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Clinical features, histopathological analysis and surgical treatment of a free floating vitreous cyst: a case report
Lira, Rodrigo Pessoa Cavalcanti;Jungmann, Patrícia;Moraes, Luis Felipe Lynch de;Silveira, Ana Paula Teles;
Arquivos Brasileiros de Oftalmologia , 2006, DOI: 10.1590/S0004-27492006000500026
Abstract: the authors present a report of a 44-year-old female patient, with complaints of visual disturbances in the left eye. the symptoms were present for at least 5 years and worsened in the last 2 years, impairing her activities. the patient reported perception of a floating circle, which blurred her vision. there was no previous history of trauma, infectious or inflammatory disease. clinical evaluation included physical examination, laboratory testing, abdominal ultrasonography, thorax x-ray and head tomography. ophthalmologic examination consisted of visual acuity, motility tests, biomicroscopy, tonometry and indirect ophthalmoscopy. complementary investigation was done with a and b scan ocular ultrasonography. the chosen therapeutic approach to excise the cyst was pars plana vitrectomy, successfully performed. anatomopathologic analysis revealed a pigmented vitreous cyst, of possible congenital origin, described as a cystic choristoma from the primitive hyaloid system. benign evolution, clinical findings and histopathological analysis corroborated the diagnostic hypothesis of a cystic choristoma of the primitive hyaloid system. surgery (pars plana vitrectomy) was successful and the patient returned with visual acuity of 20/20 in both eyes, and with no further complaints.
Histopathological finding as a prognostic factor of the surgical treatment outcome in colorectal cancer  [PDF]
Se?en Svetozar,Moljevi? Neboj?a,Vukovi? Milivoje,Somer Ljiljana
Vojnosanitetski Pregled , 2010, DOI: 10.2298/vsp1008638s
Abstract: Background/Aim. Adenocarcinomas of the colon are the most common malignant colorectal tumors. Macroscopic and histopahtological features of colorectal cancer significantly affect its outcome. The aim of this study was to analyze the impact of histopahological finding as a prognostic factor on the surgical treatment outcome and the course of the disease. Methods. In the first part of this study the distribution (numerical and proportional) of certain histopathological parameters in the examined groups of patients were reviewed; in the second part of the study the statistical significance of the impact of the certain elements of a histopahtological finding on the surgical treratment outcome was analyzed. The histopathological elements analyzed included: the hsitological tumor type grading according to Duke, ie Astler-Coller, and tumor, nodes, metastases (TNM) staging in the examined sample of 100 patients. Results. Statistically significant prognostic factors of the outcome of surgical treatment were selected after multivariant analysis. These factors comprise Astler-Coller-Dukes stage D (revealed in 77.78% patients died), stage IV according TNM classification (T1-4, N0-2, M1), histological structure (poorly diferentiated adenocarcinoma in 85.2% patents died) and type of tumor (mucynous adenocarcinoma was more often present in died, 77.78%). Since φ = 0.000 for four risk factors were formed using discriminant analysus, it was proved their significant influence on the outcome of surgical treatment. Discriminant coefficient showed that the greatest influence on surgical treatment were registred in patients with tumor of Astler-Coller-Dukes stage D (0.255), poorly differentiated adenocarcinoma (histological structure) (0.139), mucynous adenocarcinoma (type of tumor) (0.074) and stage IV according to the TNM elassification (T1-4, N0-2, M1) (0.39). Conclusion. The prognostic factors influencing the outcome of surgery for colorectal carcinoma were defined. Patients with pathohistological finding of Astler-Coller-Dukes stage D, stage IV according to the TNM classification (T1-4, N0-2, M1) and poorly differentiated adenocarcioma have statistically highly significant mortality during the perioperative course of the disease.
