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2-Octyl-Cyanoacrylate Skin Adhesive Used as a Splinting Material in Auricular Surgery  [PDF]
Naoto Yamamoto, Satoshi Yanagibayashi, Ryuichi Yoshida, Hiroyuki Ogi, Megumi Takikawa, Akio Nishijima, Eri Maruyama
Modern Plastic Surgery (MPS) , 2016, DOI: 10.4236/mps.2016.64004
Abstract: In cases of auricular surgery, postoperative dressings are thought to be important for keeping auricular contour and in helping to prevent from dressing failures due to edema or subcutaneous hematoma, which may result in fibrous or cartilaginous proliferation. However, it is often difficult to achieve success with standard dressings because of the complicated shape of the auricle. We used 2-octyl-cyanoacrylate skin adhesive to dress the auricle after different types of auricular procedures (five cases of cryptotia, two of prominent ear, two of severe auricular laceration, two of skin grafting and one of flap repair of the partial auricle defect). The 2-octyl-cyanoacrlaate skin adhesive was applied to the suture line and the operated and peripheral areas for wider coverage. No dressing materials were placed over the surface. In all cases, the desired outcome was achieved, without subcutaneous hematoma, wound dehiscence, and wound infection. Contact dermatitis caused by the skin adhesive was not observed in any of the cases. Dressing and splinting after auricular surgery can be simply and successfully achieved using 2-octyl-cyanoacrylate skin adhesive. There is no need for more complicated dressings and post-surgical dressing changes, resulting in higher patient satisfaction.
Quality of Scar after Total Thyroidectomy: A Single Blinded Randomized Trial Comparing Octyl-Cyanoacrylate and Subcuticular Absorbable Suture  [PDF]
Fabrizio Consorti,Rosaria Mancuso,Annalisa Piccolo,Eugenio Pretore,Alfredo Antonaci
ISRN Surgery , 2013, DOI: 10.1155/2013/270953
Abstract: Objective. To compare the quality of resulting scar at 6 weeks after total thyroidectomy with the use of the tissue adhesive octyl-cyanoacrylate or subcuticular absorbable suture for the closure of cervicotomy. Material and Methods. There are 50 patients undergoing a cervicotomy for total thyroidectomy. Twenty-five patients were randomly assigned to closure with tissue adhesive and 25 with subcuticular absorbable suture. At week 6 the scar was evaluated by blinded assessors with the Italian version of POSAS questionnaire, a validated wound scale composed of an observer’s and a patient’s subscale. Results. Assessment of scar appearance showed a statistically significant difference ( ) in favor of subcuticular suture with respect to tissue adhesive on observer’s assessment. The difference on patients’ self-assessment was not significant. A multivariate analysis of six qualitative features of scars showed a significant influence on assessment for hyperpigmentation and relief of scar. The Italian version of POSAS proved to be reliable. Conclusion. Though tissue adhesive represents a valid method of skin closure, subcuticular absorbable suture provides a better aesthetic outcome in small cervical incisions in the early phase after thyroid surgery. 1. Background Aesthetic outcome is particularly relevant in thyroid surgery since patients are mostly women and young adults and since the incision is in a highly sensitive and visible anatomic location. Cosmetic concern about the final scar appearance contributed to motivate the development of minimally invasive approaches for thyroid surgery and parathyroid surgery over the last decade [1–3]. Minimally invasive thyroid surgery techniques (MIT) are different but all share the same goals: reduction of tissue trauma, early hospital discharge, and better neck wound cosmetic appearance, while maintaining the same surgical outcome as traditional thyroidectomy [4]. In addition to MIT, methods of skin closure contribute to the overall aesthetic outcome and patient’s satisfaction. Methods of skin closure vary in published series and are largely the results of surgeon’s choice based upon the need for a rapid, economic, and reproducible technique [5]. Skin closure techniques include the use of the tissue adhesive octyl-cyanoacrylate, introduced 15 years ago in clinical practice as an ideal system of wound closure [6]. Many studies showed that tissue adhesive is an acceptable alternative to standard wound closure since it yields similar clinical and aesthetic results, even if early wound dehiscence occurs in the 1% to 5% of
Application of 2-octyl-cyanoacrylate for corneal perforation and glaucoma filtering bleb leak  [cached]
Okabe M,Kitagawa K,Yoshida T,Koike C
Clinical Ophthalmology , 2013,
