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Non-Hodgkin lymphoma of the bladder
Antunes, Alberto A.;Nesrallah, Luciano J.;Srougi, Miguel;
International braz j urol , 2004, DOI: 10.1590/S1677-55382004000600009
Abstract: lymphomas of the bladder are rare lesions, representing approximately 0.2% of the primary neoplastic lesions and approximately 1.8% of the secondary lesions in this organ. the authors report the case of a 41-year old patient with secondary lymphoma of the bladder occurring 2 years after treatment for non-hodgkin lymphoma, diagnosed by biopsy of cervical lymph node, and analyze the clinical and prognostic aspects of bladder lymphomas.
Primary Non-Hodgkin Lymphoma of The Cervix
Nasim Valizadeh,Haleh Ayatollahi,Siamak Naji
International Journal of Hematology-Oncology and Stem Cell Research , 2011,
Abstract: Background: There are only a few reports that exist regarding primary non-Hodgkin lymphoma of the genital tract. In this article, one case of primary B-cell type non-Hodgkin lymphoma (NHL) of the cervix is presented. Case history: A 45 year-old woman presented bloody vaginal discharge. Upon vaginal examination, the cervix was found to be enlarged. Cervical biopsy revealed B-cell type non-Hodgkin lymphoma. The patient was treated with CHOP chemotherapy. Conclusion: Systemic chemotherapy and radiation are recommended and effective treatments for genital tract B-cell type non-Hodgkin lymphoma.
Localsied Orbital Non-Hodgkin's Lymphoma
Imtiyar Ahmad,Abdul Wahab,Junaid Salam,Reyaz Ahamad Untoo
JK Science : Journal of Medical Education & Research , 2003,
Abstract: Localized orhital non-Hodgkin's lymphoma is a rare form of cxtranodallymphoma. which has 1101been reported much in the literature. The orbit difTers from the rest 01" the body. excluding thet.:l:llIralncn OllS system. as concerns lymph drainage. This ma) be possible to explain some of thepeculiar I"ealllres in lymphoid orbital lesions. A localized orbital non-Hodgkin's lymphoma in "ndderl) man is hereb) presented for its entlY.
Autonomic dysfunction in Hodgkin and non-Hodgkin lymphoma. A paraneoplastic syndrome?
Franca Bilora,Francesco Veronese,Alice Zancan,Michela Biasiolo
Hematology Reports , 2010, DOI: 10.4081/hr.2010.e8
Abstract: We wanted to determine whether autonomic dysfunction in patients with lymphoma is related to chemotherapy or represent a paraneoplastic syndrome. 40 patients with current or cured Hodgkin or non-Hodgkin lymphoma and 40 healthy controls, matched for age, gender, hypertension and diabetes mellitus underwent autonomic evaluation (Deep Breath, Valsalva Maneuver, Hand Grip, Lying to Standing, Tilt Test). Current patients also suffering from diabetes or hypertension, or still on chemotherapy revealed autonomic changes, while cured or healthy subjects did not. Autonomic dysfunction in lymphoma is a transient manifestation of a paraneoplastic syndrome.
Rhinoscleroma and nasal non-Hodgkin lymphoma  [cached]
Oliveira, Henrique Fernandes de,Carvalho, Ada Simone P. Alencar,Argollo, Núbia Cardoso Santana,Neves, Caio Athayde
International Archives of Otorhinolaryngology , 2009,
Abstract: Introduction: Rhinoscleroma, a rare nasal granulomatous disease, is caused by Klebsiella rhinoscleromatis. The nose is the primary occurrence region. Nasal non-Hodgkin lymphoma is a rare cancer, and could be of T or B type. The rhinoscleroma and the nasal non-Hodgkin lymphoma present with nasal obstruction as the main symptom, and are part of the nasal granulomatosis differential diagnosis. Objective: To report the association of rhinoscleroma and non-Hodgkin lymphoma in the same patient, by remarking the importance of the nasal granulomatosis' differential diagnosis. Case Report: A forty-nine year old female patient that appeared with a one-month progressive nasal obstruction. Rhinoscopy showed papillomatous feature lesion in left middle meatus. The immunohistochemical analysis confirmed rhinoscleroma. The patient was duly treated with total remission of the lesion. Ten months after, she returned with the same symptoms, but the histologic study confirmed non-Hodgkin lymphoma. Final Comments: Both pathologies may cause more severe nasal symptoms and complications. The early diagnostic enables the choice for the right treatment and contributes for the prognosis. The immunohistochemical study was essential for the diagnostic differentiation.
Primary non-Hodgkin′s lymphoma of the mandible  [cached]
Dinakar J,Priya Lakshmi,Reddy Samyukta
Journal of Oral and Maxillofacial Pathology , 2010,
Abstract: Primary non-Hodgkins′s lymphoma is a very uncommon lesion, accounting for 0.6% in jaws. As the lesions frequently resemble other disease such as chronic osteomyelitis, odontogenic or any secondary neoplasms, further evaluation and histopathologic examination allow early identification for appropriate treatment. The purpose of this case report is to describe a rare case of non-Hodgkin′s lymphoma of the mandible, explore the diagnosis and workup based on immunohistochemistry.
