of primary graft non-function or initial function failure post-transplantation. In this study, we examined the effects of sodium nitrite supplementation on liver IRI in either Lactated Ringer's (LR) solution or University of Wisconsin (UW) solution. The syngeneic recipients of liver grafts were also treated with or without nitrite by intra-peritoneal injection. Liver AST and LDH release were significantly reduced in both nitrite-supplemented LR and UW preservation solutions compared to their controls. The protective effect of nitrite was more efficacious with longer cold preservation times. Liver histological examination demonstrated better preserved morphology and architecture with nitrite treatment. Hepatocellular apoptosis was significantly reduced in the nitrite-treated livers compared their controls. Moreover, liver grafts with extended cold preservation time of 12 to 24 hours demonstrated improved liver tissue histology and function post-reperfusion with either the nitrite-supplemented preservation solution or in nitrite-treated recipients. Interestingly, combined treatment of both the liver graft and recipient did not confer protection. Thus, nitrite treatment affords significant protection from cold ischemic and reperfusion injury to donor livers and improves liver graft acute function post-transplantation. The results from this study further support the potential for nitrite therapy to mitigate ischemia-reperfusion injury in solid organ transplantation.
The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury  [PDF]
Wei Li,Zihui Meng,Yuliang Liu,Rakesh P. Patel,John D. Lang
Journal of Transplantation , 2012, DOI: 10.1155/2012/635179
Abstract: Liver ischemia-reperfusion injury is a major cause of primary graft non-function or initial function failure post-transplantation. In this study, we examined the effects of sodium nitrite supplementation on liver IRI in either Lactated Ringer's (LR) solution or University of Wisconsin (UW) solution. The syngeneic recipients of liver grafts were also treated with or without nitrite by intra-peritoneal injection. Liver AST and LDH release were significantly reduced in both nitrite-supplemented LR and UW preservation solutions compared to their controls. The protective effect of nitrite was more efficacious with longer cold preservation times. Liver histological examination demonstrated better preserved morphology and architecture with nitrite treatment. Hepatocellular apoptosis was significantly reduced in the nitrite-treated livers compared their controls. Moreover, liver grafts with extended cold preservation time of 12 to 24 hours demonstrated improved liver tissue histology and function post-reperfusion with either the nitrite-supplemented preservation solution or in nitrite-treated recipients. Interestingly, combined treatment of both the liver graft and recipient did not confer protection. Thus, nitrite treatment affords significant protection from cold ischemic and reperfusion injury to donor livers and improves liver graft acute function post-transplantation. The results from this study further support the potential for nitrite therapy to mitigate ischemia-reperfusion injury in solid organ transplantation. 1. Introduction Liver ischemia-reperfusion injury (IRI) is a major cause of primary graft nonfunction or initial function failure posttransplantation, both of which can ultimately lead to acute and/or chronic rejection. Moreover, the occurrence of significant IRI in marginal liver donors serves to limit the number of organs available for transplantation. Therefore, insights into therapies targeted toward attenuating liver IRI should assist in thwarting liver graft primary nonfunction or poor function, reduce the episodes of acute and chronic graft rejection, extend the usage of marginal donors, and thus aid in reducing the donor organ shortage. Interestingly, to date, clinically translatable mechanisms of liver IR have not yet been well characterized, resulting in a paucity of available therapies for prevention and treatment of liver IRI. Nitric oxide (NO) is a free radical produced from L-arginine and is a versatile signaling mediator involved in a multitude of critical cellular events [1]. NO is also an important effector molecule produced by
Biochemical Studies On The Effect Of Sodium Nitrite And/Or Glutathione Treatment On Male Rats
Eman Helal; *Zahkok, S; **Ghada Z A Soliman; * Al-Kassas, M;
Egyptian Journal of Hospital Medicine , 2008,
Abstract: Introduction: Using food preservatives as sodium nitrite are increased in industrial food productions. Teratogenic, mutagenic and carcinogenic effects have been related to using of some food preservatives. Purpose: To study the effect of sodium nitrite (food additives) and treated with glutathione (nature antitoxic) on rats. Material And Methods: Certain parameters were measured as percentage of body weight change, body temperature, heart rates, Red & white blood cells count (RBCs & WBCs), hemoglobin (Hb) level, hematocrite (Hct) value, serum total lipids, serum cholesterol, serum total protein, serum albumin, serum glucose, serum alanine transaminase and aspartate transaminase (ALT & AST) activity and serum total cholinesterase. The organs, body weight were detected. Organs were prepared for biochemical analysis. Results: Body weight, respiration rate, hepatosomatic index, RBCs & WBCs count, Hb, Hct, serum total lipids, protein, albumin, A/G ratio, liver and muscle total lipids and cholesterol were significantly reduced while serum cholesterol, kidney total lipids and cholesterol, serum ALT & AST was significantly increased. Supplementation of sodium nitrite to rats had no effect on serum glucose level or cholinesterase activity Conclusion: Due to the hazardous effect of food additives as sodium nitrite, it is recommended that the use of sodium nitrite as food additives must be limited and gluathione has the ability to prevent its toxic effect
Two cases of methemoglobinaemia caused by suspected sodium nitrite poisoning
Osvaldo Matteucci,Gianfranco Diletti,Vincenza Prencipe,Elisabetta Di Giannatale
Veterinaria Italiana , 2008,
Abstract: Among the causes of acute methemo-globinaemia are the ingestion and inhalation of over 40 oxidising substances, including nitrite, nitrate, carbon monoxide, some medicines, chlorine. The authors describe a case of acute methemoglobinaemia in two people that most probably suffered from food poisoning resulting from the consumption of a preparation of a dish called turkey alla canzanese that contained significant amounts of sodium nitrite. Both subjects who were treated promptly with methylene blue and hyperbaric oxygen therapy room recovered fully. Epidemiological investigations performed to clarify the dynamics of the episode suggested that among the causes of contamination were the swapping of products at the time of sale and the non-compliance to rules for the preparation of foods for human consumption.
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