Abstract: Motonori Okabe,1 Kiyotaka Kitagawa,2 Toshiko Yoshida,1 Chika Koike,1 Takeshi Katsumoto,2 Etsuko Fujihara,2 Toshio Nikaido1 1Department of Regenerative Medicine, University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Toyama, 2Division of Ophthalmology, Matsue Red Cross Hospital, Japanese Red Cross Society, Shimane, Japan Background: This paper reports on the efficacy of a tissue adhesive, 2-octyl-cyanoacrylate, in the treatment of corneal perforation and glaucoma filtering bleb leak. Methods: Two eyes from two patients with corneal perforation or laceration and two eyes from two patients with bleb leak were included. The patients underwent application of 2-octyl-cyanoacrylate onto the perforated or leaking site, and a hydrogel contact lens was applied as a bandage. We also evaluated the in vitro cell toxicity of 2-octyl-cyanoacrylate in HeLa cells. Results: The two cases of corneal perforation were repaired within 22 days with one application of the tissue adhesive. The two cases of bleb leak were repaired with 2–4 applications of the tissue adhesive over 134 (range 17–134) days). There were no recurrences or adverse effects during a mean follow-up period of 12.7 months. In vitro testing revealed that 2-octyl-cyanoacrylate was markedly toxic to HeLa cells. Conclusion: Four patients with corneal perforation or bleb leak were successfully managed using 2-octyl-cyanoacrylate tissue adhesive. This simple and easy surgical technique may become an alternative therapeutic option for corneal perforation or bleb leak, although several applications of this tissue adhesive may be required. Although 2-octyl-cyanoacrylate was toxic to HeLa cells, no adverse clinical effects were noted using this adhesive. Keywords: corneal perforation, bleb leak, tissue adhesive, 2-octyl-cyanoacrylate
Effects of ethyl-cyanoacrylate and octyl-cyanoacrylate on experimental corneal lesions in rabbits
Barbosa, V.T.;Thiesen, R;Soares, E.G.;Machado, M.R.F.;Laus, J.L.;
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2009, DOI: 10.1590/S0102-09352009000500009
Abstract: the use of ethyl-cyanoacrylate and octyl-cyanoacrylate were clinically and histopathologically compared on the corneas of 36 rabbits after lamellar keratectomy (standardized diameter and depth). the animals were distributed into two groups, one for each type of adhesive. from each group, six subgroups were histopathologically evaluated on the 3rd, 7th, 14th, 21st, 30th, and 60th day post-operative. general (daily) and ophthalmic (days 0, 1, 3, 5, 7, 14, 21, 30, 44, and 60) evaluations clinically indicated that there were significant differences for the variables water intake, attitude, blepharitis, corneal edema, and fluorescein test. the adhesive permanence time for octyl-cyanoacrylate (17.22 days) was greater than that for ethyl-cyanoacrylate (7.66 days). with respect to the histopathological evaluation, corneal epithelization and collagen organization occurred without severe complications. however, treatment with ethyl-cyanoacrylate led to a moderate inflammatory reaction in the initial phases. with octyl-cyanoacrylate, re-epithelization and collagen organization proceeded more slowly with a discrete inflammatory reaction in the initial phases. from clinical and histopathologic points of view, octyl-cyanoacrylate showed advantages over ethyl-cyanoacrylate, whereas wound healing was achieved in both groups without major complications.
Estudo experimental comparando o uso do 2-octil cianoAcrilato ao nylon 4-0 na sutura da pele
Freitas-Júnior, Ruffo de;Paulinelli, Régis Resende;Rahal, Rosemar Macedo Sousa;Moreira, Marise Amaral Rebou?as;Oliveira, Evelling Lorena Cerqueira de;Aiko, Kariza Frantz;Approbato, Mário Silva;
Revista do Colégio Brasileiro de Cirurgi?es , 2008, DOI: 10.1590/S0100-69912008000300011
Abstract: background: tissue adhesive 2-octyl cyanoacrylate was developed to have more strength, less inflammatory reaction, and less histotoxicity than its shorter-chain derivates. methods: to evaluate the use of 2-octil cyanoacrylate in comparison with "nylon" suture in skin closure of rats. methods: twenty-five female wistar rats were submitted to a 3cm surgical incision in each side of the abdomen. the wound was closed with intradermic suture using "nylon" 4-0 in one side, and 2-octil cyanoacrylate on the other side. after 7 days the thread was removed and the wound was checked for complications. after 40 days the wound aspect was clinically evaluated. the rats were sacrificed; the scars were resected, and sent to the pathologist without the information of which closing method was used. results: there were 2 deaths during anesthesia or few days after surgery. the mean surgical time was 136 seconds with the adhesive and 176 with "nylon" (p=0.003). the complications were: one hematoma in each method (p=0.8), fifteen wound dehiscence with the adhesive and 11 with "nylon" (p=0.2), seven scars with a bad or fair aspect with adhesive and 4 with "nylon" (p=0.3), three infections with adhesive and 2 with "nylon" 2 (p=0.4). histological examination showed median scar width of 1.119 micron with the adhesive and 1.800 with "nylon" (p=0.7). the mean thickness was 1.795 in the adhesive group versus 1.705 micron (p=0.7). conclusion: surgical adhesive showed the same aesthetical results, the same strength, and the same complications as for "nylon" 4.0 sutures, but the adhesive decreased the surgical time.
