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Effectiveness of Apricots (Prunus armeniaca), Pomegranate (Punica granatum) Juice and Lactic Acid Fermented Sobya on Plasma Levels of Lipid Profile Parameters and Total Homocysteine among Egyptian Adults  [PDF]
Laila Hussein, Emam A. Abdel-Rahim, Abd El-Moneim MR Afify, Aly Ezz El-Arab, Eid Labib
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.522236
Abstract: Objectives: The aim of this study was to investigate the effectiveness of dietary intervention with apricots, pomegranate juice or lactic acid fermented sobya on improving the plasma levels of lipid profile parameters and total plasma homocysteine (tHcy) among healthy adults. Design of the study: Thirty-five men and women (28.9 ± 3.0 years) with mean body mass index of 23.5 ± 1.2 kg/m2 were randomly assigned to a dietary intervention study. During the pre-feeding study records of 24-hour food intake, anthropometric measurements and blood sampling were collected for biochemical investigations. Thereafter the volunteers were divided into five groups: a control group (C); the other four groups received daily one of the following supplements: 200 g of deep yellow apricots (Prunus armeniaca) (AF); 250 g pomegranate (Punica granatum) juice (PJ); mixture of 100 g (PJ) and 150 g of fermented sobya (FS), (PJ-FS) or 165 g (FS). After completing the three-week dietary intervention, blood samples were collected and blood indices were again evaluated. Biochemical analysis of total lipids (TL), total glycerides (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) and tHcy were completed. The low density lipoprotein-cholesterol level and three indices of risk factors were calculated using the appropriate equations. Results: Three-week dietary intervention improved the levels of lipid profile parameters TG, TC, HDL-C and LDL-C as compared to the respective baseline levels and the response of the control group that did not receive any supplement. Consuming (PJ-FS) had a synergistic beneficially added value on some of the above mentioned lipid profile parameters. The mean plasma tHcy concentrations; a marker for occlusive vascular disease was reduced significantly following the three week consumption of (PJ) or (FS), compared with the respective pre-feeding levels. Conclusion: Pomegranate juice (PJ) or lactic acid fermented sobya (FS) or mixture of both are potential natural agents in lowering the plasma levels of lipid profile parameters and tHcy among apparently healthy young women and men, without dyslipidemic symptoms.
Antimicrobial Ellagitannin of Punica granatum Fruits
Machado, Thelma de B.;Leal, Ivana C. R.;Amaral, Ana Claudia F.;Santos, Kátia R. N. dos;Silva, Marlei G. da;Kuster, Ricardo M.;
Journal of the Brazilian Chemical Society , 2002, DOI: 10.1590/S0103-50532002000500010
Abstract: the ethyl acetate extract of punica granatum fruits was fractionated by chromatographic techniques to afford the ellagitannin punicalagin. the substance was found to be active against methicillin-resistant staphylococcus aureus strains and was identified by hplc/uv and 1hnmr. the antibacterial assays which guided the isolation of the tannin were conducted using the disc diffusion method. minimum inhibitory concentration (mic) was determined by the dilution method according to nccls (national committee for clinical laboratory standards) procedure.
Antimicrobial Ellagitannin of Punica granatum Fruits  [cached]
Machado Thelma de B.,Leal Ivana C. R.,Amaral Ana Claudia F.,Santos Kátia R. N. dos
Journal of the Brazilian Chemical Society , 2002,
Abstract: The ethyl acetate extract of Punica granatum fruits was fractionated by chromatographic techniques to afford the ellagitannin punicalagin. The substance was found to be active against methicillin-resistant Staphylococcus aureus strains and was identified by HPLC/UV and 1HNMR. The antibacterial assays which guided the isolation of the tannin were conducted using the disc diffusion method. Minimum inhibitory concentration (MIC) was determined by the dilution method according to NCCLS (National Committee for Clinical Laboratory Standards) procedure.
Pharmacological Characterization and Beneficial Uses of Punica granatum  [PDF]
Nakuleshwar Dut Jasuja,Richa Saxena,Subhash Chandra,Richa Sharma
Asian Journal of Plant Sciences , 2012,
Abstract: Punica granatum L. commonly known as Pomegranate belongs to the Family Punicaceae. Pomegranate has been known to be a reservoir of secondary metabolites which are being exploited as source of bioactive substance for various pharmacological purposes. Many researchers have focused their interest to investigate the bioactive compounds of Punica granatum for human health. In order to facilitate the further investigation and exploit the said plant, this study summarized herein the research achievements on some of the phytochemical and pharmacological properties of Punica granatum. The different types of phytochemicals have been identified from various parts of the pomegranate tree and from pomegranate juice, leaves, flower, fruits and seeds. The constituents of this plant were thoroughly reviewed discussed based on literatures.
P. P. Lasure*, N. M. Munot and S. S. Lawande
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Punica granatum L. belongs to the family Punicaceae, which is originating from the Middle East, extending throughout the Mediterranean, eastward to China and India. Punica granatum has been used extensively as a traditional medicine in many countries for the treatment of dysentery, diarrhea, helminthiasis, acidosis, hemorrhage and respiratory pathologies. In addition, P. granatum is reported to have antioxidant, anti-atherosclerotic and antiviral properties. The dried pomegranate peels (20gms) were extracted using water (100ml) & ethanol (100 ml). The Ethanolic Extract of Punica granatum (EPG) was active against the tested bacteria. EPG demonstrated promising antibacterial activity against tested gram positive and gram negative bacteria. The E. coli and S. aureus shows more susceptibility to EPG.