Ten-year follow-up of a case series of primary epithelial neoplasms of the lacrimal gland: clinical features, surgical treatment and histopathological findings
Santos, Rodrigo Ribeiro;Damasceno, Renato Wendell Ferreira;de Pontes, Fernanda Silva Lopes;Cursino, Sylvia Regina T.;Nishiwaki-Dantas, Maria Cristina;Vital Filho, José;Dantas, Paulo Elias Correa;
Arquivos Brasileiros de Oftalmologia , 2010, DOI: 10.1590/S0004-27492010000100006
Abstract: purpose: to describe and analyze the features of a cases series of patients with primary epithelial neoplasms of the lacrimal gland, its surgical treatment, and histopathological findings. methods: retrospective evaluation of files from patients with primary epithelial neoplasms of the lacrimal gland in the period from 1997 to 2007. all patients with primary epithelial tumors of the lacrimal gland were included in this study. data on gender, age, clinical features, surgical treatment, histopathological findings and follow-up were collected. the slides with histological sections of the tumors were reviewed by the same pathologist. results: during the study period, there were 12 patients, 5 (41.7%) with benign tumors, all pleomorphic adenomas (benign mixed tumor) and 7 (58.3%) with malignant neoplasms, thus distributed: four cases of adenoid cystic carcinoma, two of mucoepidermoid carcinoma and one carcinoma expleomorphic adenoma. globally, patients mean age was 54.1 years-old (ranging from 14 to 70 years-old), with mean age of 52.4 years-old (ranging from 14 to 65 years-old) for benign neoplasms, and 55.3years-old for malignant neoplasms (ranging from 26 to 70 years-old). clinical follow-up information, ranging from 2 to 10 years-old, was available for all patients. three patients developed distant metastasis and died of disease. conclusions: the most frequent primary epithelial neoplasms of the lacrimal gland were pleomorphic adenoma and adenoid cystic carcinoma during the study period. malignant tumors were more frequent than benign tumors. the histopathological diagnosis and the disease initial stage can play a significant role in patient's survival.
Outcome analysis of surgical treatment of Blount disease in Nigeria
AA Kawu, OOA Salami, A Olawepo, MA Ugbeye, W Yinusa, OO Odunubi
Nigerian Journal of Clinical Practice , 2012,
Abstract: Objective: The objective was to evaluate the results of surgery of Blount diseases using the postoperative metaphysealdiaphyseal angle (MDA) at 2-year follow-up. Background: The goal of surgery in Blount disease is to restore the normal configuration of the articular surface of the proximal end of the tibia in proper relationship to the mechanical axis of the limb. Our hypothesis is that patients will demonstrate significant clinical improvements following surgery and predictive models can be developed. Materials and Methods: All patients who had surgery for Blount disease from January 2002 till December 2007 at the National Orthopaedic Hospital Lagos Nigeria and follow-up for 2 years were included. Data extracted were gender, affected limb, Blount’s type, age when deformity was noted, and age at presentation, preoperative femoral tibial angle (TFA), Langenskiold score, preoperative MDA, and postoperative MDA. Linear regression was used to assess the predictive effect of selected clinical and radiographic measures on post-MDA. The model was adjusted for confounders: age deformity noted, age at presentation, affected limb, Blount’s type, and gender. Variables in the adjusted model achieving significance at P < 0.05 were included in a multiple regression analysis. Results: Eighty-six knees in 57 patients were included. The mean preoperative and postoperative MDA at 2 years was 34.6° ± 8.9° and 10.6° ± 4.3°, respectively. Seventy-three knees (84.9%) have correction of ≤10° with recurrence in 13 (15.1%) knees at 2 years (P < 0.001). The postoperative MDA was graded into good outcome if ≤10°. There was a significant improvement between preoperative MDA and postoperative MDA (P < 0.001). The multilinear analysis demonstrated that the preoperative MDA was a significant predictor of the postoperative MDA. The postoperative MDA was predicted with a standard error of 0.92 with the following formula: post-MDA = 1.027 + 0.404 pre-MDA. Conclusion: The mean postoperative MDA of 84.9% of the knees operated at 2 years was 9.4° ± 3.1° with recurrence rate of 15.1%. Postoperative MDA is a good outcome measure for surgical treatment of Blount disease and surgical correction should aim at producing post MDA ≤10°.
HISTOPATHOLOGICAL AND CYTOLOGICAL ANALYSIS OF TRANSMISSIBLE VENEREAL TUMOR IN DOGS AFTER TWO TREATMENT PROTOCOLS
Fabiana Aguena Sales Lapa,Silvia Franco Andrade,Eduardo Roberto Gervazoni,Vanessa Massumi Kaneko
Colloquium Agrariae , 2012, DOI: 10.5747/ca.2012.v08.n1.a077
Abstract: The transmissible venereal tumor (TVT) is a contagious neoplasm of round cells that frequently affect dogs. The treatment consists of chemotherapy being more effective the vincristine alone, however the resistance emergence to this agent due multidrug resistance of the P-glycoprotein (P-gp), a transporter protein encoded by the MDR1 gene, has been taking the association with other drugs. Recent studies demonstrated the antitumoral effect of the avermectins when associated to the vincristine in the treatment of some neoplasms. Therefore, the objective of the present study was to compare the effectiveness of standard treatment of TVT with vincristine only when compared to combined treatment with vincristine and ivermectin, evaluated through number of applications of the two protocols, histopathological and cytological analysis from 50 dogs diagnosed with TVT during the period of 2007 to 2010. The combined protocol significant reduced the number of applications and cytological and histopathological findings collaborate with the hypothesis that the combination of vincristine and ivermectin promotes faster healing than the use of vincristine alone. Combination treatment with vincristine and ivermectin could be in the future an excellent therapeutic alternative for the treatment of TVT for probably reducing the resistance to vincristine, simultaneously reducing the cost of TVT treatment and promoting a faster recovery of the dog.
