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A clinicopathologic study of orbital and ocular adnexal lymphoproliferative lesions with immunohistochemical staining of indeterminate cases
"Ghasemi M,Asadi Amoli F,Gransar A "
Acta Medica Iranica , 2003,
Abstract: The histopathologic diagnosis of orbital and ocular adnexal lymphoproliferative lesions is difficult, resulting controversy in classification, determining benignity or malignancy of them and treatment modality selection. We designed the following study to evaluate clinical, histopathologic and if necessary immunochemical features of them in decreasing indeterminate cases. The study includes 51 subjects of biopsy-proven orbital lymphoid lesions and inflammatory pseudotumors from pathologic practices of Farabi and Imain Khomeini Hospitals, from April 1994 to March 2000. We reviewed H&E stained slides. Then we examined clonality of indeterminate cases with evaluation of clonal immunoglobulin light chains ( or λ) expression to find neoplastic cells. CD markers were used for excluding other closed morphologic differential diagnosis. In conclusion we determined 40 cases of lymphoproliferative lesions, divided to the following there groups: malignant lymphoma with sixty-five percent frequency were the most common type of them, reactive lymphoid hyperplasia with twenty percent was the second one and atypical lymphoid hyperplasia with fifteen percent was the third one. The most common site of involvement was orbit (57.5%). Males were affected slightly higher than females. Median age at diagnosis was 62 years. The most common type of lymphoma group was low-grade small lymphocytic lymphoma. It is necessary to note that 11 out of total 51 subjects were excluded under other pathologic diagnosis. On the other hand 4 cases of already diagnosed pseudo-tumors were reclassified into three lymphoid lesion categories above.
A Clinico-Histopathological Study of Orbital and Ocular Lesions; a Multicenter Study  [PDF]
P Bastola,S Koirala,G Pokhrel,P Ghimire,RK Adhikari
Journal of Chitwan Medical College , 2013, DOI: 10.3126/jcmc.v3i2.8442
Abstract: The study aimed at finding out the morphological and clinico-pathological correlation of Orbital and Ophthalmic lesions in various eye institutes of Nepal. The study also aimed at finding out the prevalence of Ophthalmic lesions needing histo-pathological examination. This cross sectional descriptive study was carried out in various tertiary eye hospitals of Nepal from 2008 – 2012. The department of pathology was also incorporated in giving the correct histopathological findings in time. All the relevant data were entered in a specifically designed proforma for the study and analyzed. One hundred Oph-thalmic and Orbital lesions were studied in various age groups. Ophthalmic and Orbital lesions were highest (18%) in 31-40 year age group patients. Eyelid (57%) was the most commonly involved site. Clinical diagnosis was consistent with histo-pathological diagnosis in more than 60% of the cases. Among eyelid lesions, incidence of dermoid cyst (21%) was highest. While in Conjunctival lesions, granuloma pyogenicum (22.5%) was highest followed by other lesions. A clinico-patho-logical diagnosis of malignant orbital tumors or ocular tumors was made in 30% of cases. While 70% cases of Ophthalmic or orbital lesions were benign in nature. All Ophthalmic lesions removed surgically should always (without exception) be subjected to histopathological examination to establish correct diagnosis for further management. However this study has shown that a good clinical examination and diagnosis before subjecting the patient for histopathological examination gives the patient and the treating surgeon a better outcome. DOI: http://dx.doi.org/10.3126/jcmc.v3i2.8442 Journal of Chitwan Medical College Vol.3(2) 2013 40-44
Surgical Treatment of Hemoptysis: Analysis of 17 Cases  [PDF]
Ufuk ?obano?lu,Fuat Say?r,Bünyamin Serto?ullar?ndan Serto?ullar?ndan
Journal of Clinical and Analytical Medicine , 2012, DOI: 10.4328
Abstract: Aim: In this study, the patients who underwent surgery for hemoptysis were analyzed retrospectively. The cases were discussed with the literature. Material and Method: Seventeen patients who were admitted to our hospital and underwent surgery for hemoptysis between 2004 and 2010, were retrospectively reviewed. Age, gender, underlying pulmonary disease, symptoms, diagnosis, treatment type, surgical indication, morbidity, recurrence, mortality of the patients were reviewed. Results: Mean age of the 17 patients (6 women, 11 men) was 37.4713.25. The most common causes of hemoptysis were lung cancer (29.41%), active pulmonary tuberculosis, bronchiectasis and hydatid cyst (17.64%). It was the first hemoptysis attack in 12(70.59%) cases and was recurrent in 5(29.41%) cases. 6 of 17 cases (32.30%) had mild hemoptysis and in 3 of those (50%) the reason of hemoptysis was lung cancer. The most common associating symptoms were cough and weakness (44.17%). There were abnormal findings on chest radiograph of the 8 (47.05%) of the cases, while in thorax CT images of 13 (76.47%) and 7 (58.33%) of bronchoscopy. We treated these patients with posterolateral thoracotomy (12 cases) and Video-Assisted Thoracoscopic Surgery (5 cases). The morbidity was seen in 3 patients (17.64%). The mortality rate was 5.88% (n:1). Recurrence developed in 1 (5.88%) patients in this series. Discussion: As a result, the leading cause of the hemoptysis was lung cancer. It was seen that computed tomography has a higher value than fiberoptic bronchoscopy in diagnostic evaluation. Especially, if cause of hemoptysis in localized lesions, surgery should be considered a priority. Massive bleeding may require emergency surgical intervention.