Assessment of mutagenic and antimutagenic effects of Punica granatum in mice
Valadares, Marize Campos;Pereira, Enir Raquel Tavares;Benfica, Polyana Lopes;Paula, José Realino;
Brazilian Journal of Pharmaceutical Sciences , 2010, DOI: 10.1590/S1984-82502010000100014
Abstract: in the present study, the ability of punica granatum ethanolic leaf extract (pgl) and punica granatum ethanolic fruit extract (pgf) to induce mutagenicity or to modulate the genotoxic effects induced by the alkylating agent cyclophosphamide (cp) was evaluated. swiss male mice were treated by gavage for 10 days with pgl or pgf (12.5, 25, 50, and 75 mg/kg/day) prior to exposure to cp (i.p. 200 mg/kg), 24 h after the end of the treatment. initial observations revealed that normal mice treated with both extracts (12.5, 25, 50, and 75 mg/kg/day) showed a similar micronucleated polychromatic erythrocyte (mnpce) frequency to that of the control group. investigation of the protective effect of pgl and pgf based on data analysis revealed that, irrespective of dose or extract, oral administration of pgl or pgf for 10 days prior to exposure had reduced, in a dose-dependent manner, the frequency of mnpce induced by cp in all groups studied. higher reductions were observed at pgf doses of 50 and 75 mg/kg. taken together, these results demonstrate that mice treated with p. granatum showed an absence of mutagenic effects and dose-dependent protective effects against cp-induced oxidative dna damage.
Neelam Arun* and D. P. Singh
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: A wide range of medicinal plant parts is used as raw drugs and they possess varied medicinal properties. The different parts used as raw drugs include root, stem, flower, fruit, twigs exudates and modified plant organs. The Punica granatum is a native shrub of occidental Asia and Mediterranean Europe that has a rich history of traditional use in medicine. For centuries, the barks, leaves, flowers, fruits, and seeds of this plant have been used to treat various diseases. The aim of this present review is to throw light on the therapeutic utility of various parts of pomegranate.
Isolation and Characterization of Novel Microsatellite Markers in Pomegranate (Punica granatum L.)  [PDF]
Seyed Mostafa Pirseyedi,Sahar Valizadehghan,Mohsen Mardi,Mohammad Reza Ghaffari,Parvaneh Mahmoodi,Mehdi Zahravi,Mehrshad Zeinalabedini,Seyed Mojtaba Khayam Nekoui
International Journal of Molecular Sciences , 2010, DOI: 10.3390/ijms11052010
Abstract: Pomegranate ( Punica granatum L.) has been cultivated from ancient times for its economic, ornamental and medicinal properties globally. Here, we report the isolation and characterization of 12 polymorphic microsatellite markers from a repeat-enriched genomic library of Punica granatum L. The genetic diversity of these loci was assessed in 60 genotypes of Punica granatum L. All loci were variable: the number of polymorphic alleles per locus ranged from two to five (average 2.9). The observed and expected heterozygosities ranged from 0.15 to 0.87 and 0.29 to 0.65, respectively. The polymorphic information content ranged from 0.26 to 0.61 (average: 0.43). To the best of our knowledge, this is the first time that polymorphic microsatellite markers have been reported for P. granatum L. These new markers should allow studies of the population structure and genetic diversity of pomegranate to be performed in the future.
Analgesic activity of various extracts of Punica granatum (Linn) flowers  [cached]
Chakraborthy Guno
International Journal of Green Pharmacy , 2008,
Abstract: The extracts of flowers of Punica granatum (Linn). (N.O. Family Punicaceae) were investigated for analgesic activity in mice using hot plate method. The flowers of Punica granatum (Linn) were collected from the local market of Mumbai, Maharashtra and were in a dried condition. The dried powdered flowers (500 gm) were extracted in a soxhlet apparatus by using different solvents. Mice weighing 15-25 gm were taken for the experiment. The reaction time of animals in all the groups was noted at 30, 60 and 120 min after drug administration. All data were analyzed with Student-t test. The various extract of the flowers of Punica granatum (Linn) showed significant analgesic activity at a dose of 50 mg/kg body weight. A maximum analgesic activity was found at 60 min, after drug administration, which was equivalent to the standard drug used as morphine sulphate.
Garachh Dipak,Patel Axay,Chakraborty Manodeep,Kamath Jagdish V
International Research Journal of Pharmacy , 2012,
Abstract: The pomegranate, Punica granatum belongs to family lythraceae is an ancient, mystical, unique fruit borne on a small, long-living tree cultivated throughout the Mediterranean region, as far north as the Himalayas, in Southeast Asia, and in California and Arizona in the United States. Phytochemical investigation for current research seems to indicate the most therapeutically beneficial pomegranate constituents are ellagic acid ellagitannins (including punicalagins), punicic acid, flavonoids, anthocyanidins, anthocyanins, and estrogenic flavonols and flavones. Pharmacological activity proved its an antioxidant, an anticarcinogenic, and an anti-inflammatory properties of pomegranate constituents have been published, focusing on treatment and prevention of cancer, cardiovascular disease, diabetes, dental conditions, erectile dysfunction, bacterial infections and antibiotic resistance and ultraviolet radiation-induced skin damage. Other potential applications include infant brain ischemia, male infertility, Alzheimer’s disease, arthritis and obesity.
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