Analysis of results of surgical treatment of posttraumatic stiff elbow  [cached]
Rex Chandrabose,Suresh Kumar P,Srimannarayana Addagalla,Chugh S
Indian Journal of Orthopaedics , 2008,
Abstract: Background: Surgical management of posttraumatic elbow stiffness has been reported with poor outcome following treatment. Sequential release in earlier stages of stiffness yielded much better results. The goal of our study was to assess the outcome in improvement of the range of motion of the elbow after surgical release and to analyze a tailor-made approach according to individual needs to yield good result. Materials and Methods: A prospective study was conducted in 47 cases of elbow stiffness due to various types of injuries. All the cases were treated with sequential release if there was no progress after adequate supervised conservative management except in unreduced dislocations. All the cases were followed up for a minimum period of 24 months. Overall outcome was rated with the functional scoring system by Mayo Clinic Performance Index. Results: Twenty-five (44.68%) out of 47 patients had excellent results with a mean preoperative range of motion of 33.9° and postoperative range of motion of 105° with net gain in range of motion of 71.1° (′ t ′ test value is 19.27, P < 0.01). None of the patients had elbow instability. Patients not having heterotopic ossification, who underwent surgery from three to six months post injury had a mean gain of 73.5°. In patients who waited for more than six months had mean gain of 66.8°. However, the results in cases having heterotopic ossification followed a slightly different pattern. In cases where release was performed from three months to six months had mean gain of 77.5°. Cases in which release was performed after six months had gain of 57.1°. Conclusions: In cases of posttraumatic elbow stiffness after a failed initial conservative treatment, early arthrolysis with sequential surgical soft tissue release yields good result than delayed surgery.
Sebaceous adenoma in the region of the medial canthus causing proptosis.  [cached]
Bhattacharya A,Nayak S,Kirtane M,Ingle M
Journal of Postgraduate Medicine , 1995,
Abstract: A case of sebaceous adenoma in the region of the medial canthus causing proptosis is presented along with a review of the medical literature. The clinicopathological aspects of the tumour are discussed. The mode of treatment was surgical excision. A six month follow-up showed a reduction in the proptosis with no recurrence.
Surgical treatment of esophageal leiomyoma: an analysis of our experience
Priego,P.; Lobo,E.; Rodríguez,G.; Alonso,N.; Gil Olarte,M. A.; Pérez de Oteyza,J.; Fresneda,V.;
Revista Espa?ola de Enfermedades Digestivas , 2006, DOI: 10.4321/S1130-01082006000500005
Abstract: introduction: leiomyoma is the most common benign esophageal neoplasm. surgical treatment (enucleation) has traditionally been the therapy of choice. the advent of minimally invasive techniques has produced an increase in endoscopic approaches to the detriment of open surgery. objective: the aim of this study was to compare the results obtained with open surgery and with laparoscopic surgery in this kind of pathology. material and methods: we performed a retrospective study of all leiomyomas operated for in our center between 1986 and 2004, and obtained 9 cases of esophageal leiomyoma. four were women and five men, between the ages of 40 and 70, with a mean age of 53.5 years. the most frequent symptoms were heartburn (5 cases), dysphagia (3 cases), and retrosternal pain (3 cases). surgery was in all the cases an enucleation. an open approach was performed in 5 cases (3 thoracotomies and 2 laparotomies), and an endoscopic approach in 4 (2 thoracoscopies and 2 laparoscopies). results: the mean postoperative hospital stay was 5.12 days (range 2-8 days). this was shorter for endoscopic approaches versus open surgery (3.25 vs. 7 days). there was no case of esophageal mucosal perforation or reconversion. no death, intraoperative complication, or tumor relapse was described. only 2 patients had complications: post-surgical thoracic pain, and intestinal obstruction by adhesions 8 years after surgery. conclusion: enucleation is an easier procedure and constitutes the therapy of choice for esophageal leiomyoma. this approach has to be laparoscopic. we think that muscle borders should be closed after enucleation, and that biopsy is not indicated preoperatively.