Reappearing CT lesions : 4 cases.
Singh G,Bhatia R,Khurana D,Khurana S
Neurology India , 1999,
Abstract: An overwhelming majority of disappearing CT lesions in India have been aetiologically linked to cysticercosis. We report 4 patients with disappearing CT lesions in whom the lesion later reappeared at the same (3 patients) or different site (1 patient). One patient was a Taenia carrier. Serial MRI evaluation in one patient revealed a persisting lesion in the interval period. The contribution of these observations towards the understanding of the aetiology of disappearing CT lesions is discussed.
Clinical cases covering management of borderline lesions
A Evans
Breast Cancer Research , 2006, DOI: 10.1186/bcr1427
Abstract: The management of lesions of uncertain malignant potential has become a more common and complex problem in recent years. The introduction of first core biopsy and then vacuum-assisted biopsy devices has led to an increase in the nonoperative diagnosis of such lesions. These lesions may be incidental findings that do not represent the clinical or radiological abnormality.In the past, such lesions were managed by surgical excision (radial scar, papillary lesion and ADH) or by mammographic follow-up (lobular neoplasia). It is now recognised that the upgrade rates to ductal carcinoma in situ or invasive cancer vary in proportion to the degree of cellular atypia present and by the amount of tissue removed at percutaneous biopsy. Vacuum biopsy excision is also an option for some of these lesions.In this session we shall discuss a number of such cases to highlight the difficulties and dilemmas found when managing these lesions.
Three Adult Cases of Orbital Hidrocystoma Presenting with Blepharoptosis  [PDF]
Lucieni B. Ferraz,John R. Burroughs,Larissa H. Satto,Kryscia L. Natsuaki,Roberta L. F. S. Meneguin,Mariangela E. A. Marques,Silvana A. Schellini
Journal of Clinical Medicine , 2015, DOI: 10.3390/jcm4010150
Abstract: Purpose: To report adult cases of superior orbital apocrine hidrocystoma. Methods: Retrospective case series of three patients with superior orbital apocrine hidrocystoma and blepharoptosis with review of the clinical aspects of each of the cases. Results: All three cases presented with blepharoptosis. Two of the cases had occult hidrocystoma, and one was visibly subcutaneous at presentation. Conclusions: Although rare and more common along the eyelid margin, apocrine hidrocystomas may occur in the orbit leading to secondary blepharoptosis and should be included within the differential diagnosis of orbital cysts. Physicians should therefore be aware of this possibility.
Analysis of mediastinal lesions: a study of 27 cases  [PDF]
S Karki,S Chalise
Journal of Pathology of Nepal , 2011, DOI: 10.3126/jpn.v1i2.5404
Abstract: Background: Mediastinum is a site of non-neoplastic and neoplastic lesions, many of which present as mediastinal masses. The purpose of this study was to study our institutional experience of mediastinal lesions on fine needle aspiration cytology or biopsy. Materials and Methods: This was a retrospective study of 27 patients, who had undergone fine needle aspiration cytology or biopsy for mediastinal lesions from April 2009 to November 2010 in the Department of Pathology, Institute of Medicine, Tribhuwan University Teaching Hospital. All details of the patients pertinent clinical history was obtained from case record file in the department. Results: Out of 27 cases, 18 cases (66.6%) were benign and 7 (26%) were malignant and 2 (7.4%) were inconclusive. Among the malignant lesions, primary tumors constituted 71.5% of cases while metastases were 28.5%. Most of the lesions were seen in the anterior compartment followed by the posterior compartment. Age range was 4 months to 70 years with a mean age of 35.5 years. Thymoma (8 cases) was the commonest lesion seen in mediastinum followed by germ cell tumor and neurogenic tumor. Conclusion: Benign mediastinal lesions are more common than malignant lesions with thymoma being the most commonly diagnosed mediastinal lesion. Keywords: Mediastinum; Germ cell tumor; Thymoma; Non Hodgkin Lymphoma DOI: http://dx.doi.org/10.3126/jpn.v1i2.5404 JPN 2011; 1(2): 114-117
Oral lichenoid lesions associated with amalgam restorations: report of two cases
Barbosa, Marília Oliveira;Silva, Adriana Fernandes da;Carvalho, Rodrigo Varella de;Tarquinio, Sandra Beatriz Chaves;Demarco, Flávio Fernando;
Revista Odonto Ciência , 2011, DOI: 10.1590/S1980-65232011000300012