Cianoacrilato: Definición y propiedades. Toxicidad y efectos secundarios. Aplicaciones en medicina y odontología Cyanoacrylate: Definition and properties. Toxicity and side effects. Applications in medicine and dentistry  [cached]
J.M. González González
Avances en Odontoestomatología , 2012,
Abstract: Introducción: el cianoacrilato es un líquido incoloro con propiedades adhesivas. Se emplea habitualmente en trabajos de bricolaje. En medicina y odontología ha sido utilizado generalmente como sutura de piel. Material y métodos: se hizo una revisión bibliográfica acerca del cianoacrilato y su uso en medicina y odontología. Resultados: en diferentes tablas se recogen productos comerciales que contienen cianoacrilato, sus utilidades no médicas, los requisitos para uso médico, aplicaciones en medicina y odontología, y sus efectos nocivos. Discusión: Los cianoacrilatos de cadena corta (etil y metilcianoacrilato) no son aptos para uso médico, pues se degradan rápidamente dando productos tóxicos. Sin embargo se emplean de cadena larga (octil y butilcianoacrilato) que dan menos toxicidad. Se aconseja emplear en zonas superficiales y libres de tensión. Introduction: Cyanoacrylate is a colorless liquid with adhesive properties. It is commonly used in DIY work. In medicine and dentistry, it has been widely used as a skin suture. Material and methods: A literature review was made of cyanoacrylate and its use in medicine and dentistry. Results: In different tables are commercial products containing cyanoacrylate, general utilities, requirements for medical use, medical and dental applications, and its harmful effects. Discussion: The short-chain cyanoacrylates (ethyl and methylcyanoacrylate) are not suitable for medical use, because they degrade quickly giving toxic products. However long chain used (octyl and butylcyanoacrylate) to offer less toxicity. It is recommended for surface areas and tension free.
Temporary management of involutional entropion with octyl-2-cyanoacrylate liquid bandage application
Osaki, Teissy;Osaki, Midori Hentona;Osaki, Tammy Hentona;
Arquivos Brasileiros de Oftalmologia , 2010, DOI: 10.1590/S0004-27492010000200004
Abstract: purpose: to evaluate the use of octyl-2-cyanoacrylate liquid bandage (band-aid liquid?, ethicon, johnson & johnson, new jersey, usa) as a temporary treatment in patients awaiting surgical repair for involutional entropion. methods: thirteen patients (15 eyelids) with involutional entropion were evaluated while they waited for surgical intervention. the lids were repositioned by the application of octyl-2-cyanoacrylate liquid bandage in the malar fold. patients were followed-up at days 1, 7 and 15. assessment and duration of correction were recorded. results: all the patients presented successful correction at day 1, with significant improvements in signs and symptoms. the mean duration of action of the octyl2-cyanoacrylate liquid bandage was three days. no ocular or dermatological reactions were noted. conclusion: octyl-2-cyanoacrylate liquid bandage showed to be a simple, safe and effective option to temporarily treat involutional entropion, while patients waited for surgical intervention.