Surgical Treatment of Hemoptysis: Analysis of 17 Cases  [PDF]
Ufuk ?obano?lu,Fuat Say?r,Bünyamin Serto?ullar?ndan Serto?ullar?ndan
Journal of Clinical and Analytical Medicine , 2012, DOI: 10.4328
Abstract: Aim: In this study, the patients who underwent surgery for hemoptysis were analyzed retrospectively. The cases were discussed with the literature. Material and Method: Seventeen patients who were admitted to our hospital and underwent surgery for hemoptysis between 2004 and 2010, were retrospectively reviewed. Age, gender, underlying pulmonary disease, symptoms, diagnosis, treatment type, surgical indication, morbidity, recurrence, mortality of the patients were reviewed. Results: Mean age of the 17 patients (6 women, 11 men) was 37.4713.25. The most common causes of hemoptysis were lung cancer (29.41%), active pulmonary tuberculosis, bronchiectasis and hydatid cyst (17.64%). It was the first hemoptysis attack in 12(70.59%) cases and was recurrent in 5(29.41%) cases. 6 of 17 cases (32.30%) had mild hemoptysis and in 3 of those (50%) the reason of hemoptysis was lung cancer. The most common associating symptoms were cough and weakness (44.17%). There were abnormal findings on chest radiograph of the 8 (47.05%) of the cases, while in thorax CT images of 13 (76.47%) and 7 (58.33%) of bronchoscopy. We treated these patients with posterolateral thoracotomy (12 cases) and Video-Assisted Thoracoscopic Surgery (5 cases). The morbidity was seen in 3 patients (17.64%). The mortality rate was 5.88% (n:1). Recurrence developed in 1 (5.88%) patients in this series. Discussion: As a result, the leading cause of the hemoptysis was lung cancer. It was seen that computed tomography has a higher value than fiberoptic bronchoscopy in diagnostic evaluation. Especially, if cause of hemoptysis in localized lesions, surgery should be considered a priority. Massive bleeding may require emergency surgical intervention.
Analysis of Efficacy of Surgical Treatment for IIIa Small Cell Lung Cancer  [PDF]
Xuejun DOU, Zhiyuan WANG, Liang WANG, Weiqiang LU, Yunlei MA, Shaofa XU
- , 2017, DOI: : 10.3779/j.issn.1009-3419.2017.02.03
Abstract: Background and objective Small cell lung cancer (SCLC) accounts for nearly 15% of all cases of cancer. As a type of highly invasive tumors, SCLC has high degree of malignancy, early and extensive metastasis, and is sensitive to chemotherapy and radiotherapy. The early treatment response rate of SCLC is high but it can also relapse rapidly without any treatment. Its median survival time is merely four to six months. Although many studies on SCLC have been conducted in recent years, its clinical treatment strategies have remained unchanged. The treatment of SCLC is still confined to chemotherapy regimens of etoposide plus cisplatin (EP) and other classic treatments because the surgical treatment of SCLC, particularly for IIIa treatment, has yet to reach a consensus. This study investigated the prognostic factors and clinical therapy effect in the comprehensive treatment of IIIa SCLC after surgical treatment. Methods This study was conducted through the retrospective analysis of the clinical data of 78 patients with SCLC who underwent surgical treatment in Beijing Chest Hospital affiliated to Capital Medical University between January 1995 and December 1995. Through follow-up, we performed statistical analysis of each patient’s gender, age, tumor size, lymph node metastasis, tumor-node-metastasis (TNM) staging, surgical methods, and adjuvant radiation and chemotherapy. Results The median survival in this clinical trial team was 13.93 months. Among the participants, 47 patients accepted neoadjuvant chemotherapy and their median survival were 14.25 months. By contrast, 31 patients accepted postoperative adjuvant chemotherapy and their median survival were 13.83 months. No statistical difference was observed between the two groups. Moreover, 28 patients were of single Lymph node metastasis and their median survival was 17.1 months. By contrast, 50 patients were of multiple lymph node metastasis and their median survival was 11.9 months. Significant statistical difference was observed between the two groups (P<0.01). Conclusion In performing further evaluation of the status and value of surgical treatment in the comprehensive treatment of SCLC, several patients benefitted from IIIa SCLC surgery with comprehensive treatment.
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