Abstract: purpose: dental amalgam has been used as a dental restoration for more than 165 years. however, some patients with these restorations may present oral lichenoid lesions (oll). oll are chronic oral mucosal contact reactions to dental amalgam. their diagnosis usually is based on the direct contact of the affected mucosa with the amalgam restorations, clinical appearance, and lack of migrations. a patch-test for mercury can be performed to confirm the diagnosis. thus, the objective this work was to discuss the occurrence of this disease and your possibilities of existing differential diagnostic. case description: two clinical cases were diagnosed as related to oll. in both cases, the patients complained of a burning sensation in the oral mucosa adjacent to the amalgam restorations. the treatment involved replacing the amalgam restorations by composite. a complete remission of the painful symptoms was observed after 17 days in one case and after one month in the other, although the lesions in the oral mucosa did not disappear completely. conclusion: dentists should be aware of oll occurrence close to amalgam restorations and should be able to diagnose it and recommend the best treatment option.
Orbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases
Carmody J, Misra RP, Langford MP, Byrd WA, Ditta L, Vekovius B, Texada DE
Clinical Ophthalmology , 2011, DOI: http://dx.doi.org/10.2147/OPTH.S16751
Abstract: bital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases Case report (3258) Total Article Views Authors: Carmody J, Misra RP, Langford MP, Byrd WA, Ditta L, Vekovius B, Texada DE Published Date April 2011 Volume 2011:5 Pages 509 - 515 DOI: http://dx.doi.org/10.2147/OPTH.S16751 John Carmody1, Raghunath P Misra1,2, Marlyn P Langford1, William A Byrd1, Lauren Ditta1, Bryan Vekovius1, Donald E Texada1 1Department of Ophthalmology, 2Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA Abstract: A case of sporadic Burkitt lymphoma (sBL) presenting with jaw and lid involvement in a diabetic adult African American female and a review of adult orbital Burkitt lymphoma cases are presented. Lid edema, visual loss, ophthalmoparesis, proptosis, and sinusitis progressed over 4 weeks despite antibiotic and steroid treatment. Upper lid biopsy histopathological evaluation and immunophenotyping revealed a homogenous mass of atypical CD10 and CD20-negative B-cells and tingible body macrophages yielding a "starry sky" appearance. Cytogenetic analysis detected a minor variant c-MYC translocation, but no Epstein–Barr virus RNA. Detection of multiple lesions prompted a diagnosis of stage IV disease that totally regressed following radiation and chemotherapy. Review results of the six adult orbital sBL cases support a poor prognosis and a heightened suspicion of variant CD10, CD20 and BCL6 positive sBL in adults presenting with jaw pain and rapidly progressive orbital symptoms, particularly in female, African American, and diabetic patients.
Interhemispheric epidermoids - An uncommon lesion in an uncommon location: A report of 15 cases  [cached]
Bhat Dhananjaya,Devi B,Raghunath A,Somanna Sampath
Neurology India , 2011,
Abstract: Of the intracranial epidermoids, interhemispheric epidermoids are extremely rare and only about 19 cases have been reported. This is a retrospective study of 15 patients with interhemispheric epidermoids surgically treated over a 13-year period. The age at the time of presentation varied between 17 and 45 years and there were 9 males. The presenting feature was seizures (focal with secondary generalization) in 12 patients, hemiparesis in 5 and features of raised intracranial pressure in 3. On computerized tomography scan the lesions were hypodense in the interhemispheric region. On magnetic resonance imaging, the lesions were located in the interhemispheric region with heterogenous signal intensities. Restricted diffusion was evident on diffusion-weighted images and apparent diffusion co-efficient images. All the lesions were predominantly located in the anterior interhemispheric region, with either basal or parietal extension along the interhemispheric fissure. Eleven patients underwent frontal or fronto-parietal craniotomies, 3 underwent bifrontal craniotomies and 1 patient underwent supra-orbital craniotomy and endoscopic procedure. Total excision could be achieved in 11 patients; near-total, in 3; and partial excision, in 1 patient. Follow-up was available in 10 patients. Three patients had recurrence of lesion at 5 , 8 and 10 years, respectively.
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