Efficacy of percutaneous transhepatic variceal embolization with 2-Octyl-cyanoacrylate in patients with severe recurrent hepatic encephalopathy  [cached]
WANG Guangchuan
Journal of Clinical Hepatology , 2013,
Abstract: ObjectiveTo investigate the efficacy and safety of percutaneous transhepatic variceal embolization (PTVE) performed with 2-Octyl-cyanoacrylate (2-OCA) tissue adhesive for treating recurrent hepatic encephalopathy (HE) involving large portosystemic shunts. MethodsTwelve cirrhotic patients (8 males, 4 females; mean age: 62 years old) with recurrent HE (≥3 episodes/year, despite drug therapy) were treated by PTVE with 2-OCA. The surgery was performed under local anesthesia with B ultrasound- or X-ray-guided percutaneous needle injection of the adhesive into the hepatic portal vein with balloon dilation to occlude the portosystemic shunts. Preoperative and postoperative clinical and laboratory parameters, including HE episodes, with or without gastrointestinal bleeding, markers of liver and renal function and coagulation indicators, were recorded. Significance of surgery-induced change in portal vein pressure was assessed by paired t-test. ResultsThe PTVE was performed successfully in all 12 patients. The average injected volume of 2-OCA was 8.6 ml (range: 4-16 ml). The most frequent postoperative complications were pyrexia (6/12, 50.0%) and abdominal pain (5/12, 41.7%). The mean follow-up period was 22.7±9.8 months (range: 6-37 months). During the follow-up period, two patients (16.7%) developed transient ascites and two (16.7%) patients developed upper gastrointestinal bleeding (due to esophageal varices and portal hypertensive gastropathy, respectively). In addition, three patients (25.0%) experienced HE recurrence (at postoperative months 16, 19, and 30, respectively). Two patients (16.7%) died, one from progression of hepatic failure and the other from liver cancer. In general, the PTVE procedure significantly increased the portal pressure (preoperative: (21.9±1.8) mm Hg vs. postoperative: (26.3±3.2) mm Hg; P=000). ConclusionPTVE with 2-OCA is an effective and safe procedure for managing recurrent HE with large portosystemic shunts.
Cyanoacrylate adhesive with conjunctival resection and superficial keratectomy in mooren′s ulcer  [cached]
Agrawal Vinay,Kumar Aashish,Sangwan Virender,Rao Gullapalli
Indian Journal of Ophthalmology , 1996,
Abstract: Seventeen eyes of thirteen patients with Mooren′s ulcer were treated with a combination therapy of local and systemic steroids, conjunctival resection, superficial keratectomy and application of cyanoacrylate tissue adhesive. The pathology was classified as acute, subacute and chronic. Ulcers were graded based on the extent of corneal thinning, degree and extent of ulceration, and amount of inflammation. Fourteen eyes (82.4%) healed completely with formation of a vascularised scars, while three eyes (17.6%) failed to respond to treatment and either went into phthisis bulbi or healed with gross tissue distortion. Our study suggests an early intervention of this therapy with cyanoacrylate tissue adhesive application for effective control of Mooren′s ulceration.
Comparative study of the healing process of the aponeurosis of the anterior abdominal wall of rats after wound closure using 3-0 nylon suture and N-butil-2-cyanoacrylate tissue adhesive
Batista, Carlos Augusto Marques;Colleoni Neto, Ramiro;Lopes Filho, Gaspar de Jesus;
Acta Cirurgica Brasileira , 2008, DOI: 10.1590/S0102-86502008000400010
Abstract: purpose: to investigate the healing process of the aponeurosis of the anterior abdominal wall of rats, comparing two different materials for wound closure: 3-0 nylon suture and tissue adhesive n-butyl-2-cyanoacrylate. methods: forty-four wistar rats were randomly divided into four groups according to the type of material used (suture or adhesive) and the number of days until reoperation (seven or 14 days). after a 4 cm incision in the aponeurosis, 22 rats underwent wound closure using 3-0 nylon suture and the other 22, the tissue adhesive. after seven days, 11 rats from each group were weighed again, submitted to reoperation and then euthanized. the same procedure was carried out after 14 days with the remaining rats. the surgical wound was macroscopically examined, the tensile strength was measured and the tissue edges were histologically examined. the statistical analysis was performed using analysis of variance and cox's proportional hazards model. significance level was set at p < 0.05. results: the animals lost on average 20 g over the period between the two operations. wound closure was faster using the tissue adhesive. only one animal, from the tissue adhesive group, had a small abscess with wound dehiscence. with regard to tensile strength, the best results were obtained with the tissue adhesive 14 days after the first surgery. the results of the histological examination showed no significant difference between groups. conclusions: upon morphological evaluation, the two types of material analyzed in this study (3-0 nylon suture and n-butyl-2-cyanoacrylate, a tissue adhesive) were not significantly different with regard to the healing process of the aponeurosis of the anterior abdominal wall of rats. wound closure using the tissue adhesive was faster. higher tensile strength was observed in the tissue adhesive group 14 days after the first surgery.
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