Primary Thyroid Non-Hodgkin’s Lymphoma  [PDF]
Madiha Mahfoudhi, Khaled Khammassi, Imen Gorsane, Mounira El Euch, Sami Turki, Mamia Ben Salah, Taieb Ben Abdallah
Open Journal of Pathology (OJPathology) , 2015, DOI: 10.4236/ojpathology.2015.54015
Abstract: Primary non-Hodgkin’s lymphoma of the thyroid gland was rarely described. We report the case of a 44-year-old man admitted for an anterior neck swelling, hoarseness and dyspnea. The chest radiograph showed a trachea deviation. He had no clinical, biological or radiological sign of other lymphoma locations. Ultrasound examination of the neck revealed a bilateral heterogeneous thyroid lesion. Cytology revealed lymphoid cells having high nuclear-cytoplasmic ratio with multiple and irregular nucleoli. An urgent thyroid surgery consisting of total thyroidectomy had been performed since the presence of compressive signs due to the tumor. The histopathological examination of a biopsy from the thyroid tissue confirmed a high-grade non-Hodgkin’s lymphoma. Then, L-thyroxin substitution therapy, chemotherapy and radiotherapy were initiated. A prolonged remission was noted.
Non-Hodgkin′s lymphoma of the hard palate  [cached]
Jayakrishnan R,Thomas Gigi,Kumar Aswin,Nair Rekha
Journal of Oral and Maxillofacial Pathology , 2008,
Abstract: Background: Non-Hodgkin′s lymphoma usually involves lymph nodes but can also involve extranodal sites. Oral lymphomas are relatively rare and often difficult to diagnose in a clinical setting. We present a case of a patient of non-Hodgkin′s lymphoma of the hard palate who had undergone external beam radiation therapy and was found to be well 1 year following treatment. Case presentation: A 43-year-old male attended the Community Oncology Division of Regional Cancer Centre with complaints of painless swelling on the right side of face of three months′ duration. A computed tomography (CT) scan confirmed irregular destruction of the hard palate towards the right side of the midline with adjacent soft tissue component. Histopathology report confirmed the diagnosis of follicular lymphoma. He was given radical external beam radiation therapy (40 Gy in 20 fractions over 4 weeks). Clinical examination at the end of radiation revealed complete disappearance of the palatal swelling. Conclusion: Oral lymphomas are relatively rare and often difficult to diagnose as the clinical features mimic other pathological entities such as periodontal disease, osteomyelitis, and other malignancies. A careful clinical evaluation supported by radiologic and histopathologic investigations will help in identifying the disease at an early stage, which will result in better prognosis.
Primary Extradural Non-Hodgkin's Lymphoma  [PDF]
Rakesh Kapoor, Vinay Kumar, S.C. Sharma
JK Science : Journal of Medical Education & Research , 2006,
Abstract: A 28 years old male presented to our institute with 3 months history of paraparesis with decreased sensationover left foot and loss of bladder and bowel control .The diagnostic work up revealed an extradural massat spinal level L3 L4.Had laminectomy and the tumour was sub totally resected. Histological examinationrevealed non hodgkin's lymphoma. The patient was worked up for disease anywhere else and was confirmedto have primary extra-dural non-hodgkin's lympoma(PENHL). Patient was treated with corticosteroides,adjuvant radiotherapy and chemotherapy. The residual tumour completely disappeared and patient isliving normal healthy life and is walking without support after 9 years of follow-up.
Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma
Sonja Eberth, Bj?rn Schneider, Andreas Rosenwald, Elena M Hartmann, Julia Romani, Margarete Zaborski, Reiner Siebert, Hans G Drexler, Hilmar Quentmeier
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-517
Abstract: We screened for TSG methylation using methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) in 40 lymphoma-derived cell lines representing anaplastic large cell lymphoma, Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Hodgkin lymphoma and mantle cell lymphoma (MCL) as well as in 50 primary lymphoma samples. The methylation status of differentially methylated CD44 was verified by methylation-specific PCR and bisulfite sequencing. Gene expression of CD44 and its reactivation by DNA demethylation was determined by quantitative real-time PCR and on the protein level by flow cytometry. Induction of apoptosis by anti-CD44 antibody was analyzed by annexin-V/PI staining and flow cytometry.On average 8 ± 2.8 of 24 TSG were methylated per lymphoma cell line and 2.4 ± 2 of 24 TSG in primary lymphomas, whereas 0/24 TSG were methylated in tonsils and blood mononuclear cells from healthy donors. Notably, we identified that CD44 was hypermethylated and transcriptionally silenced in all BL and most FL and DLBCL cell lines, but was usually unmethylated and expressed in MCL cell lines. Concordant results were obtained from primary lymphoma material: CD44 was not methylated in MCL patients (0/11) whereas CD44 was frequently hypermethylated in BL patients (18/29). In cell lines with CD44 hypermethylation, expression was re-inducible at mRNA and protein levels by treatment with the DNA demethylating agent 5-Aza-2'-deoxycytidine, confirming epigenetic regulation of CD44. CD44 ligation assays with a monoclonal anti-CD44 antibody showed that CD44 can mediate apoptosis in CD44+ lymphoma cells. CD44 hypermethylated, CD44- lymphoma cell lines were consistently resistant towards anti-CD44 induced apoptosis.Our data show that CD44 is epigenetically regulated in lymphoma and undergoes de novo methylation in distinct lymphoma subtypes like BL. Thus CD44 may be a promising new epigenetic marker for diagnosis and a potential therape
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